公开(公告)号：US3506679A

公开(公告)日：1970-04-14

申请号：US3506679D

申请日：1968-05-27

申请人： WYETH JOHN & BROTHER LTD

发明人： CAVALLA JOHN F ,  BROWN KEVAN

IPC分类号： A61K31/00 ,  A61M25/02 ,  C07D263/32 ,  C07D277/22 ,  C07D277/24 ,  C07D277/30 ,  C07D91/32

CPC分类号： C07D277/22 ,  A61K31/00 ,  A61M25/02 ,  C07D263/32 ,  C07D277/24 ,  C07D277/30

公开(公告)号：US3845073A

公开(公告)日：1974-10-29

申请号：US25667472

申请日：1972-05-25

申请人： WYETH JOHN & BROTHER LTD

发明人： NEWBERRY R

IPC分类号： C07D209/60 ,  C07D27/56

CPC分类号： C07D209/60

摘要： 1. A COMPOUND HAVING THE FORMULA

2-R3,3-(R-OOC-CH2-)-1H-BENZ(G)INDOLE

WHEREIN R3 REPRESENTS A MONOHALOPHENYL RADICAL AND IN WHICH R REPRESENTS HYDROGEN OR LOWER ALKYL.

公开(公告)号：US3743656A

公开(公告)日：1973-07-03

申请号：US3743656D

申请日：1971-09-15

申请人： WYETH JOHN & BROTHER LTD

发明人： BROWN K ,  CAVALLA J

IPC分类号： C07C45/46 ,  C07C49/813 ,  C07C59/88 ,  C07D207/32 ,  C07D207/337 ,  C07D307/38 ,  C07D307/42 ,  C07D307/54 ,  C07D307/68 ,  C07D63/12

CPC分类号： C07D207/337 ,  C07C45/46 ,  C07C49/813 ,  C07C59/88 ,  C07D307/38 ,  C07D307/42 ,  C07D307/54 ,  C07D307/68

摘要： THE INVENTION CONCERNS DIARYL FURAN AND THIOPHENE LOWER ALKANOIC ACIDS AND DERIVATIVES WHICH ARE PHARMACOLOGICALLY EFFICACIOUS AS ANTI-INFLAMMATORY AGENTS.

公开(公告)号：US3729465A

公开(公告)日：1973-04-24

申请号：US3729465D

申请日：1971-02-03

申请人： WYETH JOHN & BROTHER LTD

发明人： CAVALLA J ,  WHITE A

IPC分类号： C07D223/04 ,  C07D41/04

CPC分类号： C07C255/00

摘要： A NEW GROUP OF SUBSTITUTED HEXAHYDROAZEPINES USEFUL AS ANALGESICS IS DESCRIBED. THESE COMPOUNDS ARE SUBSTITUTED AT EITHER POSITION 3 OR 4 BY A LOWER ALKYL GROUP AND A M-OXYGENATED PHENYL RADICAL (SUCH AS M-HYDROXYPHENYL, M - METHOXYPHENYL, M - BENZYLOXYPHENYL, OR M-ACYLOXYPHENYL), OPTIONALLY SUBSTITUTED AT POSITION 2 BY A LOWER ALKYL RADICAL, AND OPTIONALLY SUBSTITUTED AT POSITION 1 BY LOWER ALKYL, LOWER ALKENYL, LOWER ALKYNYL, CYCLOPROPYLMETHYL, LOWER ALKANOYL, OR BY RING-SUBSTITUTED OR UNSUBSTITUTED PHENETHYL, PHENACYL, OR B-BENZOYLETHYL.

公开(公告)号：US3644399A

公开(公告)日：1972-02-22

申请号：US3644399D

申请日：1969-05-01

申请人： WYETH JOHN & BROTHER LTD

发明人： BROWN KEVAN ,  CAVALLA JOHN FREDERICK

IPC分类号： C07D207/333 ,  C07C59/84 ,  C07C59/88 ,  C07D207/32 ,  C07D207/337 ,  C07D307/54 ,  C07D333/24 ,  C07D27/26

CPC分类号： C07D207/337 ,  C07C59/84 ,  C07C59/88 ,  C07D307/54 ,  C07D333/24 ,  Y10S514/96 ,  Y10S514/962

摘要： THE INVENTION CONCERNS DIARYL FURAN, THIOPHENE, AND PYRROLE LOWER ALKANOIC ACIDS AND DERIVATIVES WHICH ARE PHARMACOLOGICALLY EFFICACIOUS AS ANTI-INFLAMMATORY AGENTS.

公开(公告)号：US3621028A

公开(公告)日：1971-11-16

申请号：US3621028D

申请日：1969-04-08

申请人： WYETH JOHN & BROTHER LTD

发明人： NEWBERRY ROBERT ANTHONY

IPC分类号： C07D277/10 ,  C07D277/14 ,  C07D277/30 ,  C07D277/32

CPC分类号： C07D277/30 ,  C07D277/10 ,  C07D277/14

摘要： This invention concerns 2-cycloalkyl or aryl-4-hydroxy-2thiazoline-4 and 5-alkanoic acids which are pharmacologically efficacious as anti-inflammatory agents and which are useful as intermediates in the preparation of the corresponding thiazoles.

公开(公告)号：US3576845A

公开(公告)日：1971-04-27

申请号：US3576845D

申请日：1967-11-14

申请人： WYETH JOHN & BROTHER LTD

发明人： CAVALLA JOHN F ,  WHITE ALAN C ,  SANDISON GILLIAN M

IPC分类号： A61K31/27 ,  C07C333/02 ,  C07C125/06

CPC分类号： A61K31/27 ,  C07C333/02

摘要： A GROUP OF ACETYLENICALLY- (E.G., PROPARGYL-) SUBSTITUTED ARALKYL CARBAMATES AND THIOCARBAMATES IS DESCRIBED. REPRESENTATIVE MEMBERS OF THIS GROUP EXHIBIT ANTI-INFLMMATORY ACTIVITY WHEN TESTED ON LABORATORY ANIMALS ACCORDING TO STANDARD TEST PROCEDURES.

公开(公告)号：US3574228A

公开(公告)日：1971-04-06

申请号：US3574228D

申请日：1968-06-12

申请人： WYETH JOHN & BROTHER LTD

发明人： BROWN KEVAN

IPC分类号： A61K31/00 ,  C07D263/32 ,  C07D277/22 ,  C07D277/24 ,  C07D277/30 ,  C07D85/44

CPC分类号： C07D277/22 ,  A61K31/00 ,  C07D263/32 ,  C07D277/24 ,  C07D277/30

摘要： IT HAS BEEN FOUND THAT A SMALL GROUP OF 2-ARYL OXAZOLES, NAMELY, 2,5-DIPHENYLOXAZOL-4-YLACETIC ACID, 2-(P-CHLOROPHENYL)-OXAZOL-4-YLACETAMIDE, 2-(P-CHLOROPHENYL)OXAZOL4-YLACETIC ACID, AND 2,4-DIPHENYLOXAZOL-5-YLACETIC ACID, HAVE ANTINFLAMMATORY ACTION AS SHOWN BY STANDARD PHARMACOLOGICAL TESTS ON LABORATORY ANIMALS, AND ARE THEREFORE OF VALUE IN EXPERIMENTAL PHARMACOLOGY AND THERAPY FOR THE CONTROL, PREVENTION, AND RELIEF OF INFLAMMATION.

公开(公告)号：US3573320A

公开(公告)日：1971-03-30

申请号：US3573320D

申请日：1968-07-24

申请人： WYETH JOHN & BROTHER LTD

发明人： JANSEN ALEXANDER B A ,  HOLLOWOOD JOHN

IPC分类号： C07D263/58 ,  C07D277/82 ,  C07D91/46

CPC分类号： C07D263/58 ,  C07D277/82

摘要： ANILIDES OF THE GENERAL FORMULA

R1-X-(PHENYLENE)-N(-R2)-CO-R3 AND

1,2-(-X-C(-N(-R2)-CO-R3)=N-)BENZENE

1,2-(-X-C(-N=C(-R3)-O-R2)=N-)BENZENE

AND ACID ADDITION SALTS THEREOF, IN WHICH X IS OXYGEN OR SULPHUR, R1 IS A METHYL RADICAL WITH THE PROVISO THAT, WHEN X IS A SULPHUR ATOM, R1 IS SELECTED FROM METHYL RADICALS AND RADICALS OF THE FORMULA

-S-(PHENYLENE)-N(-R2)-CO-R3

R2 IS A

-(CH2)N-N(-R4)-R5

RADICAL WHERE N IS A WHOLE NUMBER FROM 2 TO 3 AND R4 AND R5 EACH REPRESENT A HYDROGEN ATOM OR AN ALKYL RADICAL OR TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED COMPLETE A MORPHOLINE, PIPERIDINE, PYRROLIDINE OR PIPERAZING RING SYSTEM, AND R3 IS AN ALKYL, ARYL, ARALKYL OR ARALKENYL RADICAL, ARE EFFECTIVE AS ANTI-DEPRESSANT AGENTS.

公开(公告)号：US3532705A

公开(公告)日：1970-10-06

申请号：US3532705D

申请日：1967-11-02

申请人： WYETH JOHN & BROTHER LTD

发明人： CAVALLA JOHN FREDERICK ,  BROWN KEVAN

IPC分类号： C07D277/22 ,  C07D277/30 ,  C07D91/32

CPC分类号： C07D277/30