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49 条记录 (耗时 0.017 秒)

    2-Benzyl aziridines
    1.
    发明授权
    2-Benzyl aziridines 失效
    2-苄基氮丙啶

    公开(公告)号：US3925360A

    公开(公告)日：1975-12-09

    申请号：US42203173

    申请日：1973-12-05

    申请人： WYETH JOHN & BROTHER LTD

    发明人： JACKSON JOHN LAMBERT

    IPC分类号： C07D203/08

    CPC分类号： C07D203/08 ,  Y10S514/91

    摘要： Aziridines of the formula (I)

    and the pharmaceutically acceptable acid addition salts thereof, in which Ar is a phenyl group optionally substituted by one or more hydroxy, halo, lower alkyl, lower alkoxy, halo(lower)alkyl, nitro, amino or mono- or di-(lower)alkyl-amino groups and R is hydrogen or lower alkyl possess anorectic properties. The appetite of a mammal may be inhibited by administering to it an aziridine of formula (I) or a pharmaceutically acceptable acid addition salt thereof. Aziridines of formula (I) in which Ar and R have the above defined meanings with the proviso that R is lower alkyl when Ar is phenyl, p-chlorophenyl or p-methoxyphenyl are novel compounds.

    摘要翻译： 式（I）Ar-CH 2 -CH-CH 2（I）ANGLE NR的吡咯烷酮及其药学上可接受的酸加成盐，其中Ar是任选被一个或多个羟基，卤素，低级烷基，低级烷氧基 ，卤代（低级）烷基，硝基，氨基或单 - 或二 - （低级）烷基 - 氨基，R为氢或低级烷基具有无穷极性。 通过向其施用式（I）的氮丙啶或其药学上可接受的酸加成盐，可以抑制哺乳动物的食欲。 其中Ar和R具有上述定义含义，条件是当Ar为苯基，对氯苯基或对甲氧基苯基时，R为低级烷基的式（I）的氮杂环丁烷为新化合物。

    Thiazole penicillins
    2.
    发明授权
    Thiazole penicillins 失效
    噻唑青霉素

    公开(公告)号：US3905961A

    公开(公告)日：1975-09-16

    申请号：US32491573

    申请日：1973-01-19

    申请人： WYETH JOHN & BROTHER LTD

    发明人： ARCHIBALD JOHN LEHEUP

    IPC分类号： C07D499/00 ,  C07D499/46

    CPC分类号： C07D499/00

    摘要： Acylation of 6-aminopenicillanic acid with oxazole or thiazole compounds of formula

    IN WHICH A is an ethylene or a trimethylene radical, R1 is an aryl radical or a cycloalkyl radical, and R2 is a hydrogen atom, an amino group or a lower alkyl or aryl radical, and X is oxygen or sulphur, produces synthetic penicillins useful by reason of their effectiveness against a variety of Gram-positive and Gramnegative bacteria.

    摘要翻译： 6-氨基青霉烷酸用式IN的恶唑或噻唑化合物的酰化，其中A是亚乙基或三亚甲基，R 1是芳基或环烷基，R 2是氢原子，氨基或低级烷基或芳基 自由基，X是氧或硫，由于其对各种革兰氏阳性和革兰氏阴性细菌的有效性而产生合成的青霉素。

    Wax-coated and micronized acetoxymethyl benzylpenicillinate
    5.
    发明授权
    Wax-coated and micronized acetoxymethyl benzylpenicillinate 失效
    紫外线涂布和微量化乙酰氧基苯乙烯

    公开(公告)号：US3639605A

    公开(公告)日：1972-02-01

    申请号：US3639605D

    申请日：1968-07-23

    申请人： WYETH JOHN & BROTHER LTD

    发明人： RULE ARTHUR W T ,  SHIMMIN ROY E ,  LAUNDY TIMOTHY

    IPC分类号： A61K9/16 ,  A61K31/43 ,  C07D499/32 ,  A61K27/00

    CPC分类号： A61K31/43 ,  A61K9/1617

    摘要： ACETOXYMETHYL BENZYLPENICILLINATE OF IMPROVED PROPERTIES IN RESPECT TO EASE OF HANDLING AND BLOOD LEVELS ATTAINABLE IS PREPARED BY MICRONIZING THE KNOWN (BULK) PRODUCT; PREFERABLY THE MICRONIZED PRODUCT IS ALSO ADMIXED OR COATED WITH A COMPATIBLE AND PHARMACEUTICALLY ACCEPTABLE WAX. THE NOVEL PRODUCT MAY BE ADMINISTERED AS AN AQUEOUS SUSPENSION OR AS A SOLID IN CAPSULES OR TABLETS. DESIRABLY HIGHER BLOOD LEVELS OF PENCILLIN RESULT FOR ITS ADMINISTRATION THAN ARE ACHIEVED BY USE OF THE PRIOR ART UNMICRONIZED ACETOXYMETHYL BENZYLPENICILLINATE.

    Oxazoles
    7.
    发明授权
    Oxazoles 失效
    OXAZOLES

    公开(公告)号：US3578671A

    公开(公告)日：1971-05-11

    申请号：US3578671D

    申请日：1967-11-06

    申请人： WYETH JOHN & BROTHER LTD

    发明人： BROWN KEVAN

    IPC分类号： C07D263/32 ,  C07D85/44 ,  C07D99/02

    CPC分类号： C07D263/32

    摘要： A CLASS OF OXAZOLE-2-POLYCARBON ALIPHATIC MONOCARBOXYLIC ACIDS ARYLATED AT THE 4- AND/OR 5-POSITIONS IN THE OXAZOLE RING IS DESCRIBED. COMPOUNDS OF THIS CLASS ARE ACTIVE ANTI-INFLAMMATORY AGENTS.