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公开(公告)号：US20220106281A1
公开(公告)日：2022-04-07
申请号：US17108416
申请日：2020-12-01
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Lawrence A. Black , Xiangdong Xu , Ramzi Farah Sweis , Lei Shi , Qingwei Zhang , Yunsong Tong , Charles W. Hutchins , SeungWon Chung , Michael J. Dart
IPC: C07D307/82 , C07D213/74 , C07D231/14 , C07D237/10 , C07D241/12 , C07D241/44 , C07D261/08 , C07D277/32 , C07D213/57 , C07D307/56 , C07C233/74 , C07D213/54 , C07C235/54 , C07C233/79 , C07C255/41 , C07C255/57 , C07C235/14
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20210393599A1
公开(公告)日：2021-12-23
申请号：US16761388
申请日：2018-11-02
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , Lei Shi , Qingwei I. Zhang , Zhaoming Xiong , Ramzi Farah Sweis , Michael J. Dart , Kathleen J. Murauski
IPC: A61K31/44 , A61K45/06 , C07C237/24 , C07D213/40 , C07D241/12 , C07D261/08 , C07D277/28 , C07D213/64 , C07D263/32 , C07D231/12 , C07D213/71 , C07D307/52 , C07C323/40 , C07D213/85 , C07D213/75 , C07D271/06 , C07D405/12 , C07D401/12 , C07D239/47 , C07D233/64 , C07D333/20 , C07D471/04 , C07D237/14 , C07C311/46 , C07D235/14 , C07D239/34 , C07D471/08 , C07D493/08 , A61K31/165 , A61K31/4402 , A61K31/4965 , A61K31/426 , A61K31/42 , A61K31/4409 , A61K31/421 , A61K31/415 , A61K31/4406 , A61K31/341 , A61K31/4245 , A61K31/443 , A61K31/444 , A61K31/505 , A61K31/437 , A61K31/381 , A61K31/4045 , A61K31/4184 , A61K31/50 , A61K31/18 , A61K31/439 , A61K31/35 , A61P25/28
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20210205277A1
公开(公告)日：2021-07-08
申请号：US16761349
申请日：2018-11-02
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , Zhaoming Xiong , Michael J. Dart
IPC: A61K31/4245 , A61K45/06 , C07D271/10 , C07D207/33 , C07D263/32 , C07D271/06 , C07D233/64 , C07D231/12 , A61K31/40 , A61K31/4164 , C07D413/12 , A61K31/415 , A61P25/28
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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Patent Agency Ranking
公开(公告)号：US20200347033A1
公开(公告)日：2020-11-05
申请号：US16761394
申请日：2018-11-02
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , Lei Shi , SeungWon Chung , Zhaoming Xiong , Kathleen J. Murauski , Qingwei I. Zhang , Brian S. Brown , Michael J. Dart
IPC: C07D403/12 , C07D207/273 , C07D401/04 , C07D401/12 , C07D239/88 , C07D413/12 , C07D263/22 , C07D265/10 , C07D209/48 , C07D405/14 , C07D405/10 , C07D209/46
Abstract: Provided herein are compounds of Formula (I) or Formula (II), compositions, and methods there of useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：US20190194135A1
公开(公告)日：2019-06-27
申请号：US16098946
申请日：2017-05-05
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Lawrence A. Black , Xiangdong Xu , Ramzi Farah Sweis , Lei Shi , Qingwei I. Zhang , Yunsong Tong , Charles W. Hutchins , Seungwon Chung , Michael J. Dart
IPC: C07D213/42 , C07D261/08 , C07D231/12 , C07D241/12 , C07D213/89 , C07D271/10 , C07D307/36 , C07D277/28 , C07D471/04 , C07D333/20 , C07D209/14 , A61K31/44 , A61K31/42 , A61K31/415 , A61K31/4965 , A61K31/4245 , A61K31/341 , A61K31/426 , A61K31/4439 , A61K31/381 , A61K31/4045 , C07D263/32 , A61K31/421 , C07D235/00 , A61K31/417 , C07D239/34 , A61K31/505 , C07D237/08 , A61K31/50 , C07C235/22 , A61K31/197 , C07C311/16 , A61K31/18 , C07C323/09
CPC classification number: C07D213/42 , A61K31/18 , A61K31/197 , A61K31/341 , A61K31/381 , A61K31/4045 , A61K31/415 , A61K31/417 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/44 , A61K31/4439 , A61K31/4965 , A61K31/50 , A61K31/505 , C07C235/22 , C07C311/16 , C07C323/09 , C07C2602/38 , C07C2602/40 , C07C2602/42 , C07C2602/44 , C07C2603/90 , C07D209/14 , C07D213/40 , C07D213/64 , C07D213/89 , C07D231/12 , C07D235/00 , C07D237/08 , C07D239/34 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/07 , C07D271/10 , C07D277/28 , C07D307/36 , C07D307/52 , C07D333/20 , C07D471/04
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20190135772A1
公开(公告)日：2019-05-09
申请号：US16098679
申请日：2017-05-05
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Lawrence A. Black , Xiangdong Xu , Ramzi Farah Sweis , Lei Shi , Qingwei I. Zhang , Yunsong Tong , Charles W. Hutchins , Seungwon Chung , Michael J. Dart
IPC: C07D307/82 , C07D307/56 , C07D277/32 , C07D261/08 , C07D241/44 , C07D241/12 , C07D237/10 , C07D231/14 , C07D213/74 , C07D213/57
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20180243298A1
公开(公告)日：2018-08-30
申请号：US15563888
申请日：2016-03-30
Applicant: AbbVie Inc.
Inventor： Lawrence Black , Brian S. Brown , Bruce Clapham , Marlon D. Cowart , Michael J. Dart , Ramin Faghih , Jennifer Frost , Arthur R. Gomtsyan , Philip R. Kym , Huaqing Liu , Robert G. Schmidt , Lei Shi , Anurupa Shrestha , Kevin Sippy
IPC: A61K31/506 , A61P17/06 , A61P17/04
CPC classification number: A61K31/506 , A61P17/04 , A61P17/06 , C07D417/12 , C07D417/14 , C07D491/048 , C07D491/107
Abstract: A compound of Formula (I) having efficacy for the treatment or prevention of conditions and disorders related to TRPV3 activity, e.g. pain, atopic dermatitis, eczema, itch or psoriasis, is disclosed. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
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38.发明申请公开(公告)号：US20150231141A1
公开(公告)日：2015-08-20
申请号：US14628131
申请日：2015-02-20
Applicant: AbbVie Inc.
Inventor： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
IPC: A61K31/5377 , A61K31/4439 , A61K31/428 , A61K31/427 , A61K31/506 , A61K31/426 , A61K31/4709
CPC classification number: A61K31/429 , C07D277/46 , C07D277/48 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D493/08 , C07D513/04
Abstract: The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L2, are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，前药，前体药物或其组合的盐，其中R1，R2，R3，R4和L2在说明书中定义，包含这些化合物的组合物， 以及使用这些化合物和组合物治疗病症和病症的方法。
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