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公开(公告)号：US09617226B2
公开(公告)日：2017-04-11
申请号：US14845727
申请日：2015-09-04
发明人： Wilfried Braje , Jayne Froggett , Hervé Geneste , Wilfried Hornberger , Katja Jantos , Andreas Kling , Marcel van Gaalen
IPC分类号： C07D239/91 , C07D401/12 , C07D403/12 , C07D455/02 , C07D491/107
CPC分类号： C07D239/91 , C07D401/12 , C07D403/12 , C07D455/02 , C07D491/107
摘要： The present invention relates to novel fused heterocyclic or carbocyclic compounds of formula I wherein the variables are as defined in the claims and the description. The invention further relates to pharmaceutical compositions comprising these compounds, and to their use for the treatment of vasopressin-related disorders.
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32.发明申请OXINDOLE COMPOUNDS CARRYING A CO-BOUND SPIRO SUBSTITUENT AND USE THEREOF FOR TREATING VASOPRESSIN-RELATED DISEASES 有权携带共轭螺旋体替代物的氧化物化合物及其用于治疗相关疾病的用途公开(公告)号：US20150344489A1
公开(公告)日：2015-12-03
申请号：US14713824
申请日：2015-05-15
发明人： Wilfried Braje , Hervé Geneste , Wilfried Hornberger , Katja Jantos , Andreas Kling , Claudia Krack , Marcel Van Gaalen
IPC分类号： C07D487/10 , C07D401/14 , C07D471/10
CPC分类号： C07D487/10 , C07D209/40 , C07D213/64 , C07D295/135 , C07D305/08 , C07D401/14 , C07D471/10
摘要： The present invention relates to novel substituted oxindole derivatives of formula I wherein the variables are as defined in the claims and the description. The invention further relates to pharmaceutical compositions comprising compounds I and their use for the treatment of vasopressin-related disorders.
摘要翻译： 本发明涉及式I的新的取代的羟基吲哚衍生物，其中变量如权利要求和说明书所定义。 本发明还涉及包含化合物I及其用于治疗加压素相关病症的用途的药物组合物。
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33.发明申请Oxindole Derivatives Carrying An Oxetane Substituent and use thereof for Treating Vasopressine-Related Diseases 有权携带氧杂环丁烷取代基的羟吲哚衍生物及其用于治疗血管加压素相关疾病的用途公开(公告)号：US20140343074A1
公开(公告)日：2014-11-20
申请号：US14214154
申请日：2014-03-14
发明人： Katja Jantos , Wilfred Braje , Herve Geneste , Andreas Kling , Liliane Unger , Berthold Behl , Marcel van Gaalen , Wilfried Hornberger , Loic Laplanche , Silke Weber
IPC分类号： C07D405/14
CPC分类号： C07D405/14 , C07D487/08
摘要： The present invention relates to novel substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-related disorders.
摘要翻译： 本发明涉及新型取代的羟基吲哚衍生物，包含它们的药物组合物及其用于治疗加压素相关病症的用途。
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34.发明申请Oxindole Derivatives Carrying An Oxetane Substituent and Use Thereof For Treating Vassopressin-Related Diseases 有权携带Oxetane取代基的Oxindole衍生物及其用于治疗加压素相关疾病的用途公开(公告)号：US20140315918A1
公开(公告)日：2014-10-23
申请号：US14214264
申请日：2014-03-14
发明人： Katja Jantos , Wilfred Braje , Herve Geneste , Andreas Kling , Liliane Unger , Berthold Behl , Marcel van Gaalen , Wilfried Hornberger , Loic Laplanche , Silke Weber
IPC分类号： C07D405/14
CPC分类号： C07D405/14 , C07D487/08
摘要： The present invention relates to novel substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-related disorders.
摘要翻译： 本发明涉及新型取代的羟基吲哚衍生物，包含它们的药物组合物及其用于治疗加压素相关病症的用途。
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35.发明申请AMINOTETRALINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 有权氨基嘌呤衍生物，含有它们的药物组合物及其在治疗中的使用公开(公告)号：US20140031331A1
公开(公告)日：2014-01-30
申请号：US14031265
申请日：2013-09-19
发明人： Wilhelm Amberg , Michael Ochse , Udo Lange , Andreas Kling , Berthold Behl , Wilfried Hornberger , Mario Mezler , Charles W. Hutchins
IPC分类号： C07C311/05 , C07D233/84 , C07D231/18 , C07D213/71 , C07D409/12 , C07D207/12 , C07D275/02 , C07D205/04 , C07D403/12 , C07D401/12 , C07C271/24 , C07D333/34
CPC分类号： C07C311/05 , C07C215/64 , C07C217/74 , C07C233/18 , C07C233/19 , C07C233/69 , C07C255/58 , C07C271/24 , C07C307/06 , C07C309/65 , C07C311/07 , C07C311/09 , C07C311/10 , C07C311/13 , C07C311/14 , C07C311/17 , C07C311/18 , C07C311/20 , C07C311/24 , C07C317/18 , C07C317/28 , C07C2601/02 , C07C2601/04 , C07C2602/10 , C07D205/04 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/27 , C07D207/36 , C07D207/48 , C07D213/71 , C07D231/18 , C07D233/84 , C07D249/12 , C07D261/08 , C07D265/30 , C07D275/02 , C07D295/096 , C07D295/135 , C07D305/08 , C07D333/34 , C07D401/12 , C07D403/12 , C07D409/12 , C07F7/081
摘要： The present invention relates to aminotetraline derivatives of the formula (I) or a physiologically tolerated salt thereof.The invention relates to pharmaceutical compositions comprising such aminotetraline derivatives, and the use of such aminotetraline derivatives for therapeutic purposes. The aminotetraline derivatives are GlyT1 inhibitors.
摘要翻译： 本发明涉及式（I）的氨基四氢化萘衍生物或其生理上耐受的盐。 本发明涉及包含这种氨基四氢化萘衍生物的药物组合物，以及这种氨基四氢化萘衍生物用于治疗目的的用途。 氨基四氢叶酸衍生物是GlyT1抑制剂。
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