公开(公告)号：US3154556A

公开(公告)日：1964-10-27

申请号：US24208562

申请日：1962-12-04

Applicant: AMERICAN HOME PROD

Inventor： FREED MEIER E ,  RICE LEONARD M

IPC: C07D401/06

CPC classification number: C07D401/06

公开(公告)号：US3142678A

公开(公告)日：1964-07-28

申请号：US16524862

申请日：1962-01-09

Applicant: AMERICAN HOME PROD

Inventor： RICE LEONARD M ,  FREED MEIER E ,  ELISABETH HERTZ

IPC: C07D495/04

CPC classification number: C07D495/04

公开(公告)号：US2819952A

公开(公告)日：1958-01-14

申请号：US43346854

申请日：1954-06-01

Applicant: AMERICAN HOME PROD

Inventor： FREED MEIER E

IPC: B01F15/00

CPC classification number: B01F7/16 ,  B01F2015/0009 ,  B01F2015/0011 ,  B01F2215/0037

公开(公告)号：US2746959A

公开(公告)日：1956-05-22

申请号：US35921253

申请日：1953-06-02

Applicant: AMERICAN HOME PROD

Inventor： BRUCE WILLIAM F ,  HANSLICK ROY S ,  FREED MEIER E

IPC: C07D307/52 ,  C07D499/00 ,  C07D499/24

CPC classification number: C07D499/00 ,  C07D307/52

公开(公告)号：US3869512A

公开(公告)日：1975-03-04

申请号：US33381473

申请日：1973-02-20

Applicant: AMERICAN HOME PROD

Inventor： FREED ELISABETH H ,  FREED MEIER E ,  POTOSKI JOHN R

IPC: C07C49/755 ,  C07C91/42 ,  C07C49/76 ,  C07C93/14 ,  C07C119/14 ,  C07C131/00

CPC classification number: C07C49/755

Abstract: Dibenzobicycloalkane amines, their pharmacologically acceptable addition salts, intermediates for their preparation, and process for their use. The compounds of the invention exert analgesic activity.

Abstract translation: 二苄基双环链烷胺，其药理学上可接受的加成盐，其制备中间体及其用途。 本发明化合物发挥止痛活性。

公开(公告)号：US3869460A

公开(公告)日：1975-03-04

申请号：US34794073

申请日：1973-04-04

Applicant: AMERICAN HOME PROD

Inventor： FREED MEIER E ,  CHILDRESS SCOTT J

IPC: C07D241/08 ,  C07D51/72

CPC classification number: C07D241/08

Abstract: The disclosure is directed to substituted 3,3diphenylpiperazines, substituted 3,3-diphenylpiperazin-2-ones and related compounds. The compounds are useful as sympathomimetic agents as evidenced by their production of mydriasis in standard laboratory animals.

Abstract translation: 本公开涉及取代的3,3-二苯基哌嗪，取代的3,3-二苯基哌嗪-2-酮和相关化合物。 这些化合物可用作交感神经兴奋剂，如在标准实验室动物中产生散瞳证明的。

公开(公告)号：US3692791A

公开(公告)日：1972-09-19

申请号：US3692791D

申请日：1970-05-18

Applicant: AMERICAN HOME PROD

Inventor： POTOSKI JOHN R ,  FREED MEIER E

IPC: C07D455/02 ,  C07D39/12

CPC classification number: C07D455/02

Abstract: The disclosure is directed to 2-t-butyl-octahydro-2H quinolizines substituted in the two position and having the following formula:

Abstract translation: 本公开涉及在两个位置上取代的具有下式的2-叔丁基 - 八氢-2H-喹嗪：

公开(公告)号：US3660430A

公开(公告)日：1972-05-02

申请号：US3660430D

申请日：1969-11-04

Applicant: AMERICAN HOME PROD

Inventor： FREED MEIER E ,  BELL STANLEY C ,  WEI PETER H L

IPC: C07D209/04 ,  C07D209/12 ,  C07D27/56

CPC classification number: C07D209/04 ,  C07C255/00

Abstract: WHERE R1, R2, R3 AND R4 ARE AS DEFINED BELOW. THE DISCLOSURE IS ALSO DIRECTED TO THE INTERMEDIATES AND PRODUCTS OF THE PROCESS. THE PRODUCTS ARE USEFUL AS CENTRAL NERVOUS SYSTEM-DEPRESSANTS IN THAT THEY PRODUCE A CALMING EFFECT IN THE HOST.

1-R3,2-R1,3-R2,R4-INDOLE

THE DISCLOSURE IS DIRECTED TO A METHOD OF PREPARATION OF 3-ARYLINDOLES CONTAINING CERTAIN ELECTRON WITHDRAWING GROUPS IN THE 2-POSITION BY ALKYLATING A 2-AMINOBENZOPHENONE AND CYCLIZING THE PRODUCT TO FORM AN INDOLE HAVING THE STRUCTURE:

公开(公告)号：US3647790A

公开(公告)日：1972-03-07

申请号：US3647790D

申请日：1969-04-08

Applicant: AMERICAN HOME PROD

Inventor： POTOSKI JOHN R ,  FREED MEIER E

IPC: C07D207/06 ,  C07D207/08 ,  C07D207/12 ,  C07D207/20 ,  C07D207/26 ,  C07D87/06

CPC classification number: C07D207/08 ,  C07D207/06 ,  C07D207/12 ,  C07D207/20 ,  C07D207/26 ,  Y10S514/826

Abstract: NOVEL 2-QUINOXALINYL-OXAZOLIDINE-3-AMIDES AND -SULFONAMIDES AND 2-QUINOXALINYL-OXAZINE-3-AMIDES AND -SULFONAMIDES (I) ARE PROVIDED, WITH PHARMACOLOGICAL ACTIVITY AS NERVOUS SYSTEM DEPRESSANTS AND UTILITY TO INDUCE CALMING. COMPOUNDS (I) ARE PREPARED BY CONDENSING A ((2-QUINOXALINYLMETHYLENE)AMINE)ALKANOL (II) WITH A BENZYOL- OR PHENYLSULFONYL-CHLORIDE (III).

公开(公告)号：US3542780A

公开(公告)日：1970-11-24

申请号：US3542780D

申请日：1967-07-25

Applicant: AMERICAN HOME PROD

Inventor： FREED MEIER E ,  HERTZ ELISABETH

IPC: C07D487/04 ,  C07D57/00

CPC classification number: C07D487/04