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公开(公告)号：US20240010724A1
公开(公告)日：2024-01-11
申请号：US17933277
申请日：2022-09-19
发明人： Shouhua Xiao , Zheng Pan , Dineli Wickramasinghe , M. Shawn Jeffries , Chadwick Terence King , Brian Mingtung Chan , Peter Kufer , Ralf Lutterbüse , Tobias Raum , Patrick Hoffmann , Doris Rau , Roman Kischel , Bryan Lemon , Holger Wesche
CPC分类号： C07K16/2809 , C07K16/28 , C07K16/3053 , A61K2039/505 , C07K16/2896 , C07K16/468 , A61K47/60
摘要： The present invention provides to a antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. Moreover, the invention relates to a nucleic acid sequence encoding the antibody construct, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention relates a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20230357444A1
公开(公告)日：2023-11-09
申请号：US18066972
申请日：2022-12-15
发明人： Peter Kufer , Tobias Raum , Roman Kischel , Ralf Lutterbüse , Patrick Hoffmann , Matthias Klinger , Doris Rau , Susanne Mangold
CPC分类号： C07K16/468 , A61P35/00 , C07K2317/565 , C07K2317/24 , C07K2317/31
摘要： The present invention relates to a polypeptide comprising a human binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 (epsilon) chain as well as to a process for the production of the mentioned polypeptide. The invention further relates to nucleic acids encoding for the polypeptide, to vectors comprising the same and to host cells comprising the vector. In another aspect, the invention provides for a pharmaceutical composition comprising the mentioned polypeptide and medical uses of the polypeptide. In a further aspect the invention provides a method for the identification of polypeptides comprising a cross-species specific binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3ε (CD3 epsilon).
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公开(公告)号：US11591396B2
公开(公告)日：2023-02-28
申请号：US16868257
申请日：2020-05-06
发明人： Tobias Raum , Claudia Blümel , Christoph Dahlhoff , Patrick Hoffmann , Peter Kufer , Ralf Lutterbüse , Elisabeth Nahrwold , Jochen Pendzialek
IPC分类号： A61K39/395 , C07K16/18 , C07K16/22 , C07K16/28 , C07K16/30 , A61K39/00 , C12N15/63 , C12N5/07 , C07K14/475 , C07K14/725
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human DLL3 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising the polynucleotide and a host cell transformed or transfected with the polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of the antibody construct and a kit comprising the antibody construct.
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公开(公告)号：US11498964B2
公开(公告)日：2022-11-15
申请号：US16040927
申请日：2018-07-20
发明人： Shouhua Xiao , Zheng Pan , Dineli Wickramasinghe , M. Shawn Jeffries , Chadwick Terence King , Brian Mingtung Chan , Peter Kufer , Ralf Lutterbüse , Tobias Raum , Patrick Hoffmann , Doris Rau , Roman Kischel , Bryan Lemon , Holger Wesche
摘要： The invention provides a bispecific antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. Moreover, the invention provides a nucleic acid encoding the antibody construct, a vector comprising the nucleic acid and a host cell transformed or transfected with the vector. Furthermore, the invention provides a process for the production of the bispecific antibody construct, a medical use of the antibody construct and a kit comprising the antibody construct. The bispecific antibody construct may be useful in the treatment of melanoma.
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公开(公告)号：US20220356268A1
公开(公告)日：2022-11-10
申请号：US17336152
申请日：2021-06-01
发明人： Peter Kufer , Tobias Raum , Patrick Hoffmann , Roman Kischel , Ralf Lutterbuese , Doris Rau , Paul Adam , Eric Borges , Barbara Hebeis , Susanne Hipp
IPC分类号： C07K16/46 , C07K16/28 , A61K39/00 , C07K14/705
摘要： The present invention relates to a binding molecule which is at least bispecific comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope cluster 3 of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
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公开(公告)号：US11434302B2
公开(公告)日：2022-09-06
申请号：US15422647
申请日：2017-02-02
发明人： Tobias Raum , Markus Münz , Johannes Brozy , Peter Kufer , Patrick Hoffmann , Matthias Friedrich , Benno Rattel , Pamela Bogner , Andreas Wolf , Cornelius Pompe
IPC分类号： C07K16/30 , C07K16/28 , A61K39/395 , C07K16/46
摘要： The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to a target cell surface antigen, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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公开(公告)号：US10851170B2
公开(公告)日：2020-12-01
申请号：US15225282
申请日：2016-08-01
发明人： Tobias Raum , Claudia Blümel , Wibke Deisting , Patrick Hoffmann , Ralf Lutterbüse , Elisabeth Nahrwold , Olivier Nolan-Stevaux , Marc Panzer
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human CD70 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US10294300B2
公开(公告)日：2019-05-21
申请号：US15225107
申请日：2016-08-01
发明人： Tobias Raum , Claudia Blümel , Christoph Dahlhoff , Patrick Hoffmann , Peter Kufer , Ralf Lutterbüse , Elisabeth Nahrwold , Jochen Pendzialek
IPC分类号： A61K39/395 , C07K16/18 , C07K16/22 , C07K16/28 , C07K16/30 , A61K39/00 , C07K14/475 , C07K14/725
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human DLL3 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20180142021A1
公开(公告)日：2018-05-24
申请号：US15566444
申请日：2016-04-18
发明人： Bertram Weiss , Ann-Lena Frisk , Ruprecht Zierz , Peter Kufer , Tobias Raum , Doris Rau , Jonas Anlahr , Ralf Lutterbüse , Lisa Nahrwold , Christoph Dahlhoff , Claudia Blümel , Patrick Hoffmann
CPC分类号： C07K16/2809 , A61K2039/505 , A61P35/00 , C07K16/28 , C07K16/3053 , C07K2317/31 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to a bispecific antibody construct comprising a first human binding domain which binds to human CDH3 on the surface of a target cell and a second binding domain which binds to human CDS on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20170349668A1
公开(公告)日：2017-12-07
申请号：US15329672
申请日：2015-07-31
发明人： Benno Rattel , Matthias Friedrich , Peter Kufer , Patrick Hoffmann , Tobias Raum , Markus Münz , Ines Herrmann , Ralf Lutterbüse , Elisabeth Nahrwold
IPC分类号： C07K16/46 , C07K16/28 , C07K14/765 , A61K39/00
CPC分类号： C07K16/468 , A61K2039/505 , C07K14/765 , C07K16/2803 , C07K16/2809 , C07K2317/14 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/622 , C07K2317/73 , C07K2317/94 , C07K2319/31
摘要： The present invention provides to a bispecific single chain antibody construct binding to a target cell surface antigen via a first binding domain and to the T cell surface antigen CD3 via a second binding domain, wherein serum albumin is fused to the C-terminus of the antibody construct. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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