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31.发明申请公开(公告)号：US20180251426A1
公开(公告)日：2018-09-06
申请号：US15783993
申请日：2017-10-13
Applicant: AbbVie, Inc.
Inventor： Milan Bruncko , Yujia Dai , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , William J. McClellan
IPC: C07D209/08 , A61K31/635 , C07D211/58 , C07D401/12 , C07D309/08 , C07D471/04 , C07D413/12 , C07D405/14 , C07D405/12 , C07D403/12 , C07D401/14 , C07D309/04 , C07D295/30 , C07D277/24 , C07D235/06 , C07D231/56 , C07D213/84 , C07D213/74 , C07D417/12
CPC classification number: C07D209/08 , A61K31/635 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D309/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号：US09877958B2
公开(公告)日：2018-01-30
申请号：US14994824
申请日：2016-01-13
Applicant: AbbVie Inc.
Inventor： Le Wang , George Doherty , Xilu Wang , Zhi-Fu Tao , Milan Bruncko , Aaron R. Kunzer , Michael D. Wendt , Xiaohong Song , Robin Frey , Todd M. Hansen , Gerard M. Sullivan , Andrew Judd , Andrew Souers
IPC: A61K31/535 , A61K31/4725 , A61K31/5377 , C07D417/14 , A61K45/06 , C07D471/04
CPC classification number: A61K31/4725 , A61K31/5377 , A61K45/06 , C07D417/14 , C07D471/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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33.发明申请公开(公告)号：US20160304451A1
公开(公告)日：2016-10-20
申请号：US15048901
申请日：2016-02-19
Applicant: AbbVie Inc.
Inventor： Steven W. Elmore , Aaron R. Kunzer , Robert A. Mantei , Andrew J. Souers , Gerard M. Sullivan , Gary T. Wang , Le Wang , Michael D. Wendt
IPC: C07D209/08 , C07D401/12 , C07D405/12 , C07D405/14 , C07D403/12 , A61K31/635 , C07D413/12
CPC classification number: C07D209/08 , A61K31/635 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D309/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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34.发明授权公开(公告)号：US09303025B2
公开(公告)日：2016-04-05
申请号：US14582144
申请日：2014-12-23
Applicant: AbbVie Inc.
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , Cheol-Min Park , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt
IPC: C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D209/08 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D471/04 , C07D309/08
CPC classification number: C07D209/08 , A61K31/635 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D309/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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35.发明申请BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES 审中-公开用于治疗癌症和免疫疾病的BCL-2-选择性病毒诱导剂公开(公告)号：US20160009687A1
公开(公告)日：2016-01-14
申请号：US14726337
申请日：2015-05-29
Applicant: AbbVie Inc.
Inventor： Hong Ding , Steven W. Elmore , Lisa Hasvold , Laura A. Hexamer , Aaron R. Kunzer , William J. McClellan , Gerard M. Sullivan , Andrew J. Souers , Zhi-Fu Tao , Michael D. Wendt
IPC: C07D401/12 , C07D211/58 , C07D209/08 , C07D309/04 , C07D295/155
CPC classification number: C07D401/12 , A61K31/407 , A61K31/495 , A61K31/496 , A61K31/501 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D209/32 , C07D211/58 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D241/04 , C07D249/04 , C07D295/125 , C07D295/14 , C07D295/155 , C07D309/04 , C07D309/14 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12 , C07D471/04 , C07D487/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
Abstract translation: 公开了抑制抗凋亡Bcl-2或Bcl-xL蛋白活性的化合物，含有化合物的组合物和治疗疾病的方法，其中表达有抗凋亡Bcl-2蛋白。
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Patent Agency Ranking
36.发明授权公开(公告)号：US09227963B2
公开(公告)日：2016-01-05
申请号：US14543817
申请日：2014-11-17
Applicant: AbbVie Inc.
Inventor： Le Wang , George Doherty , Xilu Wang , Zhi-Fu Tao , Milan Bruncko , Aaron R. Kunzer , Michael D. Wendt , Xiaohong Song , Robin Frey , Todd M. Hansen , Gerard M. Sullivan , Andrew Judd , Andrew J. Souers
IPC: A61K31/535 , C07D417/14 , C07D401/04 , C07D471/04 , C07D487/04 , C07D493/08 , C07D513/04
CPC classification number: A61K31/4725 , A61K31/4985 , A61K31/5025 , A61K31/5377 , A61K31/541 , C07D401/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D493/08 , C07D513/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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公开(公告)号：US20150284328A1
公开(公告)日：2015-10-08
申请号：US14683839
申请日：2015-04-10
Applicant: AbbVie Inc.
Inventor： Xilu Wang , Xiaohong Song , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Lisa A. Hasvold , Le Wang , Zhi-Fu Tao , Aaron R. Kunzer
IPC: C07D209/42 , C07D405/06 , C07D491/113 , C07D401/04
CPC classification number: C07D209/42 , A61K31/5377 , C07D209/34 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D491/113
Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.
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38.发明申请公开(公告)号：US20140113910A1
公开(公告)日：2014-04-24
申请号：US14038409
申请日：2013-09-26
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert A. Mantei , Todd M. Hansen
IPC: C07D471/04 , A61K31/496
CPC classification number: C07D401/12 , A61K31/496 , C07D209/82 , C07D401/14 , C07D403/12 , C07D471/04 , C07D519/00 , Y02A50/463
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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39.发明申请公开(公告)号：US20140057890A1
公开(公告)日：2014-02-27
申请号：US14058164
申请日：2013-10-18
Applicant: AbbVie Inc.
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura A. Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt
IPC: A61K31/5377 , A61K31/496 , C07D413/06 , C07D401/06 , A61K45/06 , A61K31/407 , C07D403/06 , A61K31/501 , C07D241/04 , A61K31/495 , C07D405/06 , C07D487/04
CPC classification number: C07D401/12 , A61K31/407 , A61K31/495 , A61K31/496 , A61K31/501 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D209/32 , C07D211/58 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D241/04 , C07D249/04 , C07D295/125 , C07D295/14 , C07D295/155 , C07D309/04 , C07D309/14 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12 , C07D471/04 , C07D487/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
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40.发明申请APOPTOSIS-INDUCED AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权用于治疗癌症和免疫和自发性疾病的病毒诱导剂公开(公告)号：US20130096120A1
公开(公告)日：2013-04-18
申请号：US13649900
申请日：2012-10-11
Applicant: AbbVie Inc.
Inventor： LE WANG , George Doherty , Xilu Wang , Zhi-Fu Tao , Milan Bruncko , Aaron R. Kunzer , Michael D. Wendt , Xiaohong Song , Robin Frey , Todd M. Hansen , Gerard M. Sullivan , Andrew Judd , Andrew Souers
IPC: A61K31/4725 , A61K31/437 , A61P35/02 , C07D401/04 , C07D417/14 , A61P35/00 , A61K31/5377 , C07D471/04
CPC classification number: A61K31/4725 , A61K31/4985 , A61K31/5025 , A61K31/5377 , A61K31/541 , C07D401/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D493/08 , C07D513/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
Abstract translation: 公开了抑制抗凋亡Bcl-xL蛋白活性的化合物，含有该化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-xL蛋白。
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