公开(公告)号：US20140094471A1

公开(公告)日：2014-04-03

申请号：US14038304

申请日：2013-09-26

Applicant: AbbVie Inc. ,  The Walter and Eliza Hall Institute of Medical Research ,  Genentech, Inc.

Inventor： Milan Bruncko ,  Hong Ding ,  George A. Doherty ,  Steven W. Elmore ,  Lisa A. Hasvold ,  Laura Hexamer ,  Aaron R. Kunzer ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Xilu Wang ,  Michael D. Wendt ,  Robert A. Mantei ,  Todd M. Hansen

IPC: C07D471/04 ,  C07D403/12 ,  C07D209/82

CPC classification number: C07D401/12 ,  A61K31/496 ,  C07D209/82 ,  C07D401/14 ,  C07D403/12 ,  C07D471/04 ,  C07D519/00 ,  Y02A50/463

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：US20130267534A1

公开(公告)日：2013-10-10

申请号：US13830926

申请日：2013-03-14

Applicant: ABBVIE INC.

Inventor： Milan Bruncko ,  Hong Ding ,  George A. Doherty ,  Steven W. Elmore ,  Lisa A. Hasvold ,  Laura Hexamer ,  Aaron R. Kunzer ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Xilu Wang ,  Michael D. Wendt ,  Robert Mantei ,  Todd M. Hansen

IPC: C07D471/04

CPC classification number: C07D401/12 ,  A61K31/496 ,  C07D209/82 ,  C07D401/14 ,  C07D403/12 ,  C07D471/04 ,  C07D519/00 ,  Y02A50/463

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：US20130267514A1

公开(公告)日：2013-10-10

申请号：US13831184

申请日：2013-03-14

Applicant: ABBVIE INC.

Inventor： Milan Bruncko ,  Hong Ding ,  George A. Doherty ,  Steven W. Elmore ,  Lisa A. Hasvold ,  Laura Hexamer ,  Aaron R. Kunzer ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Xilu Wang ,  Michael D. Wendt ,  Robert Mantei ,  Todd M. Hansen

IPC: C07D471/04

CPC classification number: C07D471/04 ,  C07D491/052 ,  C07D519/00

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：US20250019364A1

公开(公告)日：2025-01-16

申请号：US18883472

申请日：2024-09-12

Applicant: AbbVie Inc. ,  Genentech, Inc. ,  The Walter and Eliza Hall Institute of Medical Research

Inventor： Milan Bruncko ,  Hong Ding ,  George A. Doherty ,  Steven W. Elmore ,  Lisa A. Hasvold ,  Laura Hexamer ,  Aaron R. Kunzer ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Xilu Wang ,  Michael D. Wendt ,  Robert Mantei ,  Todd M. Hansen

IPC: C07D401/12 ,  A61K31/496 ,  C07D209/82 ,  C07D401/14 ,  C07D403/12 ,  C07D471/04 ,  C07D519/00

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：US11897864B2

公开(公告)日：2024-02-13

申请号：US17938835

申请日：2022-10-07

Applicant: AbbVie Inc. ,  Genentech, Inc. ,  The Walter and Eliza Hall Institute of Medical Research

Inventor： Milan Bruncko ,  Hong Ding ,  George A. Doherty ,  Steven W. Elmore ,  Lisa A. Hasvold ,  Laura Hexamer ,  Aaron R. Kunzer ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Xilu Wang ,  Michael D. Wendt ,  Robert Mantei ,  Todd M. Hansen

IPC: C07D401/12 ,  C07D401/14 ,  C07D519/00 ,  C07D471/04 ,  C07D209/82 ,  C07D403/12 ,  A61K31/496

CPC classification number: C07D401/12 ,  A61K31/496 ,  C07D209/82 ,  C07D401/14 ,  C07D403/12 ,  C07D471/04 ,  C07D519/00 ,  Y02A50/30

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：US20230143532A1

公开(公告)日：2023-05-11

申请号：US17938835

申请日：2022-10-07

Applicant: AbbVie Inc. ,  Genentech, Inc. ,  The Walter and Eliza Hall Institute of Medical Research

Inventor： Milan Bruncko ,  Hong Ding ,  George A. Doherty ,  Steven W. Elmore ,  Lisa A. Hasvold ,  Laura Hexamer ,  Aaron R. Kunzer ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Xilu Wang ,  Michael D. Wendt ,  Robert Mantei ,  Todd M. Hansen

IPC: C07D401/12 ,  C07D401/14 ,  C07D519/00 ,  C07D471/04 ,  C07D209/82 ,  C07D403/12 ,  A61K31/496

CPC classification number: C07D401/12 ,  A61K31/496 ,  C07D209/82 ,  C07D401/14 ,  C07D403/12 ,  C07D471/04 ,  C07D519/00 ,  Y02A50/30

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：US20200010480A1

公开(公告)日：2020-01-09

申请号：US16575114

申请日：2019-09-18

Applicant: AbbVie Inc. ,  AbbVie Deutschland GmbH & Co. KG

Inventor： Patrick B. Brady ,  Wilfried Braje ,  Yujia Dai ,  George A. Doherty ,  Jane Gong ,  Katja Jantos ,  Cheng Ji ,  Andrew S. Judd ,  Aaron R. Kunzer ,  Chunqiu Lai ,  Anthony Mastracchio ,  Roberto M. Risi ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Jesse A. Teske ,  Xilu Wang ,  Michael D. Wendt ,  Yiyun Yu ,  Guidong Zhu ,  Thomas D. Penning

IPC: C07D498/18 ,  A61P35/00 ,  C07D519/00 ,  C07D495/18 ,  C07D495/16

Abstract: The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).

公开(公告)号：US20190055264A1

公开(公告)日：2019-02-21

申请号：US15998688

申请日：2018-08-15

Applicant: AbbVie Inc. ,  AbbVie Deutschland GmbH & Co. KG

Inventor： Patrick B. Brady ,  Wilfried Braje ,  Yujia Dai ,  George A. Doherty ,  Jane Gong ,  Katja Jantos ,  Cheng Ji ,  Andrew S. Judd ,  Aaron R. Kunzer ,  Chunqiu Lai ,  Anthony Mastracchio ,  Roberto M. Risi ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Jesse A. Teske ,  Xilu Wang ,  Michael D. Wendt ,  Yiyun Yu ,  Guidong Zhu ,  Thomas D. Penning

IPC: C07D498/18 ,  C07D495/18 ,  C07D519/00 ,  A61P35/00

Abstract: The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).

公开(公告)号：US20180251426A1

公开(公告)日：2018-09-06

申请号：US15783993

申请日：2017-10-13

Applicant: AbbVie, Inc.

Inventor： Milan Bruncko ,  Yujia Dai ,  Hong Ding ,  George A. Doherty ,  Steven W. Elmore ,  Lisa Hasvold ,  Laura Hexamer ,  Aaron R. Kunzer ,  Robert A. Mantei ,  Chang H. Park ,  Cheol-Min Park ,  Andrew M. Petros ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Xilu Wang ,  Michael D. Wendt ,  William J. McClellan

IPC: C07D209/08 ,  A61K31/635 ,  C07D211/58 ,  C07D401/12 ,  C07D309/08 ,  C07D471/04 ,  C07D413/12 ,  C07D405/14 ,  C07D405/12 ,  C07D403/12 ,  C07D401/14 ,  C07D309/04 ,  C07D295/30 ,  C07D277/24 ,  C07D235/06 ,  C07D231/56 ,  C07D213/84 ,  C07D213/74 ,  C07D417/12

CPC classification number: C07D209/08 ,  A61K31/635 ,  C07D211/58 ,  C07D213/74 ,  C07D213/84 ,  C07D231/56 ,  C07D235/06 ,  C07D277/24 ,  C07D295/30 ,  C07D309/04 ,  C07D309/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/411

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：US09877958B2

公开(公告)日：2018-01-30

申请号：US14994824

申请日：2016-01-13

Applicant: AbbVie Inc.

Inventor： Le Wang ,  George Doherty ,  Xilu Wang ,  Zhi-Fu Tao ,  Milan Bruncko ,  Aaron R. Kunzer ,  Michael D. Wendt ,  Xiaohong Song ,  Robin Frey ,  Todd M. Hansen ,  Gerard M. Sullivan ,  Andrew Judd ,  Andrew Souers

IPC: A61K31/535 ,  A61K31/4725 ,  A61K31/5377 ,  C07D417/14 ,  A61K45/06 ,  C07D471/04

CPC classification number: A61K31/4725 ,  A61K31/5377 ,  A61K45/06 ,  C07D417/14 ,  C07D471/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.