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    VACCINE ENGINEERING
    34.
    发明申请
    VACCINE ENGINEERING 有权
    疫苗工程

    公开(公告)号：US20130287838A1

    公开(公告)日：2013-10-31

    申请号：US13816461

    申请日：2011-08-12

    申请人： David Hickman ,  Maria Pilar Lopez-Deber ,  Andreas Muhs

    发明人： David Hickman ,  Maria Pilar Lopez-Deber ,  Andreas Muhs

    IPC分类号： A61K39/385 ,  C07K16/18

    CPC分类号： A61K39/385 ,  A61K39/0007 ,  A61K2039/55555 ,  A61K2039/6018 ,  A61K2039/64 ,  C07K16/18 ,  G01N2405/00 ,  G01N2440/10

    摘要： The method and constructs disclosed and claimed herein allow to control peptide conformation by modulation of the peptide lipidation pattern, spacer and liposome composition, or via co-administration with small molecules. Accordingly, this technology can be applied to the rational design of liposomal vaccines and for the generation of safer and more efficacious therapies for a range of human disease, in particular those based on misfolded proteins.

    摘要翻译： 本文公开和要求保护的方法和构造允许通过调节肽脂质化模式，间隔物和脂质体组成或通过与小分子的共同给药来控制肽构象。 因此，该技术可以应用于脂质体疫苗的合理设计，以及为一系列人类疾病，特别是基于错误折叠的蛋白质的那些产生更安全和更有效的治疗方法。

    Monoclonal antibody
    35.
    发明授权
    Monoclonal antibody 有权
    单克隆抗体

    公开(公告)号：US08048420B2

    公开(公告)日：2011-11-01

    申请号：US12213007

    申请日：2008-06-12

    申请人： Andrea Pfeifer ,  Maria Pihlgren ,  Andreas Muhs ,  Ryan Watts

    发明人： Andrea Pfeifer ,  Maria Pihlgren ,  Andreas Muhs ,  Ryan Watts

    IPC分类号： A61K39/395 ,  G01N33/53

    CPC分类号： G01N33/6896 ,  A61K39/0007 ,  A61K39/3955 ,  A61K47/6911 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/76 ,  G01N2333/4709 ,  G01N2800/2821

    摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).

    摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉状蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组障碍和异常，例如 阿尔茨海默氏病。 本发明提供了包含高度特异性和高效抗体的新型方法和组合物，其具有特异性识别并结合来自一系列淀粉样蛋白质的特定表位的能力。 通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样斑块形成相关的一组疾病和病症，包括继发性淀粉样变性 和年龄相关的淀粉样变性病，包括但不限于神经障碍如阿尔茨海默病（AD）。

    Monoclonal antibody
    36.
    发明申请
    Monoclonal antibody 审中-公开
    单克隆抗体

    公开(公告)号：US20100297132A1

    公开(公告)日：2010-11-25

    申请号：US12589570

    申请日：2009-10-23

    申请人： Ruth Greferath ,  David Hickman ,  Andreas Muhs ,  Andrea Pfeifer ,  Claude Nicolau

    发明人： Ruth Greferath ,  David Hickman ,  Andreas Muhs ,  Andrea Pfeifer ,  Claude Nicolau

    IPC分类号： A61K39/395 ,  A61P25/00 ,  A61P25/28

    CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K2039/505 ,  G01N2333/4709 ,  A61K2300/00

    摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).

    摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉状蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组障碍和异常，例如 阿尔茨海默氏病。 本发明提供了包含高度特异性和高效抗体的新型方法和组合物，其具有特异性识别并结合来自一系列淀粉样蛋白质的特定表位的能力。 通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样斑块形成相关的一组疾病和病症，包括继发性淀粉样变性 和年龄相关的淀粉样变性病，包括但不限于神经障碍如阿尔茨海默病（AD）。

    Monoclonal Antibody
    38.
    发明申请
    Monoclonal Antibody 有权
    单克隆抗体

    公开(公告)号：US20100098707A2

    公开(公告)日：2010-04-22

    申请号：US11637213

    申请日：2006-12-11

    申请人： Ruth Greferath ,  David Hickman ,  Andreas Muhs ,  Andrea Pfeifer ,  Nicolau Claude

    发明人： Ruth Greferath ,  David Hickman ,  Andreas Muhs ,  Andrea Pfeifer ,  Nicolau Claude

    IPC分类号： A61K39/395 ,  C07K16/40

    CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K2039/505 ,  G01N2333/4709 ,  A61K2300/00

    摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).

    摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉状蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组障碍和异常，例如 阿尔茨海默氏病。 本发明提供了包含高度特异性和高效抗体的新型方法和组合物，其具有特异性识别并结合来自一系列淀粉样蛋白质的特定表位的能力。 通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样斑块形成相关的一组疾病和病症，包括继发性淀粉样变性 和年龄相关的淀粉样变性病，包括但不限于神经障碍如阿尔茨海默病（AD）。

    Plug connector with an adaptor housing for receiving a plug or socket arrangement
    39.
    发明授权
    Plug connector with an adaptor housing for receiving a plug or socket arrangement 有权
    插头连接器带有适配器外壳，用于接收插头或插座装置

    公开(公告)号：US07670060B2

    公开(公告)日：2010-03-02

    申请号：US12319305

    申请日：2009-01-06

    申请人： Juergen Ziemke ,  Ralf Schumacher ,  Michaela Muecke ,  Andreas Muhs ,  Volker Schroeder

    发明人： Juergen Ziemke ,  Ralf Schumacher ,  Michaela Muecke ,  Andreas Muhs ,  Volker Schroeder

    IPC分类号： G02B6/38

    CPC分类号： H01R13/6275 ,  G02B6/3893 ,  H01R13/502 ,  H01R13/5045 ,  H01R13/506 ,  H01R13/512 ,  H01R13/639

    摘要： A fiber optic connector arrangement includes a locking device for fastening together a pair of male plug and female socket components, which locking device consists of locking elements mounted solely on a pair of telescopic adapter housings that support the plug and socket components when in the engaged condition. In order to increase the operational life of the connector components, one of the plug and socket components contains a recess for receiving an auxiliary second locking device that extends longitudinally in a normally non-stressed unlocked inoperative condition from the other component.

    摘要翻译： 光纤连接器装置包括用于将一对公插头和母插座部件紧固在一起的锁定装置，该锁定装置包括仅在安装在接合状态下支撑插头和插座部件的一对伸缩式适配器外壳上的锁定元件 。 为了增加连接器部件的使用寿命，插头和插座部件中的一个包含用于接收辅助第二锁定装置的凹部，该辅助第二锁定装置在正常不受应力的解锁非工作状态下从另一部件纵向延伸。

    Adapter for attaching an insertion device to a cable fitting
    40.
    发明授权
    Adapter for attaching an insertion device to a cable fitting 有权
    用于将插入装置连接到电缆配件的适配​​器

    公开(公告)号：US07367832B2

    公开(公告)日：2008-05-06

    申请号：US11593417

    申请日：2006-11-06

    申请人： Andreas Muhs ,  Claudia Hanning ,  Juergen Ziemke ,  Michael Hoeing ,  Michael Schnatwinkel ,  Michaela Muecke ,  Simon Seereiner ,  Ulrich Luetkemeier

    发明人： Andreas Muhs ,  Claudia Hanning ,  Juergen Ziemke ,  Michael Hoeing ,  Michael Schnatwinkel ,  Michaela Muecke ,  Simon Seereiner ,  Ulrich Luetkemeier

    IPC分类号： H01R13/213

    CPC分类号： H01R31/06 ,  G02B6/3879 ,  G02B6/3887 ,  H01R13/6273 ,  H01R24/62

    摘要： An adapter assembly for connecting a multi-contact electrical plug within a cable support arrangement includes an elongated adapter body containing a through passage and having a rectangular first end portion containing a chamber for receiving the electrical plug, and a tubular second end portion threadably connected adjacent its free extremity with a concentrically arranged cable sleeve, an annular sealing device being provided for sealing one end of the annular space defined between the cylindrical outer surface of the adapter body tubular end portion and the inner surface of the adjacent end portion of the concentrically arranged sleeve. A second annular seal is supported within the cable sleeve for sealing the entrance of the cable into the adapter through passage, and a third sealing ring is provided for sealing the space between the outer surface of the adapter body rectangular end portion and a slidably mounted outer sleeve member.

    摘要翻译： 用于将多接触电插塞连接在电缆支撑装置内的适配器组件包括细长的适配器主体，其包含通孔，该适配器本体包含容纳用于接收电插头的腔室的矩形第一端部分，以及与第二端部螺纹连接的管状第二端部 其自由端具有同心布置的电缆套筒，环形密封装置用于密封限定在适配器主体管状端部的圆柱形外表面与同心布置的相邻端部的内表面之间的环形空间的一端 袖。 第二环形密封件被支撑在电缆套筒内，用于通过通道将电缆的入口密封到适配器中，并且提供第三密封环以密封适配器主体矩形端部的外表面与可滑动安装的外部 袖子成员。