公开(公告)号：US08297107B2

公开(公告)日：2012-10-30

申请号：US11751327

申请日：2007-05-21

申请人： Andrew Tipler ,  Richard G. Edwards ,  Michael Paul Dinsmore

发明人： Andrew Tipler ,  Richard G. Edwards ,  Michael Paul Dinsmore

IPC分类号： G01N30/04

CPC分类号： G01N30/32 ,  G01N30/461 ,  G01N30/8693 ,  G01N2030/324

摘要： Disclosed are systems and methods that include a sampling device, a chromatographic column, and a transfer line through which a fluid containing analytes to be measured are communicated from the sampling device to the column. The pressure at which the fluid containing the analytes is applied at the inlet of the transfer line is adjusted as the temperature of the column increases in accordance with certain relationships in order to maintain a substantially constant flow rate or velocity for the fluid exiting the column. In this way, the system compensates for changes in the viscosity of the fluid flowing through the column that result from changes in the column temperature.

摘要翻译： 公开了包括采样装置，色谱柱和传输线的系统和方法，含有待测量待分析物的流体通过该传输线从采样装置传送到塔。 随着塔的温度根据某些关系而增加包含分析物的流体在输送管线的入口处的压力，以便为离开塔的流体保持基本上恒定的流速或速度。 以这种方式，该系统补偿由柱温变化引起的流经塔的流体的粘度变化。

公开(公告)号：US08182768B2

公开(公告)日：2012-05-22

申请号：US11251187

申请日：2005-10-14

申请人： Andrew Tipler ,  John H. Vanderhoef ,  James E. Botelho

发明人： Andrew Tipler ,  John H. Vanderhoef ,  James E. Botelho

IPC分类号： G01N30/02

CPC分类号： G01N30/16 ,  G01N35/1095 ,  G01N2030/085 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/255 ,  Y10T436/2575

摘要： A system for interfacing a sampling device and a chromatograph and for pre-concentrating analytes in a sample prior to introducing the sample into the chromatographic column is generally disclosed comprising an interface housing with a first channel and an adsorbent housing with a second channel, which contains at least one adsorbent. Valveless conduits permit fluid to be communicated between the sampling device and the first channel, between the first channel and the second channel, and the first channel and the column. In some embodiments, fluid flows in one direction when the analytes are adsorbed and in the opposite direction when analytes are desorbed. In certain embodiments, two different adsorbents are disposed in the second channel to adsorb different types of analytes.

摘要翻译： 通常公开了用于在将样品引入色谱柱之前将取样装置和色谱仪连接并用于预先浓缩样品中的分析物的系统，其包括具有第一通道的界面壳体和具有第二通道的吸附剂壳体，其包含 至少一种吸附剂。 无阀管道允许流体在采样装置和第一通道之间，第一通道和第二通道之间以及第一通道和塔之间连通。 在一些实施方案中，当分析物被吸附时，流体沿一个方向流动，并且当分析物被解吸时在相反方向流动。 在某些实施方案中，两个不同的吸附剂设置在第二通道中以吸附不同类型的分析物。

公开(公告)号：US08017081B2

公开(公告)日：2011-09-13

申请号：US12262907

申请日：2008-10-31

申请人： Andrew Tipler

发明人： Andrew Tipler

IPC分类号： G01N7/00

CPC分类号： G01K11/00 ,  G01K11/02 ,  Y10T436/25875

摘要： A system and method of measuring the effective temperature inside a sealed container having a headspace is provided. A liquid solvent is added to the container, and a solid compound is added to the liquid solvent to create a saturated solution. Vapor of the saturated solution is allowed to equilibrate in the headspace of the sealed container, and a volume thereof is transferred to a chromatographic column, where chromatographic readings of the equilibrated vapor are taken. A temperature within the sealed container is then calculated based upon the chromatographic readings of the equilibrated vapor, wherein the temperature calculation is based upon the concentrations of the liquid solvent and the solid compound in the equilibrated vapor.

摘要翻译： 提供一种测量具有顶部空间的密封容器内的有效温度的系统和方法。 将液体溶剂加入到容器中，并将固体化合物加入到液体溶剂中以产生饱和溶液。 允许饱和溶液的蒸气在密封容器的顶部空间中平衡，并将其体积转移到色谱柱，其中取平衡蒸气的色谱读数。 然后基于平衡蒸气的色谱读数计算密封容器内的温度，其中温度计算基于平衡蒸气中的液体溶剂和固体化合物的浓度。

公开(公告)号：US07572319B2

公开(公告)日：2009-08-11

申请号：US11963938

申请日：2007-12-24

申请人： Andrew Tipler ,  Gary Campbell ,  Mark Collins

发明人： Andrew Tipler ,  Gary Campbell ,  Mark Collins

IPC分类号： B01D53/22

CPC分类号： B01D53/025 ,  B01D2253/102 ,  G01N30/12 ,  G01N2001/2229 ,  G01N2030/085 ,  G01N2030/121 ,  G01N2030/127 ,  G01N2030/128

摘要： An analyte pre-concentrator for gas chromatography is disclosed generally comprising a tube packed with an adsorbent, wherein the tube may serve as the liner of a chromatographic injector, as an adsorbent trap coupled to a chromatographic column, and/or as an adsorbent trap coupled to a headspace sampler. Preferably, a heating device allows the tube to be heated. In a preferred embodiment, the analyte pre-concentrator further comprises a column isolating accessory so that a chromatographic column can be temporarily isolated from substances flowing through the tube.

摘要翻译： 公开了用于气相色谱的分析物预浓缩器，其通常包括填充有吸附剂的管，其中该管可用作色谱注射器的衬垫，作为与色谱柱耦合的吸附阱，和/或作为吸附阱捕获 到顶空进样器。 优选地，加热装置允许管被加热。 在优选实施方案中，分析物预浓缩器还包括柱分离附件，使得色谱柱可以暂时与流过管的物质隔离。

公开(公告)号：US07459313B2

公开(公告)日：2008-12-02

申请号：US10621942

申请日：2003-07-17

申请人： Andrew Tipler

发明人： Andrew Tipler

IPC分类号： G01N7/00

CPC分类号： G01K11/00 ,  G01K11/02 ,  Y10T436/25875

摘要： A method of measuring the effective temperature inside a sealed container having a headspace is provided. A liquid solvent is added to the container, and a solid compound is added to the liquid solvent to create a saturated solution. Vapor of the saturated solution is allowed to equilibrate in the headspace of the sealed container, and a volume thereof is transferred to a chromatographic column, where chromatographic readings of the equilibrated vapor are taken. A temperature within the sealed container is then calculated based upon the chromatographic readings of the equilibrated vapor, wherein the temperature calculation is based upon the concentrations of the liquid solvent and the solid compound in the equilibrated vapor.

摘要翻译： 提供一种测量具有顶部空间的密封容器内的有效温度的方法。 将液体溶剂加入到容器中，并将固体化合物加入到液体溶剂中以产生饱和溶液。 允许饱和溶液的蒸气在密封容器的顶部空间中平衡，并将其体积转移到色谱柱，其中取平衡蒸气的色谱读数。 然后基于平衡蒸气的色谱读数计算密封容器内的温度，其中温度计算基于平衡蒸气中的液体溶剂和固体化合物的浓度。

公开(公告)号：US20070261474A1

公开(公告)日：2007-11-15

申请号：US11751327

申请日：2007-05-21

申请人： Andrew Tipler ,  Richard Edwards ,  Michael Dinsmore

发明人： Andrew Tipler ,  Richard Edwards ,  Michael Dinsmore

IPC分类号： G01N30/26

CPC分类号： G01N30/32 ,  G01N30/461 ,  G01N30/8693 ,  G01N2030/324

摘要： Disclosed are systems and methods that include a sampling device, a chromatographic column, and a transfer line through which a fluid containing analytes to be measured are communicated from the sampling device to the column. The pressure at which the fluid containing the analytes is applied at the inlet of the transfer line is adjusted as the temperature of the column increases in accordance with certain relationships in order to maintain a substantially constant flow rate or velocity for the fluid exiting the column. In this way, the system compensates for changes in the viscosity of the fluid flowing through the column that result from changes in the column temperature.

摘要翻译： 公开了包括采样装置，色谱柱和传输线的系统和方法，含有待测量待分析物的流体通过该传输线从采样装置传送到塔。 随着塔的温度根据某些关系而增加包含分析物的流体在输送管线的入口处的压力，以便为离开塔的流体保持基本恒定的流速或速度。 以这种方式，该系统补偿由柱温变化引起的流经塔的流体的粘度变化。

公开(公告)号：US07237430B2

公开(公告)日：2007-07-03

申请号：US11280994

申请日：2005-11-17

申请人： Otto J. Prohaska ,  Avinash Dalmia ,  Andrew Tipler

发明人： Otto J. Prohaska ,  Avinash Dalmia ,  Andrew Tipler

IPC分类号： G01N27/26 ,  G01N27/407 ,  G01N30/62

CPC分类号： G01N30/62 ,  G01N27/4045 ,  G01N30/64 ,  G01N2030/025 ,  G01N2030/125 ,  G01N2030/645

摘要： The invention includes a method and apparatus for a chromatography system having a chromatographic column for separating gases in a mixture from one another and an electrochemical gas sensor coupled to the chromatographic column for detecting a gas being emitted from the column. The electrochemical gas sensor further includes a substrate having a surface for depositing electrodes thereon, an ionomer membrane in contact with the surface, an electrode in contact with the surface, and an opening in the ionomer membrane in a location proximate to the electrode for permitting a gas to diffuse through the opening to simultaneously contact the electrode and the ionomer membrane within the opening.

摘要翻译： 本发明包括用于色谱系统的方法和装置，其具有用于分离彼此混合物中的气体的色谱柱和耦合到色谱柱的电化学气体传感器，用于检测从柱发射的气体。 电化学气体传感器还包括具有用于在其上沉积电极的表面的基底，与表面接触的离子交联聚合物膜，与表面接触的电极以及靠近电极的位置处的离聚物膜中的开口， 气体通过开口扩散以同时接触开口内的电极和离聚物膜。

公开(公告)号：US07219532B2

公开(公告)日：2007-05-22

申请号：US11189467

申请日：2005-07-26

申请人： Andrew Tipler ,  Richard G. Edwards

发明人： Andrew Tipler ,  Richard G. Edwards

IPC分类号： G01N30/04

CPC分类号： G01N30/32 ,  G01N30/461 ,  G01N30/8693 ,  G01N2030/324

摘要： Disclosed are systems and methods that include a sampling device, a chromatographic column, and a transfer line through which a fluid containing analytes to be measured are communicated from the sampling device to the column. The pressure at which the fluid containing the analytes is applied at the inlet of the transfer line is adjusted as the temperature of the column increases in accordance with certain relationships in order to maintain a substantially constant flow rate or velocity for the fluid exiting the column. In this way, the system compensates for changes in the viscosity of the fluid flowing through the column that result from changes in the column temperature.

摘要翻译： 公开了包括采样装置，色谱柱和传输线的系统和方法，含有待测量待分析物的流体通过该传输线从采样装置传送到塔。 随着塔的温度根据某些关系而增加包含分析物的流体在输送管线的入口处的压力，以便为离开塔的流体保持基本恒定的流速或速度。 以这种方式，该系统补偿由柱温变化引起的流经塔的流体的粘度变化。

公开(公告)号：US20070068385A1

公开(公告)日：2007-03-29

申请号：US11559760

申请日：2006-11-14

申请人： Andrew Tipler ,  Neil Plant

发明人： Andrew Tipler ,  Neil Plant

IPC分类号： B01D53/02

CPC分类号： G01N30/89 ,  G01N15/0826 ,  G01N30/32 ,  G01N30/60 ,  G01N2030/324 ,  G01N2030/524 ,  G01N2030/626 ,  G01N2030/525

摘要： Disclosed are systems and methods that include providing a vessel having an adsorbent disposed therein, the vessel having an inlet and an outlet for communicating a carrier gas through the vessel; determining a differential pressure between the inlet and the outlet for a known flow rate at the outlet; and, determining a geometric measure for the vessel based on a ratio of the known flow rate and the differential pressure. In some embodiments, the methods and systems can include a viscosity in the ratio, determining a flow rate at ambient pressure using a factor based on a ratio of a gas pressure at the output and ambient pressure, and/or, determining a flow rate at ambient temperature using a factor based on a ratio of a temperature at the output and ambient temperature.

摘要翻译： 公开了包括提供其中设置有吸附剂的容器的系统和方法，所述容器具有用于使载气通过容器连通的入口和出口; 确定出口处的已知流速的入口和出口之间的压差; 并且基于已知流量和压差的比率确定容器的几何度量。 在一些实施方案中，方法和系统可以包括该比例的粘度，使用基于输出处的气体压力和环境压力的比率的因子确定环境压力下的流速，和/或确定 使用基于输出温度和环境温度的比率的因子的环境温度。

公开(公告)号：US20060021504A1

公开(公告)日：2006-02-02

申请号：US11233162

申请日：2005-09-22

申请人： Andrew Tipler ,  Gary Campbell ,  Mark Collins

发明人： Andrew Tipler ,  Gary Campbell ,  Mark Collins

IPC分类号： B01D53/02

CPC分类号： B01D53/025 ,  B01D2253/102 ,  G01N30/12 ,  G01N2001/2229 ,  G01N2030/085 ,  G01N2030/121 ,  G01N2030/127 ,  G01N2030/128

摘要： An analyte pre-concentrator for gas chromatography is disclosed generally comprising a tube having a restricted outlet and packed with an adsorbent, wherein the tube serves as the liner of a chromatographic injector, as an adsorbent trap coupled to a chromatographic column, and/or as an adsorbent trap coupled to a headspace sampler. Preferably, a heating device allows the tube to be heated. In a preferred embodiment, the analyte pre-concentrator further comprises a column isolating accessory so that a chromatographic column can be temporarily isolated from substances flowing through the tube.

摘要翻译： 公开了用于气相色谱的分析物预浓缩器，其通常包括具有限制出口并装有吸附剂的管，其中管用作色谱注射器的衬垫，作为与色谱柱耦合的吸附阱，和/或 耦合到顶空采样器的吸附阱。 优选地，加热装置允许管被加热。 在优选实施方案中，分析物预浓缩器还包括柱分离附件，使得色谱柱可以暂时与流过管的物质隔离。