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公开(公告)号：US20160354779A1
公开(公告)日：2016-12-08
申请号：US15244039
申请日：2016-08-23
申请人： JOHNSON & JOHNSON AB
发明人： Ove Per Öhman , Ib Mendel-Hartvig
CPC分类号： B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L2200/0668 , B01L2300/18 , B01L2400/0406 , B01L2400/086 , G01N30/6065 , G01N30/6095 , G01N2030/525 , Y10T436/25
摘要： A micro fluidic system includes a substrate, and, provided on said substrate, at least one flow path interconnecting with functional means in which liquid samples can be treated by desired procedures. The flow paths are laid out to form a pattern for the transport of liquid samples to and from said functional means. These flow paths comprise a plurality of micro posts protruding upwards from said substrate, the spacing between the micro posts being small enough to induce a capillary action in a liquid sample applied anywhere within any of said flow paths, so as to force said liquid to move from where said liquid sample was applied.
摘要翻译： 微流体系统包括衬底，并且在所述衬底上提供与功能装置相互连接的至少一个流路，其中液体样品可以通过期望的程序进行处理。 布置流动路径以形成用于将液体样品运送到所述功能装置和从所述功能装置输送液体样品的图案。 这些流动路径包括从所述基底向上突出的多个微柱，微柱之间的间隔足够小，以在任何一个所述流动路径内的任何地方施加液体样品中的毛细管作用，以迫使所述液体移动 从其中应用所述液体样品。
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公开(公告)号：US20160236171A1
公开(公告)日：2016-08-18
申请号：US15028632
申请日：2014-10-14
申请人： KANEKA CORPORATION
发明人： Masaru HIRANO , Kana WATANABE
IPC分类号： B01J20/24 , C07K1/22 , B01D15/38 , B01J20/285 , B01J20/30
CPC分类号： B01J20/24 , B01D15/38 , B01D15/3828 , B01J20/267 , B01J20/28078 , B01J20/285 , B01J20/3085 , C07K1/22 , C08B1/003 , C08B1/08 , C08J9/16 , C08J9/28 , C08J2201/0543 , C08J2301/00 , C08L1/02 , G01N2030/525
摘要： The present invention provides a method for easily and efficiently producing cellulose beads which has narrow pore size distribution and pore structure suitable for an adsorbent and of which adsorption performance is excellent without using highly toxic and highly corrosive auxiliary raw material and without industrially disadvantageous cumbersome step. The method for producing porous cellulose beads according to the present invention is characterized in comprising (a) the step of preparing a fine cellulose dispersion by mixing a low temperature alkaline aqueous solution and cellulose, (b) the step of preparing a mixed liquid by adding a water-soluble low molecular organic compound to the fine cellulose dispersion, (c) the step of preparing an emulsion by dispersing the mixed liquid in a dispersion medium, (d) the step of contacting the emulsion with a coagulating solvent.
摘要翻译： 本发明提供一种容易且有效地制造纤维素珠粒的方法，该纤维素珠粒具有窄的孔径分布和适用于吸附剂的孔结构，并且其吸附性能优异，而不使用高毒性和高腐蚀性的辅助原料，并且在工业上不利的繁琐步骤。 根据本发明的多孔纤维素珠粒的制造方法的特征在于，（a）通过混合低温碱性水溶液和纤维素来制备细纤维素分散液的步骤，（b）通过添加制备混合液体的步骤 （c）通过将混合液体分散在分散介质中制备乳液的步骤，（d）使乳液与凝固溶剂接触的步骤。
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公开(公告)号：US20120028818A1
公开(公告)日：2012-02-02
申请号：US13213685
申请日：2011-08-19
申请人： Ove Per Öhman , Ib Mendel-Hartvig
发明人： Ove Per Öhman , Ib Mendel-Hartvig
IPC分类号： C40B30/00 , C12Q1/68 , C12P19/34 , C12N5/00 , C12M1/00 , B01D15/08 , G01N30/02 , G01N1/00 , C40B60/12 , C07K1/00 , C07H21/00 , B01J19/00 , B01L3/00 , G01N33/566
CPC分类号： B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L2200/0668 , B01L2300/18 , B01L2400/0406 , B01L2400/086 , G01N30/6065 , G01N30/6095 , G01N2030/525 , Y10T436/25
摘要： A micro fluidic system includes a substrate, and, provided on said substrate, at least one flow path interconnecting with functional means in which liquid samples can be treated by desired procedures. The flow paths are laid out to form a pattern for the transport of liquid samples to and from said functional means. These flow paths comprise a plurality of micro posts protruding upwards from said substrate, the spacing between the micro posts being small enough to induce a capillary action in a liquid sample applied anywhere within any of said flow paths, so as to force said liquid to move from where said liquid sample was applied.
摘要翻译： 微流体系统包括衬底，并且在所述衬底上提供与功能装置相互连接的至少一个流路，其中液体样品可以通过期望的程序进行处理。 布置流动路径以形成用于将液体样品运送到所述功能装置和从所述功能装置输送液体样品的图案。 这些流动路径包括从所述基底向上突出的多个微柱，微柱之间的间隔足够小，以在任何一个所述流动路径内的任何地方施加液体样品中的毛细管作用，以迫使所述液体移动 从其中应用所述液体样品。
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公开(公告)号：US07918979B2
公开(公告)日：2011-04-05
申请号：US12209789
申请日：2008-09-12
申请人： Jongyoon Han , Harold G. Craighead
发明人： Jongyoon Han , Harold G. Craighead
IPC分类号： G01N27/447
CPC分类号： C07K1/26 , B01D57/02 , B01L3/502761 , B01L2200/0668 , B01L2400/0421 , B01L2400/086 , C02F1/469 , C07K1/34 , G01N30/02 , G01N30/6082 , G01N30/6095 , G01N2030/285 , G01N2030/525 , B01D15/34 , G01N30/74
摘要： Nanofluidic entropic traps, comprising alternating thin and thick regions, sieve small molecules such as DNA or protein polymers and other molecules. The thick region is comparable or substantially larger than the molecule to be separated, while the thin region is substantially smaller than the size of the molecules to be separated. Due to the molecular size dependence of the entropic trapping effect, separation of molecules may be achieved. In addition, entropic traps are used to collect, trap and control many molecules in the nanofluidic channel. A fabrication method is disclosed to provide an efficient way to make nanofluidic constrictions in any fluidic devices.
摘要翻译： 纳米流体熵陷阱，包括交替的薄和厚区域，筛小分子如DNA或蛋白质聚合物和其他分子。 厚区域与待分离的分子相当或基本上大，而薄区域显着小于要分离的分子的大小。 由于熵捕获效应的分子尺寸依赖性，可以实现分子的分离。 此外，熵陷阱用于收集，捕获和控制纳米流体通道中的许多分子。 公开了制造方法以提供在任何流体装置中制造纳米流体收缩的有效方式。
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公开(公告)号：US07833398B2
公开(公告)日：2010-11-16
申请号：US11938141
申请日：2007-11-09
IPC分类号： B01D59/42
CPC分类号： G01N30/6052 , B01L3/502753 , B01L3/502761 , B01L2200/0663 , B01L2400/0409 , B01L2400/0415 , B01L2400/0487 , G01N30/02 , G01N30/6082 , G01N2030/285 , G01N2030/525 , G01N2030/527 , B01D15/34
摘要： Separation of long molecules by length is obtained by forcing such molecules to traverse a boundary between a low free-energy region and a high free-energy region. In one embodiment, the high free-energy region is a dense pillar region or other structure formed on a semiconductor substrate. One or more membranes are used in further embodiments. The low free-energy region is a larger chamber formed adjacent the high free-energy region. A recoil phase allows longer molecules not fully driven into the high free-energy region to recoil into the low free-energy region. In a further variation, the high free-energy region is a membrane having nanoscale holes.
摘要翻译： 通过强迫这样的分子穿过低自由能区域和高自由能区域之间的边界来获得长分子长度的分离。 在一个实施例中，高自由能区域是形成在半导体衬底上的致密柱状区域或其它结构。 在另外的实施方案中使用一种或多种膜。 低自由能区域是在高自由能区域附近形成的较大室。 反冲阶段允许更长的分子不完全驱动到高自由能区域以反冲到低自由能区域。 在另一变型中，高自由能区域是具有纳米孔的膜。
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6.发明授权公开(公告)号：US07745616B2
公开(公告)日：2010-06-29
申请号：US11918331
申请日：2006-04-28
IPC分类号： C08B3/12
CPC分类号： C08B33/00 , B01D15/3833 , B01J20/24 , B01J20/265 , B01J20/267 , B01J20/28004 , B01J20/28016 , B01J20/285 , B01J20/29 , B01J20/30 , B01J2220/4825 , C08B15/06 , C08B15/10 , G01N2030/525 , Y10T428/2982 , Y10T428/2998
摘要： There is provided a process for producing beads for enantiomeric isomer resolution with a satisfactory separation efficiency. The beads for enantiomeric isomer resolution include a polysaccharide derivative, in which the polysaccharide derivative has a structure crosslinked at the 6-position hydroxy group of constituent units of the polysaccharide with a crosslinking agent. The process for producing the beads for enantiomeric isomer resolution includes: the step of adding dropwise an organic solvent solution of the polysaccharide derivative to a coagulation bath being stirred to thereby produce beads; the step of taking out the beads and then optionally drying the same after washing; and the step of reacting the beads with a crosslinking agent in an organic solvent to react at least part of the 6-position hydroxy groups in the constituent units of the polysaccharide with the crosslinking agent, thereby obtaining a reaction mixture containing beads having a crosslinked structure.
摘要翻译： 提供了一种以令人满意的分离效率制备对映异构体拆分的珠的方法。 用于对映体异构体拆分的珠子包括多糖衍生物，其中多糖衍生物具有在多糖的构成单元的6-位羟基与交联剂交联的结构。 用于制备对映体异构体拆分的珠粒的方法包括：将滴加有机溶剂的多糖衍生物的溶液搅拌至凝固浴的步骤，从而产生珠粒; 取出珠粒，然后洗涤后任选地干燥珠粒的步骤; 和将珠粒与交联剂在有机溶剂中反应的步骤，使多糖的构成单元中的6位羟基的至少一部分与交联剂反应，得到含有交联结构的珠粒的反应混合物 。
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公开(公告)号：US20100032357A1
公开(公告)日：2010-02-11
申请号：US12377274
申请日：2007-08-14
CPC分类号： G01N30/6095 , G01N30/52 , G01N2030/525
摘要： A high separation efficiency column 10 for chromatography and a manufacturing method thereof are provided. The column 10 for chromatography includes a first substrate 11 having a plurality of pillars 22 formed on one surface thereof and a second substrate 12 bonded to the one surface of the first substrate 11 and constituting a flow path 13 together with the plurality of pillars 22 formed on the first substrate. At least a surface of each pillar is formed in a porous shape.
摘要翻译： 提供了用于色谱法的高分离效率柱10及其制造方法。 用于层析的柱10包括：第一基板11，其具有在其一个表面上形成的多个柱22;以及第二基板12，其与第一基板11的一个表面接合，并与形成的多个柱22一起构成流路13 在第一基板上。 每个柱的至少一个表面形成为多孔形状。
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公开(公告)号：US20090047681A1
公开(公告)日：2009-02-19
申请号：US12209789
申请日：2008-09-12
申请人： Jongyoon Han , Harold G. Craighead
发明人： Jongyoon Han , Harold G. Craighead
IPC分类号： C12Q1/68
CPC分类号： C07K1/26 , B01D57/02 , B01L3/502761 , B01L2200/0668 , B01L2400/0421 , B01L2400/086 , C02F1/469 , C07K1/34 , G01N30/02 , G01N30/6082 , G01N30/6095 , G01N2030/285 , G01N2030/525 , B01D15/34 , G01N30/74
摘要： Nanofluidic entropic traps, comprising alternating thin and thick regions, sieve small molecules such as DNA or protein polymers and other molecules. The thick region is comparable or substantially larger than the molecule to be separated, while the thin region is substantially smaller than the size of the molecules to be separated. Due to the molecular size dependence of the entropic trapping effect, separation of molecules may be achieved. In addition, entropic traps are used to collect, trap and control many molecules in the nanofluidic channel. A fabrication method is disclosed to provide an efficient way to make nanofluidic constrictions in any fluidic devices.
摘要翻译： 纳米流体熵陷阱，包括交替的薄和厚区域，筛小分子如DNA或蛋白质聚合物和其他分子。 厚区域与待分离的分子相当或基本上大，而薄区域显着小于要分离的分子的大小。 由于熵捕获效应的分子尺寸依赖性，可以实现分子的分离。 此外，熵陷阱用于收集，捕获和控制纳米流体通道中的许多分子。 公开了制造方法以提供在任何流体装置中制造纳米流体收缩的有效方式。
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公开(公告)号：US07488603B2
公开(公告)日：2009-02-10
申请号：US10920960
申请日：2004-08-17
CPC分类号： B01L3/0275 , B01D15/325 , B01D15/327 , B01D15/3804 , B01J20/285 , B01J20/291 , B01J2220/64 , B01L2200/0631 , B82Y30/00 , G01N30/6004 , G01N35/10 , G01N2030/009 , G01N2035/103 , G01N2035/1039 , G01N2035/1053 , Y10T436/153333 , Y10T436/25375 , Y10T436/255 , Y10T436/2575 , G01N2030/525
摘要： The invention provides extraction columns for the purification of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution, as well as methods for making and using such columns. The columns typically include a bed of extraction media positioned in the column between two frits. In some embodiments, the extraction columns employ modified pipette tips as column bodies. In some embodiments, the invention provides methods characterized by the elution of analyte in a small volume of liquid.
摘要翻译： 本发明提供了用于从样品溶液中纯化分析物（例如生物大分子，如肽，蛋白质或核酸）的提取柱，以及制备和使用这些色谱柱的方法。 柱通常包括位于两个玻璃料之间的柱中的提取介质床。 在一些实施方案中，提取柱使用改进的移液管尖作为柱体。 在一些实施方案中，本发明提供了以分析物在小体积液体中洗脱为特征的方法。
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公开(公告)号：US07427343B2
公开(公告)日：2008-09-23
申请号：US10648725
申请日：2003-08-25
申请人： Jongyoon Han , Harold G. Craighead
发明人： Jongyoon Han , Harold G. Craighead
IPC分类号： G01N27/453
CPC分类号： C07K1/26 , B01D57/02 , B01L3/502761 , B01L2200/0668 , B01L2400/0421 , B01L2400/086 , C02F1/469 , C07K1/34 , G01N30/02 , G01N30/6082 , G01N30/6095 , G01N2030/285 , G01N2030/525 , B01D15/34 , G01N30/74
摘要： Nanofluidic entropic traps, comprising alternating thin and thick regions, sieve small molecules such as DNA or protein polymers and other molecules. The thick region is comparable or substantially larger than the molecule to be separated, while the thin region is substantially smaller than the size of the molecules to be separated. Due to the molecular size dependence of the entropic trapping effect, separation of molecules may be achieved. In addition, entropic traps are used to collect, trap and control many molecules in the nanofluidic channel. A fabrication method is disclosed to provide an efficient way to make nanofluidic constrictions in any fluidic devices.
摘要翻译： 纳米流体熵陷阱，包括交替的薄和厚区域，筛小分子如DNA或蛋白质聚合物和其他分子。 厚区域与待分离的分子相当或基本上大，而薄区域显着小于要分离的分子的大小。 由于熵捕获效应的分子尺寸依赖性，可以实现分子的分离。 此外，熵陷阱用于收集，捕获和控制纳米流体通道中的许多分子。 公开了制造方法以提供在任何流体装置中制造纳米流体收缩的有效方式。
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