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31.发明申请System, Device and Method for Preparing Tracers and Transferring Materials During Radiosynthesis 审中-公开在放射合成过程中制备示踪剂和转移材料的系统，装置和方法公开(公告)号：US20120283490A1
公开(公告)日：2012-11-08
申请号：US13445147
申请日：2012-04-12
申请人： Umesh B. Gangadharmath , Joseph C. Walsh , Hartmuth C. Kolb , Ricardo Rodriguez , Arkadij M. Elizarov , Carroll Edward Ball
发明人： Umesh B. Gangadharmath , Joseph C. Walsh , Hartmuth C. Kolb , Ricardo Rodriguez , Arkadij M. Elizarov , Carroll Edward Ball
CPC分类号： B01J19/004 , A61K51/0455 , A61K51/08 , A61K51/082 , B01J4/008 , C07B59/00 , Y10T137/86035
摘要： A system, apparatus, and method for transferring chemical solutions and synthesizing a tracer. For transferring chemical solutions, the system comprises a primary container; a secondary container; a first line in communication with the primary container and the secondary container. The first line facilitates the flow of gas and/or liquid between the primary container and the secondary container. A valve located upstream of the secondary container and downstream of the primary container regulates flow within the first line; a second line in communication with the secondary container. For synthesizing a tracer, the system includes a source of a solution having a radionuclide. A first container has a tracer precursor and is in communication with the source of solution.
摘要翻译： 用于转移化学溶液并合成示踪剂的系统，装置和方法。 为了转移化学溶液，该系统包括主容器; 次级容器 与第一容器和次容器连通的第一线。 第一行有利于主容器和次容器之间的气体和/或液体的流动。 位于次级容器上游并且在主容器下游的阀调节第一管线内的流动; 与第二容器通信的第二行。 为了合成示踪剂，该系统包括具有放射性核素的溶液源。 第一容器具有示踪剂前体并与溶液源连通。
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32.发明授权公开(公告)号：US09345792B2
公开(公告)日：2016-05-24
申请号：US13813687
申请日：2011-08-15
CPC分类号： A61K51/121 , A61J1/065 , A61K9/0019 , A61K47/02 , A61K47/12 , A61K51/0402 , A61K51/0453 , A61K51/0455 , A61K51/0459 , A61K51/0491 , A61K51/1282 , B65D81/2069
摘要： A formulation for stabilizing a radiopharmaceutical. The formulation includes a radiopharmaceutical (or a pharmaceutically acceptable salt thereof), a gas which has oxygen, a stabilizer, and a solvent.
摘要翻译： 用于稳定放射性药物的制剂。 该制剂包括放射性药物（或其药学上可接受的盐），具有氧气，稳定剂和溶剂的气体。
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33.发明申请公开(公告)号：US20130183238A1
公开(公告)日：2013-07-18
申请号：US13813687
申请日：2011-08-15
IPC分类号： A61K51/04
CPC分类号： A61K51/121 , A61J1/065 , A61K9/0019 , A61K47/02 , A61K47/12 , A61K51/0402 , A61K51/0453 , A61K51/0455 , A61K51/0459 , A61K51/0491 , A61K51/1282 , B65D81/2069
摘要： A formulation for stabilizing a radiopharmaceutical. The formulation includes a radiopharmaceutical (or a pharmaceutically acceptable salt thereof), a gas which has oxygen, a stabilizer, and a solvent.
摘要翻译： 用于稳定放射性药物的制剂。 该制剂包括放射性药物（或其药学上可接受的盐），具有氧气，稳定剂和溶剂的气体。
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34.发明申请公开(公告)号：US20080213175A1
公开(公告)日：2008-09-04
申请号：US11901704
申请日：2007-09-17
申请人： Hartmuth C. Kolb , Kai Chen , Joseph C. Walsh , Umesh Gangadharmath , Dhanalakshmi Kasi , Bing Wang , Brian Duclos , Qianwa Liang , Henry Clifton Padgett , Farhad Karimi
发明人： Hartmuth C. Kolb , Kai Chen , Joseph C. Walsh , Umesh Gangadharmath , Dhanalakshmi Kasi , Bing Wang , Brian Duclos , Qianwa Liang , Henry Clifton Padgett , Farhad Karimi
CPC分类号： C07K7/56
摘要： The present application is directed to radiolabeled cyclic peptidomimetics, pharmaceutical compositions comprising radiolabeled cyclic peptidomimetics, and methods of using the radiolabeled cyclic peptidomimetics. Such peptidomimetics can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).
摘要翻译： 本申请涉及放射性标记的环肽模拟物，包含放射性标记的环肽模拟物的药物组合物，以及使用放射性标记的环肽模拟物的方法。 这种肽模拟物可用于成像研究，例如正电子发射断层扫描（PET）或单光子发射计算机断层扫描（SPECT）。
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35.发明授权公开(公告)号：US08133472B2
公开(公告)日：2012-03-13
申请号：US12433258
申请日：2009-04-30
申请人： Hartmuth C. Kolb , Kai Chen , Joseph C. Walsh , Qianwa Liang
发明人： Hartmuth C. Kolb , Kai Chen , Joseph C. Walsh , Qianwa Liang
CPC分类号： C07K7/64 , A61K51/082 , A61K51/088 , G01N2333/70546
摘要： Radiolabeled cyclic polypeptides, pharmaceutical compositions comprising radiolabeled cyclic polypeptides, and methods of using the radiolabeled cyclic polypeptides. Such polypeptides can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).
摘要翻译： 放射性标记的环状多肽，包含放射性标记的环状多肽的药物组合物，以及使用放射性标记的环状多肽的方法。 这样的多肽可用于成像研究，例如正电子发射断层扫描（PET）或单光子发射计算机断层扫描（SPECT）。
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公开(公告)号：US07928210B2
公开(公告)日：2011-04-19
申请号：US12074538
申请日：2008-03-03
申请人： Hartmuth C. Kolb , Joseph C. Walsh , Robert M Yeh , Kai Chen , Umesh Gangadharmath , Brian Duclos , Vani P. Mocharla , Farhad Karimi , Henry C. Padgett , Qianwa Liang , Tieming Zhao
发明人： Hartmuth C. Kolb , Joseph C. Walsh , Robert M Yeh , Kai Chen , Umesh Gangadharmath , Brian Duclos , Vani P. Mocharla , Farhad Karimi , Henry C. Padgett , Qianwa Liang , Tieming Zhao
CPC分类号： C07H19/073 , A61K51/0491 , C07H19/06 , C07H19/067
摘要： Disclosed herein are novel radiolabeled nucleosides and methods for detecting cellular proliferation in a mammal, the method comprising administrating an effective amount of a radiolabeled nucleoside; the method comprising: a) administering to the mammal a diagnostically effective amount of the nucleoside to the mammal; b) allowing the nucleoside to distribute into the effective tissue; and c) imaging the tissue, wherein an increase in binding of the compound to tissue compared to a normal control level of binding indicates that the mammal is suffering from a disease involving cellular proliferation.
摘要翻译： 本文公开了新型放射性标记核苷和用于检测哺乳动物细胞增殖的方法，该方法包括施用有效量的放射性标记的核苷; 所述方法包括：a）向哺乳动物施用诊断有效量的核苷; b）允许核苷分布到有效组织中; 和c）对所述组织进行成像，其中与正常对照结合水平相比，所述化合物与组织的结合增加指示所述哺乳动物患有涉及细胞增殖的疾病。
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公开(公告)号：US20090016958A1
公开(公告)日：2009-01-15
申请号：US12074538
申请日：2008-03-03
申请人： Hartmuth C. Kolb , Joseph C. Walsh , Robert M. Yeh , Kai Chen , Umesh Gangadharmath , Brian Duclos , Vani P. Mocharla , Farhad Karimi , Henry C. Padgett , Qianwa Liang , Tieming Zhao
发明人： Hartmuth C. Kolb , Joseph C. Walsh , Robert M. Yeh , Kai Chen , Umesh Gangadharmath , Brian Duclos , Vani P. Mocharla , Farhad Karimi , Henry C. Padgett , Qianwa Liang , Tieming Zhao
CPC分类号： C07H19/073 , A61K51/0491 , C07H19/06 , C07H19/067
摘要： Disclosed herein are novel radiolabeled nucleosides and methods for detecting cellular proliferation in a mammal, the method comprising administrating an effective amount of a radiolabeled nucleoside; the method comprising: a) administering to the mammal a diagnostically effective amount of the nucleoside to the mammal; b) allowing the nucleoside to distribute into the effective tissue; and c) imaging the tissue, wherein an increase in binding of the compound to tissue compared to a normal control level of binding indicates that the mammal is suffering from a disease involving cellular proliferation.
摘要翻译： 本文公开了新型放射性标记核苷和用于检测哺乳动物细胞增殖的方法，该方法包括施用有效量的放射性标记的核苷; 所述方法包括：a）向哺乳动物施用诊断有效量的核苷; b）允许核苷分布到有效组织中; 和c）对所述组织进行成像，其中与正常对照结合水平相比，所述化合物与组织的结合增加指示所述哺乳动物患有涉及细胞增殖的疾病。
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38.发明申请公开(公告)号：US20100074844A1
公开(公告)日：2010-03-25
申请号：US12433258
申请日：2009-04-30
申请人： Hartmuth C. Kolb , Kai Chen , Joseph C. Walsh , Qianwa Liang
发明人： Hartmuth C. Kolb , Kai Chen , Joseph C. Walsh , Qianwa Liang
CPC分类号： C07K7/64 , A61K51/082 , A61K51/088 , G01N2333/70546
摘要： Radiolabeled cyclic polypeptides, pharmaceutical compositions comprising radiolabeled cyclic polypeptides, and methods of using the radiolabeled cyclic polypeptides. Such polypeptides can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).
摘要翻译： 放射性标记的环状多肽，包含放射性标记的环状多肽的药物组合物，以及使用放射性标记的环状多肽的方法。 这样的多肽可用于成像研究，例如正电子发射断层扫描（PET）或单光子发射计算机断层扫描（SPECT）。
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39.发明授权Click chemistry-derived cyclopeptide derivatives as imaging agents for integrins 有权点击化学衍生的环肽衍生物作为整合素的成像剂公开(公告)号：US07666392B2
公开(公告)日：2010-02-23
申请号：US11901730
申请日：2007-09-17
申请人： Hartmuth C. Kolb , Kai Chen , Joseph C. Walsh , Qianwa Liang , Henry Clifton Padgett , Farhad Karimi
发明人： Hartmuth C. Kolb , Kai Chen , Joseph C. Walsh , Qianwa Liang , Henry Clifton Padgett , Farhad Karimi
IPC分类号： A61K49/00
CPC分类号： A61K51/088 , A61K51/082
摘要： The present application is directed to radiolabeled cyclic polypeptides, pharmaceutical compositions comprising radiolabeled cyclic polypeptides, and methods of using the radiolabeled cyclic polypeptides. Such polypeptides can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).
摘要翻译： 本申请涉及放射性标记的环状多肽，包含放射性标记的环状多肽的药物组合物，以及使用放射性标记的环状多肽的方法。 这样的多肽可用于成像研究，例如正电子发射断层扫描（PET）或单光子发射计算机断层扫描（SPECT）。
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40.发明申请Click chemistry-derived cyclopeptide derivatives as imaging agents for integrins 有权点击化学衍生的环肽衍生物作为整合素的成像剂公开(公告)号：US20080170992A1
公开(公告)日：2008-07-17
申请号：US11901730
申请日：2007-09-17
申请人： Hartmuth C. Kolb , Kai Chen , Joseph C. Walsh , Qianwa Liang , Henry Clifton Padgett , Farhad Karimi
发明人： Hartmuth C. Kolb , Kai Chen , Joseph C. Walsh , Qianwa Liang , Henry Clifton Padgett , Farhad Karimi
CPC分类号： A61K51/088 , A61K51/082
摘要： The present application is directed to radiolabeled cyclic polypeptides, pharmaceutical compositions comprising radiolabeled cyclic polypeptides, and methods of using the radiolabeled cyclic polypeptides. Such polypeptides can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).
摘要翻译： 本申请涉及放射性标记的环状多肽，包含放射性标记的环状多肽的药物组合物，以及使用放射性标记的环状多肽的方法。 这样的多肽可用于成像研究，例如正电子发射断层扫描（PET）或单光子发射计算机断层扫描（SPECT）。
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