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271 条记录 (耗时 0.028 秒)

    Osmotic drug delivery devices with hydrophobic wall materials
    32.
    发明授权
    Osmotic drug delivery devices with hydrophobic wall materials 失效
    具有疏水壁材料的渗透性药物输送装置

    公开(公告)号：US5795591A

    公开(公告)日：1998-08-18

    申请号：US299867

    申请日：1994-09-01

    申请人： Eun Soo Lee ,  Scott A. Bura ,  Su Il Yum ,  Patrick S.-L. Wong ,  Felix Theeuwes

    发明人： Eun Soo Lee ,  Scott A. Bura ,  Su Il Yum ,  Patrick S.-L. Wong ,  Felix Theeuwes

    IPC分类号： A61M37/00 ,  A61K9/00 ,  A61K9/52 ,  A61K9/26

    CPC分类号： A61K9/0004

    摘要： Osmotically driven drug delivery devices with walls of porous hydrophobic material as the sole diffusion-limiting wall component are disclosed. Despite pores which are considerably larger than the molecular dimensions of osmotically active species in the interior of the device, despite pores which by their hydrophobic character do not permit the passage of liquid water, and despite the absence of a cellulosic semi-permeable membrane, the devices absorb water by osmosis without loss of the osmotically active species, and function in a manner analogous to osmotic pumps of the prior art. By permitting the use of hydrophobic substances as the wall material, the invention permits the device to be constructed entirely from biodegradable materials.

    摘要翻译： 公开了具有作为唯一扩散限制壁部件的多孔疏水材料壁的渗透驱动药物输送装置。 尽管孔远远大于装置内部的渗透活性物质的分子尺寸，尽管孔具有疏水性，但不允许液态水通过，尽管不存在纤维素半透膜， 装置通过渗透吸收水分而不损失渗透活性物质，并且以类似于现有技术的渗透泵的方式起作用。 通过允许使用疏水物质作为壁材料，本发明允许该装置完全由可生物降解的材料构成。

    Osmotic device for delayed delivery of agent
    34.
    发明授权
    Osmotic device for delayed delivery of agent 失效

    公开(公告)号：US5531736A

    公开(公告)日：1996-07-02

    申请号：US424692

    申请日：1995-04-19

    申请人： Patrick S.-L. Wong ,  Felix Theeuwes ,  Steven D. Larsen ,  Liang C. Dong

    发明人： Patrick S.-L. Wong ,  Felix Theeuwes ,  Steven D. Larsen ,  Liang C. Dong

    IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/48

    CPC分类号： A61K9/0004 ,  A61K9/4808

    摘要： The present invention is directed to a fluid-imbibing dispensing device for the initially delayed delivery of an active agent to a fluid environment of use and to a method of using the dispensing device. The dispenser comprises a housing having a first wall section and a second wall section in reversibly sliding telescopic arrangement with each other, which housing maintains its integrity in the environment of use; an internal compartment surrounded and defined by the housing; at least one active agent formulation in the compartment; and expansion means and a push plate in the compartment for separating apart the first and second wall sections of the housing after exposure to the environment of use to expose the active agent formulation to the environment of use.

    Controlled-release system with constant pushing source
    37.
    发明授权
    Controlled-release system with constant pushing source 失效
    具有恒定推压源的控制释放系统

    公开(公告)号：US5082668A

    公开(公告)日：1992-01-21

    申请号：US595140

    申请日：1990-10-09

    申请人： Patrick S. L. Wong ,  Brian L. Barclay ,  Joseph C. Deters ,  Felix Theeuwes

    发明人： Patrick S. L. Wong ,  Brian L. Barclay ,  Joseph C. Deters ,  Felix Theeuwes

    IPC分类号： A61K9/00 ,  A61K9/22

    CPC分类号： A61K9/0004

    摘要： A device is disclosed comprising a wall that surrounds a compartment. The compartment comprises a beneficial agent composition and a push composition. A passageway in the wall connects the compartment with the exterior of the device for delivering the beneficial agent at a rate governed, in combination, by the wall, the beneficial agent composition and the push composition through the passageway of the device over time.

    摘要翻译： 公开了一种包括围绕隔室的壁的装置。 隔室包含有益剂组合物和推组合物。 壁中的通道将隔室与装置的外部连接，用于通过墙壁，有益剂组合物和推动组合物通过装置的通道随时间而被组合地传递有益剂。

    Delayed onset transdermal delivery device
    38.
    发明授权
    Delayed onset transdermal delivery device 失效
    延迟发作透皮递送装置

    公开(公告)号：US5071656A

    公开(公告)日：1991-12-10

    申请号：US271207

    申请日：1988-11-14

    申请人： Eun Soo Lee ,  Felix Theeuwes ,  Patrick S. L. Wong ,  Su Il Yum ,  Alejandro Zaffaroni

    发明人： Eun Soo Lee ,  Felix Theeuwes ,  Patrick S. L. Wong ,  Su Il Yum ,  Alejandro Zaffaroni

    IPC分类号： A61K9/70 ,  A61K31/21

    CPC分类号： A61K9/7069 ,  A61K31/21 ,  A61K9/7084 ,  A61K9/7092

    摘要： A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are released in a predetermined temporal pattern at optimal release rates. Delayed permeability enables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continuous administration over extended time periods.

    摘要翻译： 描述了扩散药物递送装置，其可以提供治疗效果的延迟开始和以最佳速率以预定时间模式递送治疗剂。 在药剂储存器和通过扩散释放药剂的表面之间提供延迟装置，以在施用后以治疗速率延迟药剂释放预定时间。 合适的方法包括设置在释放表面和试剂储存器之间的延迟膜，该膜优选不含未溶解的试剂和/或最初对试剂不渗透，然后变为可渗透的。 可以提供由一个或多个这样的膜限定的一个或多个试剂室，由此以最佳释放速率以预定的时间模式释放试剂。 延迟渗透性使得能够从连续和同时使用用于施用诸如硝酸盐的药物的装置获得程序性洗脱期，患者可以在延长的时间段内持续施用耐受性。

    Delayed release osmotically driven fluid dispenser
    40.
    发明授权
    Delayed release osmotically driven fluid dispenser 失效
    延迟释放渗透驱动的流体分配器

    公开(公告)号：US4976966A

    公开(公告)日：1990-12-11

    申请号：US291725

    申请日：1988-12-29

    申请人： Felix Theeuwes ,  Patrick S. L. Wong

    发明人： Felix Theeuwes ,  Patrick S. L. Wong

    IPC分类号： A61K9/00 ,  A61K9/22

    CPC分类号： A61K9/0004

    摘要： An osmotically driven pump is provided that is capable of being miniaturized to a size suited for swallowing or implanting in an animal. The pump may be used to administer a drug in fluid form after an initial activation period during which substantially no drug is administered. The basic components of the pump are a shaped semipermeable membrane that encapsulates an osmotically effective solute and preferably a drug or other beneficial agent and a discharge port through which the drug or other beneficial agent is dispensed. A semipermeable or microporous outer cover surrounds the semipermeable membrane and seals it from an external aqueous environment. A water-swellable composition is operatively positioned between the end of the semipermeable membrane and the outer cover. Preferably, a water wicking layer at least partially surrounds the semipermeable membrane and is also sealed within the outer cover. In operation, the pump is placed in an aqueous environment. Water from the environment passes through the semipermeable/microporous portion of the outer cover into the water-swellable composition. The water-swellable composition absorbs water, expands, and in piston-like fashion displaces the outer cover, thereby exposing the semipermeable membrane to the aqueous environment and activating the osmotic pump. The time required for the water-swellable composition to absorb water, expand and displace the outer cover provides an initial activation period during which substantially no drug is delivered by the pump.

    摘要翻译： 提供了一种渗透驱动的泵，其能够被小型化成适合于在动物中吞咽或植入的尺寸。 在基本上不施用药物的初始活化期之后，泵可以用于以流体形式施用药物。 泵的基本组分是封装渗透有效溶质，优选药物或其它有益剂的成形半透膜和药物或其它有益剂通过其分配的排出口。 半透膜或微孔外壳围绕半透膜并将其与外部水性环境密封。 可水膨胀组合物可操作地定位在半透膜的端部和外覆盖件之间。 优选地，吸水层至少部分地包围半透膜并且也被密封在外盖内。 在操作中，将泵放置在水性环境中。 来自环境的水通过外盖的半透/微孔部分进入水溶胀性组合物。 水溶胀性组合物吸收水，膨胀，并且以活塞样的方式取代外盖，从而将半透膜暴露于水性环境并激活渗透泵。 水溶胀性组合物吸收水，膨胀和置换外盖所需的时间提供初始激活期，在此期间基本上没有药物由泵输送。