公开(公告)号：US07408042B2

公开(公告)日：2008-08-05

申请号：US10145958

申请日：2002-05-14

申请人： Kevin P. Baker ,  Maureen Beresini ,  Laura DeForge ,  Luc Desnoyers ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  William I. Wood ,  Zemin Zhang

发明人： Kevin P. Baker ,  Maureen Beresini ,  Laura DeForge ,  Luc Desnoyers ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  William I. Wood ,  Zemin Zhang

IPC分类号： C07K16/18

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  C07K1/00 ,  C07K14/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K14/705 ,  C07K14/70578 ,  C07K14/82 ,  C07K16/18 ,  C07K17/00 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/30 ,  C12N5/06 ,  C12N9/00 ,  C12N9/001 ,  C12N9/1051 ,  C12N15/00 ,  C12N2799/026 ,  C12P21/02 ,  C12P21/06 ,  C12Q1/68 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5014 ,  G01N33/502 ,  G01N33/5044 ,  G01N33/505 ,  G01N33/5061 ,  G01N33/53 ,  G01N33/574 ,  G01N33/57484 ,  G01N33/68 ,  G01N33/6845 ,  G01N2800/042 ,  Y10S530/828 ,  Y10S530/866

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US07385031B2

公开(公告)日：2008-06-10

申请号：US10145632

申请日：2002-05-14

申请人： Kevin P. Baker ,  Maureen Beresini ,  Laura DeForge ,  Luc Desnoyers ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  William I. Wood ,  Zemin Zhang

发明人： Kevin P. Baker ,  Maureen Beresini ,  Laura DeForge ,  Luc Desnoyers ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  William I. Wood ,  Zemin Zhang

IPC分类号： C07K14/705

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  C07K1/00 ,  C07K14/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K14/705 ,  C07K14/70578 ,  C07K14/82 ,  C07K16/18 ,  C07K17/00 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/30 ,  C12N5/06 ,  C12N9/00 ,  C12N9/001 ,  C12N9/1051 ,  C12N15/00 ,  C12N2799/026 ,  C12P21/02 ,  C12P21/06 ,  C12Q1/68 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5014 ,  G01N33/502 ,  G01N33/5044 ,  G01N33/505 ,  G01N33/5061 ,  G01N33/53 ,  G01N33/574 ,  G01N33/57484 ,  G01N33/68 ,  G01N33/6845 ,  G01N2800/042 ,  Y10S530/828 ,  Y10S530/866

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US07375184B2

公开(公告)日：2008-05-20

申请号：US10012754

申请日：2001-12-07

申请人： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Timothy A. Stewart ,  William I. Wood

发明人： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Timothy A. Stewart ,  William I. Wood

IPC分类号： C07K1/00

CPC分类号： C07K14/47 ,  C07K14/575 ,  C07K2319/30 ,  C07K2319/40

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US07309775B2

公开(公告)日：2007-12-18

申请号：US09998041

申请日：2001-11-15

申请人： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Colin K. Watanabe ,  William I. Wood ,  Timothy A. Stewart

发明人： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Colin K. Watanabe ,  William I. Wood ,  Timothy A. Stewart

IPC分类号： C07K16/00 ,  A61K39/395 ,  A61K39/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  C07K14/52 ,  C07K14/705 ,  C07K16/18 ,  C07K2319/00 ,  C12N9/00 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/57484 ,  G01N33/68 ,  G01N33/6842 ,  Y10S530/866

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US07193050B2

公开(公告)日：2007-03-20

申请号：US10145087

申请日：2001-10-18

申请人： Kevin P. Baker ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Timothy A. Stewart ,  William I. Wood

发明人： Kevin P. Baker ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Timothy A. Stewart ,  William I. Wood

IPC分类号： C07K14/47 ,  C07K19/00

CPC分类号： C07K14/47 ,  Y10S530/866

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US07491529B2

公开(公告)日：2009-02-17

申请号：US09989734

申请日：2001-11-19

申请人： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Timothy A. Stewart ,  Colin K. Watanabe ,  William I. Wood

发明人： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Timothy A. Stewart ,  Colin K. Watanabe ,  William I. Wood

IPC分类号： C12N15/85 ,  C12N15/63 ,  C12N1/15 ,  C12N1/20 ,  C12N15/11 ,  C07H21/04 ,  C07K14/00 ,  C12N15/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  C07K14/52 ,  C07K14/705 ,  C07K16/18 ,  C07K2319/00 ,  C12N9/00 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/57484 ,  G01N33/68 ,  G01N33/6842 ,  Y10S530/866

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US07160993B2

公开(公告)日：2007-01-09

申请号：US10152375

申请日：2002-05-21

申请人： Kevin P. Baker ,  Maureen Beresini ,  Laura DeForge ,  Luc Desnoyers ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  William I. Wood ,  Zemin Zhang

发明人： Kevin P. Baker ,  Maureen Beresini ,  Laura DeForge ,  Luc Desnoyers ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  William I. Wood ,  Zemin Zhang

IPC分类号： C07H21/04 ,  C12N15/00 ,  C12N15/12 ,  C12N15/63 ,  C07K14/00

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  C07K1/00 ,  C07K14/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K14/705 ,  C07K14/70578 ,  C07K14/82 ,  C07K16/18 ,  C07K17/00 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/30 ,  C12N5/06 ,  C12N9/00 ,  C12N9/001 ,  C12N9/1051 ,  C12N15/00 ,  C12N2799/026 ,  C12P21/02 ,  C12P21/06 ,  C12Q1/68 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5014 ,  G01N33/502 ,  G01N33/5044 ,  G01N33/505 ,  G01N33/5061 ,  G01N33/53 ,  G01N33/574 ,  G01N33/57484 ,  G01N33/68 ,  G01N33/6845 ,  G01N2800/042 ,  Y10S530/828 ,  Y10S530/866

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US07074910B2

公开(公告)日：2006-07-11

申请号：US10152398

申请日：2002-05-21

申请人： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  William I. Wood

发明人： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  William I. Wood

IPC分类号： C07H21/04 ,  C12N15/00 ,  C12N15/12 ,  C12N15/63 ,  C07K14/00

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  C07K1/00 ,  C07K14/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K14/705 ,  C07K14/70578 ,  C07K14/82 ,  C07K16/18 ,  C07K17/00 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/30 ,  C12N5/06 ,  C12N9/00 ,  C12N9/001 ,  C12N9/1051 ,  C12N15/00 ,  C12N2799/026 ,  C12P21/02 ,  C12P21/06 ,  C12Q1/68 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5014 ,  G01N33/502 ,  G01N33/5044 ,  G01N33/505 ,  G01N33/5061 ,  G01N33/53 ,  G01N33/574 ,  G01N33/57484 ,  G01N33/68 ,  G01N33/6845 ,  G01N2800/042 ,  Y10S530/828 ,  Y10S530/866

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US20090209732A1

公开(公告)日：2009-08-20

申请号：US11538714

申请日：2006-10-04

申请人： Kevin P. Baker ,  Maureen Beresini ,  Laura DeForge ,  Luc Desnoyers ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  William I. Wood ,  Zemin Zhang

发明人： Kevin P. Baker ,  Maureen Beresini ,  Laura DeForge ,  Luc Desnoyers ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  William I. Wood ,  Zemin Zhang

IPC分类号： C07K16/00 ,  C07K14/00

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  C07K1/00 ,  C07K14/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K14/705 ,  C07K14/70578 ,  C07K14/82 ,  C07K16/18 ,  C07K17/00 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/30 ,  C12N5/06 ,  C12N9/00 ,  C12N9/001 ,  C12N9/1051 ,  C12N15/00 ,  C12N2799/026 ,  C12P21/02 ,  C12P21/06 ,  C12Q1/68 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5014 ,  G01N33/502 ,  G01N33/5044 ,  G01N33/505 ,  G01N33/5061 ,  G01N33/53 ,  G01N33/574 ,  G01N33/57484 ,  G01N33/68 ,  G01N33/6845 ,  G01N2800/042 ,  Y10S530/828 ,  Y10S530/866

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US07538086B2

公开(公告)日：2009-05-26

申请号：US10006856

申请日：2001-12-06

申请人： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Timothy A. Stewart ,  William I. Wood

发明人： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Timothy A. Stewart ,  William I. Wood

IPC分类号： A61K38/00 ,  A61K39/00

CPC分类号： C07K14/47 ,  C07K14/705

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。