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公开(公告)号：US20050214308A1
公开(公告)日：2005-09-29
申请号：US10964263
申请日：2004-10-12
申请人： Avi Ashkenazi , Karim Helmy , Sherman Fong , Audrey Goddard , Austin Gurney , Kenneth Katschke , Mary Napier , Daniel Tumas , Menno Lookeren , William Wood
发明人： Avi Ashkenazi , Karim Helmy , Sherman Fong , Audrey Goddard , Austin Gurney , Kenneth Katschke , Mary Napier , Daniel Tumas , Menno Lookeren , William Wood
IPC分类号： A61K39/395 , C07K14/705 , C07K16/28
CPC分类号： C07K14/70503 , A61K2039/505 , C07K16/2803 , C07K2317/76 , C07K2319/30 , Y10S424/809 , Y10S424/81
摘要： The present invention concerns a recently discovered macrophage specific receptor, STIgMA, and its use in the treatment of complement-associated disorders.
摘要翻译： 本发明涉及最近发现的巨噬细胞特异性受体STIgMA及其在补体相关疾病的治疗中的应用。
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公开(公告)号：US20070190049A1
公开(公告)日：2007-08-16
申请号：US11725076
申请日：2007-03-15
申请人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin Gurney , Mary Napier , Daniel Tumas , Menno Lookeren , William Wood
发明人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin Gurney , Mary Napier , Daniel Tumas , Menno Lookeren , William Wood
IPC分类号： C07K16/46 , A61K39/395 , C07K14/705
CPC分类号： C07K14/705 , A61K2039/505 , C07K16/28 , C07K16/2803 , C07K2317/56 , C07K2319/30 , C12Q1/6883 , C12Q2600/158 , G01N33/564 , G01N33/566 , G01N33/574 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/705 , G01N2800/065 , G01N2800/102 , G01N2800/122 , G01N2800/127 , G01N2800/24
摘要： The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer.
摘要翻译： 本发明涉及治疗和诊断疾病的组合物和方法，其特征在于与炎性疾病和/或癌症相关的抗原的存在。
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公开(公告)号：US20060002944A1
公开(公告)日：2006-01-05
申请号：US11159919
申请日：2005-06-22
申请人： Avi Ashkenazi , Karim Helmy , Sherman Fong , Audrey Goddard , Austin Gurney , Kenneth Katschke , Menno Lookeren , William Wood
发明人： Avi Ashkenazi , Karim Helmy , Sherman Fong , Audrey Goddard , Austin Gurney , Kenneth Katschke , Menno Lookeren , William Wood
IPC分类号： A61K39/395
CPC分类号： A61K38/177 , A61K38/17 , A61K38/1709 , A61K2039/505 , C07K14/705 , C07K16/28 , C07K2317/77 , C07K2319/30 , Y02A50/463 , A61K2300/00
摘要： The present invention concerns a recently discovered macrophage specific receptor, CRIg, and its use in the treatment of complement-associated disorders.
摘要翻译： 本发明涉及最近发现的巨噬细胞特异性受体CRIg及其在补体相关疾病的治疗中的应用。
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34.发明申请Novel tumor necrosis factor receptor homolog and nucleic acids encoding the same 审中-公开新型肿瘤坏死因子受体同源物和核酸编码相同公开(公告)号：US20050069983A1
公开(公告)日：2005-03-31
申请号：US10959537
申请日：2004-10-06
申请人： Avi Ashkenazi , Audrey Goddard , Austin Gurney , Scot Marsters , Robert Pitti , William Wood
发明人： Avi Ashkenazi , Audrey Goddard , Austin Gurney , Scot Marsters , Robert Pitti , William Wood
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P29/00 , A61P37/06 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/28 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68 , C07K14/715 , C12P21/04
CPC分类号： C07K14/70578 , A61K38/00 , C07K14/4747 , C07K14/70575 , C07K2319/00 , C12N2799/026
摘要： The present invention is directed to novel polypeptides having homology to members of the tumor necrosis factor receptor family and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及与肿瘤坏死因子受体家族的成员具有同源性的新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US07074592B2
公开(公告)日：2006-07-11
申请号：US09909320
申请日：2001-07-18
申请人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jenni P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
发明人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jenni P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
CPC分类号： C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US20060020114A1
公开(公告)日：2006-01-26
申请号：US11116746
申请日：2005-04-28
申请人： Avi Ashkenazi , Kevin Baker , Austin Gurney , William Wood
发明人： Avi Ashkenazi , Kevin Baker , Austin Gurney , William Wood
IPC分类号： C07K14/705 , C12Q1/68 , C07H21/04 , C12P21/06
CPC分类号： C07K14/70575 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A61K38/00 , C07K14/70578 , C07K2319/00 , C07K2319/30
摘要： Novel polypeptides, designated Apo-2DcR, which are capable of binding Apo-2 ligand are provided. Compositions including Apo-2DcR chimeras, nucleic acid encoding Apo-2DcR, and antibodies to Apo-2DcR are also provided.
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公开(公告)号：US20070041969A1
公开(公告)日：2007-02-22
申请号：US11474010
申请日：2006-06-23
申请人： Avi Ashkenazi , Kevin Baker , Austin Gurney , William Wood
发明人： Avi Ashkenazi , Kevin Baker , Austin Gurney , William Wood
IPC分类号： A61K39/395 , C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/705 , A61K38/17
CPC分类号： C07K14/70575 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A61K38/00 , C07K14/70578 , C07K2319/00 , C07K2319/30
摘要： Novel polypeptides, designated Apo-2DcR, which are capable of binding Apo-2 ligand are provided. Compositions including Apo-2DcR chimeras, nucleic acid encoding Apo-2DcR, and antibodies to Apo-2DcR are also provided.
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公开(公告)号：US20070037191A1
公开(公告)日：2007-02-15
申请号：US11475718
申请日：2006-06-27
申请人： Avi Ashkenazi , Kevin Baker , Anan Chuntharapai , Austin Gurney , Kyung Kim , William Wood
发明人： Avi Ashkenazi , Kevin Baker , Anan Chuntharapai , Austin Gurney , Kyung Kim , William Wood
IPC分类号： C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K2039/505 , C07K14/4747 , C07K14/70578 , C07K16/2878 , C07K2319/00 , G01N33/57484 , G01N33/68
摘要： Novel polypeptides, designated Apo-2DcR, which are capable of binding Apo-2 ligand are provided. Compositions including Apo-2DcR chimeras, nucleic acid encoding Apo-2DcR, and antibodies to Apo-2DcR are also provided.
摘要翻译： 提供了能够结合Apo-2配体的新型多肽，称为Apo-2DcR。 还提供了包含Apo-2DcR嵌合体，编码Apo-2DcR的核酸和Apo-2DcR抗体的组合物。
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公开(公告)号：US07741056B2
公开(公告)日：2010-06-22
申请号：US11725063
申请日：2007-03-15
申请人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
发明人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
CPC分类号： C07K14/705 , A61K2039/505 , C07K16/28 , C07K16/2803 , C07K2317/56 , C07K2319/30 , C12Q1/6883 , C12Q2600/158 , G01N33/564 , G01N33/566 , G01N33/574 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/705 , G01N2800/065 , G01N2800/102 , G01N2800/122 , G01N2800/127 , G01N2800/24
摘要： The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer.
摘要翻译： 本发明涉及治疗和诊断疾病的组合物和方法，其特征在于与炎性疾病和/或癌症相关的抗原的存在。
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公开(公告)号：US07557192B2
公开(公告)日：2009-07-07
申请号：US09904786
申请日：2001-07-12
申请人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Giang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jennie P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
发明人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Giang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jennie P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
IPC分类号： C07K16/00
CPC分类号： C07K14/47 , G01N33/68 , G01N2333/485
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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