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公开(公告)号：US20070190054A1
公开(公告)日：2007-08-16
申请号：US11249825
申请日：2005-10-12
申请人： Avi Ashkenazi , Karim Helmy , Sherman Fong , Audrey Goddard , Austin Gurney , Kenneth Katschke , Menno Lookeren , William Wood
发明人： Avi Ashkenazi , Karim Helmy , Sherman Fong , Audrey Goddard , Austin Gurney , Kenneth Katschke , Menno Lookeren , William Wood
IPC分类号： A61K39/395
CPC分类号： G01N33/57484 , A61K38/00 , C07K14/705 , C07K16/28 , C07K2317/24 , C07K2319/30 , G01N33/6893
摘要： The present invention concerns a recently discovered macrophage specific receptor, CRIg, and its use in the prevention and treatment of complement-associated disorders, including complement-associated eye conditions, such as age-related macular degeneration (AMD) and choroidal neovascularization (CNV).
摘要翻译： 本发明涉及最近发现的巨噬细胞特异性受体CRIg及其在预防和治疗补体相关疾病（包括补体相关性眼病）如年龄相关性黄斑变性（AMD）和脉络膜新生血管形成（CNV）中的用途。 。
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公开(公告)号：US20060002944A1
公开(公告)日：2006-01-05
申请号：US11159919
申请日：2005-06-22
申请人： Avi Ashkenazi , Karim Helmy , Sherman Fong , Audrey Goddard , Austin Gurney , Kenneth Katschke , Menno Lookeren , William Wood
发明人： Avi Ashkenazi , Karim Helmy , Sherman Fong , Audrey Goddard , Austin Gurney , Kenneth Katschke , Menno Lookeren , William Wood
IPC分类号： A61K39/395
CPC分类号： A61K38/177 , A61K38/17 , A61K38/1709 , A61K2039/505 , C07K14/705 , C07K16/28 , C07K2317/77 , C07K2319/30 , Y02A50/463 , A61K2300/00
摘要： The present invention concerns a recently discovered macrophage specific receptor, CRIg, and its use in the treatment of complement-associated disorders.
摘要翻译： 本发明涉及最近发现的巨噬细胞特异性受体CRIg及其在补体相关疾病的治疗中的应用。
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公开(公告)号：US20070178486A1
公开(公告)日：2007-08-02
申请号：US11535718
申请日：2006-09-27
申请人： Avi Ashkenazi , Dan Eaton , Audrey Goddard , Austin Gurney , William Wood , Thomas Wu
发明人： Avi Ashkenazi , Dan Eaton , Audrey Goddard , Austin Gurney , William Wood , Thomas Wu
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C07K16/30 , C12Q1/6886 , C12Q2600/158
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
摘要翻译： 本发明涉及用于哺乳动物肿瘤诊断和治疗的物质组合物，以及使用这些物质组合物的方法。
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公开(公告)号：US20050176046A1
公开(公告)日：2005-08-11
申请号：US11046650
申请日：2005-01-28
申请人： Avi Ashkenazi , Dan Eaton , Audrey Goddard , Austin Gurney , William Wood , Thomas Wu
发明人： Avi Ashkenazi , Dan Eaton , Audrey Goddard , Austin Gurney , William Wood , Thomas Wu
IPC分类号： C07K16/44 , C07K16/46 , C12Q1/68 , G01N33/53 , G01N33/574
CPC分类号： C07K16/30 , C12Q1/6886 , C12Q2600/158
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
摘要翻译： 本发明涉及用于哺乳动物肿瘤诊断和治疗的物质组合物，以及使用这些物质组合物的方法。
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公开(公告)号：US07741056B2
公开(公告)日：2010-06-22
申请号：US11725063
申请日：2007-03-15
申请人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
发明人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
CPC分类号： C07K14/705 , A61K2039/505 , C07K16/28 , C07K16/2803 , C07K2317/56 , C07K2319/30 , C12Q1/6883 , C12Q2600/158 , G01N33/564 , G01N33/566 , G01N33/574 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/705 , G01N2800/065 , G01N2800/102 , G01N2800/122 , G01N2800/127 , G01N2800/24
摘要： The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer.
摘要翻译： 本发明涉及治疗和诊断疾病的组合物和方法，其特征在于与炎性疾病和/或癌症相关的抗原的存在。
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公开(公告)号：US07419663B2
公开(公告)日：2008-09-02
申请号：US10964263
申请日：2004-10-12
申请人： Avi Ashkenazi , Karim Yussef Helmy , Sherman Fong , Audrey Goddard , Austin L. Gurney , Kenneth James Katschke, Jr. , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
发明人： Avi Ashkenazi , Karim Yussef Helmy , Sherman Fong , Audrey Goddard , Austin L. Gurney , Kenneth James Katschke, Jr. , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K14/70503 , A61K2039/505 , C07K16/2803 , C07K2317/76 , C07K2319/30 , Y10S424/809 , Y10S424/81
摘要： The present invention concerns a recently discovered macrophage specific receptor, STIgMA, and its use in the treatment of complement-associated disorders.
摘要翻译： 本发明涉及最近发现的巨噬细胞特异性受体STIgMA及其在补体相关疾病的治疗中的应用。
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37.发明授权Nucleic acids encoding proteins that stimulate the proliferation of t-lymphocytes 有权编码刺激T淋巴细胞增殖的蛋白质的核酸公开(公告)号：US06838554B2
公开(公告)日：2005-01-04
申请号：US09953499
申请日：2001-09-14
申请人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , William I. Wood
发明人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , William I. Wood
CPC分类号： C07K14/705 , C07K16/28 , C07K2317/24 , C07K2319/30
摘要： The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer, and nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing such antigens PRO301, PRO362 or PRO245.
摘要翻译： 本发明涉及治疗和诊断疾病的组合物和方法，其特征在于存在与炎性疾病和/或癌症相关的抗原，以及核苷酸序列，包括表达的序列标签（EST），寡核苷酸探针，多肽，载体和宿主细胞 表达这种抗原PRO301，PRO362或PRO245。
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公开(公告)号：US06410708B1
公开(公告)日：2002-06-25
申请号：US09254465
申请日：1999-03-05
申请人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , William I. Wood
发明人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , William I. Wood
IPC分类号： C07H2104
CPC分类号： C07K14/47 , A61K38/00 , C07K14/705 , C07K16/28 , C07K2317/24 , C07K2319/00 , C07K2319/30 , G01N33/5008 , G01N33/5011 , G01N33/5017 , G01N33/5047 , G01N33/505 , G01N33/5064 , G01N33/5091 , G01N33/57484 , G01N33/68 , G01N33/6845
摘要： The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer, and nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing such antigens PRO301, PRO362 or PRO245.
摘要翻译： 本发明涉及治疗和诊断疾病的组合物和方法，其特征在于存在与炎性疾病和/或癌症相关的抗原，以及核苷酸序列，包括表达的序列标签（EST），寡核苷酸探针，多肽，载体和宿主细胞 表达这种抗原PRO301，PRO362或PRO245。
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公开(公告)号：US20090275738A1
公开(公告)日：2009-11-05
申请号：US11725063
申请日：2007-03-15
申请人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
发明人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
IPC分类号： C07K19/00 , C07K14/435
CPC分类号： C07K14/705 , A61K2039/505 , C07K16/28 , C07K16/2803 , C07K2317/56 , C07K2319/30 , C12Q1/6883 , C12Q2600/158 , G01N33/564 , G01N33/566 , G01N33/574 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/705 , G01N2800/065 , G01N2800/102 , G01N2800/122 , G01N2800/127 , G01N2800/24
摘要： The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer.
摘要翻译： 本发明涉及治疗和诊断疾病的组合物和方法，其特征在于与炎性疾病和/或癌症相关的抗原的存在。
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公开(公告)号：US20080312421A1
公开(公告)日：2008-12-18
申请号：US11725027
申请日：2007-03-15
申请人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
发明人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
CPC分类号： C07K14/705 , A61K2039/505 , C07K16/28 , C07K16/2803 , C07K2317/56 , C07K2319/30 , C12Q1/6883 , C12Q2600/158 , G01N33/564 , G01N33/566 , G01N33/574 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/705 , G01N2800/065 , G01N2800/102 , G01N2800/122 , G01N2800/127 , G01N2800/24
摘要： The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer.
摘要翻译： 本发明涉及治疗和诊断疾病的组合物和方法，其特征在于与炎症性疾病和/或癌症相关的抗原的存在。
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