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38 条记录 (耗时 0.037 秒)

    System and method for hydrological analysis
    31.
    发明授权
    System and method for hydrological analysis 有权
    水文分析系统和方法

    公开(公告)号：US07865835B2

    公开(公告)日：2011-01-04

    申请号：US11924592

    申请日：2007-10-25

    申请人： Touraj Farahmand ,  Peter Hudson ,  Edward J Quilty

    发明人： Touraj Farahmand ,  Peter Hudson ,  Edward J Quilty

    IPC分类号： G06F3/048

    CPC分类号： G06F8/34

    摘要： A computer-based graphical user interface for graphically controlling processing of hydrological data, comprising a display menu interface listing executable tools from the group comprising one or more of: hydrological data input, hydrological data validity checking and correction, and hydrological modeling, a GUI for selecting and arranging tools from the display menu in a graphical display area to construct a hydrological process, the selected tools each being represented by icons on the graphical display, and for establishing a connection between at least one output of a first tool and an input of a second tool said tools by graphically displaying the connection between said tools representative icon and input means for receiving user input to arrange and execute said constructed hydrological data processing process.

    摘要翻译： 一种用于图形地控制水文数据处理的基于计算机的图形用户界面，包括显示菜单界面，列出来自包括水文数据输入，水文数据有效性检查和校正以及水文建模中的一个或多个的组的可执行工具，GUI 在图形显示区域中从显示菜单中选择和排列工具以构建水文过程，所选择的工具各自由图形显示器上的图标表示，并且用于建立第一工具的至少一个输出和第一工具的输入之间的连接 第二工具通过图形地显示所述工具代表图标之间的连接和输入装置，用于接收用户输入以布置和执行所述构造的水文数据处理过程。

    Condensed azepines as vasopressin agonists
    33.
    发明申请
    Condensed azepines as vasopressin agonists 审中-公开
    浓缩吖庚因作为血管加压素激动剂

    公开(公告)号：US20080261951A1

    公开(公告)日：2008-10-23

    申请号：US12213651

    申请日：2008-06-23

    申请人： Doreen Mary Ashworth ,  Gary Robert William Pitt ,  Peter Hudson ,  Christopher Martyn Yea ,  Richard Jeremy Franklin

    发明人： Doreen Mary Ashworth ,  Gary Robert William Pitt ,  Peter Hudson ,  Christopher Martyn Yea ,  Richard Jeremy Franklin

    IPC分类号： C07D403/12 ,  C07D495/04 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  A61K31/55 ,  A61K31/551 ,  A61K31/553 ,  A61P13/00

    CPC分类号： C07D403/12 ,  C07D413/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

    摘要： This invention provides novel compounds according to general formula (1) wherein A is a bicyclic or tricyclic azepine derivative, V1 and V2 are both H, OMe or F, or one of V1 and V2 is Br, Cl, F, OH, OMe, OBn, OPh, O-acyl, N3, NH2, NHBn or NH-acyl and the other is H, or V1 and V2 together are ═O, —O(CH2)pO— or —S(CH2)S—; W1 is either O or S; X1 and X2 are both H, or together are ═O or ═S; Y is OR5 or NR6R7; R1, R2, R3 and R4 are independently selected from H, lower alkyl, lower alkyloxy, F, Cl and Br; R5 is selected from H and lower alkyl; R6 and R7 are independently selected from H and lower alkyl, or together are —(CH2)n—; n=3, 4, 5, 6; and p is 2 or 3. The compounds are agonists at the vasopressin V2 receptor and are useful as antidiuretics and procoagulants. The invention further comprises pharmaceutical compositions incorporating these vasopressin agonists, which compositions are particularly useful in the treatment of central diabetes insipidus, nocturnal enuresis and nocturia.

    摘要翻译： 本发明提供了根据通式（1）的新化合物，其中A是双环或三环吖庚因衍生物，V 1和V 2均为H，OMe或F，或 V 1和V 2之一是Br，Cl，F，OH，OMe，OBn，OPh，O-酰基，N 3， NH 2，NHBn或NH-酰基，另一个是H，或V 1和V 2一起是-O，-O（CH O-或-S（CH 2 CH 2）S - ; O 1或O 2是O或S; X 1和X 2均为H或一起为-O或-S; Y是OR 5或NR 6 R 7; R 1，R 2，R 3和R 4独立地选自H，低级烷基，低级烷氧基 ，F，Cl和Br; R 5选自H和低级烷基; R 6和R 7独立地选自H和低级烷基，或者一起是 - （CH 2）n - ; n = 3,4,5,6; p是2或3.化合物是加压素V2受体的激动剂，可用作抗利尿剂和促凝剂。 本发明还包括掺入这些加压素激动剂的药物组合物，该组合物特别可用于治疗中枢性尿崩症，夜间遗尿和夜尿症。

    In vivo affinity maturation scheme
    36.
    发明申请
    In vivo affinity maturation scheme 审中-公开
    体内亲和力成熟方案

    公开(公告)号：US20060099611A1

    公开(公告)日：2006-05-11

    申请号：US11156014

    申请日：2005-06-17

    申请人： Robert Irving ,  Peter Hudson ,  Huseyin Mustafa ,  Kim Wark ,  Matias Abregu

    发明人： Robert Irving ,  Peter Hudson ,  Huseyin Mustafa ,  Kim Wark ,  Matias Abregu

    IPC分类号： C12Q1/68 ,  C12P21/06 ,  C12N1/21 ,  C12N1/18 ,  C12N5/06

    CPC分类号： C40B40/02 ,  C12N15/102 ,  C12N15/1037

    摘要： The present invention relates to the field of evolution of nucleic acids in vivo and provides methods and compositions for introducing diversity into gene products. The present invention allows generation of new sequences that have desirable properties by virtue of high frequency mutation events within a cell. The high frequency mutation of a polynucleotide sequence results in, the production of a large population of new sequence variants. Appropriate selection and/or screening permits identification and isolation of mutant forms of the polynucleotide sequence as well as products resulting from expression of the mutant sequences.

    摘要翻译： 本发明涉及体内核酸进化领域，并提供了将多样性引入基因产物的方法和组合物。 本发明允许通过细胞内的高频突变事件产生具有期望特性的新序列。 多核苷酸序列的高频突变导致大量新序列变体的产生。 适当的选择和/或筛选允许鉴定和分离突变形式的多核苷酸序列以及由突变序列的表达产生的产物。