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公开(公告)号:US20120149694A1
公开(公告)日:2012-06-14
申请号:US13321790
申请日:2010-05-14
申请人: Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Ulrich Rester , Eckhard Bender , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Mark Jean Gnoth , Kersten Matthias Gericke , Mario Jeske
发明人: Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Ulrich Rester , Eckhard Bender , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Mark Jean Gnoth , Kersten Matthias Gericke , Mario Jeske
IPC分类号: A61K31/541 , C07D413/14 , A61P35/00 , A61K31/5377 , A61P7/02 , A61P9/00 , C07D413/06 , C07D417/06
CPC分类号: C07D211/34 , C07D211/20 , C07D211/22 , C07D211/24 , C07D211/26 , C07D401/06 , C07D417/06
摘要: The invention relates to novel substituted piperidines, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders and tumour disorders.
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公开(公告)号:US20120046268A1
公开(公告)日:2012-02-23
申请号:US13202707
申请日:2010-03-12
申请人: Mario Jeske , Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Kersten Matthias Gericke
发明人: Mario Jeske , Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Kersten Matthias Gericke
IPC分类号: A61K31/4523 , C07D405/06 , C07D401/06 , C07D417/06 , C07D413/06 , A61K31/445 , A61K31/453 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K31/496 , A61K31/541 , A61P7/02 , C12N5/078 , C07D211/60
CPC分类号: C07D417/06 , A61K9/0019 , A61K9/10 , A61K9/2018 , A61K31/451 , A61K31/4523 , A61K31/4525 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K47/10 , A61K47/36 , C07D211/42 , C07D211/56 , C07D211/60 , C07D211/62 , C07D401/06 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12
摘要: The invention relates to novel substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular disorders and tumour disorders.
摘要翻译: 本发明涉及新的取代的哌啶,其制备方法,其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病,特别是心血管疾病和肿瘤的药物的用途 疾病
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公开(公告)号:US20110021489A1
公开(公告)日:2011-01-27
申请号:US12788529
申请日:2010-05-27
申请人: Dirk HEIMBACH , Susanne Röhrig , Yolanda Cancho Grande , Eckhard Bender , Katja Zimmermann , Anja Buchmüller , Christoph Gerdes , Mark Jean Gnoth , Kersten Matthias Gericke , Mario Jeske
发明人: Dirk HEIMBACH , Susanne Röhrig , Yolanda Cancho Grande , Eckhard Bender , Katja Zimmermann , Anja Buchmüller , Christoph Gerdes , Mark Jean Gnoth , Kersten Matthias Gericke , Mario Jeske
IPC分类号: A61K31/397 , C07D401/04 , A61K31/454 , C07D413/14 , C07D417/14 , A61K31/541 , C07D401/14 , A61K31/4545 , A61K31/5377 , A61P7/02
CPC分类号: C07D413/04 , C07D413/14
摘要: The invention relates to novel substituted piperidines, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders and tumour disorders.
摘要翻译: 本发明涉及新型取代的哌啶,其制备方法,其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病,特别是心血管疾病和肿瘤的药物的用途 疾病
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公开(公告)号:US09051323B2
公开(公告)日:2015-06-09
申请号:US13625086
申请日:2012-09-24
申请人: Stephan Siegel , Andreas Wilmen , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Dmitry Zubov , Jochen Strayle , Michael Sperzel
发明人: Stephan Siegel , Andreas Wilmen , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Dmitry Zubov , Jochen Strayle , Michael Sperzel
IPC分类号: A01N43/90 , A61K31/519 , C07D487/00 , C07D487/04
CPC分类号: C07D487/04 , A61K31/519
摘要: The invention relates to substituted imidazo- and triazolopyrimidines and processes for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of haematological disorders, preferably of leucopenias and neutropenias.
摘要翻译: 本发明涉及取代的咪唑并 - 三唑并嘧啶类及其制备方法及其制备用于治疗和/或预防疾病,特别是血液病,优选白细胞减少和中性粒细胞减少症的药物的用途。
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公开(公告)号:US08476267B2
公开(公告)日:2013-07-02
申请号:US12668633
申请日:2008-06-28
申请人: Stephan Siegel , Andreas Wilmen , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Adrian Tersteegen , Michael Gerisch
发明人: Stephan Siegel , Andreas Wilmen , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Adrian Tersteegen , Michael Gerisch
IPC分类号: A61K31/535
CPC分类号: C07D487/04 , C12N5/0647
摘要: The invention relates to substituted imidazo-, pyrazolopyrazines and imidazotriazines and processes for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of hematological disorders, preferably of leukopenias and neutropenias.
摘要翻译: 本发明涉及取代的咪唑并,吡唑并吡嗪和咪唑并嗪及其制备方法,以及它们用于制备用于治疗和/或预防疾病,特别是血液病症,优选白细胞减少症和中性粒细胞减少症的药物的用途。
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公开(公告)号:US08440657B2
公开(公告)日:2013-05-14
申请号:US13322593
申请日:2010-05-18
申请人: Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Eckhard Bender , Katja Zimmermann , Anja Buchmüller , Christoph Gerdes , Mark Jean Gnoth , Kersten Matthias Gericke , Mario Jeske
发明人: Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Eckhard Bender , Katja Zimmermann , Anja Buchmüller , Christoph Gerdes , Mark Jean Gnoth , Kersten Matthias Gericke , Mario Jeske
IPC分类号: C07D417/14 , A61K31/541
CPC分类号: C07D413/04 , C07D417/14
摘要: The invention relates to novel substituted piperidines, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular diseases and tumour diseases.
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公开(公告)号:US08383822B2
公开(公告)日:2013-02-26
申请号:US12665729
申请日:2008-06-07
申请人: Swen Allerheiligen , Marcus Bauser , Dirk Heimbach , Stefan Heitmeier , Mark Jean Gnoth , Christoph Gerdes , Georges Von Degenfeld , Susanne Röhrig , Ulrich Rester , Elke Dittrich-Wengenroth , Uwe Saatmann , Adrian Tersteegen , Joachim Krüger , Holger Paulsen
发明人: Swen Allerheiligen , Marcus Bauser , Dirk Heimbach , Stefan Heitmeier , Mark Jean Gnoth , Christoph Gerdes , Georges Von Degenfeld , Susanne Röhrig , Ulrich Rester , Elke Dittrich-Wengenroth , Uwe Saatmann , Adrian Tersteegen , Joachim Krüger , Holger Paulsen
IPC分类号: A61K31/44 , C07D413/00
CPC分类号: C07D413/14
摘要: The invention relates to novel substituted oxazolidinones, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolic disorders.
摘要翻译: 本发明涉及新的取代的恶唑烷酮,其制备方法,其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病,特别是血栓栓塞性疾病的药物的用途。
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公开(公告)号:US08202862B2
公开(公告)日:2012-06-19
申请号:US12788641
申请日:2010-05-27
申请人: Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Eckhard Bender , Katja Zimmermann , Anja Buchmüller , Christoph Gerdes , Mark Jean Gnoth , Kersten Matthias Gericke , Mario Jeske
发明人: Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Eckhard Bender , Katja Zimmermann , Anja Buchmüller , Christoph Gerdes , Mark Jean Gnoth , Kersten Matthias Gericke , Mario Jeske
IPC分类号: C07D417/14 , A61K31/541
CPC分类号: C07D413/04 , C07D417/14
摘要: The invention relates to compounds of the formula to processes for the preparation thereof, and to the use thereof for treatment and/or prophylaxis of cardiovascular diseases and tumour diseases.
摘要翻译: 本发明涉及式的化合物,其制备方法及其用于治疗和/或预防心血管疾病和肿瘤疾病的用途。
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公开(公告)号:US20120142690A1
公开(公告)日:2012-06-07
申请号:US13321921
申请日:2010-05-18
申请人: Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Ulrich Rester , Eckhard Bender , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gnoth , Kersten Matthias Gericke , Mario Jeske
发明人: Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Ulrich Rester , Eckhard Bender , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gnoth , Kersten Matthias Gericke , Mario Jeske
IPC分类号: C07D413/14 , A61P35/00 , A61P9/00 , A61P7/02 , A61K31/5377 , A01N1/02
CPC分类号: C07D401/06 , C07D211/18
摘要: The invention relates to novel substituted piperidines, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders and tumour disorders.
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公开(公告)号:US20110053929A1
公开(公告)日:2011-03-03
申请号:US12668633
申请日:2008-06-28
申请人: Stephan Siegel , Andreas Wilman , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Adrian Tersteegen , Michael Gerisch
发明人: Stephan Siegel , Andreas Wilman , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Adrian Tersteegen , Michael Gerisch
IPC分类号: A61K31/4985 , C07D487/04 , A61K31/5377 , A61P7/00 , C12N5/0789
CPC分类号: C07D487/04 , C12N5/0647
摘要: The invention relates to substituted imidazo-, pyrazolopyrazines and imidazotriazines and processes for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of hematological disorders, preferably of leukopenias and neutropenias.
摘要翻译: 本发明涉及取代的咪唑并,吡唑并吡嗪和咪唑并嗪及其制备方法,以及它们用于制备用于治疗和/或预防疾病,特别是血液病症,优选白细胞减少症和中性粒细胞减少症的药物的用途。
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