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公开(公告)号：US20120214788A1
公开(公告)日：2012-08-23
申请号：US13400491
申请日：2012-02-20
申请人： Dirk Heimbach , Susanne Röhrig , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Yolanda Cancho Grande , Mario Jeske , Kersten Matthias Gericke
发明人： Dirk Heimbach , Susanne Röhrig , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Yolanda Cancho Grande , Mario Jeske , Kersten Matthias Gericke
IPC分类号： A61K31/454 , A61P9/10 , A61P7/00 , A61K31/5377 , A61K31/4545
CPC分类号： C07D413/04 , C07D413/14 , C07D417/14
摘要： The invention relates to novel heteroaryl-substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular diseases and tumour diseases.
摘要翻译： 本发明涉及新颖的杂芳基取代的哌啶，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物的用途 和肿瘤疾病。
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公开(公告)号：US08987248B2
公开(公告)日：2015-03-24
申请号：US13202707
申请日：2010-03-12
申请人： Mario Jeske , Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Kersten Matthias Gericke
发明人： Mario Jeske , Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Kersten Matthias Gericke
IPC分类号： A61K31/5377 , C07D413/06 , C07D211/60 , C07D211/42 , C07D211/56 , C07D211/62 , C07D401/06 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/06
CPC分类号： C07D417/06 , A61K9/0019 , A61K9/10 , A61K9/2018 , A61K31/451 , A61K31/4523 , A61K31/4525 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K47/10 , A61K47/36 , C07D211/42 , C07D211/56 , C07D211/60 , C07D211/62 , C07D401/06 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The invention relates to novel substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular disorders and tumor disorders.
摘要翻译： 本发明涉及新的取代的哌啶，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管疾病和肿瘤的药物的用途 疾病
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公开(公告)号：US20120046268A1
公开(公告)日：2012-02-23
申请号：US13202707
申请日：2010-03-12
申请人： Mario Jeske , Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Kersten Matthias Gericke
发明人： Mario Jeske , Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Kersten Matthias Gericke
IPC分类号： A61K31/4523 , C07D405/06 , C07D401/06 , C07D417/06 , C07D413/06 , A61K31/445 , A61K31/453 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K31/496 , A61K31/541 , A61P7/02 , C12N5/078 , C07D211/60
CPC分类号： C07D417/06 , A61K9/0019 , A61K9/10 , A61K9/2018 , A61K31/451 , A61K31/4523 , A61K31/4525 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K47/10 , A61K47/36 , C07D211/42 , C07D211/56 , C07D211/60 , C07D211/62 , C07D401/06 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The invention relates to novel substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular disorders and tumour disorders.
摘要翻译： 本发明涉及新的取代的哌啶，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管疾病和肿瘤的药物的用途 疾病
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公开(公告)号：US20120129831A1
公开(公告)日：2012-05-24
申请号：US13322602
申请日：2010-05-14
申请人： Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Kersten Matthias Gericke , Mario Jeske
发明人： Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Kersten Matthias Gericke , Mario Jeske
IPC分类号： A61K31/454 , A61K31/4545 , A01N1/02 , A61P9/00 , A61P35/00 , C07D413/14 , A61P7/02
CPC分类号： C07D413/14
摘要： The invention relates to novel substituted piperidines, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders and tumour disorders.
摘要翻译： 本发明涉及新型取代的哌啶，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病，特别是心血管疾病和肿瘤的药物的用途 疾病
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公开(公告)号：US08119663B2
公开(公告)日：2012-02-21
申请号：US12323454
申请日：2008-11-25
申请人： Dirk Heimbach , Susanne Röhrig , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Yolanda Cancho Grande , Mario Jeske , Kersten Matthias Gericke
发明人： Dirk Heimbach , Susanne Röhrig , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Yolanda Cancho Grande , Mario Jeske , Kersten Matthias Gericke
IPC分类号： A61K31/445 , C07D401/00
CPC分类号： C07D413/04 , C07D413/14 , C07D417/14
摘要： The invention relates to novel heteroaryl-substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular diseases and tumor diseases.
摘要翻译： 本发明涉及新颖的杂芳基取代的哌啶，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物的用途 和肿瘤疾病。
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公开(公告)号：US20090306139A1
公开(公告)日：2009-12-10
申请号：US12323454
申请日：2008-11-25
申请人： Dirk Heimbach , Susanne Rohrig , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmuller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Yolanda Cancho Grande , Mario Jeske , Kersten Matthias Gericke
发明人： Dirk Heimbach , Susanne Rohrig , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmuller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Yolanda Cancho Grande , Mario Jeske , Kersten Matthias Gericke
IPC分类号： A61K31/454 , C07D401/14 , A61P7/02
CPC分类号： C07D413/04 , C07D413/14 , C07D417/14
摘要： The invention relates to novel heteroaryl-substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular diseases and tumour diseases.
摘要翻译： 本发明涉及新颖的杂芳基取代的哌啶，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物的用途 和肿瘤疾病。
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公开(公告)号：US20120149694A1
公开(公告)日：2012-06-14
申请号：US13321790
申请日：2010-05-14
申请人： Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Ulrich Rester , Eckhard Bender , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Mark Jean Gnoth , Kersten Matthias Gericke , Mario Jeske
发明人： Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Ulrich Rester , Eckhard Bender , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Mark Jean Gnoth , Kersten Matthias Gericke , Mario Jeske
IPC分类号： A61K31/541 , C07D413/14 , A61P35/00 , A61K31/5377 , A61P7/02 , A61P9/00 , C07D413/06 , C07D417/06
CPC分类号： C07D211/34 , C07D211/20 , C07D211/22 , C07D211/24 , C07D211/26 , C07D401/06 , C07D417/06
摘要： The invention relates to novel substituted piperidines, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders and tumour disorders.
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公开(公告)号：US20120142690A1
公开(公告)日：2012-06-07
申请号：US13321921
申请日：2010-05-18
申请人： Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Ulrich Rester , Eckhard Bender , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gnoth , Kersten Matthias Gericke , Mario Jeske
发明人： Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Ulrich Rester , Eckhard Bender , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gnoth , Kersten Matthias Gericke , Mario Jeske
IPC分类号： C07D413/14 , A61P35/00 , A61P9/00 , A61P7/02 , A61K31/5377 , A01N1/02
CPC分类号： C07D401/06 , C07D211/18
摘要： The invention relates to novel substituted piperidines, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders and tumour disorders.
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公开(公告)号：US20120220563A1
公开(公告)日：2012-08-30
申请号：US13321966
申请日：2010-05-19
申请人： Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Eckhard Bender , Katja Zimmermann , Anja Buchmüller , Christoph Gerdes , Mark Jean Gnoth , Kersten Matthias Gericke , Mario Jeske
发明人： Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Eckhard Bender , Katja Zimmermann , Anja Buchmüller , Christoph Gerdes , Mark Jean Gnoth , Kersten Matthias Gericke , Mario Jeske
IPC分类号： A61K31/454 , A61K31/5377 , A61K31/4545 , C07D417/14 , A01N1/02 , C07D413/04 , A61P7/02 , A61P9/00 , A61P35/00 , C07D413/14 , A61K31/541
CPC分类号： C07D413/04 , C07D413/14
摘要： The invention relates to novel substituted piperidines, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders and tumour disorders.
摘要翻译： 本发明涉及新型取代的哌啶，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病，特别是心血管疾病和肿瘤的药物的用途 疾病
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公开(公告)号：US20100305111A1
公开(公告)日：2010-12-02
申请号：US12788641
申请日：2010-05-27
申请人： Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Eckhard Bender , Katja Zimmermann , Anja Buchmüller , Christoph Gerdes , Mark Jean Gnoth , Kersten Matthias Gericke , Mario Jeske
发明人： Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Eckhard Bender , Katja Zimmermann , Anja Buchmüller , Christoph Gerdes , Mark Jean Gnoth , Kersten Matthias Gericke , Mario Jeske
IPC分类号： A61K31/541 , C07D419/14 , A61P7/02
CPC分类号： C07D413/04 , C07D417/14
摘要： The invention relates to novel substituted piperidines, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular diseases and tumour diseases.
摘要翻译： 本发明涉及新型取代的哌啶，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防特别是心血管疾病和肿瘤的疾病的药物的用途 疾病
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