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104 条记录 (耗时 0.033 秒)

    Crystal structure of aurora-2 protein and binding pockets thereof
    34.
    发明申请
    Crystal structure of aurora-2 protein and binding pockets thereof 失效
    极光-2蛋白的晶体结构及其结合口袋

    公开(公告)号：US20050143402A1

    公开(公告)日：2005-06-30

    申请号：US10979375

    申请日：2004-11-01

    申请人： Graham Cheetham ,  Ronald Knegtel ,  Lovorka Swenson ,  Joyce Coll ,  Suzanne Renwick ,  Peter Weber

    发明人： Graham Cheetham ,  Ronald Knegtel ,  Lovorka Swenson ,  Joyce Coll ,  Suzanne Renwick ,  Peter Weber

    IPC分类号： C12N9/12 ,  G06F19/00 ,  A61K31/517 ,  G01N33/48 ,  G01N33/50

    CPC分类号： C12N9/1205 ,  C07K2299/00

    摘要： The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data storage medium encoded with the structural coordinates of Aurora-2 binding pockets and methods of using a computer to evaluate the ability of a compound to bind to the molecule or molecular complex. This invention also provides methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention provides methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to Aurora-2 or homologues thereof.

    摘要翻译： 本发明提供包含Aurora-2或其同系物的结合口袋的结晶分子或分子复合物。 本发明还提供了包含Aurora-2的晶体。 本发明还涉及包含用Aurora-2结合口袋的结构座标编码的数据存储介质的计算机，以及使用计算机评价化合物结合分子或分子复合物的能力的方法。 本发明还提供了使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明提供了使用结构坐标筛选和设计结合Aurora-2或其同系物的化合物（包括抑制性化合物）的方法。

    Press connector
    35.
    发明授权
    Press connector 失效
    按连接器

    公开(公告)号：US6145892A

    公开(公告)日：2000-11-14

    申请号：US155277

    申请日：1998-09-24

    申请人： Peter Weber

    发明人： Peter Weber

    IPC分类号： F16L33/01 ,  F16L33/18 ,  F16L33/30 ,  F16L33/00

    CPC分类号： F16L13/143 ,  F16L33/01 ,  F16L33/18 ,  F16L33/30

    摘要： The invention concerns a connector for producing a press connection with at least one pipe, which is pressed tightly against the connector radially by irreversible deformation or by a collar. The invention also concerns a press connection consisting of a connector and connecting pipe. The connector is composed of a basic pipe-shaped body 12, on whose outer periphery there is at least one area 14 against which the pipe 16 is tightly pressed radially. The basic body 12 is made of polyvinylidene fluoride which has a long life and high pressure and temperature resistance.

    摘要翻译： PCT No.PCT / IB98 / 00226 Sec。 371日期：1998年9月24日 102（e）1998年9月24日PCT 1998年2月4日PCT PCT。 第WO98 / 38449号公报 日期1998年9月3日本发明涉及一种用于生产具有至少一个管的压力连接件的连接器，其通过不可逆变形而被径向地压靠在连接器上或通过套环。 本发明还涉及由连接器和连接管组成的压力连接。 连接器由基本的管状体12构成，其外周上具有至少一个区域14，管16径向紧紧地与其对应。 基体12由具有长寿命和高耐压和耐温性的聚偏二氟乙烯制成。

    Measuring apparatus of the vibratory string type
    36.
    发明授权
    Measuring apparatus of the vibratory string type 失效
    振弦式测量装置

    公开(公告)号：US4470314A

    公开(公告)日：1984-09-11

    申请号：US448483

    申请日：1982-12-10

    申请人： Peter Weber

    发明人： Peter Weber

    IPC分类号： G01G3/16 ,  G01L1/10

    CPC分类号： G01L1/106 ,  G01G3/16 ,  Y10S73/01

    摘要： Improved measuring apparatus of the vibratory string type including a molded synthetic plastic body member containing a horizontal through passage for receiving the permanent magnet excitation and sensing system, and a pair of integral parallel horizontal wing-like projections that extend from the body member in supporting relation on opposite sides of the exciting magnet system. The body member also contains a through bore arranged in spaced relation directly beneath the through passage, a rear recess being provided in the rear face of the body member for receiving clamping means having a bearing portion that extends through the through bore for connection with the lower end of the vertically arranged measuring string. Additional apertures are formed in the body member for connecting the same to a fixed support or console.

    摘要翻译： 改进的振弦式测量装置包括一个包含用于接收永磁体激励和感测系统的水平通过通道的模制合成塑料本体构件，以及一对整体平行的水平翼形突起，其以支撑关系从主体构件延伸 在励磁磁体系统的相对两侧。 主体构件还包括直接在通道下面以间隔开的关系布置的通孔，后凹部设置在主体构件的后表面中，用于接收夹紧装置，该夹紧装置具有延伸穿过通孔的轴承部分，用于与下部连接 垂直排列的测量串的末端。 在主体部件中形成有用于将其连接到固定支撑件或控制台的附加孔。

    Ultrasonic medical device and associated method
    37.
    发明授权
    Ultrasonic medical device and associated method 失效
    超声波医疗器械及相关方法

    公开(公告)号：US08235907B2

    公开(公告)日：2012-08-07

    申请号：US12074869

    申请日：2008-03-06

    申请人： Peter J. Wilk ,  Timothy J. Nohara ,  Peter Weber

    发明人： Peter J. Wilk ,  Timothy J. Nohara ,  Peter Weber

    IPC分类号： A61B8/00

    CPC分类号： A61B8/483 ,  A61B5/6804 ,  A61B8/00 ,  A61B8/08 ,  A61B8/13 ,  A61B8/4227 ,  A61B8/4281 ,  A61B8/4494 ,  A61B17/3403 ,  A61B34/10 ,  A61B2017/3413 ,  A61B2017/3492 ,  A61B2090/378 ,  Y10S128/916

    摘要： A medical system includes a carrier and a multiplicity of electromechanical transducers mounted to the carrier, the transducers being disposable in effective pressure-wave-transmitting contact with a patient. Energization componentry is operatively connected to a first plurality of the transducers for supplying the same with electrical signals of at least one pre-established ultrasonic frequency to produce first pressure waves in the patient. A control unit is operatively connected to the energization componentry and includes an electronic analyzer operatively connected to a second plurality of the transducers for performing electronic 3D volumetric data acquisition and imaging (which includes determining three-dimensional shapes) of internal tissue structures of the patient by analyzing signals generated by the second plurality of the transducers in response to second pressure waves produced at the internal tissue structures in response to the first pressure waves. The control unit includes phased-array signal processing circuitry for effectuating an electronic scanning of the internal tissue structures which facilitates one-dimensional (vector), 2D (planar), and 3D (volume) data acquisition. The control unit further includes circuitry for defining multiple data gathering apertures and for coherently combining structural data from the respective apertures to increase spatial resolution. When the data gathering apertures are contained in a flexible web or carrier so that the instantaneous positions of the data gathering apertures are unknown, a self-cohering algorithm is used to determine their positions so that coherent aperture combining can be performed.

    摘要翻译： 医疗系统包括载体和安装到载体上的多个机电换能器，换能器与患者有效的压力波传播接触一次。 通电组件可操作地连接到第一组多个换能器，以向其提供至少一个预先建立的超声频率的电信号，以在患者体内产生第一压力波。 控制单元可操作地连接到通电组件，并且包括可操作地连接到第二多个换能器的电子分析器，用于通过以下步骤执行电子3D体积数据采集和成像（其包括确定三维形状）的患者的内部组织结构 响应于在第一压力波响应于在内部组织结构处产生的第二压力波来分析由第二多个换能器产生的信号。 控制单元包括相控阵信号处理电路，用于实现促进一维（矢量），2D（平面）和3D（体积）数据采集的内部组织结构的电子扫描。 控制单元还包括用于定义多个数据收集孔并用于相干地组合来自相应孔的结构数据以增加空间分辨率的电路。 当数据收集孔被包含在柔性幅材或载体中，使得数据收集孔的瞬时位置是未知的时，使用自我聚焦算法来确定它们的位置，从而可以执行相干孔结合。

    Interfacing messages between a host and a network
    38.
    发明授权
    Interfacing messages between a host and a network 有权
    在主机和网络之间接口消息

    公开(公告)号：US08144606B1

    公开(公告)日：2012-03-27

    申请号：US12291082

    申请日：2008-11-06

    申请人： Frank Viehweg ,  Markus Althoff ,  Peter Weber

    发明人： Frank Viehweg ,  Markus Althoff ,  Peter Weber

    IPC分类号： G08C15/00

    CPC分类号： H04L12/4625 ,  H04L43/00 ,  H04L49/00

    摘要： Devices, systems, methods, and other embodiments associated with a network device for interfacing a host with a network are described. One example network device includes a transmit path, and a receive path. A loopback path connects the transmit path and the receive path. A frame detection logic is configured to monitor network traffic on the transmit path to identify loopback frames. When a loopback frame is detected, a loopback logic routes the identified loopback frame onto the loopback path and then to the receive path. The rerouted loopback frame may then be received by a host or an embedded client from the receive path.

    摘要翻译： 描述了与用于将主机与网络接口的网络设备相关联的设备，系统，方法和其他实施例。 一个示例性网络设备包括发送路径和接收路径。 环回路径连接发送路径和接收路径。 帧检测逻辑被配置为监视发送路径上的网络流量以识别回送帧。 当检测到环回帧时，环回逻辑将所识别的环回帧路由到环回路径上，然后路由到接收路径。 重新路由的环回帧然后可以由主机或嵌入式客户端从接收路径接收。

    Method and plant for the heat treatment of solids containing iron oxide
    39.
    发明授权
    Method and plant for the heat treatment of solids containing iron oxide 有权
    用于对含有氧化铁的固体进行热处理的方法和设备

    公开(公告)号：US08025836B2

    公开(公告)日：2011-09-27

    申请号：US12610821

    申请日：2009-11-02

    申请人： Martin Hirsch ,  Michael Stroeder ,  Peter Weber

    发明人： Martin Hirsch ,  Michael Stroeder ,  Peter Weber

    IPC分类号： F27B15/02

    CPC分类号： B01J8/0055 ,  B01J8/1827 ,  B01J8/1872 ,  B01J2208/00274 ,  B01J2208/00548 ,  B01J2219/00006 ,  C21B13/0033 ,  C22B5/14 ,  Y02P10/136

    摘要： A plant for the heat treatment of solids containing iron oxide includes a fluidized bed reactor. The reactor includes at least one gas supply tube at least partly surrounded by an annular chamber in which a stationary annular fluidized bed is located, and a mixing chamber being located above the upper orifice region of the at least one gas supply tube. The gas flowing through the at least one gas supply tube entrains solids from the stationary annular fluidized bed-into the mixing chamber when passing through the upper orifice region of the at least one gas supply tube.

    摘要翻译： 用于对含有氧化铁的固体进行热处理的设备包括流化床反应器。 反应器包括至少一个气体供应管，其至少部分地被环形室围绕，其中定位有固定环形流化床，并且混合室位于至少一个气体供应管的上孔区域上方。 当通过至少一个气体供应管的上孔区域时，流过至少一个气体供应管的气体将固体从固定的环形流化床引入混合室。

    CONVEYING UNIT
    40.
    发明申请
    CONVEYING UNIT 有权
    输送单元

    公开(公告)号：US20100008809A1

    公开(公告)日：2010-01-14

    申请号：US12444058

    申请日：2007-09-19

    申请人： Adam Wilhelm ,  Peter Weber ,  Johann Rothkopf ,  Mehmet Gueluem ,  Fevzi Yildirim ,  Thomas Wuensch ,  Reinhard Dittmann

    发明人： Adam Wilhelm ,  Peter Weber ,  Johann Rothkopf ,  Mehmet Gueluem ,  Fevzi Yildirim ,  Thomas Wuensch ,  Reinhard Dittmann

    IPC分类号： F04C15/00

    CPC分类号： F01C21/106 ,  F01C21/104 ,  F02M37/045 ,  F02M37/08 ,  F04C2/3445 ,  F04C2270/13 ,  F05C2225/00

    摘要： A pumping unit having a pump chamber in which a rotor is mounted in a rotatable manner, and which is formed by a circumferential wall and two end walls, is already known. The circumferential wall is formed on an annular collar of a pump part and, on the inside, forms a track on which sealing bodies of a rotor roll. The track of the pump chamber is subjected to high compressive loading which, if the pump part is made of plastic, may result in the track rupturing. In the case of the pumping unit according to the invention, the pump part is improved in respect of strength and service life. Deformation of the pump part by hydraulic forces or by pressing-in forces is avoided. The invention provides that ribs are arranged on the outside of the circumferential wall, the outside being directed away from the pump chamber, or that arranged on that side of the end wall which is directed away from the pump chamber is at least one shoulder which is connected in a force-fitting manner, by means of a press fit, to the pump housing and is designed with thin walls to the extent where the pressing forces do not result in any deformation to the end wall of the pump chamber.

    摘要翻译： 具有可旋转地安装有转子并且由周向壁和两个端壁形成的泵室的泵送单元是已知的。 圆周壁形成在泵部件的环形套环上，并且在内侧上形成有转子卷轴的密封体的轨道。 泵室的轨道受到高压缩负荷，如果泵部分由塑料制成，则可能导致轨道破裂。 在根据本发明的泵送单元的情况下，泵的部件在强度和使用寿命方面得到改进。 通过液压力或压入力避免泵部件的变形。 本发明提供的肋条布置在圆周壁的外侧上，外部远离泵室，或者设置在远离泵室的端壁的该侧的至少一个肩部 通过压力配合方式以压配合的方式连接到泵壳体，并且被设计成具有薄壁，其压力不会导致对泵室的端壁的任何变形。