公开(公告)号：US08512283B2

公开(公告)日：2013-08-20

申请号：US11211571

申请日：2005-08-26

Applicant: Atul Kumar ,  Alka Kumar

Inventor： Atul Kumar ,  Alka Kumar

IPC: A61M1/00 ,  A61M37/00

CPC classification number: A61M3/0237 ,  A61B1/015 ,  A61M1/0058

Abstract: The present invention provides a system and a method for distending a body tissue cavity of a subject by continuous flow irrigation by using a positive displacement pump, such as a pneumatic pump, on the inflow side and a positive displacement pump, such as a peristaltic pump, on the outflow side, such that the amplitude of the pressure pulsations created by a the two positive displacement pump inside the said tissue cavity is substantially dampened to almost negligible levels. The present invention also provides a method for accurately determining the rate of fluid loss, into the subject's body system, during any endoscopic procedure without utilizing any deficit weight or fluid volume calculation, the same being accomplished by using two fluid flow rate sensors. The present invention also provides a system of creating and maintaining any desired pressure in a body tissue cavity for any desired cavity outflow rate. The system and the methods of the present invention described above can be used in any endoscopic procedure requiring continuous flow irrigation few examples of such endoscopic procedures being hysteroscopic surgery, arthroscopic surgery, trans uretheral surgery, endoscopic surgery of the brain and endoscopic surgery of the spine.

Abstract translation: 本发明提供一种系统和方法，其通过在流入侧使用诸如气动泵的容积式泵，以及容积式泵（例如蠕动泵）来连续流动冲洗来膨胀受试者的身体组织腔 在流出侧，使得由所述组织空腔内部的两个正位移泵产生的压力脉动的振幅基本上被抑制到几乎可忽略的水平。 本发明还提供了一种用于在任何内窥镜程序中精确地确定流体损失速率的方法，而不使用任何缺陷重量或流体体积计算，这通过使用两个流体流速传感器来实现。 本发明还提供了一种在任何期望的腔体流出速率下，在身体组织腔中产生和维持任何所需压力的系统。 上述本发明的系统和方法可用于需要连续流动灌洗的任何内窥镜程序中，这种内窥镜手术的例子是宫腔镜手术，关节镜手术，经皮穿刺手术，脑内窥镜手术和脊柱内窥镜手术 。

公开(公告)号：US08388570B2

公开(公告)日：2013-03-05

申请号：US11211489

申请日：2005-08-26

Applicant: Atul Kumar ,  Alka Kumar

Inventor： Atul Kumar ,  Alka Kumar

IPC: A61M1/00 ,  A61M31/00

CPC classification number: A61B1/015 ,  A61B1/00094 ,  A61M1/0058 ,  A61M3/0258

Abstract: The present invention provides a system and a method for distending a body tissue cavity of a subject by continuous flow irrigation by using a dynamic pump, such as a centrifugal pump, on the inflow side and a positive displacement pump, such as a peristaltic pump, on the outflow side, such that the amplitude of the pressure pulsations created by a the said outflow positive displacement pump inside the said tissue cavity is substantially dampened to almost negligible levels. The present invention also provides a method for accurately determining the rate of fluid loss, into the subject's body system, during any endoscopic procedure without utilizing any deficit weight or fluid volume calculation, the same being accomplished by using two fluid flow rate sensors. The present invention also provides a system of creating and maintaining any desired pressure in a body tissue cavity for any desired cavity outflow rate. The system and the methods of the present invention described above can be used in any endoscopic procedure requiring continuous flow irrigation few examples of such endoscopic procedures being hysteroscopic surgery, arthroscopic surgery, trans uretheral surgery, endoscopic surgery of the brain and endoscopic surgery of the spine.

Abstract translation: 本发明提供一种通过在流入侧使用诸如离心泵的动态泵和诸如蠕动泵的容积式泵，通过连续流动冲洗来膨胀受试者的身体组织腔的系统和方法， 在流出侧，使得由所述组织空腔内的所述流出正位移泵产生的压力脉动的幅度基本上被抑制到几乎可忽略的水平。 本发明还提供了一种用于在任何内窥镜程序中精确地确定流体损失速率的方法，而不使用任何缺陷重量或流体体积计算，这通过使用两个流体流速传感器来实现。 本发明还提供了一种在任何期望的腔体流出速率下，在身体组织腔中产生和维持任何所需压力的系统。 上述本发明的系统和方法可用于需要连续流动灌洗的任何内窥镜程序中，这种内窥镜手术的例子是宫腔镜手术，关节镜手术，经皮穿刺手术，脑内窥镜手术和脊柱内窥镜手术 。

公开(公告)号：US20120271110A1

公开(公告)日：2012-10-25

申请号：US13540849

申请日：2012-07-03

Applicant: Alka Kumar ,  Atul Kumar

Inventor： Alka Kumar ,  Atul Kumar

IPC: A61B1/00

CPC classification number: A61B1/015 ,  A61B1/00068 ,  A61B1/00071 ,  A61M1/0058 ,  A61M3/0258

Abstract: A continuous flow irrigation endoscope and a continuous flow irrigation fluid management system, both designed to be compatible to each other and meant to function as a single system. The endoscope and the fluid management system are synergistic to each other such that both enhance the efficiency of each other. The system allows a body tissue cavity to be distended by continuous flow irrigation so that the detached tissue pieces and waste fluid present inside a body tissue cavity are continuously automatically evacuated from the tissue cavity without causing the cavity to collapse at any stage and without the need of withdrawing the endoscope or a part of the endoscope from the tissue cavity.

Abstract translation: 连续流动灌溉内窥镜和连续流动灌溉流体管理系统，其被设计为彼此兼容并且意图用作单个系统。 内窥镜和流体管理系统彼此协同，从而提高彼此的效率。 该系统允许通过连续流动灌洗来扩张身体组织腔，使得存在于身体组织腔内的分离的组织片和废液不断地从组织腔排出，而不会导致腔在任何阶段崩溃，而不需要 从组织腔抽出内窥镜或内窥镜的一部分。

公开(公告)号：US07678070B2

公开(公告)日：2010-03-16

申请号：US11240393

申请日：2005-10-03

Applicant: Atul Kumar ,  Alka Kumar

Inventor： Atul Kumar ,  Alka Kumar

IPC: A61M1/00

CPC classification number: A61M3/0258 ,  A61M3/0216

Abstract: A system for distending body tissue cavities of subjects by continuous flow irrigation during endoscopic procedures, the system including: a fluid source reservoir containing a non viscous physiologic fluid meant for cavity distension; a fluid supply conduit tube connecting the fluid source reservoir to an inlet port of a variable speed positive displacement inflow pump and an outlet port of the said inflow pump being connectable to an inflow port of an endoscope instrument through an inflow tube for pumping the fluid at a controlled flow rate into the cavity, the flow rate of the said inflow pump being termed as the inflow rate; an inflow pressure transducer being located anywhere in the inflow tube between the outlet port of the inflow pump and the inflow port of the endoscope; an outflow port of the endoscope being connectable to a waste fluid collecting container via a waste fluid carrying tube, and characterized in that an active inflow pressure pulsation dampening means is connected to the inflow tube for dampening the pressure pulsations inside the cavity created by the positive displacement inflow pump.

Abstract translation: 一种用于在内窥镜程序期间通过连续流动灌注来增加受试者的身体组织腔的系统，所述系统包括：含有用于腔膨胀的非粘性生理液的流体源储存器; 将流体源储存器连接到变速正排量流入泵的入口和所述流入泵的出口的流体供应管道，其可通过流入管连接到内窥镜器械的流入口，用于将流体泵送 进入空腔的受控流速，所述流入泵的流量被称为流入速率; 流入压力传感器位于流入管的出口与内窥镜的流入口之间的流入管的任何地方; 所述内窥镜的流出口经由废液输送管可连接到废液收集容器，其特征在于，主动流入压力脉动阻尼装置连接到所述流入管，用于阻尼所述空腔内产生的压力脉动 排量流入泵。

公开(公告)号：US07582653B2

公开(公告)日：2009-09-01

申请号：US11812251

申请日：2007-06-15

Applicant: Sangita ,  Atul Kumar ,  Man Mohan Singh ,  Girish Kumar Jain ,  Puvvada Sri Ramanchandra Murthy ,  Suprabhat Ray

Inventor： Sangita ,  Atul Kumar ,  Man Mohan Singh ,  Girish Kumar Jain ,  Puvvada Sri Ramanchandra Murthy ,  Suprabhat Ray

IPC: A61K31/4453 ,  A61K31/40 ,  A61K31/135 ,  A61K31/12 ,  C07D295/04 ,  C07C317/14 ,  C07C321/00

CPC classification number: C07D295/088 ,  C07C317/22 ,  C07C317/24 ,  C07C323/19 ,  C07C323/22 ,  C07C323/25

Abstract: Novel mercaptophenyl naphthyl methane compounds, their pharmaceutically acceptable salts and compositions comprised thereof are useful for the prevention or treatment of various medical indications associated with estrogen dependent diseases or syndromes related to osteoporosis, bone loss, bone formation, cardiovascular disorders, neurodegenerative disorders, menopausal disorders, physiological disorders, diabetes disorders, prostatic carcinoma, cancer of breast, cancer of uterus, cancer of the cervix and cancer of the colon, threatened or habitual abortion, obesity, ovarian development or function, post-partum lactation and depression.

Abstract translation: 新的巯基苯基萘基甲烷化合物，其药学上可接受的盐和组合物可用于预防或治疗与与雌激素依赖性疾病或与骨质疏松症，骨丢失，骨形成，心血管疾病，神经变性疾病，绝经障碍相关的综合征相关的各种医学适应症 ，生理障碍，糖尿病，前列腺癌，乳腺癌，子宫癌，宫颈癌和结肠癌，威胁或习惯性流产，肥胖，卵巢发育或功能，产后泌乳和抑郁症。

公开(公告)号：US07549905B2

公开(公告)日：2009-06-23

申请号：US11239988

申请日：2005-09-30

Applicant: Chung J. Lee ,  Atul Kumar ,  Chieh Chen ,  George Tzeng

Inventor： Chung J. Lee ,  Atul Kumar ,  Chieh Chen ,  George Tzeng

IPC: H01J9/00

CPC classification number: H01L51/5253

Abstract: A method of forming an organic light emitting device on a substrate is provided, wherein the method includes forming an active device structure on the substrate, adhering a mask to the substrate, wherein the mask covers an electrical contact portion of the substrate while exposing the active device structure, forming an encapsulant layer over the active device structure and the mask, forming a separation between a portion of the encapsulant layer that covers the active device structure and a portion of the encapsulant layer that covers the mask, and removing the mask from the substrate.

Abstract translation: 提供一种在衬底上形成有机发光器件的方法，其中该方法包括在衬底上形成有源器件结构，将掩模粘贴到衬底上，其中掩模覆盖衬底的电接触部分，同时暴露活性物质 在活性器件结构和掩模上形成密封剂层，在覆盖有源器件结构的封装剂层的一部分和覆盖掩模的封装剂层的一部分之间形成间隔， 基质。

公开(公告)号：US07309395B2

公开(公告)日：2007-12-18

申请号：US10816179

申请日：2004-03-31

Applicant: Chung J. Lee ,  Atul Kumar ,  Chieh Chen ,  Yuri Pikovsky

Inventor： Chung J. Lee ,  Atul Kumar ,  Chieh Chen ,  Yuri Pikovsky

IPC: C23C16/52 ,  C23C16/04 ,  C23C16/22 ,  C23C16/452 ,  C23C16/48 ,  C23F1/00 ,  H01L21/306

CPC classification number: H01L21/0212 ,  B05D1/185 ,  B05D1/60 ,  B05D3/065 ,  B05D3/067 ,  B05D7/52 ,  H01L21/02263 ,  H01L21/02304 ,  H01L21/02337 ,  H01L21/02362 ,  H01L21/3121 ,  H01L21/3127

Abstract: A system for depositing a composite polymer dielectric film on a substrate is disclosed, wherein the composite polymer dielectric film includes a low dielectric constant polymer layer disposed between a first silane-containing layer and a second silane-containing layer. The system includes a process module having a processing chamber and a monomer delivery system configured to admit a gas-phase monomer into the processing chamber for deposition of the low dielectric constant polymer layer, a post-treatment module for annealing the composite polymer dielectric film, and a silane delivery system configured to admit a vapor flow containing a silane precursor into at least one of the process module and the post-treatment module for the formation of the first silane-containing layer and the silane-containing layer.

Abstract translation: 公开了一种用于在基板上沉积复合聚合物电介质膜的系统，其中复合聚合物电介质膜包括设置在第一含硅烷层和第二含硅烷层之间的低介电常数聚合物层。 该系统包括具有处理室和单体输送系统的处理模块，该单体输送系统构造成将气相单体进入处理室以沉积低介电常数聚合物层，用于退火复合聚合物电介质膜的后处理模块， 以及硅烷输送系统，其被构造成允许含有硅烷前体的蒸汽流进入至少一个工艺模块和后处理模块中，用于形成第一含硅烷层和含硅烷层。

公开(公告)号：US20050070597A1

公开(公告)日：2005-03-31

申请号：US10677116

申请日：2003-09-30

Applicant: Sangita ,  Atul Kumar ,  Man Singh ,  Suprabhat Ray ,  Girish Jain

Inventor： Sangita ,  Atul Kumar ,  Man Singh ,  Suprabhat Ray ,  Girish Jain

IPC: C07D311/58 ,  A61K31/541 ,  A61K31/353 ,  A61K31/452 ,  A61K31/496 ,  A61K31/5377 ,  C07D45/02

CPC classification number: C07D311/58

Abstract: The present invention relates to compounds of the formula I in which substituents R2 and R3 are arranged in trans-configuration: wherein: R1 is H or C1-C6 alkyl; C3-C7 cycloalkyl; R2 is phenyl, optionally substituted with 1 to 5 substituents independently selected from the group comprising OH, C1-C6-alkyl, halogen, nitro, cyano, SH, SR4, trihalo-C1-C6-alkyl, C1-C6-alkoxy and phenyl, wherein R4 is C1-C6 alkyl; R3 is phenyl substituted with OR5 wherein R5 has the formula (II), (III) or (IV) wherein Y is chosen from NHR4, NR42, NHCOR4, NHSO2R4, CONHR4, CONR4, CONR42, COOH, COOR4, SO2R4, SOR4, SONHR4, SONR42, a C3-C7 heterocyclic ring, saturated or unsaturated, containing one or two heteroatoms independently selected from the group consisting of O, S and N, optionally being substituted with 1 to 3 substituents independently selected from the group comprising H, OH, halogen, nitro, cyano, SH, SR4, trihalo-C1-C6-alkyl, C1-C6-alkyl and C1-C6-alkoxy, preferably NHR4, NR24, or a nitrogen heterocycle, wherein R4 is as defined above, and the esters, ethers, and salts of the compounds of formula I, optionally along pharmaceutically acceptable excipients, a process for the preparation of the same, and a method of preventing and/or treating estrogen-related disease conditions in a subject using compounds of formula 1, or its salts, optionally along with pharmaceutically acceptable excipients.

Abstract translation: 本发明涉及式I化合物，其中取代基R 2和R 3以反式构型排列：其中：R 1是H或C 1 -C 6烷基; C3-C7环烷基; R 2是苯基，任选地被1至5个独立地选自OH，C 1 -C 6 - 烷基，卤素，硝基，氰基，SH，SR 4， - 3卤代-C 1 -C 6烷基，C 1 C 1-6 - 烷氧基和苯基，其中R 4是C 1 -C 6烷基; R 3是被OR 5取代的苯基，其中R 5具有式（II），（III）或（IV），其中Y选自NHR 4，NR 4，NHCOR 4 >，NHSO 2 R 4，CONHR 4，CONR 4，CONR 4，COOH，COOR 4，SO 2 R 4，SOR 4，SONHR 4，SONR 4 饱和或不饱和的C3-C7杂环，其含有一个或两个独立地选自O，S和N的杂原子，任选被1至3个独立地选自H，OH，卤素， 硝基，氰基，SH，SR 4，三卤代-C 1 -C 6烷基，C 1 -C 6烷基和C 1 -C 6烷氧基，优选NH 4，NR 2 4或氮杂环， 4>如上所定义，并且式I化合物的酯，醚和盐，任选地沿着药学上可接受的赋形剂，其制备方法，以及预防和/或治疗雌激素相关疾病的方法 使用式1化合物的受试者的条件，或其盐，任选地与药物 lly可接受的赋形剂。

公开(公告)号：US06527855B2

公开(公告)日：2003-03-04

申请号：US09974178

申请日：2001-10-10

Applicant: Mark J. DelaRosa ,  Toh-Ming Lu ,  Atul Kumar

Inventor： Mark J. DelaRosa ,  Toh-Ming Lu ,  Atul Kumar

IPC: C30B2500

CPC classification number: C23C16/18

Abstract: Cobalt thin films were prepared by atomic layer deposition (ALD). The precursor cobalt(II) acetylacetonate [Co(C5H7O2)2] was used to selectively deposit films onto iridium substrates using hydrogen reduction. Cobalt growth was observed on SiO2, silicon, fluorinated silica glass (FSG), and tantalum when silane was used as a reducing agent.

Abstract translation: 通过原子层沉积（ALD）制备钴薄膜。 使用乙酸丙酮前体钴（II）[Co（C 5 H 7 O 2）2]使用氢还原将膜选择性地沉积在铱底物上。 当使用硅烷作为还原剂时，在SiO2，硅，氟化石英玻璃（FSG）和钽上观察到钴生长。

公开(公告)号：US4113013A

公开(公告)日：1978-09-12

申请号：US738494

申请日：1976-11-04

Applicant: Will A. Ledoux ,  William Schoen ,  Atul Kumar

Inventor： Will A. Ledoux ,  William Schoen ,  Atul Kumar

IPC: C09K8/60 ,  E21B43/22

CPC classification number: C09K8/607

Abstract: A process for producing petroleum from subterranean formations is disclosed wherein production from the formation is obtained by driving a fluid from an injection well to a production well. The process involves injecting into the formation via the injection well asphaltenes as sacrificial agents to inhibit the deposition of chemical recovery agents such as surfactant on the reservoir matrix. Normally the process would be carried out by first injecting the asphaltenes into the formation through the injection well and following them with a chemical recovery agent. The chemical recovery agent would then be followed by a drive fluid such as water to push the materials to the production well.