公开(公告)号：US20230394662A1

公开(公告)日：2023-12-07

申请号：US18454364

申请日：2023-08-23

Applicant: Cleerly, Inc.

Inventor： James K. Min ,  James P. Earls ,  Shant Malkasian ,  Hugo Miguel Rodrigues Marques ,  Chung Chan ,  Shai Ronen

IPC: G06T7/00 ,  A61B5/00 ,  G06T7/62

CPC classification number: G06T7/0012 ,  A61B5/7275 ,  G06T7/62 ,  G06T2207/10108 ,  G06T2207/10101 ,  G06T2207/10081 ,  G06T2207/30101 ,  G06T2207/20081 ,  G06T2207/10104 ,  G06T2207/10116 ,  G06T2207/10048 ,  G06T2207/10132

Abstract: Systems and methods of facilitating determination of risk of coronary artery disease (CAD) based at least in part on one or more measurements derived from non-invasive medical image analysis. The methods can include accessing a non-invasive generated medical image, identifying one or more arteries, identifying, regions of plaque within an artery, analyzing the regions of plaque to identify low density non-calcified plaque, non-calcified plaque, or calcified plaque based at least in part on density, determining a distance from identified regions of low density non-calcified plaque to one or more of a lumen wall or vessel wall, determining embeddedness of the regions of low density non-calcified plaque by one or more of non-calcified plaque or calcified plaque, determining a shape of the more regions of low density non-calcified plaque, and generating a display of the analysis to facilitate determination of one or more of a risk of CAD of the subject.

公开(公告)号：US11832982B2

公开(公告)日：2023-12-05

申请号：US18149025

申请日：2022-12-30

Applicant: CLEERLY, INC.

Inventor： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques ,  Ben Hootnick

IPC: A61B6/00 ,  A61B8/14 ,  A61B6/03 ,  A61B5/00 ,  G06T7/00 ,  A61B8/12 ,  A61B5/055 ,  A61K49/04 ,  A61B5/02 ,  G06F18/10 ,  G06V10/74 ,  G06V10/764 ,  G06V10/20 ,  G06V10/24 ,  G06V40/14

CPC classification number: A61B6/481 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/02007 ,  A61B5/055 ,  A61B5/7267 ,  A61B5/742 ,  A61B5/7475 ,  A61B6/032 ,  A61B6/037 ,  A61B6/504 ,  A61B6/5205 ,  A61B6/5217 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T7/0012 ,  G06V10/20 ,  G06V10/245 ,  G06V10/761 ,  G06V10/764 ,  G06V40/14 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10101 ,  G06T2207/10132 ,  G06T2207/20081 ,  G06T2207/30048 ,  G06T2207/30101 ,  G06V10/247

Abstract: The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US11766230B2

公开(公告)日：2023-09-26

申请号：US18148712

申请日：2022-12-30

Applicant: CLEERLY, INC.

Inventor： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques

IPC: A61B6/00 ,  G06T7/00 ,  A61B5/055 ,  A61B6/03 ,  A61B8/14 ,  A61B8/12 ,  A61B5/00 ,  A61K49/04 ,  G06F18/10 ,  G06V10/74 ,  G06V10/764 ,  G06V10/82 ,  G06V10/20 ,  G06V10/24

CPC classification number: A61B6/504 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/055 ,  A61B5/7267 ,  A61B5/742 ,  A61B5/7475 ,  A61B6/032 ,  A61B6/037 ,  A61B6/463 ,  A61B6/467 ,  A61B6/481 ,  A61B6/5205 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T7/0012 ,  G06V10/20 ,  G06V10/245 ,  G06V10/761 ,  G06V10/764 ,  G06V10/82 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10101 ,  G06T2207/10132 ,  G06T2207/20081 ,  G06T2207/30048 ,  G06T2207/30101 ,  G06V10/247

Abstract: The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US20230154000A1

公开(公告)日：2023-05-18

申请号：US18148995

申请日：2022-12-30

Applicant: CLEERLY, INC.

Inventor： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques ,  Shant Malkasian ,  Ben Hootnick

IPC: G06T7/00 ,  A61B8/14 ,  A61B6/00 ,  A61B6/03 ,  A61B5/00 ,  A61B8/12 ,  A61B5/055 ,  A61K49/04 ,  G06F18/10

CPC classification number: G06T7/0012 ,  A61B8/14 ,  A61B6/481 ,  A61B6/037 ,  A61B6/5205 ,  A61B5/0066 ,  A61B6/032 ,  A61B8/12 ,  A61B5/7267 ,  A61B5/7475 ,  A61B6/504 ,  A61B5/055 ,  A61B5/742 ,  A61B5/0075 ,  A61K49/04 ,  G06F18/10 ,  G06T2207/10081 ,  G06T2207/10101 ,  G06T2207/30101 ,  G06T2207/30048 ,  G06T2207/20081 ,  G06T2207/10088 ,  G06T2207/10132

Abstract: The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, perform computational fluid dynamics analysis, facilitate assessment of risk of heart disease and coronary artery disease, enhance drug development, determine a CAD risk factor goal, provide atherosclerosis and vascular morphology characterization, and determine indication of myocardial risk, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US20230145596A1

公开(公告)日：2023-05-11

申请号：US18148985

申请日：2022-12-30

Applicant: CLEERLY, INC.

Inventor： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques ,  Shant Malkasian ,  Ben Hootnick

IPC: G06T7/00 ,  A61B8/14 ,  A61B6/00 ,  A61B6/03 ,  A61B5/00 ,  A61B8/12 ,  A61B5/055 ,  A61K49/04 ,  G06F18/10

CPC classification number: G06T7/0012 ,  A61B8/14 ,  A61B6/481 ,  A61B6/037 ,  A61B6/5205 ,  A61B5/0066 ,  A61B6/032 ,  A61B8/12 ,  A61B5/7267 ,  A61B5/7475 ,  A61B6/504 ,  A61B5/055 ,  A61B5/742 ,  A61B5/0075 ,  A61K49/04 ,  G06F18/10 ,  G06T2207/10081 ,  G06T2207/10101 ,  G06T2207/30101 ,  G06T2207/30048 ,  G06T2207/20081 ,  G06T2207/10088 ,  G06T2207/10132

Abstract: The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, perform computational fluid dynamics analysis, facilitate assessment of risk of heart disease and coronary artery disease, enhance drug development, determine a CAD risk factor goal, provide atherosclerosis and vascular morphology characterization, and determine indication of myocardial risk, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US11642092B1

公开(公告)日：2023-05-09

申请号：US18148309

申请日：2022-12-29

Applicant: Cleerly, Inc.

Inventor： James K. Min

IPC: A61B6/00 ,  A61B6/03 ,  G06T7/00

CPC classification number: A61B6/504 ,  A61B6/032 ,  A61B6/5217 ,  A61B6/5223 ,  G06T7/0012 ,  G06T7/97 ,  G06T2207/10028 ,  G06T2207/10072 ,  G06T2207/30101

Abstract: A method for characterization of coronary plaque tissue data and perivascular tissue data using image data gathered from a computed tomography (CT) scan along a blood vessel, the image information including radiodensity values of coronary plaque and perivascular tissue located adjacent to the coronary plaque, the method comprising quantifying radiodensity in regions of coronary plaque, quantifying, radiodensity in at least one region of corresponding perivascular tissue adjacent to the coronary plaque, determining gradients of the quantified radiodensity values within the coronary plaque and the quantified radiodensity values within the corresponding perivascular tissue, and determining a ratio of the quantified radiodensity values within the coronary plaque and the corresponding perivascular tissue; and characterizing the coronary plaque by analyzing a gradient of the quantified radiodensity values in the coronary plaque and the corresponding perivascular, and/or the ratio of the coronary plaque radiodensity values and the radiodensity values of the corresponding perivascular tissue.

公开(公告)号：US20230132940A1

公开(公告)日：2023-05-04

申请号：US18149020

申请日：2022-12-30

Applicant: CLEERLY, INC.

Inventor： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques ,  Ben Hootnick

IPC: A61B6/00 ,  A61B8/14 ,  A61B6/03 ,  A61B5/00 ,  G06T7/00 ,  A61B8/12 ,  A61B5/055 ,  A61K49/04 ,  A61B5/02 ,  G06F18/10 ,  G06V10/74 ,  G06V10/764 ,  G06V10/20 ,  G06V10/24 ,  G06V40/14

Abstract: The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US11120550B2

公开(公告)日：2021-09-14

申请号：US17214500

申请日：2021-03-26

Applicant: CLEERLY, INC.

Inventor： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques

IPC: G06T7/00 ,  A61B8/14 ,  A61B6/00 ,  A61B6/03 ,  A61B5/00 ,  A61B8/12 ,  A61B5/055 ,  G06K9/62 ,  A61K49/04

Abstract: The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US11120549B2

公开(公告)日：2021-09-14

申请号：US17214077

申请日：2021-03-26

Applicant: CLEERLY, INC.

Inventor： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques

IPC: G06T7/00 ,  A61B8/14 ,  A61B6/00 ,  A61B6/03 ,  A61B5/00 ,  A61B8/12 ,  G06K9/62 ,  A61B5/055 ,  A61K49/04

Abstract: The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US20250143657A1

公开(公告)日：2025-05-08

申请号：US18508098

申请日：2023-11-13

Applicant: Cleerly, Inc.

Inventor： James K. Min ,  James P. Earis ,  Hugo Miquel Rodriques Marques ,  Chung Chan ,  Tami Crabtree ,  Nicholas Michael Nieslanik

IPC: A61B6/00 ,  A61B6/03 ,  A61B6/50 ,  G06T7/00 ,  G06T7/62 ,  G06V10/22 ,  G06V10/26 ,  G16H30/40 ,  G16H50/20

Abstract: Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.