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    Method and Apparatus for Phrenic Nerve Activation Detection with Respiration Cross-Checking
    31.
    发明申请
    Method and Apparatus for Phrenic Nerve Activation Detection with Respiration Cross-Checking 有权
    用于呼吸交叉检查的膈神经激活检测方法和装置

    公开(公告)号：US20100305638A1

    公开(公告)日：2010-12-02

    申请号：US12787557

    申请日：2010-05-26

    申请人： Aaron R. McCabe ,  Holly E. Rockweiler ,  Jacob L. Laughner

    发明人： Aaron R. McCabe ,  Holly E. Rockweiler ,  Jacob L. Laughner

    IPC分类号： A61N1/36

    CPC分类号： A61N1/3706 ,  A61N1/36521 ,  A61N1/36542

    摘要： The present invention concerns phrenic nerve activation detection algorithms for characterization of phrenic nerve activation and phrenic nerve activation avoidance in cardiac pacing therapy.Various embodiments concern receiving a respiration signal indicative of respiratory activity of the patient, identifying respiratory phases based on the respiration signal, delivering cardiac pacing pulses within each of the identified respiratory phases, receiving a phrenic nerve activation signal indicative of activation of the patient's phrenic nerve, analyzing the phrenic nerve stimulation signal to determine if one or more of the pacing pulses activated the phrenic nerve of the patient, and determining if at least one of the delivered pacing pulses activated the phrenic nerve of the patient based on the phrenic nerve activation signal indicating activation of the patient's phrenic nerve associated with delivery of the at least one cardiac pacing pulse.

    摘要翻译： 本发明涉及用于表征心脏起搏治疗中的膈神经激活和膈神经激活避免的膈神经激活检测算法。 各种实施方案涉及接收指示患者的呼吸活动的呼吸信号，基于呼吸信号识别呼吸相位，在每个所识别的呼吸相中输送心脏起搏脉冲，接收指示患者膈神经激活的膈神经激活信号 分析膈神经刺激信号以确定一个或多个起搏脉冲是否激活了患者的膈神经，并且基于膈神经激活信号确定所输送的起搏脉冲中的至少一个是否激活了患者的膈神经 指示与递送至少一个心脏起搏脉冲相关的患者膈神经的活化。

    METHOD AND APPARATUS FOR SYNCHRONIZING NEURAL STIMULATION TO CARDIAC CYCLES
    33.
    发明申请
    METHOD AND APPARATUS FOR SYNCHRONIZING NEURAL STIMULATION TO CARDIAC CYCLES 有权
    方法和装置同步神经刺激到心脏循环

    公开(公告)号：US20090228060A1

    公开(公告)日：2009-09-10

    申请号：US12469012

    申请日：2009-05-20

    申请人： Imad Libbus ,  Paul A. Haefner ,  Aaron R. McCabe ,  Yi Zhang

    发明人： Imad Libbus ,  Paul A. Haefner ,  Aaron R. McCabe ,  Yi Zhang

    IPC分类号： A61N1/365

    CPC分类号： A61N1/36135 ,  A61N1/36114 ,  A61N1/365 ,  A61N1/36542 ,  A61N1/36564 ,  A61N1/36571

    摘要： A neural stimulator senses a reference signal indicative of cardiac cycles each including a predetermined type timing reference event using a sensor external to the heart and blood vessels. The delivery of the neural stimulation pulses are synchronized to that timing reference event. Examples of the timing reference event include a predetermined cardiac event such as a P-wave or an R-wave detected from a subcutaneous ECG signal, a predetermined type heart sound detected from an acoustic signal, and a peak detected from a hemodynamic signal related to blood flow or pressure.

    摘要翻译： 神经刺激器感测指示心脏周期的参考信号，每个参考信号包括使用心脏和血管外部的传感器的预定类型的定时参考事件。 神经刺激脉冲的输送与该定时参考事件同步。 定时参考事件的示例包括预定的心脏事件，例如从皮下ECG信号检测到的P波或R波，从声信号检测到的预定类型心音，以及从与 血流或压力。

    Automatic Capture Verification using Electrocardiograms Sensed from Multiple Implanted Electrodes
    34.
    发明申请
    Automatic Capture Verification using Electrocardiograms Sensed from Multiple Implanted Electrodes 失效
    使用从多个植入电极感测的心电图进行自动捕获验证

    公开(公告)号：US20090198301A1

    公开(公告)日：2009-08-06

    申请号：US12409348

    申请日：2009-03-23

    申请人： Yi Zhang ,  Jiang Ding ,  Aaron R. McCabe ,  Scott A. Meyer

    发明人： Yi Zhang ,  Jiang Ding ,  Aaron R. McCabe ,  Scott A. Meyer

    IPC分类号： A61N1/37

    CPC分类号： A61N1/3712 ,  A61N1/365

    摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed for automatic capture verification using cardiac activation sequence information. Devices and methods sense composite cardiac signals using implantable electrodes. A source separation is performed using the composite signals. One or more signal vectors are produced that are associated with all or a portion of one or more cardiac activation sequences based on the source separation. A cardiac response to the pacing pulses is classified using characteristics associated with cardiac signal vectors and the signals associated with the vectors. Further embodiments may involve classifying the cardiac response as capture or non-capture, fusion or intrinsic cardiac activity. The characteristics may include an angle or an angle change of the cardiac signal vectors, such as a predetermined range of angles of the one or more cardiac signal vectors.

    摘要翻译： 提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。 心脏信号分离被用于使用心脏激活序列信息的自动捕获验证。 装置和方法使用可植入电极感测复合心脏信号。 使用复合信号进行源分离。 产生与基于源分离的一个或多个心脏激活序列的全部或一部分相关联的一个或多个信号载体。 使用与心脏信号矢量相关联的特征和与矢量相关联的信号来分类对起搏脉冲的心脏反应。 进一步的实施方案可以包括将心脏反应分类为捕获或非捕获，融合或内在心脏活动。 特征可以包括心脏信号矢量的角度或角度变化，例如一个或多个心脏信号矢量的预定角度范围。

    Determination of cardiac pacing parameters based on non-localized sensing
    35.
    发明申请
    Determination of cardiac pacing parameters based on non-localized sensing 审中-公开
    基于非局部感知的心脏起搏参数的确定

    公开(公告)号：US20080004665A1

    公开(公告)日：2008-01-03

    申请号：US11478428

    申请日：2006-06-29

    申请人： Aaron R. McCabe ,  Alok S. Sathaye ,  Yinghong Yu

    发明人： Aaron R. McCabe ,  Alok S. Sathaye ,  Yinghong Yu

    IPC分类号： A61N1/00

    CPC分类号： A61N1/3627 ,  A61N1/3682

    摘要： An atrioventricular delay (AVD) for cardiac pacing therapy is determined based, at least in part, on one or more cardiac activation signals sensed using body-implantable electrodes providing non-local sensing. A conduction delay is estimated using a non-local cardiac activation signal and the AVD is determined based on the conduction delay. Estimating the conduction delay may involve measuring a P-wave width or measuring a QRS complex width of the non-local signal. If multiple signals are sensed, the conduction delay may be estimated from a selected signal or may be estimated by forming a representative signal such as through averaging or other methods. The AVD may be determined as a function of the estimated conduction delay.

    摘要翻译： 至少部分地基于使用提供非局部感测的体内植入电极感测到的一种或多种心脏激活信号来确定用于心脏起搏治疗的房室延迟（AVD）。 使用非局部心脏激活信号估计导通延迟，并且基于导通延迟来确定AVD。 估计传导延迟可能涉及测量P波宽度或测量非本地信号的QRS复数宽度。 如果感测到多个信号，则可以从所选择的信号估计导通延迟，或者可以通过形成诸如通过平均或其它方法的代表性信号来估计导通延迟。 AVD可以被确定为估计的传导延迟的函数。

    MANAGEMENT OF FUSION BEAT DETECTION DURING CAPTURE THRESHOLD DETERMINATION
    39.
    发明申请
    MANAGEMENT OF FUSION BEAT DETECTION DURING CAPTURE THRESHOLD DETERMINATION 有权
    在捕获阈值确定期间的熔断波纹检测的管理

    公开(公告)号：US20130018433A1

    公开(公告)日：2013-01-17

    申请号：US13546820

    申请日：2012-07-11

    申请人： Shibaji Shome ,  Yanting Dong ,  Aaron R. McCabe

    发明人： Shibaji Shome ,  Yanting Dong ,  Aaron R. McCabe

    IPC分类号： A61N1/37

    CPC分类号： A61N1/3712

    摘要： An improved technique is described for dealing with the detection of fusion beats when capture verification is performed by a cardiac pacing device such as during a capture threshold determination procedure. Schemes for classifying heart beats may misclassify beats as fusion beats due to feature/m orphology changes in the test electrogram waveform that may occur even when capture is achieved.

    摘要翻译： 描述了一种改进的技术，用于处理在心脏起搏装置执行捕获验证时，例如在捕获阈值确定过程期间的融合节拍的检测。 分类心脏跳动的方案可能将拍击误分为融合节拍，这是由于甚至在捕获时可能发生的测试电描绘图波形中的特征/ m形态变化。

    ESTIMATION OF DEDICATED BIPOLAR PACING VECTOR THRESHOLD
    40.
    发明申请
    ESTIMATION OF DEDICATED BIPOLAR PACING VECTOR THRESHOLD 有权
    专用双极板矢量阈值的估计

    公开(公告)号：US20110098773A1

    公开(公告)日：2011-04-28

    申请号：US12906849

    申请日：2010-10-18

    申请人： Amy Jean Brisben ,  Aaron R. McCabe ,  Kevin John Stalsberg ,  Jacob I. Laughner ,  Clayton S. Foster ,  David W. Yost

    发明人： Amy Jean Brisben ,  Aaron R. McCabe ,  Kevin John Stalsberg ,  Jacob I. Laughner ,  Clayton S. Foster ,  David W. Yost

    IPC分类号： A61N1/36

    CPC分类号： A61N1/371 ,  A61N1/3712 ,  A61N1/37282

    摘要： Methods and devices are described that allow estimation of an electrostimulation capture threshold, such as a dedicated bipolar pacing vector threshold. In an example, an equal-energy assumption between first and second pacing vectors can be used to estimate an electrostimulation capture threshold of a second pacing vector from a measured electrostimulation capture threshold of the first pacing vector and impedances of the first and second pacing vectors. In an example, a relationship between first and second pacing vectors can be determined from measured data, and a parameter of the relationship can be used with a measurement of an electrostimulation capture threshold of the first pacing vector to estimate an electrostimulation capture threshold of the second pacing vector.

    摘要翻译： 描述了允许估计电刺激捕获阈值（例如专用双极起搏矢量阈值）的方法和装置。 在一个示例中，可以使用第一和第二起搏向量之间的等能量假设从第一起搏向量的测量的电刺激捕获阈值和第一和第二起搏向量的阻抗来估计第二起搏向量的电刺激捕获阈值。 在一个示例中，可以从测量数据确定第一和第二起搏向量之间的关系，并且可以使用关系的参数与第一起搏向量的电刺激捕获阈值的测量来估计第二起搏向量的电刺激捕获阈值 起搏向量