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公开(公告)号：US08524753B2
公开(公告)日：2013-09-03
申请号：US13362833
申请日：2012-01-31
IPC分类号： A61K31/427 , A61K31/426 , C07D417/02 , C07D277/38
CPC分类号： C07D277/30 , A61K31/426 , A61K31/427 , A61K45/06 , C07C53/18 , C07D213/30 , C07D231/12 , C07D233/64 , C07D263/32 , C07D277/24 , C07D277/38 , C07D277/587 , C07D333/16 , C07D417/04
摘要： Novel compounds of formula 1 or a pharmaceutically acceptable salt thereof inhibit cytochrome P450 monooxygenase.
摘要翻译： 新的式1化合物或其药学上可接受的盐抑制细胞色素P450单加氧酶。
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公开(公告)号：US20120184559A1
公开(公告)日：2012-07-19
申请号：US13362833
申请日：2012-01-31
IPC分类号： A61K31/4965 , A61K31/4439 , A61K31/425 , C12N9/99 , A61K31/27
CPC分类号： C07D277/30 , A61K31/426 , A61K31/427 , A61K45/06 , C07C53/18 , C07D213/30 , C07D231/12 , C07D233/64 , C07D263/32 , C07D277/24 , C07D277/38 , C07D277/587 , C07D333/16 , C07D417/04
摘要： Novel compounds of formula 1 or a pharmaceutically acceptable salt thereof inhibit cytochrome P450 monooxygenase.
摘要翻译： 新的式1化合物或其药学上可接受的盐抑制细胞色素P450单加氧酶。
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公开(公告)号：US4543412A
公开(公告)日：1985-09-24
申请号：US548743
申请日：1983-11-04
IPC分类号： C07F9/40 , C07F9/553 , C07F9/6512 , A61K31/675 , A61K31/69 , C07F5/02 , C07F9/65
CPC分类号： C07F9/65127 , C07F9/4075 , C07F9/5532
摘要： Phenobarbital conjugates for use as enzyme inhibitors having the formula: ##STR1## wherein Z is a biologically compatible counter ion, n and m is an integer from 2 to 6 and R and R.sub.1 are each lower alkyl.
摘要翻译： 苯巴比妥缀合物用作具有下式的酶抑制剂：其中Z是生物相容的抗衡离子，n和m是2-6的整数，R和R 1各自是低级烷基。
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公开(公告)号：US4451652A
公开(公告)日：1984-05-29
申请号：US380981
申请日：1982-05-24
IPC分类号： G01N33/53 , C07D473/08 , C07F9/6561 , G01N33/94 , C07F9/65
CPC分类号： G01N33/94 , C07D473/08 , C07F9/65616
摘要： The present disclosure relates to a novel class of substituted theophylline salts useful as reagents in an irreversible enzyme inhibitor immunoassay for theophylline. The use of such reagents increases the sensitivity of the theophylline assay.
摘要翻译： 本公开涉及一种新型的取代茶碱盐，其用作茶碱不可逆酶抑制剂免疫测定中的试剂。 这些试剂的使用增加了茶碱测定的灵敏度。
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35.发明授权Reagents for an amphetamine-class fluorescence polarization immunoassay 失效AMPHETAMINE-CLASS荧光极化免疫试剂
公开(公告)号：US5101015A
公开(公告)日：1992-03-31
申请号：US335627
申请日：1989-04-10
IPC分类号： G01N33/53 , A61K39/00 , G01N33/531 , G01N33/533 , G01N33/542 , G01N33/94
CPC分类号： G01N33/542 , G01N33/533 , G01N33/946 , Y10S436/816 , Y10S436/901 , Y10T436/13
摘要： A fluorescence polarization immunoassay (FPIA) for detecting the presence of one or more amphetamine-class analytes in a test sample is provided. The immunoassay uses competition between the analyte and a fluorescently labeled tracer for the binding site on an antibody specific for phenethylamine derivatives. The concentration of amphetamine-class analyte in the sample determines the amount of tracer that binds to the antibody. The amount of tracer/antibody complex formed can be quantitatively measured and is inversely proportional to the quantity of analyte in the test sample. The invention relates to tracers, to immunogens used to elicit antibodies for use as assay reagents, and to assay kits incorporating these tracers and assay reagents.
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36.发明授权Reagents, methods and kits for an amphetamine-class fluorescence polarization immunoassy 失效苯丙胺类荧光偏振免疫用的试剂，方法和试剂盒
公开(公告)号：US5354693A
公开(公告)日：1994-10-11
申请号：US83928
申请日：1993-06-29
IPC分类号： G01N33/53 , A61K39/00 , G01N33/531 , G01N33/533 , G01N33/542 , G01N33/94
CPC分类号： G01N33/542 , G01N33/533 , G01N33/946 , Y10S436/816 , Y10S436/901 , Y10T436/13
摘要： A fluorescence polarization immunoassay (FPIA) for detecting the presence of one or more amphetamine-class analytes in a test sample is provided. The immunoassay uses competition between the analyte and a fluorescently labeled tracer for the binding site on an antibody specific for phenethylamine derivatives. The concentration of amphetamine-class analyte in the sample determines the amount of tracer that binds to the antibody. The amount of tracer-antibody complex formed can be quantitatively measured and is inversely proportional to the quantity of analyte in the test sample. The invention relates to tracers, to immunogens used to elicit antibodies for use as assay reagents, and to assay kits incorporating these tracers and assay reagents.
摘要翻译： 提供了用于检测测试样品中一种或多种苯丙胺类分析物的存在的荧光偏振免疫测定（FPIA）。 免疫测定使用分子和荧光标记的示踪剂之间的竞争，用于苯乙胺衍生物特异性抗体上的结合位点。 样品中苯丙胺类分析物的浓度决定了与抗体结合的示踪剂的量。 可以定量测量形成的示踪剂 - 抗体复合物的量，并且与测试样品中分析物的量成反比。 本发明涉及示踪剂，用于引发用作测定试剂的抗体的免疫原，以及包含这些示踪剂和测定试剂的试剂盒。
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37.发明授权Reagents, methods and kits for an amphetamine-class fluorescence polarization immunoassay 失效用于苯丙胺类荧光偏振免疫测定的试剂，方法和试剂盒
公开(公告)号：US5248791A
公开(公告)日：1993-09-28
申请号：US820729
申请日：1992-01-14
IPC分类号： G01N33/533 , G01N33/542 , G01N33/94
CPC分类号： G01N33/533 , G01N33/542 , G01N33/946
摘要： A fluorescence polarization immunoassay (FPIA) for detecting the presence of one or more amphetamine-class analytes in a test sample is provided. The immunoassay uses competition between the analyte and a fluorescently labeled tracer for the binding site on an antibody specific for phenethylamine derivatives. The concentration of amphetamine-class analyte in the sample determines the amount of tracer that binds to the antibody. The amount of tracer/antibody complex formed can be quantitatively measured and is inversely proportional to the quantity of analyte in the test sample. The invention relates to tracers, to immunogens used to elicit antibodies for use as assay reagents, and to assay kits incorporating these tracers and assay reagents.
摘要翻译： 提供了用于检测测试样品中一种或多种苯丙胺类分析物的存在的荧光偏振免疫测定（FPIA）。 免疫测定使用分子和荧光标记的示踪剂之间的竞争，用于苯乙胺衍生物特异性抗体上的结合位点。 样品中苯丙胺类分析物的浓度决定了与抗体结合的示踪剂的量。 可以定量测量形成的示踪剂/抗体复合物的量，并且与测试样品中分析物的量成反比。 本发明涉及示踪剂，用于引发用作测定试剂的抗体的免疫原，以及包含这些示踪剂和测定试剂的试剂盒。
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公开(公告)号：US4559173A
公开(公告)日：1985-12-17
申请号：US548742
申请日：1983-11-04
申请人： Charles A. Flentge
发明人： Charles A. Flentge
IPC分类号： C12N9/99 , A61K31/66 , A61P43/00 , C07F9/40 , C07F9/553 , C07F9/6512 , C07D223/22
CPC分类号： C07F9/65127 , C07F9/4075 , C07F9/5532
摘要： Carbamazepine-thiophosphonate conjugates for use as enzyme inhibitors having the formula: ##STR1## wherein Z is a biologically compatible counter ion, n is an integer from 2 to 6 and R and R.sub.1 are each lower alkyl.
摘要翻译： 用作具有下式的酶抑制剂的卡马西平硫代膦酸盐缀合物：其中Z是生物相容的抗衡离子，n是2至6的整数，R和R 1各自是低级烷基。
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