公开(公告)号：US20110152189A1

公开(公告)日：2011-06-23

申请号：US13003755

申请日：2008-12-11

Applicant: Mark William James Ferguson ,  Sharon O'Kane ,  Tracey Mason ,  Mark Cooper ,  Nick Occleston ,  David Fairlamb ,  James Bush

Inventor： Mark William James Ferguson ,  Sharon O'Kane ,  Tracey Mason ,  Mark Cooper ,  Nick Occleston ,  David Fairlamb ,  James Bush

IPC: A61K38/18 ,  A61P17/02

CPC classification number: A61K38/1841 ,  A61K9/0019 ,  A61K9/0021 ,  A61K38/00

Abstract: The invention provides new methods of treatment using TGF-β3 to inhibit scarring in humans, and TGF-β3 for new uses in the inhibition of scarring in humans. In a first incidence of treatment each centimetre of wound margin, or each centimetre of a site at which a wound is to be formed, is provided with between approximately 350 ng and 1000 ng of TGF-β3; and in a second incidence of treatment, occurring after a wound is formed, and between 8 and 48 hours after the first incidence of treatment, the wound is provided with an amount of between approximately 350 ng and 1000 ng of TGF-β3 per centimetre of wound margin in which scarring is to be inhibited. The amount of TGF-β3 provided may be the same in each incidence of treatment. The amount of TGF-β3 provided per centimetre in each incidence of treatment may preferably be approximately 500 ng. The TGF-β3 may be provided by intradermal injection. Also provided are kits and methods of selecting an appropriate treatment regime for inhibiting scarring associated with the healing of a human wound.

Abstract translation: 本发明提供使用TGF-β3抑制人类瘢痕形成的新治疗方法，以及用于抑制人瘢痕形成的新用途的TGF-β3。 在第一次治疗发生率中，每厘米的伤口边缘或要形成伤口的部位的每厘米处提供约350ng至1000ng的TGF-β1; 并且在第一次治疗发生后，在伤口形成之后发生，并且在第一次治疗后8至48小时之间，所述伤口被提供有大约350ng和1000ng之间的TGF-和bgr 3 伤口边缘的厘米，其中瘢痕形成被抑制。 所提供的TGF-β1的量可以在每次治疗发生率中相同。 在每次治疗发生率中每厘米提供的TGF-β1,3的量优选为约500ng。 TGF-β可以通过皮内注射来提供。 还提供了选择用于抑制与人类伤口愈合相关的瘢痕形成的适当治疗方案的试剂盒和方法。

公开(公告)号：US07778756B2

公开(公告)日：2010-08-17

申请号：US11770909

申请日：2007-06-29

Applicant: Ty Hartwick ,  Mark Cooper

Inventor： Ty Hartwick ,  Mark Cooper

IPC: G06F7/70 ,  G06F19/00 ,  G06G7/00 ,  G06G7/76

CPC classification number: E02F5/145 ,  B62D11/003 ,  E02F9/2246 ,  E02F9/2253 ,  E02F9/26 ,  F16H61/465 ,  F16H2059/6861

Abstract: A system and process for controlling propulsion and steering of a track trencher excavation machine powered by an engine includes a multiple mode propulsion and steering control system that performs a plurality of functions depending on a selection of one of a plurality of operational modes. A controller generates a vehicle propulsion hydrostatic drive signal using an engine speed to determine a load multiplier. The load multiplier being defined as a function of the engine speed and an operator adjustable load control setting.

Abstract translation: 用于控制由发动机供电的轨道挖掘机挖掘机的推进和转向的系统和过程包括多模式推进和转向控制系统，其根据多种操作模式之一的选择执行多种功能。 控制器使用发动机速度产生车辆推进静液压驱动信号以确定负载乘数。 负载倍增器被定义为发动机转速和操作员可调节负载控制设置的函数。

公开(公告)号：US07454851B1

公开(公告)日：2008-11-25

申请号：US11851525

申请日：2007-09-07

Applicant: Dean Whitten ,  Dan Hawks ,  Mark Cooper

Inventor： Dean Whitten ,  Dan Hawks ,  Mark Cooper

IPC: E21C35/18 ,  E02F3/24

CPC classification number: E02F3/143 ,  E02F3/08 ,  E02F3/085 ,  E02F3/20 ,  E02F5/06 ,  E02F5/08 ,  E02F9/2866 ,  E02F9/2875

Abstract: In a chain excavator including an excavation chain with links routed around a drive sprocket and an end idler with a base plate mounted to a link for supporting excavation implements, a stabilizing element extends rearwardly from directly behind the excavation implement in order to contact and be supported by its trailing base plate.

Abstract translation: 在链式挖掘机中，包括具有围绕驱动链轮布置的链节的挖掘链和具有安装到用于支撑挖掘工具的连杆的底板的端部惰轮，稳定元件从挖掘工具的正后方向后延伸以便接触并被支撑 通过其尾座。

公开(公告)号：US07152348B2

公开(公告)日：2006-12-26

申请号：US11236104

申请日：2005-09-26

Applicant: Mark Unzicker ,  Mark Cooper

Inventor： Mark Unzicker ,  Mark Cooper

IPC: B65G15/00 ,  B65G33/00 ,  E02F3/08 ,  E02F3/14 ,  E02F5/00

CPC classification number: E02F3/142 ,  E02F3/085 ,  E02F3/10 ,  E02F3/143 ,  E02F3/145 ,  E02F3/146 ,  E02F3/148

Abstract: An excavating apparatus having a prime mover with a longitudinal centerline and a main frame (30) with an engine, a ground drive system and an excavation boom operatively attached thereto wherein the excavation boom has a sub-frame (112) with a first end and a second end. The first end of the sub-frame (112) is operatively pivotally attached to the main frame (30) along a main frame pivot axis (114). The main frame pivot axis is transverse to the longitudinal centerline of the prime mover. A head shaft (150) operatively rotatably attached to the second end of the sub-frame (112) along a head shaft axis (151) and the head shaft axis (151) is transverse to the longitudinal centerline of the prime mover. An excavating drum (148) is operatively attached to the head shaft (150) for rotation about the head shaft axis (151). The head shaft (150) is operatively pivotally attached to the second end of the sub-frame (112) along an axis (124) which is fixed with or parallel to a line (124a) which is fixed with respect to the main frame pivot axis (114) and which is substantially perpendicular to the main frame pivot axis (114) whereby the position of the head shaft axis (151) can be adjusted with respect to the position of the main frame pivot axis (114) from a position parallel to the main frame pivot axis (114) to positions not parallel to the main frame pivot axis (114). Also, the excavation drum (148) is mounted onto the head shaft (150) in a manner that the excavation drum (148) cooperates with the excavation chain (142) and a fixed cutter pattern of the excavation chain (142) to stay in consistent alignment with the fixed cutter pattern of the excavation drum (148).

Abstract translation: 一种挖掘装置，具有具有纵向中心线的原动机和具有发动机，地面驱动系统和可操作地附接到其上的挖掘臂的主框架（30），其中挖掘吊杆具有带有第一端的子框架（112） 第二端 子框架（112）的第一端沿着主框架枢转轴线（114）可操作地枢转地附接到主框架（30）。 主框架枢转轴线与原动机的纵向中心线横向。 沿着主轴轴线（151）和头轴轴线（151）可操作地可旋转地附接到子框架（112）的第二端的头轴（150）横向于原动机的纵向中心线。 挖掘滚筒（148）可操作地附接到头部轴（150）上以围绕头部轴线（151）旋转。 主轴（150）可操作地沿着与固定有或平行于相对于主框架（124a）固定的线（124a）的轴线（124）可枢转地附接到子框架（112）的第二端， 枢转轴线（114）并且其基本上垂直于主框架枢转轴线（114），从而头轴线（151）的位置可以相对于主框架枢转轴线（114）从位置 平行于主框架枢转轴线（114）到不平行于主框架枢转轴线（114）的位置。 此外，挖掘筒（148）以挖掘滚筒（148）与挖掘链（142）的固定切割图案和挖掘链（142）的固定切割图案配合的方式安装在头轴（150）上，以保持在 与挖掘鼓（148）的固定切割器图案一致地对准。

公开(公告)号：US07055270B2

公开(公告)日：2006-06-06

申请号：US10962909

申请日：2004-10-12

Applicant: Dean Whitten ,  Dan Hawks ,  Mark Cooper

Inventor： Dean Whitten ,  Dan Hawks ,  Mark Cooper

IPC: E21C35/18 ,  E02F3/24

CPC classification number: E02F3/08 ,  E02F3/085 ,  E02F3/143 ,  E02F3/20 ,  E02F5/08 ,  E02F9/2866

Abstract: In a chain excavator including an excavation chain with links routed around a drive sprocket and an end idler with a base plate mounted to a link for supporting excavation implements, a stabilizing element extends rearwardly from directly behind the excavation implement in order to contact and be supported by its trailing base plate.

公开(公告)号：US06948265B2

公开(公告)日：2005-09-27

申请号：US10762406

申请日：2004-01-22

Applicant: Mark Unzicker ,  Mark Cooper

Inventor： Mark Unzicker ,  Mark Cooper

IPC: E02F3/08 ,  E02F3/10 ,  E02F3/18 ,  E02F3/20 ,  E02F3/26 ,  E02F5/08 ,  E02F9/08

CPC classification number: E02F9/085 ,  E02F3/08 ,  E02F3/085 ,  E02F3/10 ,  E02F3/18 ,  E02F3/20 ,  E02F3/26

Abstract: An excavating apparatus having a prime mover with a longitudinal centerline and a main frame with an engine, a ground drive system and an excavation boom operatively attached thereto wherein the excavation boom has a first end and a second end. The first end of the boom is operatively pivotally attached to the main frame along a main frame pivot axis. The main frame pivot axis is transverse to the longitudinal centerline of the prime mover. A head shaft operatively rotatably attached to the second end of said boom and is operatively pivotally attached to the second end of said boom. Also, the excavation drum is mounted onto the head shaft in a manner that the excavation drum cooperates with the excavation chain and a fixed cutter pattern of the excavation chain to stay in consistent alignment with the fixed cutter pattern of the excavation drum.

Abstract translation: 一种挖掘装置，具有具有纵向中心线的原动机和具有发动机的主框架，地面驱动系统和可操作地附接到其上的挖掘吊架，其中挖掘吊臂具有第一端和第二端。 悬臂的第一端可操作地沿着主框架枢转轴线枢转地附接到主框架。 主框架枢转轴线与原动机的纵向中心线横向。 主轴可操作地可旋转地附接到所述悬臂的第二端，并且可操作地枢转地附接到所述悬臂的第二端。 此外，挖掘滚筒以这样的方式安装到头轴上，即挖掘滚筒与挖掘链协作并且挖掘链的固定切割图案与挖掘滚筒的固定切割图案保持一致的对准。

公开(公告)号：US20050015827A1

公开(公告)日：2005-01-20

申请号：US10874813

申请日：2004-06-22

Applicant: Dean Podlich ,  Mark Cooper ,  Chris Winkler

Inventor： Dean Podlich ,  Mark Cooper ,  Chris Winkler

IPC: A01H1/04 ,  C12N15/82 ,  C12Q1/68 ,  G06F19/00 ,  A01H1/00 ,  A01H5/00

CPC classification number: C12Q1/68

Abstract: This invention provides methods for monitoring QTL effects and marker assisted selection (MAS) involving providing a recursively determined correlation between one or more markers and a phenotype of interest.

Abstract translation: 本发明提供了用于监测QTL效应和标记辅助选择（MAS）的方法，所述标记辅助选择（MAS）涉及提供一种或多种标记与感兴趣的表型之间的递归确定的相关性。

公开(公告)号：US09107355B2

公开(公告)日：2015-08-18

申请号：US12763250

申请日：2010-04-20

Applicant: Carlos Messina ,  Jun Wei ,  Zhanshan Dong ,  Zhisheng Qing ,  Jean-Louis Laffont ,  Mitchell Samples ,  Jeffrey R. Schussler ,  Geoffrey I. Graham ,  Carlos Loeffler ,  Mark Cooper

Inventor： Carlos Messina ,  Jun Wei ,  Zhanshan Dong ,  Zhisheng Qing ,  Jean-Louis Laffont ,  Mitchell Samples ,  Jeffrey R. Schussler ,  Geoffrey I. Graham ,  Carlos Loeffler ,  Mark Cooper

IPC: G01N33/48 ,  G01N31/00 ,  G06G7/48 ,  G06G7/58 ,  A01H1/04 ,  A01G1/00 ,  A01G25/16

CPC classification number: A01H1/04 ,  A01G2/00 ,  A01G25/16

Abstract: A method for targeting trait phenotyping of a plant breeding experiment includes collecting soil data for at least one location, applying the soil data to a crop model, performing environmental monitoring at the at least one location to generate environmental data, updating the crop model with the environmental data, and using the crop model to provide predicted crop conditions. The method further includes determining environmental conditions for each of the plant breeding experiments, determining a likelihood of trait phenotype variations for each experiment using the environmental conditions and the predicted crop conditions, selecting a subset of the plant breeding experiments for collecting trait phenotype measurements based on the likelihood of trait phenotypic variation, and collecting trait phenotype measurements from the subset of the plant breeding experiments.

Abstract translation: 用于靶向植物育种实验的性状表型的方法包括收集至少一个位置的土壤数据，将土壤数据应用于作物模型，在至少一个位置执行环境监测以产生环境数据， 环境数据，并使用作物模型来提供预测的作物条件。 该方法还包括确定每个植物育种实验的环境条件，使用环境条件和预测的作物条件确定每个实验的性状表型变异的可能性，选择植物育种实验的子集以收集基于表型的测定，基于 特征表型变异的可能性，以及从植物育种实验的子集收集性状表型测量。

公开(公告)号：US20150096426A1

公开(公告)日：2015-04-09

申请号：US13998186

申请日：2013-10-08

Applicant: Matthew A. Culver ,  Patrick J. Tennant ,  Mark Cooper

Inventor： Matthew A. Culver ,  Patrick J. Tennant ,  Mark Cooper

IPC: G10D3/16 ,  G06F17/50

CPC classification number: G10D3/163 ,  A43B17/00 ,  A43D1/025

Abstract: The original contoured thumb and finger pick for players of stringed instruments introduced an incredible innovation for guitar players and others. Improvements based on this unique concept have transformed a useful tool into an extremely comfortable and natural strumming aid. The pick saddle totally follows the thumb and finger contours for greater comfort and the band is secured to the pick with a low profile post. A new method of constructing a large inventory of 3d CAD models with the manufacture of individual custom fit models by 3d printing now makes the improved contoured pick available to all sizes and shapes of fingers and thumbs, and allows each player to select a pick which will best fit his own shape, size, and playing style.The “method of multiple variations of 3D CAD models” for creating a diverse array of “custom fit” finger products also has its application for nearly any category of human personal items made to fit a part of the human body, and an application of this method for the creation of custom fit foot products is presented.

Abstract translation: 弦乐器玩家的原始轮廓拇指和手指拾音器为吉他手和其他玩家带来了不可思议的创新。 基于这一独特概念的改进已经将一个有用的工具转变成了一种非常舒适和自然的弹力辅助工具。 鞍座完全遵循拇指和手指轮廓，以获得更大的舒适度，并且带子被固定到带有低调柱的拾屑器上。 通过3D打印制作个性化定制适合模型，构建3D CAD模型的大量库存的新方法现在可以使改进的轮廓选择适用于所有尺寸和形状的手指和拇指，并允许每个玩家选择一个选择， 最适合自己的形状，大小和演奏风格。 用于创建各种“定制适合”手指产品的“3D CAD模型的多种变体的方法”也适用于几乎任何类型的人体个人物品，以适应人体的一部分，并应用于此 介绍了定制鞋类产品创建方法。

公开(公告)号：US08809644B1

公开(公告)日：2014-08-19

申请号：US13396695

申请日：2012-02-15

Applicant: Thomas Charles Barker ,  Matthew David Smalley ,  Mark Cooper

Inventor： Thomas Charles Barker ,  Matthew David Smalley ,  Mark Cooper

IPC: A01H1/00 ,  A01H5/00 ,  A01H5/10 ,  C12N5/04 ,  C12Q1/68

CPC classification number: C12Q1/6895 ,  A01H5/10

Abstract: A novel maize variety designated X03C201 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X03C201 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X03C201 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X03C201, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X03C201. This invention further relates to methods for producing maize varieties derived from maize variety X03C201.

Abstract translation: 一种称为X03C201的新型玉米品种及其种子，植物和植物部分，由Pioneer Hi-Bred International，Inc.专有的近交玉米品种进行生产。 用于生产玉米植物的方法，其包括将杂交玉米品种X03C201与另一玉米植物杂交。 在其遗传物质中生产玉米植物的方法，通过回交转化和/或转化渗透到X03C201中的一种或多种性状，以及由此生产的玉米种子，植物和植物部分。 本发明涉及玉米品种X03C201，种子，从种子产生的植物，以及玉米品种X03C201的变体，突变体和微小修饰。 本发明还涉及从玉米品种X03C201得到的玉米品种的生产方法。