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公开(公告)号：US07556799B2
公开(公告)日：2009-07-07
申请号：US11096209
申请日：2005-03-30
申请人： Dominique Charmot , Han Ting Chang , Gerrit Klaerner , Michael J. Cope , Mingjun Liu , Futian Liu , Jerry M. Buysse
发明人： Dominique Charmot , Han Ting Chang , Gerrit Klaerner , Michael J. Cope , Mingjun Liu , Futian Liu , Jerry M. Buysse
CPC分类号： A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K45/06
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
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32.发明申请公开(公告)号：US20060100126A1
公开(公告)日：2006-05-11
申请号：US10542421
申请日：2003-12-29
申请人： Andrew Avery , Dominique Charmot , Jean Frechet , Damian Hajduk , Ezat Khoshdel , Mingjun Liu
发明人： Andrew Avery , Dominique Charmot , Jean Frechet , Damian Hajduk , Ezat Khoshdel , Mingjun Liu
CPC分类号： C11D3/3742 , A61K8/894 , A61K8/91 , A61K2800/54 , A61Q5/00 , A61Q5/12 , A61Q19/00 , C11D3/373
摘要： A composition for personal, home, or laundry treatment comprising a polymer made up of one or more crosslinked rake or comb silicone copolymer segments. A process for making copolymers for use in such compositions involves hydrosilylation in the presence of a catalyst.
摘要翻译： 一种用于个人，家庭或衣物处理的组合物，其包含由一种或多种交联的耙式或梳状硅氧烷共聚物片段组成的聚合物。 制备用于这种组合物的共聚物的方法包括在催化剂存在下的氢化硅烷化。
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公开(公告)号：US20050220890A1
公开(公告)日：2005-10-06
申请号：US10814749
申请日：2004-03-30
申请人： Dominique Charmot , John Fordtran , Han Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
发明人： Dominique Charmot , John Fordtran , Han Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
CPC分类号： A61K9/5031 , A61K9/5026 , A61K9/5047
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
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公开(公告)号：US08475780B2
公开(公告)日：2013-07-02
申请号：US13015134
申请日：2011-01-27
IPC分类号： A61K31/74
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
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公开(公告)号：US08287847B2
公开(公告)日：2012-10-16
申请号：US12055765
申请日：2008-03-26
IPC分类号： A61K31/74
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
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公开(公告)号：US08192758B2
公开(公告)日：2012-06-05
申请号：US10814749
申请日：2004-03-30
申请人： Dominique Charmot , John Fordtran , Han Ting Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
发明人： Dominique Charmot , John Fordtran , Han Ting Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
IPC分类号： A61K9/14
CPC分类号： A61K9/5031 , A61K9/5026 , A61K9/5047
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了核 - 壳组合物及其药物组合物。 本文公开了用于治疗和/或预防益处的核 - 壳组合物的使用方法。 这些方法的实例包括治疗磷酸盐不平衡障碍，高血压，慢性心力衰竭，终末期肾病，肝硬化，慢性肾功能不全，流体过载或钠过载。
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公开(公告)号：US08147873B2
公开(公告)日：2012-04-03
申请号：US12055457
申请日：2008-03-26
申请人： Dominique Charmot , Mingjun Liu
发明人： Dominique Charmot , Mingjun Liu
CPC分类号： A61K31/74
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了包含钠结合聚合物及其药物组合物的组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗高血压，慢性心力衰竭，终末期肾病，肝硬化，慢性肾功能不全，流体过载或钠过载。
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公开(公告)号：US20110033505A1
公开(公告)日：2011-02-10
申请号：US12857264
申请日：2010-08-16
申请人： Dominique Charmot , Han-Ting Chang , Mingjun Liu , Futian Liu , Gerrit Klaerner
发明人： Dominique Charmot , Han-Ting Chang , Mingjun Liu , Futian Liu , Gerrit Klaerner
IPC分类号： A61K9/00 , A61K31/663 , A61K31/662 , A61K31/185 , A61K31/194 , A61K31/19 , A61P9/12 , A61P7/10
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了包含钠结合聚合物及其药物组合物的组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗高血压，慢性心力衰竭，终末期肾病，肝硬化，慢性肾功能不全，流体过载或钠过载。
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39.发明申请METHODS AND COMPOSITIONS FOR SELECTIVELY REMOVING POTASSIUM ION FROM THE GASTROINTESTINAL TRACT OF A MAMMAL 有权从牛奶的胃肠道动物中选择性去除钾离子的方法和组合物公开(公告)号：US20090155370A1
公开(公告)日：2009-06-18
申请号：US12088625
申请日：2006-10-02
申请人： Michael J. Cope , Paul Mansky , Futian Liu , Han-Ting Chang , Dominique Charmot , Eric Connor , Kalpesh Biyani , Mingjun Liu , Tony Kwok-Kong Mong , Yan Chen
发明人： Michael J. Cope , Paul Mansky , Futian Liu , Han-Ting Chang , Dominique Charmot , Eric Connor , Kalpesh Biyani , Mingjun Liu , Tony Kwok-Kong Mong , Yan Chen
IPC分类号： A61K31/785 , A61K9/14 , A61P1/00
CPC分类号： A61K31/795 , A61K9/0053 , A61K9/14 , A61K9/1694 , A61K9/5026 , A61K31/74 , A61K31/75 , A61K31/785 , A61K33/06
摘要： The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.
摘要翻译： 本发明提供了使用核 - 壳复合材料和包含这种核 - 壳复合材料的组合物来处理离子不平衡的方法和组合物。 特别地，本发明提供了核 - 壳颗粒和包含钾结合聚合物的组合物，以及包含钠结合聚合物的核 - 壳颗粒和组合物，并且在每种情况下都是其药物组合物。 还公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 本发明的组合物和方法提供治疗高钾血症和与钾离子稳态相关的其它适应症的改进方法，以及用于治疗与钠离子稳态有关的高血压和其它指征。
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公开(公告)号：US20080241092A1
公开(公告)日：2008-10-02
申请号：US12055726
申请日：2008-03-26
申请人： Dominique Charmot , Han-Ting Chang , John Fordtran , Gerrit Klaerner , Jerry M. Buysse , Robert Alpern , Mingjun Liu
发明人： Dominique Charmot , Han-Ting Chang , John Fordtran , Gerrit Klaerner , Jerry M. Buysse , Robert Alpern , Mingjun Liu
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
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