公开(公告)号：US20070045349A1

公开(公告)日：2007-03-01

申请号：US11211395

申请日：2005-08-25

Applicant: Donald Foster ,  Philip Nelson

Inventor： Donald Foster ,  Philip Nelson

IPC: G01F11/00

CPC classification number: G01F11/028 ,  B05B11/3023 ,  B05B11/3059 ,  B05B11/306 ,  B05B11/3067 ,  B05B11/3069

Abstract: A manually operated pump dispenser is attached to the top of a bottle of liquid and pumps and dispenses liquid from the bottle. The dispenser includes a pump housing containing a liquid pump chamber, and a pump plunger that is manually reciprocated in the pump chamber. A liquid piston is mounted on the pump plunger and is reciprocated in the pump chamber by the pump plunger. The liquid piston is mounted on the pump plunger for limited axial movement of the piston on the plunger. The movement of the piston on the plunger opens and closes a liquid flow path between the interior of the liquid pump chamber and a liquid discharge passage passing through the pump plunger.

Abstract translation: 手动操作的泵分配器连接到一瓶液体的顶部并泵送并从瓶中分配液体。 分配器包括容纳液体泵室的泵壳体和在泵室中手动往复运动的泵柱塞。 液体活塞安装在泵柱塞上，并通过泵柱塞在泵室中往复运动。 液体活塞安装在泵柱塞上，用于活塞在柱塞上的有限轴向运动。 活塞在柱塞上的移动打开和关闭液体泵室内部和通过泵柱塞的液体排出通道之间的液体流路。

公开(公告)号：US20070034595A1

公开(公告)日：2007-02-15

申请号：US11200962

申请日：2005-08-10

Applicant: Donald Foster ,  Walter Clynes

Inventor： Donald Foster ,  Walter Clynes

IPC: B65D41/04 ,  B65B7/28

CPC classification number: B65D50/043

Abstract: A closure apparatus for a bottle neck and cap increases the torque necessary to remove the cap from the bottle neck. Projections are provided on one of the bottle neck exterior and cap interior, and indentations are provided on the other of the bottle neck exterior and cap interior. When the cap is secured on the bottle neck, the projections engage in the indentations. The engagement of the projections in the indentations requires an increased torque to remove the cap from the bottle neck.

Abstract translation: 用于瓶颈和盖的封闭装置增加了从瓶颈移除帽所需的扭矩。 在瓶颈外部和帽子内部之一上设置有突起，在瓶颈外部和帽子内部设置有凹痕。 当盖子固定在瓶颈上时，突出部分就啮合凹槽。 压痕中的突起的啮合需要增加扭矩以从瓶颈移除盖。

公开(公告)号：US20070014800A1

公开(公告)日：2007-01-18

申请号：US11532776

申请日：2006-09-18

Applicant: Julia Novak ,  Scott Presnell ,  Cindy Sprecher ,  Donald Foster ,  Richard Holly ,  Jane Gross ,  Janet Johnston ,  Andrew Nelson ,  Stacey Dillon ,  Angela Hammond

Inventor： Julia Novak ,  Scott Presnell ,  Cindy Sprecher ,  Donald Foster ,  Richard Holly ,  Jane Gross ,  Janet Johnston ,  Andrew Nelson ,  Stacey Dillon ,  Angela Hammond

IPC: A61K39/395 ,  C12P21/04 ,  C07K16/24

CPC classification number: C07K14/001 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  A61K38/00 ,  A61K38/18 ,  C07K14/52 ,  C07K14/535 ,  C07K14/54 ,  C07K14/5406 ,  C07K14/715 ,  C07K16/24 ,  C07K16/2866 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/24 ,  C07K2319/30 ,  C07K2319/55 ,  C12N15/62 ,  C12N15/8509 ,  C12N2799/026 ,  G01N2333/52 ,  A61K2300/00

Abstract: Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.

Abstract translation: 描述了与SEQ ID NO：2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。 抗体可以结合162个氨基酸残基或其片段的全长序列，包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。 抗体可以包括多克隆，单克隆，鼠，人源化或中和的抗体。 还描述了产生抗体的方法。

公开(公告)号：US20060263851A1

公开(公告)日：2006-11-23

申请号：US11458367

申请日：2006-07-18

Applicant: Donald Foster ,  Wenfeng Xu ,  Karen Madden ,  James Kelly ,  Cindy Sprecher ,  Cameron Brandt ,  Mark Rixon ,  Scott Presnell ,  Brian Fox

Inventor： Donald Foster ,  Wenfeng Xu ,  Karen Madden ,  James Kelly ,  Cindy Sprecher ,  Cameron Brandt ,  Mark Rixon ,  Scott Presnell ,  Brian Fox

IPC: C12P21/06 ,  C07K14/715

CPC classification number: C07K16/2866 ,  A61K38/00 ,  C07K14/7155 ,  C07K2319/00

Abstract: A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.

公开(公告)号：US20060110800A1

公开(公告)日：2006-05-25

申请号：US11331993

申请日：2006-01-13

Applicant: James Baumgartner ,  Theresa Farrah ,  Donald Foster ,  Frank Grant ,  Patrick O'Hara

Inventor： James Baumgartner ,  Theresa Farrah ,  Donald Foster ,  Frank Grant ,  Patrick O'Hara

IPC: C07K14/72 ,  C07K16/28 ,  C07H21/04 ,  C12P21/06

CPC classification number: C07K16/28 ,  A61K38/00 ,  C07K14/7155 ,  C07K19/00 ,  C07K2319/00

Abstract: Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in testis cells. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of testis cells, and may also be used in the development of male-specific contraceptives and infertility treatments.

Abstract translation: 公开了新型受体多肽，编码多肽的多核苷酸，以及相关组合物和方法。 多肽包含在睾丸细胞中表达的细胞表面受体的细胞外结构域。 多肽可用于检测促进睾丸细胞增殖和/或分化的配体的方法中，并且还可用于开发男性特异性避孕药和不孕症治疗。

公开(公告)号：US20050020824A1

公开(公告)日：2005-01-27

申请号：US10887863

申请日：2004-07-12

Applicant: James Baumgartner ,  Theresa Farrah ,  Donald Foster ,  Frank Grant ,  Patrick O'Hara

Inventor： James Baumgartner ,  Theresa Farrah ,  Donald Foster ,  Frank Grant ,  Patrick O'Hara

IPC: A61K38/00 ,  C07K14/715 ,  C07K19/00 ,  C07H21/04 ,  C07K14/705

CPC classification number: C07K16/28 ,  A61K38/00 ,  C07K14/7155 ,  C07K19/00 ,  C07K2319/00

Abstract: Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in testis cells. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of testis cells, and may also be used in the development of male-specific contraceptives and infertility treatments.

公开(公告)号：US20070181606A1

公开(公告)日：2007-08-09

申请号：US11348757

申请日：2006-02-07

Applicant: Donald Foster

Inventor： Donald Foster

IPC: B67D5/40

CPC classification number: B05B11/3011

Abstract: A manually handheld and operated trigger sprayer has a novel shroud configuration that provides an aesthetically pleasing appearance to the component parts of the trigger sprayer and also provides a pad on the shroud that provides a comfortable feel to the user's hand holding the trigger sprayer in addition to enhancing the appearance of the trigger sprayer.

Abstract translation: 手动和操作的触发式喷雾器具有新颖的护罩配置，其为触发式喷雾器的组件提供美观的外观，并且还在护罩上提供了一种垫，其对于持有扳机喷雾器的使用者的手以及除了 增强触发式喷雾器的外观。

公开(公告)号：US20070166794A1

公开(公告)日：2007-07-19

申请号：US11551811

申请日：2006-10-23

Applicant: Julia Novak ,  Scott Presnell ,  Cindy Sprecher ,  Donald Foster ,  Richard Holly ,  Jane Gross ,  Janet Johnston ,  Andrew Nelson ,  Stacey Dillon ,  Angela Hammond

Inventor： Julia Novak ,  Scott Presnell ,  Cindy Sprecher ,  Donald Foster ,  Richard Holly ,  Jane Gross ,  Janet Johnston ,  Andrew Nelson ,  Stacey Dillon ,  Angela Hammond

IPC: C12P21/02 ,  C07H21/04 ,  C07K14/53 ,  C07K14/54

CPC classification number: C07K14/001 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  A61K38/00 ,  A61K38/18 ,  C07K14/52 ,  C07K14/535 ,  C07K14/54 ,  C07K14/5406 ,  C07K14/715 ,  C07K16/24 ,  C07K16/2866 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/24 ,  C07K2319/30 ,  C07K2319/55 ,  C12N15/62 ,  C12N15/8509 ,  C12N2799/026 ,  G01N2333/52 ,  A61K2300/00

Abstract: Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.

Abstract translation: 描述了与SEQ ID NO：2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。 抗体可以结合162个氨基酸残基或其片段的全长序列，包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。 抗体可以包括多克隆，单克隆，鼠，人源化或中和的抗体。 还描述了产生抗体的方法。

公开(公告)号：US20070122382A1

公开(公告)日：2007-05-31

申请号：US11539493

申请日：2006-10-06

Applicant: Wayne Kindsvogel ,  Steven Hughes ,  Richard Holly ,  Christopher Clegg ,  Donald Foster ,  Rebecca Johnson ,  Mark Heipel ,  Pallavur Sivakumar

Inventor： Wayne Kindsvogel ,  Steven Hughes ,  Richard Holly ,  Christopher Clegg ,  Donald Foster ,  Rebecca Johnson ,  Mark Heipel ,  Pallavur Sivakumar

IPC: A61K39/395 ,  A61K38/20

CPC classification number: C07K16/32 ,  A61K38/20 ,  A61K39/395 ,  A61K39/39558 ,  C07K16/2818 ,  C07K16/2896 ,  C07K2317/732 ,  A61K2300/00

Abstract: Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.

公开(公告)号：US20070098682A1

公开(公告)日：2007-05-03

申请号：US11551136

申请日：2006-10-19

Applicant: Julia Novak ,  Scott Presnell ,  Cindy Sprecher ,  Donald Foster ,  Richard Holly ,  Jane Gross ,  Janet Johnston ,  Andrew Nelson ,  Stacey Dillon ,  Angela Hammond

Inventor： Julia Novak ,  Scott Presnell ,  Cindy Sprecher ,  Donald Foster ,  Richard Holly ,  Jane Gross ,  Janet Johnston ,  Andrew Nelson ,  Stacey Dillon ,  Angela Hammond

IPC: A61K38/19 ,  A61K38/20

CPC classification number: C07K14/001 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  A61K38/00 ,  A61K38/18 ,  C07K14/52 ,  C07K14/535 ,  C07K14/54 ,  C07K14/5406 ,  C07K14/715 ,  C07K16/24 ,  C07K16/2866 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/24 ,  C07K2319/30 ,  C07K2319/55 ,  C12N15/62 ,  C12N15/8509 ,  C12N2799/026 ,  G01N2333/52 ,  A61K2300/00

Abstract: Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.