公开(公告)号：US20070173451A1

公开(公告)日：2007-07-26

申请号：US11690915

申请日：2007-03-26

Applicant: Yasmin Chandrasekher ,  Julia Novak ,  Donald Foster ,  Wenfeng Xu ,  Stephen Jaspers

Inventor： Yasmin Chandrasekher ,  Julia Novak ,  Donald Foster ,  Wenfeng Xu ,  Stephen Jaspers

IPC: A61K38/17

CPC classification number: C07K14/7155 ,  A61K38/00 ,  C07K2319/00

Abstract: A soluble receptor that binds to IL-20 having two polypeptide subunits, IL-22R and IL-20RB. The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.

Abstract translation: 结合具有两个多肽亚基IL-22R和IL-20RB的IL-20的可溶性受体。 两个亚基优选连接在一起。 在一个实施方案中，一个亚基与免疫球蛋白的轻链的恒定区融合，另一个亚基与免疫球蛋白的重链的恒定区融合。 轻链和重链通过二硫键连接。

公开(公告)号：US20070099269A1

公开(公告)日：2007-05-03

申请号：US11549772

申请日：2006-10-16

Applicant: JULIA NOVAK ,  Scott Presnell ,  Cindy Sprecher ,  Donald Foster ,  Richard Holly ,  Jane Gross ,  Janet Johnston ,  Andrew Nelson ,  Stacey Dillon ,  Angela Hammond

Inventor： JULIA NOVAK ,  Scott Presnell ,  Cindy Sprecher ,  Donald Foster ,  Richard Holly ,  Jane Gross ,  Janet Johnston ,  Andrew Nelson ,  Stacey Dillon ,  Angela Hammond

IPC: C07K14/705 ,  C07H21/04 ,  C12P21/06 ,  C12N15/74 ,  C12N1/21

CPC classification number: C07K14/001 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  A61K38/00 ,  A61K38/18 ,  C07K14/52 ,  C07K14/535 ,  C07K14/54 ,  C07K14/5406 ,  C07K14/715 ,  C07K16/24 ,  C07K16/2866 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/24 ,  C07K2319/30 ,  C07K2319/55 ,  C12N15/62 ,  C12N15/8509 ,  C12N2799/026 ,  G01N2333/52 ,  A61K2300/00

Abstract: Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.

公开(公告)号：US20070098683A1

公开(公告)日：2007-05-03

申请号：US11551139

申请日：2006-10-19

Applicant: Julia Novak ,  Scott Presnell ,  Cindy Sprecher ,  Donald Foster ,  Richard Holly ,  Jane Gross ,  Janet Johnston ,  Andrew Nelson ,  Stacey Dillon ,  Angela Hammond

Inventor： Julia Novak ,  Scott Presnell ,  Cindy Sprecher ,  Donald Foster ,  Richard Holly ,  Jane Gross ,  Janet Johnston ,  Andrew Nelson ,  Stacey Dillon ,  Angela Hammond

IPC: A61K38/19 ,  A61K38/20 ,  A61K39/395

CPC classification number: C07K14/001 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  A61K38/00 ,  A61K38/18 ,  C07K14/52 ,  C07K14/535 ,  C07K14/54 ,  C07K14/5406 ,  C07K14/715 ,  C07K16/24 ,  C07K16/2866 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/24 ,  C07K2319/30 ,  C07K2319/55 ,  C12N15/62 ,  C12N15/8509 ,  C12N2799/026 ,  G01N2333/52 ,  A61K2300/00

Abstract: Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.

公开(公告)号：US20070092948A1

公开(公告)日：2007-04-26

申请号：US11619699

申请日：2007-01-04

Applicant: Cindy Sprecher ,  Walt Kisiel ,  Donald Foster

Inventor： Cindy Sprecher ,  Walt Kisiel ,  Donald Foster

IPC: C12N9/99 ,  C07H21/04

CPC classification number: C07K14/8114 ,  A61K38/00

Abstract: The present invention provides isolated DNA molecules comprising a DNA segment encoding novel human Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human Kunitz-type inhibitor wherein said first DNA segment is operably linked to additional DNA segments required for the expression for the first DNA segment, as well as host cells containing such DNA constructs and methods for producing proteins from the host cells.

Abstract translation: 本发明提供了分离的DNA分子，其包含编码新型人Kunitz型抑制剂的DNA区段。 还提供了包含编码新型人Kunitz型抑制剂的第一DNA区段的DNA构建体，其中所述第一DNA区段可操作地连接到第一DNA区段的表达所需的另外的DNA区段，以及含有这种DNA构建体的宿主细胞， 从宿主细胞产生蛋白质的方法。

公开(公告)号：US20050265966A1

公开(公告)日：2005-12-01

申请号：US11134489

申请日：2005-05-20

Applicant: Wayne Kindsvogel ,  Steven Hughes ,  Richard Holly ,  Christopher Clegg ,  Donald Foster ,  Rebecca Johnson ,  Mark Heipel ,  Pallavur Sivakumar

Inventor： Wayne Kindsvogel ,  Steven Hughes ,  Richard Holly ,  Christopher Clegg ,  Donald Foster ,  Rebecca Johnson ,  Mark Heipel ,  Pallavur Sivakumar

IPC: A61K38/20 ,  A61K39/395 ,  C07K16/28 ,  C07K16/32

CPC classification number: C07K16/32 ,  A61K38/20 ,  A61K39/395 ,  A61K39/39558 ,  C07K16/2818 ,  C07K16/2896 ,  C07K2317/732 ,  A61K2300/00

Abstract: Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.

Abstract translation: 描述了通过用IL-21共同施用治疗性单克隆抗体来治疗癌症的方法。 可以使用的示例性单克隆抗体是利妥昔单抗，曲妥珠单抗和抗CTLA-4抗体。 联合治疗的增强的抗肿瘤剂对于单克隆治疗顽固性，用单克隆抗体治疗后复发或增强的IL-21抗肿瘤作用降低与使用单克隆抗体治疗相关的毒性的患者群体特别有用。

公开(公告)号：US20050139969A1

公开(公告)日：2005-06-30

申请号：US11063299

申请日：2005-02-22

Applicant: Choon Lee ,  Donald Foster ,  Jeoung Choi ,  Wan Kim ,  Kyong Youn ,  Sang Lee ,  Sun Lee

Inventor： Choon Lee ,  Donald Foster ,  Jeoung Choi ,  Wan Kim ,  Kyong Youn ,  Sang Lee ,  Sun Lee

IPC: H01L23/31 ,  H01L23/495

CPC classification number: H01L24/49 ,  H01L23/3107 ,  H01L23/49503 ,  H01L24/45 ,  H01L24/48 ,  H01L24/73 ,  H01L2221/68377 ,  H01L2224/32145 ,  H01L2224/32245 ,  H01L2224/45124 ,  H01L2224/45139 ,  H01L2224/45144 ,  H01L2224/45147 ,  H01L2224/48091 ,  H01L2224/48247 ,  H01L2224/48257 ,  H01L2224/48465 ,  H01L2224/49109 ,  H01L2224/4911 ,  H01L2224/73265 ,  H01L2224/92 ,  H01L2224/92247 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01027 ,  H01L2924/01029 ,  H01L2924/01047 ,  H01L2924/01075 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/014 ,  H01L2924/12042 ,  H01L2924/14 ,  H01L2924/181 ,  H01L2924/1815 ,  H01L2924/19107 ,  H01L2924/30107 ,  H01L2924/00014 ,  H01L2924/00 ,  H01L2924/00012

Abstract: In accordance with the present invention, there is provided a semiconductor package which includes a generally planar die paddle defining multiple peripheral edge segments and including at least two slots formed therein and extending along respective ones of a pair of the peripheral edge segments thereof. The semiconductor package further comprises a plurality of first leads which are segregated into at least two sets disposed within respective ones of the slots included in the die paddle. In addition to the first leads, the semiconductor package includes a plurality of second leads which are also segregated into at least two sets extending along respective ones of at least two peripheral edge segments of the die paddle in spaced relation thereto. Electrically connected to the top surface of the die paddle is at least one semiconductor die which is electrically connected to at least some of each of the first and second leads. At least portions of the die paddle, the first and second leads, and the semiconductor die are encapsulated by a package body, the bottom surfaces of the die paddle and the first leads being exposed in a common exterior surface of the package body.

公开(公告)号：US20050011913A1

公开(公告)日：2005-01-20

申请号：US10620043

申请日：2003-07-15

Applicant: Donald Foster ,  Jeffrey Stark

Inventor： Donald Foster ,  Jeffrey Stark

IPC: B05B11/00 ,  B67D5/40

CPC classification number: B05B11/3052 ,  B05B11/0044 ,  B05B11/3002 ,  B05B11/3033

Abstract: A hand operated liquid dispenser has a simplified, in-line construction that reduces the number of component parts of the dispenser and thereby reduces the dispenser's manufacturing costs. The in-line construction of the liquid dispenser coaxially aligns a liquid discharge orifice, a liquid discharge passage, and a pump chamber of the dispenser. The construction provides a compact liquid dispenser that can be easily held in one hand by a user and manipulated by the fingers of the user's hand to pump liquid from a bottle attached to the liquid dispenser and dispense the liquid in a variety of different discharge patterns.

Abstract translation: 手动液体分配器具有简化的在线结构，其减少了分配器的部件数量，从而降低了分配器的制造成本。 液体分配器的在线构造同时对准排液孔，液体排出通道和分配器的泵室。 该结构提供了一种紧凑的液体分配器，其可以容易地由用户握持并且由用户的手的手指操纵以从附接到液体分配器的瓶子中泵送液体，并以各种不同的排放模式分配液体。

公开(公告)号：US06200356B1

公开(公告)日：2001-03-13

申请号：US09313868

申请日：1999-05-17

Applicant: Wishvender K. Behl ,  Donald Foster ,  Jeffrey Wolfenstine

Inventor： Wishvender K. Behl ,  Donald Foster ,  Jeffrey Wolfenstine

IPC: H01M616

CPC classification number: H01M10/0525 ,  H01M4/0438 ,  H01M4/0445 ,  H01M4/661 ,  H01M10/44 ,  Y10T29/10 ,  Y10T29/49108

Abstract: A lithium ion secondary electrochemical cell includes an anode comprising both a material capable of reversibly incorporating an alkali metal, and a copper current collector, a cathode capable of reversibly incorporating an alkali metal, and an electrolyte which includes a solution of an alkali metal salt dissolved in a polar organic solvent. A method of preventing the electrochemical dissolution of the copper current collector in the lithium ion battery electrolyte includes charging the lithium ion cell immediately after its assembly. By immediately charging the freshly assembled lithium ion cell, lithium will be intercalated into carbon. The copper current collector, therefore, will be at the lithium-carbon potential and thus will be cathodically protected, and will not electrochemically dissolve in the lithium ion battery electrolyte.

Abstract translation: 锂离子二次电化学电池包括包含能够可逆地掺入碱金属的材料和铜集电体，能够可逆地掺入碱金属的阴极和包含碱金属盐溶解溶液的电解质的阳极 在极性有机溶剂中。 防止铜离子集电体在锂离子电池电解质中的电化学溶解的方法包括在组装之后立即对锂离子电池进行充电。 通过立即对新组装的锂离子电池进行充电，锂将被插入碳中。 因此，铜电流收集器将处于锂碳电势，因此将被阴极保护，并且不会电化学溶解在锂离子电池电解质中。

公开(公告)号：US3947232A

公开(公告)日：1976-03-30

申请号：US489507

申请日：1974-07-18

Applicant: Donald Foster

Inventor： Donald Foster

IPC: C11C5/00

CPC classification number: C11C5/008 ,  Y10S425/803

Abstract: A decorative candle molded from candle material wherein the surface of the candle has a plurality of randomly distributed pores adjacent the surface thereof only and said pores are less than 4 millimeters diameter in size and form an attractive random pattern. There are at least 5 said pores per said centimeter of the surface of said candle and the central portion of the candle is substantially pore-free.The candle is made by melting candle material and then cooling the liquid candle material to a temperature and for a time such that a thin film is formed on the surface of the liquid candle material, then mixing the liquid and film phases until the mixture is bubbly and thereafter pouring the candle material into a candle mold from a height at least 50% greater than the height of the mold, cooling and removing the candle from the mold.

公开(公告)号：US20070178063A1

公开(公告)日：2007-08-02

申请号：US11539511

申请日：2006-10-06

Applicant: Wayne Kindsvogel ,  Steven Hughes ,  Richard Holly ,  Christopher Clegg ,  Donald Foster ,  Rebecca Johnson ,  Mark Heipel ,  Pallavur Sivakumar

Inventor： Wayne Kindsvogel ,  Steven Hughes ,  Richard Holly ,  Christopher Clegg ,  Donald Foster ,  Rebecca Johnson ,  Mark Heipel ,  Pallavur Sivakumar

IPC: A61K38/20 ,  A61K39/395

CPC classification number: C07K16/32 ,  A61K38/20 ,  A61K39/395 ,  A61K39/39558 ,  C07K16/2818 ,  C07K16/2896 ,  C07K2317/732 ,  A61K2300/00

Abstract: Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.

Abstract translation: 描述了通过用IL-21共同施用治疗性单克隆抗体来治疗癌症的方法。 可以使用的示例性单克隆抗体是利妥昔单抗，曲妥珠单抗和抗CTLA-4抗体。 联合治疗的增强的抗肿瘤剂对于单克隆治疗顽固性，用单克隆抗体治疗后复发或增强的IL-21抗肿瘤作用降低与使用单克隆抗体治疗相关的毒性的患者群体特别有用。