公开(公告)号：US11109970B2

公开(公告)日：2021-09-07

申请号：US16997866

申请日：2020-08-19

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24 ,  A61F2/95

Abstract: An assembly for replacing a native heart valve can have a prosthetic heart valve with an annular metal frame made from shape-memory material and a valve member disposed in an interior of the metal frame. The assembly can have a delivery apparatus with a handle, a shaft with a proximal end portion and a distal end portion. The proximal end portion can be coupled to the handle and the distal end portion can be releasably coupled to the prosthetic heart valve. The delivery apparatus can also have a delivery sheath and a hydraulic power source operatively connected to the delivery sheath. The prosthetic heart valve can be positioned within the delivery sheath in a radially compressed state. The hydraulic power source can be configured to move the delivery sheath longitudinally relative to the valve to allow the valve to self-expand from the radially compressed state to a radially expanded state.

公开(公告)号：US20210177595A1

公开(公告)日：2021-06-17

申请号：US17185135

申请日：2021-02-25

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24

Abstract: A prosthetic heart valve for replacing a defective aortic valve includes a self-expandable annular frame made of shape-memory material. A one-way valve structure is disposed within an interior of the frame. The frame includes a plurality of posts projecting axially from an outflow end portion of the frame, wherein each of the posts includes an axial post portion and a terminal post portion. The terminal post portions have greater circumferential dimensions than the axial post portions. The terminal post portions are preferably formed with concave inner surfaces and convex outer surfaces for conforming to the shape of a delivery catheter. Each of the posts is shaped for placement within a corresponding recess along a distal end portion of the delivery catheter for ensuring that the prosthetic heart valve remains coupled to the delivery catheter while the prosthetic heart valve is expanded within the defective aortic valve.

公开(公告)号：US20210145579A1

公开(公告)日：2021-05-20

申请号：US17158458

申请日：2021-01-26

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24

Abstract: A delivery assembly includes a prosthetic device, a catheter shaft, a release wire, a first line, and a second line. The prosthetic device has a first arm and a second arm. The release wire extends through the catheter shaft. The first line includes a first loop. The first line extends from the catheter shaft, through the first arm of the prosthetic device, and to the release wire, where the release wire extends through the first loop. The second line includes a second loop. The second line extends from the catheter shaft, through the second arm of the prosthetic device, and to the release wire, where the release wire extends through the second loop.

公开(公告)号：US20200030084A1

公开(公告)日：2020-01-30

申请号：US16593360

申请日：2019-10-04

Applicant: Edwards Lifesciences Corporation

Inventor： David L. Hauser ,  Jan Otto Solem ,  David Alon

IPC: A61F2/24

Abstract: A method of treating a defective mitral valve includes percutaneously advancing a prosthetic device into a patient's heart. The prosthetic device includes an insert member and anchoring member. The prosthetic device is contained within a sheath along a distal end of a delivery catheter during advancement. The anchoring member is secured to a muscular wall of the left ventricle and the insert member self-expands between native leaflets of the mitral valve. The insert member preferably includes a biocompatible fabric outer layer, a passageway, and a valve member disposed within the passageway. After deployment, the native leaflets of the mitral valve form a tight seal against the fabric outer layer of the insert member for preventing regurgitation, while blood passes through the passageway of the insert member for allowing blood to pass from the left atrium to the left ventricle.

公开(公告)号：US10238487B2

公开(公告)日：2019-03-26

申请号：US15181243

申请日：2016-06-13

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24 ,  A61F2/95

Abstract: Embodiments of the present disclosure provide a prosthetic heart valve and a heart valve delivery apparatus for delivery of the prosthetic heart valve to a native valve site via the human vasculature. The delivery apparatus is particularly suited for advancing a prosthetic valve through the aorta (i.e., in a retrograde approach) for replacing a diseased native aortic valve. In one embodiment, a self-expanding valve comprises an expandable stent that is shaped to maintain the valve in the aortic annulus against axial without anchors or retaining devices that engage the surrounding tissue. A delivery apparatus for delivering s self-expanding prosthetic valve can be configured to allow controlled and precise deployment of the valve from a valve sheath so as to minimize or prevent jumping of the valve from the valve sheath.

公开(公告)号：US09579199B2

公开(公告)日：2017-02-28

申请号：US14963149

申请日：2015-12-08

Applicant: Edwards Lifesciences Corporation

Inventor： David L. Hauser ,  Jan O. Solem ,  David Alon

IPC: A61F2/24

CPC classification number: A61F2/246 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2436 ,  A61F2/2445 ,  A61F2/2466 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2220/0016

Abstract: A method of using a device to improve the function of a heart valve is disclosed. In one preferred embodiment, the method includes positioning a prosthetic insert member between leaflets of mitral valve. The insert member has an elongated cross-sectional profile for conforming to gap between leaflets of a mitral valve. The device also includes an anchoring member for attachment to heart tissue for maintaining the insert member in the mitral valve. The insert member is used to plug the gap between the leaflets of the mitral valve and thereby reduce undesirable regurgitation while allowing the leaflets to function in a substantially normal manner. An anchoring member secures the prosthetic insert member to a heart wall. The anchoring member preferably includes a plurality of tissue penetrating hooks or prongs.

Abstract translation: 公开了一种使用装置改善心脏瓣膜功能的方法。 在一个优选实施例中，该方法包括将假体插入件定位在二尖瓣的瓣叶之间。 插入构件具有细长的横截面轮廓，用于与二尖瓣的小叶之间的间隙一致。 该装置还包括用于附接到心脏组织的锚固构件，用于将插入构件保持在二尖瓣中。 插入构件用于堵塞二尖瓣的小叶之间的间隙，从而减少不期望的反流，同时允许小叶以基本正常的方式起作用。 锚定构件将假体插入构件固定到心脏壁。 锚定构件优选地包括多个组织穿透钩或插脚。

公开(公告)号：US20160287386A1

公开(公告)日：2016-10-06

申请号：US15181243

申请日：2016-06-13

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24

CPC classification number: A61F2/2436 ,  A61F2/2418 ,  A61F2/2439 ,  A61F2002/9517 ,  A61F2002/9522 ,  A61F2002/9528 ,  A61F2002/9534 ,  A61F2210/0076 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0076 ,  A61F2250/0039

Abstract: Embodiments of the present disclosure provide a prosthetic heart valve and a heart valve delivery apparatus for delivery of the prosthetic heart valve to a native valve site via the human vasculature. The delivery apparatus is particularly suited for advancing a prosthetic valve through the aorta (i.e., in a retrograde approach) for replacing a diseased native aortic valve. In one embodiment, a self-expanding valve comprises an expandable stent that is shaped to maintain the valve in the aortic annulus against axial without anchors or retaining devices that engage the surrounding tissue. A delivery apparatus for delivering s self-expanding prosthetic valve can be configured to allow controlled and precise deployment of the valve from a valve sheath so as to minimize or prevent jumping of the valve from the valve sheath.

Abstract translation: 本公开的实施例提供了一种假体心脏瓣膜和心脏瓣膜输送装置，用于经由人类脉管系统将假体心脏瓣膜输送到天然瓣膜部位。 输送装置特别适用于通过主动脉推进人工瓣膜（即逆行方法），以更换患病的天然主动脉瓣。 在一个实施例中，自膨胀阀包括可扩张支架，其被成形为在不具有接合周围组织的锚固件或保持装置的情况下将阀保持在主动脉环中以抵抗轴向。 用于输送自膨胀假体瓣膜的输送装置可以构造成允许阀从阀套被控制和精确地展开，以便最小化或防止阀从阀套跳跃。

公开(公告)号：US20160089239A1

公开(公告)日：2016-03-31

申请号：US14963149

申请日：2015-12-08

Applicant: Edwards Lifesciences Corporation

Inventor： David L. Hauser ,  Jan O. Solem ,  David Alon

IPC: A61F2/24

CPC classification number: A61F2/246 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2436 ,  A61F2/2445 ,  A61F2/2466 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2220/0016

Abstract: A method of using a device to improve the function of a heart valve is disclosed. In one preferred embodiment, the method includes positioning a prosthetic insert member between leaflets of mitral valve. The insert member has an elongated cross-sectional profile for conforming to gap between leaflets of a mitral valve. The device also includes an anchoring member for attachment to heart tissue for maintaining the insert member in the mitral valve. The insert member is used to plug the gap between the leaflets of the mitral valve and thereby reduce undesirable regurgitation while allowing the leaflets to function in a substantially normal manner. An anchoring member secures the prosthetic insert member to a heart wall. The anchoring member preferably includes a plurality of tissue penetrating hooks or prongs.

Abstract translation: 公开了一种使用装置改善心脏瓣膜功能的方法。 在一个优选实施例中，该方法包括将假体插入件定位在二尖瓣的瓣叶之间。 插入构件具有细长的横截面轮廓，用于与二尖瓣的小叶之间的间隙一致。 该装置还包括用于附接到心脏组织的锚固构件，用于将插入构件保持在二尖瓣中。 插入构件用于堵塞二尖瓣的小叶之间的间隙，从而减少不期望的反流，同时允许小叶以基本正常的方式起作用。 锚定构件将假体插入构件固定到心脏壁。 锚定构件优选地包括多个组织穿透钩或插脚。

公开(公告)号：US20150173900A1

公开(公告)日：2015-06-25

申请号：US14636011

申请日：2015-03-02

Applicant: Edwards Lifesciences Corporation

Inventor： David L. Hauser ,  Jan O. Solem ,  David Alon

IPC: A61F2/24

CPC classification number: A61F2/246 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2436 ,  A61F2/2445 ,  A61F2/2466 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2220/0016

Abstract: A method of using a device to improve the function of a heart valve is disclosed. In one preferred embodiment, the method includes positioning a prosthetic insert member between leaflets of mitral valve. The insert member has an elongated cross-sectional profile for conforming to gap between leaflets of a mitral valve. The device also includes an anchoring member for attachment to heart tissue for maintaining the insert member in the mitral valve. The insert member is used to plug the gap between the leaflets of the mitral valve and thereby reduce undesirable regurgitation while allowing the leaflets to function in a substantially normal manner. An anchoring member secures the prosthetic insert member to a heart wall. The anchoring member preferably includes a plurality of tissue penetrating hooks or prongs.

Abstract translation: 公开了一种使用装置改善心脏瓣膜功能的方法。 在一个优选实施例中，该方法包括将假体插入件定位在二尖瓣的瓣叶之间。 插入构件具有细长的横截面轮廓，用于与二尖瓣的小叶之间的间隙一致。 该装置还包括用于附接到心脏组织的锚固构件，用于将插入构件保持在二尖瓣中。 插入构件用于堵塞二尖瓣的小叶之间的间隙，从而减少不期望的反流，同时允许小叶以基本正常的方式起作用。 锚定构件将假体插入构件固定到心脏壁。 锚定构件优选地包括多个组织穿透钩或插脚。

公开(公告)号：US20250161046A1

公开(公告)日：2025-05-22

申请号：US19030536

申请日：2025-01-17

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24 ,  A61F2/95

Abstract: Prosthetic valve delivery assemblies including a prosthetic heart valve and a delivery apparatus. The prosthetic heart valve includes a frame having posts extending from a terminal outflow end of the frame and a valve structure disposed within the frame. The delivery apparatus includes an inner shaft including a valve connection portion having recesses configured to receive the posts of the frame of the prosthetic heart valve, an outer shaft including a valve sheath for retaining the prosthetic valve in a radially compressed state and retaining the posts within the recesses, and a handle including a control knob for moving the valve sheath proximally and distally relative to the handle. The control knob is seated within the handle housing such that the housing partially covers a circumferentially extending outer surface of the control knob.