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公开(公告)号：US20090074774A1
公开(公告)日：2009-03-19
申请号：US11629896
申请日：2005-06-17
申请人： Elisabeth Bock , Vladimir Berezin
发明人： Elisabeth Bock , Vladimir Berezin
IPC分类号： A61K39/395 , C07K14/00 , A61K38/16 , A61P25/18 , C07K16/18
CPC分类号： C07K14/70503
摘要： The present invention relates to new peptide compounds capable of direct binding to fibroblast growth factor receptor (FGFR) and activating said receptor. The compounds of the invention comprise peptide fragments of the neural cell adhesion molecule (NCAM) derived from the fibronectin type-III module 1 (F3, 1) of NCAM. Peptide sequences of the invention are capable of stimulating learning and memory and/or neurite outgrowth and/or neural cell survival. Peptide sequences and compounds comprising thereof, according to the invention, may be beneficially used for treatment and/or prevention of different pathological conditions wherein FGFR and/or NCAM play a role in pathology and/or recovery from disease. Accordingly, pharmaceutical compositions comprising the peptide sequences and compounds of the invention are also in the scope of protection.
摘要翻译： 本发明涉及能够直接结合成纤维细胞生长因子受体（FGFR）并激活所述受体的新肽化合物。 本发明的化合物包含衍生自NCAM的纤连蛋白III型模块1（F3，1）的神经细胞粘附分子（NCAM）的肽片段。 本发明的肽序列能够刺激学习和记忆和/或神经突生长和/或神经细胞存活。 根据本发明的包含其的肽序列及其化合物可有利地用于治疗和/或预防其中FGFR和/或NCAM在病理学和/或疾病恢复中起作用的不同病理状况。 因此，包含本发明的肽序列和化合物的药物组合物也在保护范围内。
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公开(公告)号：US20080226639A1
公开(公告)日：2008-09-18
申请号：US11629077
申请日：2005-06-10
申请人： Elisabeth Bock , Vladimir Berezin
发明人： Elisabeth Bock , Vladimir Berezin
CPC分类号： C07K14/70503
摘要： The invention relates to new peptide fragments capable of stimulating neurite outgrowth, stimulating of cell survival, stimulating neural plasticity associated with memory and learning, and modulating cell motility. The biological activity of the peptide fragments is associated with their capability of binding and activating a neurotrophin receptor of the Trk family. The peptide fragments of the invention comprise an amino acid motif which is essential for binding and activating a neurotrophin receptor of the Trk family. The invention also concerns pharmaceutical compositions comprising the compounds and uses thereof for prevention and/or treatment of conditions and/or diseases, wherein neurotrophing, Tkr receptors and/or NCAM play an important role, and wherein stimulating of neurite outgrowth, cell survival, neural plasticity associated with memory and learning, and/or modulating cell motility is beneficial for treatment.
摘要翻译： 本发明涉及能够刺激神经突生长，刺激细胞存活，刺激与记忆和学习相关的神经可塑性以及调节细胞运动性的新肽片段。 肽片段的生物活性与其结合并激活Trk家族的神经营养因子受体的能力相关。 本发明的肽片段包含对于结合并激活Trk家族的神经营养因子受体必需的氨基酸基序。 本发明还涉及包含该化合物的药物组合物及其用于预防和/或治疗病症和/或疾病的用途，其中神经刺激素，Tkr受体和/或NCAM起重要作用，并且其中刺激神经突生长，细胞存活，神经元 与记忆和学习相关的可塑性和/或调节细胞运动性对治疗是有益的。
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公开(公告)号：US20060281130A1
公开(公告)日：2006-12-14
申请号：US10539440
申请日：2003-12-18
IPC分类号： G01N33/53 , G01N33/574 , A61K38/17 , A61K38/10 , A61K39/395 , A61K31/727 , C07K7/08
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K16/22 , G01N33/566 , G01N33/74 , G01N2333/50
摘要： The present invention relates to a method for modulating the interaction between at least two proteins, wherein at least one of the two proteins is a functional cell-surface receptor and the other protein is the receptor ligand. The invention features a binding site of said functional cell-surface receptor on the receptor ligand and discloses a series of amino acid sequences, which are part of the structure of said binding site and/or involved in the interaction between the receptor and the ligand. Moreover, the present invention features methods for molecular design and screening of a candidate compound capable of modulating the interaction between the functional cell-surface receptor and receptor ligand through the described binding site, and provides a screening assay for identification of such a compound. The invention further describes an antibody capable of binding to the above binding site and/or to an epitope comprising an amino acid sequence essential for executing the receptor ligand interaction through said binding site. The invention also concerns a variety of uses of the disclosed methods, peptide sequences and antibodies. The invention in preferred embodiments concerns the binding site of the fibroblast growth factor receptor (FGFR) on FGFR ligands, compounds capable of modulating the receptor ligand interaction through said binding site, and antibody capable of recognition of said binding site.
摘要翻译： 本发明涉及调节至少两种蛋白质之间的相互作用的方法，其中两种蛋白质中的至少一种是功能性细胞表面受体，而另一种蛋白质是受体配体。 本发明的特征在于所述功能性细胞表面受体在受体配体上的结合位点，并公开了一系列氨基酸序列，其是所述结合位点结构的一部分和/或参与受体和配体之间的相互作用。 此外，本发明具有分子设计和筛选能够通过所述结合位点调节功能性细胞表面受体和受体配体之间的相互作用的候选化合物的方法，并提供了鉴定这种化合物的筛选试验。 本发明还描述了能够结合上述结合位点和/或包含通过所述结合位点执行受体配体相互作用所必需的氨基酸序列的表位的抗体。 本发明还涉及所公开的方法，肽序列和抗体的各种用途。 本发明在优选实施方案中涉及成纤维细胞生长因子受体（FGFR）对FGFR配体的结合位点，能够通过所述结合位点调节受体配体相互作用的化合物和能够识别所述结合位点的抗体。
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公开(公告)号：US20050153888A1
公开(公告)日：2005-07-14
申请号：US10992287
申请日：2004-11-19
申请人： Lars Christian Ronn , Arne Holm , Marianne Olsen , Soren Ostergaard , Peter Jensen , Flemming Poulsen , Vladislav Soroka , Igor Ralets , Vladimir Berezin , Elisabeth Bock
发明人： Lars Christian Ronn , Arne Holm , Marianne Olsen , Soren Ostergaard , Peter Jensen , Flemming Poulsen , Vladislav Soroka , Igor Ralets , Vladimir Berezin , Elisabeth Bock
IPC分类号： C12N15/09 , A61K38/00 , A61K38/39 , A61K39/395 , A61K45/00 , A61P1/00 , A61P1/16 , A61P1/18 , A61P3/10 , A61P9/00 , A61P9/10 , A61P13/12 , A61P15/08 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/28 , A61P43/00 , C07K7/08 , C07K14/705 , C07K14/78 , C07K16/42 , C07K16/46 , C12P21/08 , A61K38/17 , C07K14/47
CPC分类号： C07K14/70503 , A61K38/00
摘要： The invention provides novel compounds which are capable of stimulating the proliferation or/and the outgrowth from cells presenting the neural cell adhesion molecule (NCAM). Additionally, the invention relates to methods for treatment of normal, degenerated and damaged NCAM presenting cells.
摘要翻译： 本发明提供能够刺激呈递神经细胞粘附分子（NCAM）的细胞的增殖和/或生长的新型化合物。 此外，本发明涉及用于治疗正常，退化和损伤的NCAM呈递细胞的方法。
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35.发明申请公开(公告)号：US20110115960A1
公开(公告)日：2011-05-19
申请号：US12965322
申请日：2010-12-10
申请人： Vladimir Berezin
发明人： Vladimir Berezin
IPC分类号： H04N5/335
CPC分类号： H04N5/378 , H04N5/35572 , H04N5/374
摘要： An active pixel sensor includes mixed analog and digital signal integration on the same substrate. The analog part of the array forms the active pixel sensor, and the digital part of the array does digital integration of the signal.
摘要翻译： 有源像素传感器包括在同一衬底上的混合模拟和数字信号集成。 阵列的模拟部分形成有源像素传感器，阵列的数字部分对信号进行数字积分。
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公开(公告)号：US20100168382A1
公开(公告)日：2010-07-01
申请号：US12664085
申请日：2008-06-06
申请人： Vladimir Berezin
发明人： Vladimir Berezin
CPC分类号： A61K38/17
摘要： The present invention relates to peptides derived from neuroplastin which are capable of inducing neurite outgrowth by modulating intracellular calcium concentration and activity of intracellular signalling molecules such as Akt, Erk1/2 and CREB through binding and/or modulation of receptor tyrosine kinases including but not limited to Fibroblast Growth Factor receptors (FGFRs). The peptides are derived from neuroplastin or fragments thereof. The invention further relates to use of said peptides for the production of a medicament for the treatment of different pathological conditions, wherein neuroplastin and/or receptor tyrosine kinases, including but not limited to FGFRs, play a prominent role.
摘要翻译： 本发明涉及衍生自神经淀粉蛋白的肽，其能够通过结合和/或调节受体酪氨酸激酶（包括但不限于）调节细胞内钙浓度和细胞内信号分子如Akt，Erk1 / 2和CREB的活性而诱导神经突生长 成纤维细胞生长因子受体（FGFR）。 肽衍生自神经淀粉蛋白或其片段。 本发明还涉及所述肽用于生产用于治疗不同病理状况的药物的用途，其中包括但不限于FGFR的神经淀粉蛋白和/或受体酪氨酸激酶起着突出的作用。
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公开(公告)号：US07116366B1
公开(公告)日：2006-10-03
申请号：US09653527
申请日：2000-08-31
CPC分类号： H04N5/2355 , H04N5/3741
摘要： An image sensing device, such as a CMOS Active Pixel Sensor device, including an array of pixels. Each pixel has a photoreceptor, a follower transistor connected to the photoreceptor, a select transistor connected to the follower transistor, and a reset transistor. A first bias line provides power to at least a first of the transistors for a first pixel, and a second bias line provides power to at least a second of the transistors of said first pixel different than the first transistor of the first pixel.
摘要翻译： 诸如CMOS有源像素传感器装置的图像感测装置，包括像素阵列。 每个像素具有感光体，连接到感光体的跟随器晶体管，连接到跟随器晶体管的选择晶体管和复位晶体管。 第一偏置线为第一像素的至少第一晶体管提供功率，并且第二偏置线向不同于第一像素的第一晶体管的所述第一像素的至少第二晶体管提供功率。
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公开(公告)号：US20050001917A1
公开(公告)日：2005-01-06
申请号：US10901114
申请日：2004-07-29
CPC分类号： H04N5/2355 , H04N5/3741
摘要： Signal dynamic range in a CMOS active pixel is increased by using separate set and reset lines.
摘要翻译： CMOS有源像素中的信号动态范围通过使用单独的设置和复位线增加。
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39.发明授权公开(公告)号：US07956912B2
公开(公告)日：2011-06-07
申请号：US11529634
申请日：2006-09-29
申请人： Vladimir Berezin
发明人： Vladimir Berezin
IPC分类号： H04N5/335
CPC分类号： H04N5/378 , H04N5/35572 , H04N5/374
摘要： An active pixel sensor includes mixed analog and digital signal integration on the same substrate. The analog part of the array forms the active pixel sensor, and the digital part of the array does digital integration of the signal.
摘要翻译： 有源像素传感器包括在同一衬底上的混合模拟和数字信号集成。 阵列的模拟部分形成有源像素传感器，阵列的数字部分对信号进行数字积分。
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40.再颁专利Pinned photodiode photodetector with common buffer transistor and binning capability 有权带有公共缓冲晶体管的引脚光电二极管光电检测器和合并能力公开(公告)号：USRE41340E1
公开(公告)日：2010-05-18
申请号：US11524495
申请日：2006-09-21
IPC分类号： H01L31/101 , H01L31/062
CPC分类号： G01S7/487 , H01L27/14601 , H01L27/14609 , H01L27/14643
摘要： A lock in pinned photodiode photodetector includes a plurality of output ports which are sequentially enabled. Each time when the output port is enabled is considered to be a different bin of time. A specified pattern is sent, and the output bins are investigated to look for that pattern. The time when the pattern is received indicates the time of flight. A CMOS active pixel image sensor includes a plurality of pinned photodiode photodetectors that share buffer transistors. In one configuration, the charge from two or more pinned photodiodes may be binned together and applied to the gate of a shared buffer transistor.
摘要翻译： 锁定光电二极管光电检测器的锁定器包括顺序启用的多个输出端口。 每当启用输出端口时，都被认为是不同的时间段。 发送指定的模式，并调查输出框以查找该模式。 接收到花样的时间表示飞行时间。 CMOS有源像素图像传感器包括共享缓冲晶体管的多个钉扎光电二极管光电检测器。 在一种配置中，来自两个或更多个被钉扎的光电二极管的电荷可以合并在一起并施加到共享缓冲晶体管的栅极。
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