公开(公告)号：US20110172729A1

公开(公告)日：2011-07-14

申请号：US13004582

申请日：2011-01-11

申请人： Robert J. Sweeney ,  Dan Li

发明人： Robert J. Sweeney ,  Dan Li

IPC分类号： A61N1/365 ,  A61N1/39

CPC分类号： A61N1/36507 ,  A61B5/0464 ,  A61N1/3925

摘要： An apparatus example comprises a cardiac signal sensing circuit configured to provide a sensed cardiac signal representative of cardiac depolarization events of a subject, a sampling circuit coupled to the cardiac signal sensing circuit, a therapy circuit, and a controller communicatively coupled to the sampling circuit and the therapy circuit. The controller includes a detection module configured to detect tachyarrhythmia using the cardiac signal and a signal analysis module configured to establish significant points (SPs) of the sampled cardiac signal, estimate heart rate during the tachyarrhythmia using the SPs, and provide an indication of whether noise is present in the cardiac signal using the SPs. The controller is configured to select a therapy for delivery by the therapy circuit in response to the tachyarrhythmia detection and to modify the selected therapy according to the heart rate estimation and the noise indication.

摘要翻译： 装置示例包括心脏信号感测电路，其被配置为提供表示对象的心脏去极化事件的感测心脏信号，耦合到心脏信号感测电路的采样电路，治疗电路和通信地耦合到采样电路的控制器，以及 治疗电路。 所述控制器包括检测模块，所述检测模块被配置为使用所述心脏信号来检测快速性心律失常;以及信号分析模块，所述信号分析模块被配置为建立所述采集的心脏信号的有效点（SP），使用所述SP在所述快速性心律失常期间估计心率，并且提供噪声 使用SP存在于心脏信号中。 控制器被配置为选择治疗电路响应于快速性心律失常检测的递送的治疗，并且根据心率估计和噪声指示修改所选择的治疗。

公开(公告)号：US20110071848A1

公开(公告)日：2011-03-24

申请号：US12955111

申请日：2010-11-29

申请人： Robert J. Sweeney

发明人： Robert J. Sweeney

IPC分类号： G06Q10/00 ,  G06Q50/00

CPC分类号： A61B5/0031 ,  G06F19/00 ,  G06Q50/22 ,  G06Q50/24

摘要： Advanced patient management systems include a unit for collecting data from a device associated with a patient, and a host in communication with the unit, the host identifying a time for the device to update data on the device. The system can identify a time for the device to update data associated with the device by developing a histogram of the availability of the device for interrogation. The system can also optimize processing loads for the system by developing a histogram of the time at which the caregiver is most likely to access the system to review the collected and processed data. Methods for optimizing device data update and processing times are also included.

摘要翻译： 高级患者管理系统包括用于从与患者相关联的设备收集数据的单元以及与该单元通信的主机，主机标识设备更新设备上的数据的时间。 系统可以通过开发用于询问的设备的可用性的直方图来识别设备更新与设备相关联的数据的时间。 系统还可以通过开发监护人最有可能访问系统的时间的直方图来优化收集和处理的数据来优化系统的处理负荷。 还包括优化设备数据更新和处理时间的方法。

公开(公告)号：US07805185B2

公开(公告)日：2010-09-28

申请号：US11124950

申请日：2005-05-09

申请人： Yi Zhang ,  Robert J. Sweeney

发明人： Yi Zhang ,  Robert J. Sweeney

IPC分类号： A61B5/0452

CPC分类号： A61B5/0472 ,  A61B5/1116 ,  A61B5/686 ,  A61B5/7203 ,  A61B2560/0219 ,  A61B2560/0468 ,  A61B2562/046 ,  A61N1/3627 ,  A61N1/365 ,  A61N1/3712

摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend a patient's posture using cardiac activation sequence information. Devices and methods involve sensing a plurality of composite cardiac signals using a plurality of implantable electrodes. A source separation is performed using the composite cardiac signals, which produces one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences. A change in a patient's posture is detected using the cardiac signal vectors. Further embodiments involve sensing the plurality of composite cardiac signals during the patient's predominant cardiac rhythm before detecting the change in the patient's posture. Other embodiments involve discriminating between one of a postural related change and a cardiac rhythm related change using the cardiac signal vectors.

摘要翻译： 提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。 使用心脏信号分离来使用心脏激活序列信息来检测，监测，跟踪和/或趋向于患者的姿势。 装置和方法包括使用多个可植入电极感测多个复合心脏信号。 使用复合心脏信号进行源分离，其产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号载体。 使用心脏信号矢量检测患者姿势的变化。 另外的实施例涉及在检测患者姿势的变化之前在患者的主要心律期间感测多个复合心脏信号。 其他实施例涉及使用心脏信号矢量区分姿势相关变化和心律相关变化中的一个。

公开(公告)号：US20080188730A1

公开(公告)日：2008-08-07

申请号：US12098644

申请日：2008-04-07

申请人： Robert J. Sweeney ,  Julio C. Spinelli ,  Rodney W. Salo

发明人： Robert J. Sweeney ,  Julio C. Spinelli ,  Rodney W. Salo

IPC分类号： A61B5/05

CPC分类号： A61B5/0538 ,  A61B5/053 ,  A61B5/14535 ,  A61N1/36521

摘要： A technique for determining a patient's hematocrit by an electrical impedance measurement is described. An implantable device may be configured to utilize the technique in order to assess a cardiac patient's fluid status. In order to determine the hematocrit, the electrical impedance of the blood is measured and mapped by a mapping function to a corresponding hematocrit value.

摘要翻译： 描述了通过电阻抗测量来确定患者的血细胞比容的技术。 可植入装置可被配置为利用该技术来评估心脏病人的流体状态。 为了确定血细胞比容，测量血液的电阻抗并通过映射函数映射到相应的血细胞比容值。

公开(公告)号：US20080058872A1

公开(公告)日：2008-03-06

申请号：US11468143

申请日：2006-08-29

申请人： Marina V. Brockway ,  Imad Libbus ,  Krzysztof Z. Siejko ,  Robert J. Sweeney

发明人： Marina V. Brockway ,  Imad Libbus ,  Krzysztof Z. Siejko ,  Robert J. Sweeney

IPC分类号： A61N1/00

CPC分类号： A61N1/3727 ,  A61B5/02405 ,  A61B5/4035 ,  A61B5/4839 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/36139 ,  A61N1/362 ,  A61N1/37264

摘要： Described herein are methods and devices that utilize electrical neural stimulation to treat heart failure by modulating a patient's autonomic balance in a manner that inhibits sympathetic activity and/or augments parasympathetic activity. Because other therapies for treating heart failure may also affect a patient's autonomic balance, a device for delivering neural stimulation is configured to appropriately titrate such therapy in either an open-loop or closed-loop fashion.

摘要翻译： 本文描述了利用电神经刺激来以抑制交感神经活动和/或增加副交感神经活动的方式调节患者的自主神经平衡来治疗心力衰竭的方法和装置。 因为用于治疗心力衰竭的其它治疗也可能影响患者的自主平衡，用于递送神经刺激的装置被配置为以开环或闭环方式适当地滴定这种治疗。

公开(公告)号：US20080033303A1

公开(公告)日：2008-02-07

申请号：US11457247

申请日：2006-07-13

申请人： Ramesh Wariar ,  Robert J. Sweeney

发明人： Ramesh Wariar ,  Robert J. Sweeney

IPC分类号： A61B5/02 ,  A61B5/00

CPC分类号： A61B5/16 ,  A61B5/0002 ,  A61B5/02028 ,  A61B5/7275 ,  G06F19/00

摘要： This document discusses, among other things, a system and method for remote monitoring of patient cognitive function using implanted cardiac rhythm management (CRM) devices and a patient management system. The method comprising: presenting a cognitive test to a patient via a user interface; receiving a result of the cognitive test using the user interface; and using the result of the cognitive test in determining a heart failure condition status.

摘要翻译： 本文件还讨论了使用植入式心律管理（CRM）设备和患者管理系统远程监测患者认知功能的系统和方法。 该方法包括：经由用户界面向患者呈现认知测试; 使用用户界面接收认知测试的结果; 并使用认知测试的结果来确定心力衰竭状态。

公开(公告)号：US06950702B2

公开(公告)日：2005-09-27

申请号：US10195838

申请日：2002-07-15

申请人： Robert J. Sweeney

发明人： Robert J. Sweeney

IPC分类号： A61B5/0245 ,  A61B5/0402 ,  A61B5/0452 ,  A61N1/36 ,  A61N1/365 ,  A61N1/362

CPC分类号： A61B5/0452 ,  A61B5/7239 ,  A61N1/365

摘要： A cardiac rhythm management system includes a sensing circuit to sense a cardiac signal and a sensing processor to detect cardiac depolarizations (beats) by utilizing certain morphological context of the sensed cardiac signal. The sensing processor samples the sensed cardiac signal, computes curvatures from the sampled cardiac signal to generate a cardiac curvature signal corresponding to the cardiac signal, derives cardiac signal features reflecting morphologically significant points along the cardiac signal from the cardiac curvature signal, and detects cardiac depolarizations based on an analysis of the cardiac signals features.

摘要翻译： 心律管理系统包括用于感测心脏信号的感测电路和感测处理器，以通过利用感测的心脏信号的某些形态上下文来检测心脏去极化（搏动）。 感测处理器对感测到的心脏信号进行采样，从采样的心脏信号计算曲率以产生对应于心​​脏信号的心脏曲率信号，导出心脏信号特征，反映沿着心脏曲率信号的心脏信号的形态学显着点，并且检测心脏去极化 基于对心脏信号特征的分析。

公开(公告)号：US06689117B2

公开(公告)日：2004-02-10

申请号：US09740129

申请日：2000-12-18

申请人： Robert J. Sweeney ,  Avram Scheiner ,  Ronald W. Heil, Jr.

发明人： Robert J. Sweeney ,  Avram Scheiner ,  Ronald W. Heil, Jr.

IPC分类号： A61M3100

CPC分类号： A61N1/30 ,  A61M5/1723 ,  A61M2205/3507 ,  A61M2205/3561

摘要： A drug delivery system and method in which an implantable medical device communicates with and controls an external drug delivery device with low energy potential signals. The implantable device generates potential signals modulated with digitally encoded command information by operating a current source to cause corresponding electrical potentials that can be sensed at the skin surface by the external drug delivery device. The drug delivery device then demodulates the sensed potentials and decodes the digital data to extract command information therefrom to deliver a drug accordingly.

摘要翻译： 一种药物递送系统和方法，其中可植入医疗装置与具有低能量电位信号的外部药物递送装置通信并控制其。 可植入装置通过操作电流源产生用数字编码命令信息调制的潜在信号，以引起可由外部药物输送装置在皮肤表面感测到的相应电位。 药物递送装置然后解调所感测的电位并对数字数据进行解码以从中提取命令信息以递送药物。

公开(公告)号：US06539262B2

公开(公告)日：2003-03-25

申请号：US09950276

申请日：2001-09-10

申请人： Robert J. Sweeney

发明人： Robert J. Sweeney

IPC分类号： A61N1362

CPC分类号： A61N1/36528

摘要： A cardiac rhythm management system provides ultrasound autocapture capability for determining whether a stimulation has evoked a desired response from the heart, and for adjusting an energy of the stimulation based on the observed response from the heart. A first ultrasound element is disposed on a lead in the heart. A second ultrasound element is disposed elsewhere in the heart or in the implanted device. An autocapture determination circuit determines whether motion of the heart chamber indicates a contraction in response to the stimulation, and adjusts the stimulation energy to provide only that energy which is needed to obtain capture. This saves energy, prolonging the life of the implanted device, minimizing the risk and expense to patient associated with early explantation and replacement of the implanted device. Other applications include using ultrasound for (1) determining the strength of heart contractions (2) determining dissociation between electrical and mechanical heart activity, (3) determining the volume of the heart, (4) determining the origin of sensed intrinsic electrical heart activity signals, (5) recognizing particular arrhythmias (6) disrupting cell membranes for lowering stimulation thresholds, (7) controlling the delivery of a steroid, and (8) obtaining blood flow information.

公开(公告)号：US5161528A

公开(公告)日：1992-11-10

申请号：US577974

申请日：1990-09-05

申请人： Robert J. Sweeney

发明人： Robert J. Sweeney

IPC分类号： A61N1/39

CPC分类号： A61N1/39 ,  A61N1/3956

摘要： The present invention provides a method, and apparatus for accomplishing same, for defibrillating a mammal in need of defibrillation employing multiple bursts of electrical current delivered to the mammal, the timing between said bursts being based upon the mammal's fibrillation cycle length.

摘要翻译： 本发明提供了一种用于完成其的方法和装置，用于使用输送到哺乳动物的多次电流的脉冲来对需要除颤的哺乳动物进行去纤颤，所述突发之间的时间基于哺乳动物的原纤维循环长度。