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93 条记录 (耗时 0.021 秒)

    Acylated imidazolyl-O,N-acetals, their pharmaceutically acceptable salts and metal complexes
    31.
    发明授权
    Acylated imidazolyl-O,N-acetals, their pharmaceutically acceptable salts and metal complexes 失效
    酰化咪唑基-O，N-缩醛，其药学上可接受的盐和金属络合物

    公开(公告)号：US4153708A

    公开(公告)日：1979-05-08

    申请号：US764830

    申请日：1977-02-02

    申请人： Wolfgang Kramer ,  Karl H. Buchel ,  Manfred Plempel

    发明人： Wolfgang Kramer ,  Karl H. Buchel ,  Manfred Plempel

    IPC分类号： C07D233/60 ,  C07D521/00

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： Acylated imidazolyl-O,N-acetals of the formula ##STR1## and their pharmaceutically acceptable salts and metal complexes wherein R is alkyl, alkenyl, alkinyl, cycloalkyl, halogenoalkyl, optionally substituted phenyl, optionally substituted phenoxyalkyl, alkylamino, dialkylamino or optionally substituted phenylamino;X is halogen, alkyl, cycloalkyl, alkoxy, halogenoalkyl, alkylthio, alkoxycarbonyl, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted phenylalkyl, amino, cyano or nitro; andN is 0 or an integer of from 1 to 5; are useful as antimicrobial agents, particularly for their use in treating mycotic infectins in humans and animals.

    摘要翻译： 具有式（I）的酰化咪唑基-O，N-缩醛及其药学上可接受的盐和金属络合物，其中R是烷基，烯基，炔基，环烷基，卤代烷基，任选取代的苯基，任选取代的苯氧基烷基，烷基氨基，二烷基氨基或 任选取代的苯基氨基; X是卤素，烷基，环烷基，烷氧基，卤代烷基，烷硫基，烷氧基羰基，任选取代的苯基，任选取代的苯氧基，任选取代的苯基烷基，氨基，氰基或硝基; 和N是0或1到5的整数; 有用的抗微生物剂，特别是用于治疗人类和动物中的MYCOTIC感染。

    Antimycotic agent
    32.
    发明授权
    Antimycotic agent 失效
    抗真菌剂

    公开(公告)号：US4843089A

    公开(公告)日：1989-06-27

    申请号：US55818

    申请日：1987-05-29

    申请人： Graham Holmwood ,  Wolfgang Kramer ,  Karl H. Buchel ,  Manfred Plempel

    发明人： Graham Holmwood ,  Wolfgang Kramer ,  Karl H. Buchel ,  Manfred Plempel

    IPC分类号： A61K31/41 ,  A61K31/415 ,  A61P31/00 ,  A61P31/04 ,  C07D233/60 ,  C07D233/61 ,  C07D249/08 ,  C07D521/00

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： A method of combating mycoses which comprises administering to a patient an antimycotically effective amount of a hydroxyethyl-azole of the formula ##STR1## in which R.sup.1 represents alkyl or the grouping Ar--Y--,Ar represents optionally substituted aryl,Y represents a direct bond or the groupings --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --, --OCH.sub.2 --, --SCH.sub.2 --, --CH.dbd.CH-- or --C.dbd.C--,X represents a nitrogen atom or the CH group,Z represents oxygen or the NOR.sup.2 group andR.sup.2 represents hydrogen, alkyl, alkenyl, alkinyl, optionally substituted aralkyl or optionally substituted cycloalkylalkyl, or an acid addition salt thereof.

    摘要翻译： 一种防治真菌病的方法，其包括向患者施用抗真菌有效量的式“IMAGE”的羟乙基唑，其中R 1表示烷基或Ar-Y-，Ar表示任选取代的芳基，Y表示直接键 或-CH 2 - ， - CH 2 -CH 2 - ， - OCH 2 - ， - CH 2 - ， - CH = CH-或-C = C-，X表示氮原子或CH基团，Z表示氧或NOR2基团 和R 2表示氢，烷基，烯基，炔基，任选取代的芳烷基或任选取代的环烷基烷基，或其酸加成盐。

    Antimycotically active cyclopropyl-substituted azolylmethylcarbinols
    34.
    发明授权
    Antimycotically active cyclopropyl-substituted azolylmethylcarbinols 失效
    抗菌活性环丙基取代的氨基苯乙醇

    公开(公告)号：US5059615A

    公开(公告)日：1991-10-22

    申请号：US430204

    申请日：1989-11-01

    申请人： Burkhard Fugmann ,  Manfred Plempel ,  Klaus Stroech ,  Karl H. Buchel

    发明人： Burkhard Fugmann ,  Manfred Plempel ,  Klaus Stroech ,  Karl H. Buchel

    IPC分类号： A01N53/12 ,  A61K31/41 ,  A61K31/415 ,  A61P31/04 ,  C07C255/45 ,  C07C255/46 ,  C07C323/20 ,  C07C323/62 ,  C07D233/60 ,  C07D233/61 ,  C07D249/08 ,  C07D521/00

    CPC分类号： C07D249/08 ,  C07C255/45 ,  C07D231/12 ,  C07D233/56

    摘要： Antimycotically active 1-cyano- and 1-carboxamidocyclopropylazolylmethylcarbinols have now been found of the formula ##STR1## in which R.sup.1 represents hydrogen or represents alkyl or represents alkylcarbonyl,R.sup.2 represents cyano or represents a group of the formula ##STR2## R.sup.3 represents phenyl which is optionally substituted by halogen, straight-chain or branched alkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy or halogenoalkylthio, or by phenyl or phenoxy which, in turn, may be substituted by halogen or alkyl having up to 6 carbon atoms,X represents a nitrogen atom or the CH group,Y represents a bond or represents a group of the formula ##STR3## in which R.sup.4 and R.sup.5 are identical or different and denote hydrogen or alkyl and their pharmaceutically tolerated acid addition salts.

    摘要翻译： 现已发现抗真菌活性的1-氰基 - 和1-甲酰氨基环丙基吖唑基甲基甲醇，其中R1代表氢或代表烷基或代表烷基羰基，R2代表氰基或代表下式的基团，其中R1代表苯基， 任选被卤素，直链或支链烷基，烷氧基，烷硫基，卤代烷基，卤代烷氧基或卤代烷硫基取代，或被苯基或苯氧基取代，其又可被卤素或具有至多6个碳原子的烷基取代，X代表氮 原子或CH基团，Y表示键或表示式为“IMAGE”的基团，其中R4和R5相同或不同，表示氢或烷基及其药学上可耐受的酸加成盐。

    Treating mycoses with triazolylalkanols
    38.
    发明授权
    Treating mycoses with triazolylalkanols 失效
    用三唑基烷醇处理真菌病

    公开(公告)号：US4904682A

    公开(公告)日：1990-02-27

    申请号：US260082

    申请日：1988-10-19

    申请人： Wolfgang Kramer ,  Graham Holmwood ,  Karl H. Buchel ,  Manfred Plempel

    发明人： Wolfgang Kramer ,  Graham Holmwood ,  Karl H. Buchel ,  Manfred Plempel

    IPC分类号： A61K31/41 ,  A61P31/04 ,  C07D249/08 ,  C07D521/00

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： A method of combating mycoses in a patient in need thereof which comprises administering to such patient an antimycotically effective amount of a triazolylalkanol of the formula ##STR1## in which Ar stands for optionally substituted aryl andX stands for one of the groups --CH.sub.2 --; --O--CH.sub.2 --; --S--CH.sub.2 --; --CH.sub.2 --CH.sub.2 --; --CH.dbd.CH-- or --C.tbd.C--,or a physiologically tolerable acid addition salt thereof.

    摘要翻译： 一种在有需要的患者中对抗真菌病的方法，其包括向所述患者施用抗真菌有效量的下式的三唑基烷醇：其中Ar表示任选取代的芳基，X表示基团-CH 2 - 之一; -O-CH 2 - ; -S-CH 2 - ; -CH 2 -CH 2 - ; -CH = CH-或-CB 3 C，或其生理上可耐受的酸加成盐。

    Disubstituted triphenylmethylmidazoles for treating mycotic infections
    40.
    发明授权
    Disubstituted triphenylmethylmidazoles for treating mycotic infections 失效
    用于治疗肌肉感染的三甲基甲酰胺

    公开(公告)号：US4117142A

    公开(公告)日：1978-09-26

    申请号：US726568

    申请日：1976-09-27

    申请人： Karl Heinz Buchel ,  Erik Regel ,  Manfred Plempel

    发明人： Karl Heinz Buchel ,  Erik Regel ,  Manfred Plempel

    IPC分类号： C07D521/00 ,  A61K31/415

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： Imidazoles of the formula ##STR1## and pharmaceutically acceptable nontoxic salts thereof, wherein X is methyl or chloro,Y is methyl or chloro, or, when Z is methyl or chloro, Y is hydrogen, andZ is methyl or chloro, or, when Y is methyl or chloro, Z is hydrogen,Are useful as antimycotics for the treatment of mycotic infections in humans and animals. The imidazoles may be produced by reacting the corresponding triphenylmethylcarbinol with a brominating or chlorinating agent and thereafter reacting the resultant triphenylmethyl halide, either with or without isolation, with imidazole in the presence or absence of an acid-binding agent, or they may be prepared by reacting a triphenylmethyl halide with imidazole, either in the presence or absence of an acid-binding agent.