MICROORGANISM CONCENTRATION PROCESS
    34.
    发明申请
    MICROORGANISM CONCENTRATION PROCESS 有权
    微生物浓缩过程

    公开(公告)号:US20100190171A1

    公开(公告)日:2010-07-29

    申请号:US12678362

    申请日:2008-10-02

    IPC分类号: C12Q1/02 C12Q1/68

    摘要: A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration agent that comprises an amorphous metal silicate and that has a surface composition having a metal atom to silicon atom ratio of less than or equal to about 0.5, as determined by X-ray photoelectron spectroscopy (XPS); (b) providing a sample comprising at least one microorganism strain; and (c) contacting the concentration agent with the sample such that at least a portion of the at least one microorganism strain is bound to or captured by the concentration agent.

    摘要翻译: 用于捕获或浓缩用于检测或测定的微生物的方法包括(a)提供包含无定形金属硅酸盐并且具有小于或等于约0.5的金属原子与硅原子比的表面组成的浓度试剂,如所确定的 通过X射线光电子能谱(XPS); (b)提供包含至少一种微生物菌株的样品; 和(c)使浓缩剂与样品接触,使得至少一部分微生物菌株与浓缩剂结合或捕获。

    HYDROXY AND ALKOXY SUBSTITUTED IH-IMIDAZONAPHTHYRIDINES AND METHODS
    36.
    发明申请
    HYDROXY AND ALKOXY SUBSTITUTED IH-IMIDAZONAPHTHYRIDINES AND METHODS 失效
    羟基和烷基取代的1H-咪唑并吡啶并且方法

    公开(公告)号:US20090298821A1

    公开(公告)日:2009-12-03

    申请号:US12281702

    申请日:2007-03-14

    CPC分类号: C07D471/14

    摘要: 1H-Imidazo[4,5-c]naphthyridin-4-amines with a hydroxy, alkoxy, hydroxyalkoxy, or alkoxyalkoxy substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

    摘要翻译: 在2-位具有羟基,烷氧基,羟基烷氧基或烷氧基烷氧基取代基的1H-咪唑并[4,5-c]萘啶-4-胺,含有这些化合物的药物组合物,制备化合物的方法,中间体和使用方法 的这些化合物作为免疫调节剂,用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病的疾病。

    Amide and Carbamate Derivatives of Alkyl Substituted N-[4-(4-Amino-1H-Imidazo[4,5-C] Quinolin-1-YL)Butyl]Methanesulfonamides and Methods
    38.
    发明申请
    Amide and Carbamate Derivatives of Alkyl Substituted N-[4-(4-Amino-1H-Imidazo[4,5-C] Quinolin-1-YL)Butyl]Methanesulfonamides and Methods 失效
    烷基取代的N- [4-(4-氨基-1H-咪唑并[4,5-C]喹啉-1-YL)丁基]甲磺酰胺和方法的酰胺和氨基甲酸酯衍生物

    公开(公告)号:US20090176821A1

    公开(公告)日:2009-07-09

    申请号:US11991686

    申请日:2006-09-08

    CPC分类号: C07D471/04

    摘要: Amide and carbamate derivatives of N-[4-(4-amino-1H-imidazo[4,5-c]quinolin-1-yl)butyl]methanesulfonamides with an ethyl, methyl, or n-propyl substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making the compounds, and methods of use of these compounds in modulating the immune system, for inducing cytokine biosyn-thesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

    摘要翻译: 在2-位具有乙基,甲基或正丙基取代基的N- [4-(4-氨基-1H-咪唑并[4,5-c]喹啉-1-基)丁基]甲磺酰胺的酰胺和氨基甲酸酯衍生物 公开了含有这些化合物的药物组合物,制备该化合物的方法以及这些化合物在调节免疫系统中的用途,用于诱导动物中的细胞因子生物合成论和用于治疗包括病毒和肿瘤疾病的疾病的方法。

    Amide and carbamate derivatives of N-{2-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c] quinolin-1-Yl]-1,1-dimethylethyl}methanesulfonamide and methods
    40.
    发明授权
    Amide and carbamate derivatives of N-{2-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c] quinolin-1-Yl]-1,1-dimethylethyl}methanesulfonamide and methods 失效
    N- {2- [4-氨基-2-(乙氧基甲基)-1H-咪唑并[4,5-c]喹啉-1-基] -1,1-二甲基乙基}甲磺酰胺的酰胺和氨基甲酸酯衍生物和方法

    公开(公告)号:US08476292B2

    公开(公告)日:2013-07-02

    申请号:US11991663

    申请日:2006-09-08

    CPC分类号: C07D471/04

    摘要: Amide and carbamate derivatives N-{2-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-1,1-dimethylethyl}methanesulfonamide, pharmaceutical compositions containing these compounds, methods of making the compounds, and methods of use of these compounds in modulating the immune system, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

    摘要翻译: 酰胺和氨基甲酸酯衍生物N- {2- [4-氨基-2-(乙氧基甲基)-1H-咪唑并[4,5-c]喹啉-1-基] -1,1-二甲基乙基}甲磺酰胺,含有这些化合物的药物组合物 公开了制备化合物的方法,以及这些化合物在调节免疫系统中的用途,用于在动物中诱导细胞因子生物合成和治疗包括病毒和肿瘤疾病的疾病的方法。