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公开(公告)号：US20100190171A1
公开(公告)日：2010-07-29
申请号：US12678362
申请日：2008-10-02
CPC分类号： G01N33/54313 , C12N1/02 , C12N11/14 , C12Q1/04 , C12Q1/24 , G01N33/552 , G01N33/553
摘要： A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration agent that comprises an amorphous metal silicate and that has a surface composition having a metal atom to silicon atom ratio of less than or equal to about 0.5, as determined by X-ray photoelectron spectroscopy (XPS); (b) providing a sample comprising at least one microorganism strain; and (c) contacting the concentration agent with the sample such that at least a portion of the at least one microorganism strain is bound to or captured by the concentration agent.
摘要翻译： 用于捕获或浓缩用于检测或测定的微生物的方法包括（a）提供包含无定形金属硅酸盐并且具有小于或等于约0.5的金属原子与硅原子比的表面组成的浓度试剂，如所确定的 通过X射线光电子能谱（XPS）; （b）提供包含至少一种微生物菌株的样品; 和（c）使浓缩剂与样品接触，使得至少一部分微生物菌株与浓缩剂结合或捕获。
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公开(公告)号：US08546100B2
公开(公告)日：2013-10-01
申请号：US12678579
申请日：2008-10-02
CPC分类号： C12N11/14 , B01J20/02 , B01J20/06 , B01J20/14 , B01J20/3204 , B01J20/3234 , B01J20/3236 , C12N1/02 , C12Q1/04 , C12Q1/24
摘要： A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration agent that comprises diatomaceous earth bearing, on at least a portion of its surface, a surface treatment comprising a surface modifier comprising titanium dioxide, fine-nanoscale gold or platinum, or a combination thereof; (b) providing a sample comprising at least one microorganism strain; and (c) contacting the concentration agent with the sample such that at least a portion of the at least one microorganism strain is bound to or captured by the concentration agent.
摘要翻译： 用于捕获或浓缩用于检测或测定的微生物的方法包括（a）在其表面的至少一部分上提供包含硅藻土的浓缩剂，所述表面处理包括表面改性剂，其包含二氧化钛，细纳米级金或 铂或其组合; （b）提供包含至少一种微生物菌株的样品; 和（c）使浓缩剂与样品接触，使得至少一部分微生物菌株与浓缩剂结合或捕获。
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公开(公告)号：US20100248214A1
公开(公告)日：2010-09-30
申请号：US12679063
申请日：2008-10-02
IPC分类号： C12Q1/70 , C12N11/14 , G01N33/53 , G01N33/554 , C12Q1/68
CPC分类号： C12N1/02 , B01J20/0229 , B01J20/06 , B01J20/28004 , B01J20/2803 , C12N11/14 , C12Q1/04 , C12Q1/24 , G01N1/405 , G01N33/54313
摘要： A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a particulate concentration agent that comprises gamma-FeO(OH); (b) providing a fluid sample comprising at least one microorganism strain; and (c) contacting the concentration agent with the sample such that at least a portion of the concentration agent is dispersed in the sample and at least a portion of the at least one microorganism strain is bound to or captured by the concentration agent.
摘要翻译： 用于捕获或浓缩用于检测或测定的微生物的方法包括（a）提供包含γ-FeO（OH）的颗粒浓缩剂; （b）提供包含至少一种微生物菌株的流体样品; 和（c）使浓缩剂与样品接触，使得至少一部分浓缩剂分散在样品中，并且至少一部分微生物菌株与浓缩剂结合或捕获。
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公开(公告)号：US20100247592A1
公开(公告)日：2010-09-30
申请号：US12679158
申请日：2008-10-01
CPC分类号： C23C14/18 , A01N59/16 , B01J23/52 , B01J35/0013 , B01J37/0221 , C23C14/223 , A01N25/08 , A01N25/34 , A01N2300/00
摘要： A process for limiting the growth of microorganisms comprises (a) providing an antimicrobial agent comprising fine-nanoscale gold on a support medium comprising nanoparticulate titania, the fine-nanoscale gold having been deposited on the support medium by physical vapor deposition; and (b) contacting at least one microorganism with the antimicrobial agent.
摘要翻译： 限制微生物生长的方法包括（a）在包含纳米颗粒二氧化钛的载体介质上提供包含微细纳米级金的抗微生物剂，所述微细纳米金已通过物理气相沉积沉积在载体介质上; 和（b）使至少一种微生物与抗微生物剂接触。
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公开(公告)号：US09624464B2
公开(公告)日：2017-04-18
申请号：US12678362
申请日：2008-10-02
IPC分类号： G01N33/53 , C12Q1/04 , C12Q1/02 , C12N7/02 , C12N1/20 , C12N7/00 , C12N1/12 , C12N1/10 , C12N1/02 , C12N11/14 , C12Q1/24 , G01N33/543
CPC分类号： G01N33/54313 , C12N1/02 , C12N11/14 , C12Q1/04 , C12Q1/24 , G01N33/552 , G01N33/553
摘要： A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration agent that comprises an amorphous metal silicate and that has a surface composition having a metal atom to silicon atom ratio of less than or equal to about 0.5, as determined by X-ray photoelectron spectroscopy (XPS); (b) providing a sample comprising at least one microorganism strain; and (c) contacting the concentration agent with the sample such that at least a portion of the at least one microorganism strain is bound to or captured by the concentration agent.
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公开(公告)号：US09145541B2
公开(公告)日：2015-09-29
申请号：US12679063
申请日：2008-10-02
IPC分类号： C12N1/00 , C12Q1/24 , C12N11/00 , C12N1/02 , B01J20/02 , B01J20/06 , B01J20/28 , C12N11/14 , C12Q1/04 , G01N1/40 , G01N33/543
CPC分类号： C12N1/02 , B01J20/0229 , B01J20/06 , B01J20/28004 , B01J20/2803 , C12N11/14 , C12Q1/04 , C12Q1/24 , G01N1/405 , G01N33/54313
摘要： A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a particulate concentration agent that comprises gamma-FeO(OH); (b) providing a fluid sample comprising at least one microorganism strain; and (c) contacting the concentration agent with the sample such that at least a portion of the concentration agent is dispersed in the sample and at least a portion of the at least one microorganism strain is bound to or captured by the concentration agent.
摘要翻译： 用于捕获或浓缩用于检测或测定的微生物的方法包括（a）提供包含γ-FeO（OH）的颗粒浓缩剂; （b）提供包含至少一种微生物菌株的流体样品; 和（c）使浓缩剂与样品接触，使得至少一部分浓缩剂分散在样品中，并且至少一部分微生物菌株与浓缩剂结合或捕获。
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公开(公告)号：US08372416B2
公开(公告)日：2013-02-12
申请号：US12679158
申请日：2008-10-01
IPC分类号： A01N25/08
CPC分类号： C23C14/18 , A01N59/16 , B01J23/52 , B01J35/0013 , B01J37/0221 , C23C14/223 , A01N25/08 , A01N25/34 , A01N2300/00
摘要： A process for limiting the growth of microorganisms comprises (a) providing an antimicrobial agent comprising fine-nanoscale gold on a support medium comprising nanoparticulate titania, the fine-nanoscale gold having been deposited on the support medium by physical vapor deposition; and (b) contacting at least one microorganism with the antimicrobial agent.
摘要翻译： 限制微生物生长的方法包括（a）在包含纳米颗粒二氧化钛的载体介质上提供包含微细纳米级金的抗微生物剂，所述微细纳米金已通过物理气相沉积沉积在载体介质上; 和（b）使至少一种微生物与抗微生物剂接触。
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公开(公告)号：US20100209961A1
公开(公告)日：2010-08-19
申请号：US12678579
申请日：2008-10-02
CPC分类号： C12N11/14 , B01J20/02 , B01J20/06 , B01J20/14 , B01J20/3204 , B01J20/3234 , B01J20/3236 , C12N1/02 , C12Q1/04 , C12Q1/24
摘要： A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration agent that comprises diatomaceous earth bearing, on at least a portion of its surface, a surface treatment comprising a surface modifier comprising titanium dioxide, fine-nanoscale gold or platinum, or a combination thereof; (b) providing a sample comprising at least one microorganism strain; and (c) contacting the concentration agent with the sample such that at least a portion of the at least one microorganism strain is bound to or captured by the concentration agent.
摘要翻译： 用于捕获或浓缩用于检测或测定的微生物的方法包括（a）在其表面的至少一部分上提供包含硅藻土的浓缩剂，所述表面处理包括表面改性剂，其包含二氧化钛，细纳米级金或 铂或其组合; （b）提供包含至少一种微生物菌株的样品; 和（c）使浓缩剂与样品接触，使得至少一部分微生物菌株与浓缩剂结合或捕获。
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公开(公告)号：US20090030341A1
公开(公告)日：2009-01-29
申请号：US11829493
申请日：2007-07-27
申请人： Tushar A. Kshirsagar , Jeffrey D. Smith , Paul J. Cobian , Tera M. Nordby , Manjiri T. Kshirsagar , Patrick A. Mach , Bryan S. Behun
发明人： Tushar A. Kshirsagar , Jeffrey D. Smith , Paul J. Cobian , Tera M. Nordby , Manjiri T. Kshirsagar , Patrick A. Mach , Bryan S. Behun
IPC分类号： A61B10/00
CPC分类号： G01N1/38 , A61B10/0045 , B01L3/0293 , C12M33/02 , G01N1/40 , G01N2001/028 , Y10T436/25
摘要： Devices to process a sample are configured to releasably attach a sample acquisition device to a drive mechanism that provides rotational and/or vibrational motion to the sample acquisition device. The devices can be used in sample processing methods to dislodge sample materials from the sample acquisition device. Sample processing methods using rotational or vibrational motion may further include the use of a liquid medium into which the sample is released. Sample processing methods may further include the detection of an analyte in the sample.
摘要翻译： 用于处理样品的装置被配置为将样品采集装置可释放地附接到向样品采集装置提供旋转和/或振动运动的驱动机构。 这些装置可以用于样品处理方法以从样品采集装置中移除样品材料。 使用旋转或振动运动的样品处理方法还可以包括使用样品释放到其中的液体介质。 样品处理方法还可以包括检测样品中的分析物。
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公开(公告)号：US09145410B2
公开(公告)日：2015-09-29
申请号：US13359213
申请日：2012-01-26
申请人： David S. Hays , Michael E. Danielson , John F. Gerster , Shri Niwas , Ryan B. Prince , Tushar A. Kshirsagar , Philip D. Heppner , William H. Moser , Joan T. Moseman , Matthew R. Radmer , Maureen A. Kavanagh , Sarah A. Strong , Jason D. Bonk
发明人： David S. Hays , Michael E. Danielson , John F. Gerster , Shri Niwas , Ryan B. Prince , Tushar A. Kshirsagar , Philip D. Heppner , William H. Moser , Joan T. Moseman , Matthew R. Radmer , Maureen A. Kavanagh , Sarah A. Strong , Jason D. Bonk
IPC分类号： C07D471/04 , C07D471/14 , C07D401/14 , C07D495/14
CPC分类号： C07D471/04 , C07D401/14 , C07D471/14 , C07D495/14
摘要： Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, and prodrugs thereof, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
摘要翻译： 吡唑并吡啶-4-胺，吡唑啉-4-胺，吡唑啉-4-基胺，6,7,8,9-四氢吡唑并喹啉-4-胺及其前药，含有这些化合物的药物组合物，中间体，制备方法和方法 这些化合物作为免疫调节剂的用途，用于诱导或抑制动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。
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