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    2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
    35.
    发明申请
    2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections 有权
    2'-C-甲基-3'-O-L-缬氨酸酯呋喃核糖基胞苷用于治疗黄病毒科感染

    公开(公告)号：US20070275883A1

    公开(公告)日：2007-11-29

    申请号：US11516928

    申请日：2006-09-06

    申请人： Jean-Pierre Sommadossi ,  Paolo LaColla ,  Gilles Gosselin

    发明人： Jean-Pierre Sommadossi ,  Paolo LaColla ,  Gilles Gosselin

    IPC分类号： A61K31/7072 ,  A61K31/7068

    CPC分类号： A61K31/7068 ,  A61K31/7072 ,  A61K45/06 ,  A61K2300/00

    摘要： The 3′-L-valine ester of β-D-2′-C-methyl-ribofuranosyl cytidine provides superior results against flaviviruses and pestiviruses, including hepatitis C virus. Based on this discovery, compounds, compositions, methods and uses are provided for the treatment of flaviviridae, including HCV, that include the administration of an effective amount of val-mCyd or its salt, ester, prodrug or derivative, optionally in a pharmaceutically acceptable carrier. In an alternative embodiment, val-mCyd is used to treat any virus that replicates through an RNA-dependent RNA polymerase.

    摘要翻译： β-D-2'-C-methyl-ribofuranosyl cytidine的3'-L-缬氨酸酯提供了对黄病毒和瘟病毒（包括丙型肝炎病毒）的优异结果。 基于这一发现，提供了化合物，组合物，方法和用途，用于治疗黄病毒科，包括HCV，其包括施用有效量的val-mCyd或其盐，酯，前药或衍生物，任选地在药学上可接受的 载体 在替代实施方案中，val-mCyd用于治疗通过RNA依赖性RNA聚合酶复制的任何病毒。

    2′-C-methyl-3′-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
    38.
    发明授权
    2′-C-methyl-3′-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections 有权
    2'-C-甲基-3'-O-L-缬氨酸酯呋喃核糖基胞苷用于治疗黄病毒科感染

    公开(公告)号：US07582618B2

    公开(公告)日：2009-09-01

    申请号：US11516928

    申请日：2006-09-06

    申请人： Jean-Pierre Sommadossi ,  Paolo LaColla ,  Gilles Gosselin

    发明人： Jean-Pierre Sommadossi ,  Paolo LaColla ,  Gilles Gosselin

    IPC分类号： A01N43/04 ,  A61K31/70

    CPC分类号： A61K31/7068 ,  A61K31/7072 ,  A61K45/06 ,  A61K2300/00

    摘要： The 3′-L-valine ester of β-D-2′-C-methyl-ribofuranosyl cytidine provides superior results against flaviviruses and pestiviruses, including hepatitis C virus. Based on this discovery, compounds, compositions, methods and uses are provided for the treatment of flaviviridae, including HCV, that include the administration of an effective amount of val-mCyd or its salt, ester, prodrug or derivative, optionally in a pharmaceutically acceptable carrier. In an alternative embodiment, val-mCyd is used to treat any virus that replicates through an RNA-dependent RNA polymerase.

    摘要翻译： β-D-2'-C-methyl-ribofuranosyl cytidine的3'-L-缬氨酸酯提供了对黄病毒和瘟病毒（包括丙型肝炎病毒）的优异结果。 基于这一发现，提供了化合物，组合物，方法和用途，用于治疗黄病毒科，包括HCV，其包括施用有效量的val-mCyd或其盐，酯，前药或衍生物，任选地在药学上可接受的 载体 在替代实施方案中，val-mCyd用于治疗通过RNA依赖性RNA聚合酶复制的任何病毒。