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1.发明授权Compounds and pharmaceutical compositions for the treatment of viral infections 有权用于治疗病毒感染的化合物和药物组合物公开(公告)号：US08691788B2
公开(公告)日：2014-04-08
申请号：US13116890
申请日：2011-05-26
申请人： Jean-Pierre Sommadossi , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
发明人： Jean-Pierre Sommadossi , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
IPC分类号： A61K31/70
CPC分类号： C07H17/02 , A61K31/675 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , C07F9/65586 , C07F9/65616 , C07H19/00
摘要： Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
摘要翻译： 本文提供了用于治疗肝脏疾病（包括HCV和/或HBV感染）的化合物，组合物和方法。 具体地，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。
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2.发明申请Compounds and pharmaceutical compositions for the treatment of viral infections 有权用于治疗病毒感染的化合物和药物组合物公开(公告)号：US20080286230A1
公开(公告)日：2008-11-20
申请号：US12005937
申请日：2007-12-27
申请人： Jean-Pierre Sommadossi , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
发明人： Jean-Pierre Sommadossi , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
IPC分类号： A61K31/7076 , C07H19/20 , C07F9/6558 , A61K31/675 , A61K38/21 , A61P31/12 , A61K38/20 , A61K31/7068 , C07F9/6561
CPC分类号： C07H17/02 , A61K31/675 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , C07F9/65586 , C07F9/65616 , C07H19/00
摘要： Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
摘要翻译： 本文提供了用于治疗肝脏疾病（包括HCV和/或HBV感染）的化合物，组合物和方法。 具体地，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。
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公开(公告)号：US07951789B2
公开(公告)日：2011-05-31
申请号：US12005937
申请日：2007-12-27
申请人： Jean-Pierre Sommadossi , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
发明人： Jean-Pierre Sommadossi , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
CPC分类号： C07H17/02 , A61K31/675 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , C07F9/65586 , C07F9/65616 , C07H19/00
摘要： Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
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4.发明申请公开(公告)号：US20110286962A1
公开(公告)日：2011-11-24
申请号：US13116890
申请日：2011-05-26
申请人： Jean-Pierre SOMMADOSSI , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
发明人： Jean-Pierre SOMMADOSSI , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
IPC分类号： A61K31/7076 , A61K31/661 , C07H19/20 , C07H19/10 , A61K31/7068 , A61P31/12 , A61K31/675 , C07H19/04 , A61K31/7056 , A61K38/20 , A61K38/21 , A61K38/43 , C07F9/06 , A61K31/7072
CPC分类号： C07H17/02 , A61K31/675 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , C07F9/65586 , C07F9/65616 , C07H19/00
摘要： Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
摘要翻译： 本文提供了用于治疗肝脏疾病（包括HCV和/或HBV感染）的化合物，组合物和方法。 具体地，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。
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5.发明授权Compounds and pharmaceutical compositions for the treatment of viral infections 有权用于治疗病毒感染的化合物和药物组合物公开(公告)号：US07902202B2
公开(公告)日：2011-03-08
申请号：US12150327
申请日：2008-04-25
申请人： Jean-Pierre Sommadossi , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
发明人： Jean-Pierre Sommadossi , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
IPC分类号： A61K31/497 , C07F9/02
CPC分类号： C07H17/02 , A61K31/675 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , C07F9/65586 , C07F9/65616 , C07H19/00
摘要： Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
摘要翻译： 本文提供了用于治疗肝脏疾病（包括HCV和/或HBV感染）的化合物，组合物和方法。 具体地，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。
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6.发明申请Compounds and Pharmaceutical compositions for the treatment of Viral infections 有权用于治疗病毒感染的化合物和药物组合物公开(公告)号：US20090169504A1
公开(公告)日：2009-07-02
申请号：US12150327
申请日：2008-04-25
申请人： Jean-Pierre Sommadossi , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
发明人： Jean-Pierre Sommadossi , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
IPC分类号： A61K38/20 , C07H19/20 , C07H19/10 , A61K31/708 , A61K31/7068 , A61K38/21 , A61K31/7072 , A61P31/12 , C07H19/06 , C07H19/16
CPC分类号： C07H17/02 , A61K31/675 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , C07F9/65586 , C07F9/65616 , C07H19/00
摘要： Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
摘要翻译： 本文提供了用于治疗肝脏疾病（包括HCV和/或HBV感染）的化合物，组合物和方法。 具体地，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。
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7.发明申请Compounds and pharmaceutical compositions for the treatment of liver disorders 审中-公开用于治疗肝脏疾病的化合物和药物组合物公开(公告)号：US20080261913A1
公开(公告)日：2008-10-23
申请号：US12005938
申请日：2007-12-27
申请人： Jean-Pierre Sommadossi , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
发明人： Jean-Pierre Sommadossi , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
IPC分类号： A61K31/7076 , C07H19/20 , C07H19/10 , A61K31/7068 , C07F9/06 , A61K31/661 , A61K31/708 , A61P35/00 , A61P3/10
CPC分类号： C07H17/02 , A61K31/675 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , C07F9/65586 , C07F9/65616 , C07H19/00
摘要： Provided herein are compounds, compositions and methods for the treatment of liver disorders, including liver cancer and metabolic diseases, such as diabetes, hyperlipidemia, atherosclerosis, and obesity. Specifically, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-cancer agents.
摘要翻译： 本文提供了用于治疗肝脏疾病的化合物，组合物和方法，包括肝癌和代谢疾病，例如糖尿病，高脂血症，动脉粥样硬化和肥胖症。 具体地，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗癌剂组合施用。
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公开(公告)号：US07547704B2
公开(公告)日：2009-06-16
申请号：US11005467
申请日：2004-12-06
IPC分类号： A01N43/04 , A01N43/54 , C07D239/00 , C07D239/02
CPC分类号： C07H19/16 , A61K9/20 , A61K9/48 , A61K31/675 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K38/21 , A61K38/212 , A61K45/06 , A61K47/60 , C07H19/00 , C07H19/04 , C07H19/048 , C07H19/056 , C07H19/06 , C07H19/22 , A61K2300/00
摘要： 2′ and/or 3′ prodrugs of 1′, 2′, 3′ or 4′-branched nucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and other related conditions. Compounds and compositions of the prodrugs of the present invention are described. Methods and uses are also provided that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.
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9.发明申请Methods and Compositions for Treating Flaviviruses, Pestiviruses and Hepacivirus 审中-公开治疗黄病毒，瘟病毒和肝炎病毒的方法和组合公开(公告)号：US20080280850A1
公开(公告)日：2008-11-13
申请号：US11884414
申请日：2005-09-26
IPC分类号： C07H19/10 , C07H19/06 , C07H19/04 , A61K31/7068 , A61K31/706 , A61P31/12
CPC分类号： A61K45/06 , A61K31/7076 , A61K36/00 , C07H19/00 , C07H19/048 , A61K2300/00
摘要： A method and composition for treating a host infected with flavivirus, pestivirus or hepacivirus comprising administering an effective flavivirus, pestivirus or hepacivirus treatment amount of a described base-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.
摘要翻译： 提供用于治疗感染黄病毒，瘟病毒或肝炎病毒的宿主的方法和组合物，其包括施用有效的黄病毒，瘟病毒或肝炎病毒处理量的所述碱基修饰的核苷或其药学上可接受的盐或前药。
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10.发明授权Modified 2′ and 3′-nucleoside prodrugs for treating Flavivridae infections 失效用于治疗黄病毒感染的修饰的2'和3'-核苷前药公开(公告)号：US07365057B2
公开(公告)日：2008-04-29
申请号：US11005447
申请日：2004-12-06
CPC分类号： C07H19/16 , A61K9/20 , A61K9/48 , A61K31/675 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K38/21 , A61K38/212 , A61K45/06 , A61K47/60 , C07H19/00 , C07H19/04 , C07H19/048 , C07H19/056 , C07H19/06 , C07H19/22 , A61K2300/00
摘要： 2′ and/or 3′ prodrugs of 1′, 2′, 3′ or 4′-branchednucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and other related conditions. Compounds and compositions of the prodrugs of the present invention are described. Methods and uses are also provided that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.
摘要翻译： 描述了1'，2'，3'或4'-支链核苷的2'和/或3'前药及其药学上可接受的盐和衍生物。 这些前药可用于预防和治疗黄病毒科感染，包括HCV感染和其他相关病症。 描述本发明前药的化合物和组合物。 还提供了包括施用有效量的本发明前药或其药学上可接受的盐或衍生物的方法和用途。 这些药物可以任选地与另外的抗病毒剂组合或改变来施用，以预防或治疗黄病毒科感染和其他相关病症。
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