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    Method for preparing nucleotides and related analogues by synthesis on soluble substrate, and biological tools thus prepared
    8.
    发明授权
    Method for preparing nucleotides and related analogues by synthesis on soluble substrate, and biological tools thus prepared 失效
    通过在可溶性底物上合成制备核苷酸和相关类似物的方法，以及如此制备的生物工具

    公开(公告)号：US08614312B2

    公开(公告)日：2013-12-24

    申请号：US12735871

    申请日：2009-02-23

    申请人： Suzanne Peyrottes ,  Christian Perigaud ,  Céline Crauste

    发明人： Suzanne Peyrottes ,  Christian Perigaud ,  Céline Crauste

    IPC分类号： C07H21/00 ,  C12Q1/68 ,  C07H21/02

    CPC分类号： C07H1/02 ,  C07H19/00 ,  C07H19/06 ,  C07H19/16

    摘要： The invention concerns a method for preparing monomer nucleotides or nucleotide analogues comprising the steps of: (1) coupling a soluble polyethylene glycol support provided with at least one diacid or ether-acid linker and a monomer nucleoside or nucleoside analogue to an amine group or hydroxyl group of the nucleoside with the aid of a coupling agent; (2) at least one step for phosphorylation of said nucleoside or nucleoside analogue coupled to said support with a phosphorylation agent; (3) cleavage of said support and recovery of at least one monomer nucleotide or nucleotide analogue. The nucleotides prepared are biological tools.

    摘要翻译： 本发明涉及一种制备单体核苷酸或核苷酸类似物的方法，包括以下步骤：（1）将提供有至少一种二酸或醚 - 酸接头的单体核苷或核苷类似物的可溶性聚乙二醇载体与胺基或羟基 一组核苷借助偶联剂; （2）用磷酸化剂磷酸化与所述载体偶联的所述核苷或核苷类似物的至少一个步骤; （3）所述载体的切割和至少一种单体核苷酸或核苷酸类似物的回收。 所制备的核苷酸是生物工具。

    METHOD FOR PREPARING NUCLEOTIDES AND RELATED ANALOGUES BY SYNTHESIS ON SOLUBLE SUBSTRATE, AND BIOLOGICAL TOOLS THUS PREPARED
    9.
    发明申请
    METHOD FOR PREPARING NUCLEOTIDES AND RELATED ANALOGUES BY SYNTHESIS ON SOLUBLE SUBSTRATE, AND BIOLOGICAL TOOLS THUS PREPARED 失效
    通过合成可溶性底物制备核酸和相关的类似物的方法，以及制备的生物工具

    公开(公告)号：US20110118454A1

    公开(公告)日：2011-05-19

    申请号：US12735871

    申请日：2009-02-23

    申请人： Suzanne Peyrottes ,  Christian Perigaud ,  Céline Crauste

    发明人： Suzanne Peyrottes ,  Christian Perigaud ,  Céline Crauste

    IPC分类号： C07H21/00 ,  C07H1/00

    CPC分类号： C07H1/02 ,  C07H19/00 ,  C07H19/06 ,  C07H19/16

    摘要： The invention concerns a method for preparing monomer nucleotides or nucleotide analogues comprising the steps of: (1) coupling a soluble polyethylene glycol support provided with at least one diacid or ether-acid linker and a monomer nucleoside or nucleoside analogue to an amine group or hydroxyl group of the nucleoside with the aid of a coupling agent; (2) at least one step for phosphorylation of said nucleoside or nucleoside analogue coupled to said support with a phosphorylation agent; (3) cleavage of said support and recovery of at least one monomer nucleotide or nucleotide analogue. The nucleotides prepared are biological tools.

    摘要翻译： 本发明涉及一种制备单体核苷酸或核苷酸类似物的方法，包括以下步骤：（1）将提供有至少一种二酸或醚 - 酸接头的单体核苷或核苷类似物的可溶性聚乙二醇载体与胺基或羟基 一组核苷借助偶联剂; （2）用磷酸化剂磷酸化与所述载体偶联的所述核苷或核苷类似物的至少一个步骤; （3）所述载体的切割和至少一种单体核苷酸或核苷酸类似物的回收。 所制备的核苷酸是生物工具。