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1.发明授权Compounds and pharmaceutical compositions for the treatment of viral infections 有权用于治疗病毒感染的化合物和药物组合物公开(公告)号：US08691788B2
公开(公告)日：2014-04-08
申请号：US13116890
申请日：2011-05-26
申请人： Jean-Pierre Sommadossi , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
发明人： Jean-Pierre Sommadossi , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
IPC分类号： A61K31/70
CPC分类号： C07H17/02 , A61K31/675 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , C07F9/65586 , C07F9/65616 , C07H19/00
摘要： Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
摘要翻译： 本文提供了用于治疗肝脏疾病（包括HCV和/或HBV感染）的化合物，组合物和方法。 具体地，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。
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2.发明申请Compounds and pharmaceutical compositions for the treatment of viral infections 有权用于治疗病毒感染的化合物和药物组合物公开(公告)号：US20080286230A1
公开(公告)日：2008-11-20
申请号：US12005937
申请日：2007-12-27
申请人： Jean-Pierre Sommadossi , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
发明人： Jean-Pierre Sommadossi , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
IPC分类号： A61K31/7076 , C07H19/20 , C07F9/6558 , A61K31/675 , A61K38/21 , A61P31/12 , A61K38/20 , A61K31/7068 , C07F9/6561
CPC分类号： C07H17/02 , A61K31/675 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , C07F9/65586 , C07F9/65616 , C07H19/00
摘要： Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
摘要翻译： 本文提供了用于治疗肝脏疾病（包括HCV和/或HBV感染）的化合物，组合物和方法。 具体地，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。
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公开(公告)号：US07951789B2
公开(公告)日：2011-05-31
申请号：US12005937
申请日：2007-12-27
申请人： Jean-Pierre Sommadossi , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
发明人： Jean-Pierre Sommadossi , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
CPC分类号： C07H17/02 , A61K31/675 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , C07F9/65586 , C07F9/65616 , C07H19/00
摘要： Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
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4.发明申请公开(公告)号：US20110286962A1
公开(公告)日：2011-11-24
申请号：US13116890
申请日：2011-05-26
申请人： Jean-Pierre SOMMADOSSI , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
发明人： Jean-Pierre SOMMADOSSI , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
IPC分类号： A61K31/7076 , A61K31/661 , C07H19/20 , C07H19/10 , A61K31/7068 , A61P31/12 , A61K31/675 , C07H19/04 , A61K31/7056 , A61K38/20 , A61K38/21 , A61K38/43 , C07F9/06 , A61K31/7072
CPC分类号： C07H17/02 , A61K31/675 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , C07F9/65586 , C07F9/65616 , C07H19/00
摘要： Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
摘要翻译： 本文提供了用于治疗肝脏疾病（包括HCV和/或HBV感染）的化合物，组合物和方法。 具体地，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。
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5.发明授权Compounds and pharmaceutical compositions for the treatment of viral infections 有权用于治疗病毒感染的化合物和药物组合物公开(公告)号：US07902202B2
公开(公告)日：2011-03-08
申请号：US12150327
申请日：2008-04-25
申请人： Jean-Pierre Sommadossi , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
发明人： Jean-Pierre Sommadossi , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
IPC分类号： A61K31/497 , C07F9/02
CPC分类号： C07H17/02 , A61K31/675 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , C07F9/65586 , C07F9/65616 , C07H19/00
摘要： Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
摘要翻译： 本文提供了用于治疗肝脏疾病（包括HCV和/或HBV感染）的化合物，组合物和方法。 具体地，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。
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6.发明申请Compounds and Pharmaceutical compositions for the treatment of Viral infections 有权用于治疗病毒感染的化合物和药物组合物公开(公告)号：US20090169504A1
公开(公告)日：2009-07-02
申请号：US12150327
申请日：2008-04-25
申请人： Jean-Pierre Sommadossi , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
发明人： Jean-Pierre Sommadossi , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
IPC分类号： A61K38/20 , C07H19/20 , C07H19/10 , A61K31/708 , A61K31/7068 , A61K38/21 , A61K31/7072 , A61P31/12 , C07H19/06 , C07H19/16
CPC分类号： C07H17/02 , A61K31/675 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , C07F9/65586 , C07F9/65616 , C07H19/00
摘要： Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
摘要翻译： 本文提供了用于治疗肝脏疾病（包括HCV和/或HBV感染）的化合物，组合物和方法。 具体地，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。
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7.发明申请Compounds and pharmaceutical compositions for the treatment of liver disorders 审中-公开用于治疗肝脏疾病的化合物和药物组合物公开(公告)号：US20080261913A1
公开(公告)日：2008-10-23
申请号：US12005938
申请日：2007-12-27
申请人： Jean-Pierre Sommadossi , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
发明人： Jean-Pierre Sommadossi , Gilles Gosselin , Claire Pierra , Christian Perigaud , Suzanne Peyrottes
IPC分类号： A61K31/7076 , C07H19/20 , C07H19/10 , A61K31/7068 , C07F9/06 , A61K31/661 , A61K31/708 , A61P35/00 , A61P3/10
CPC分类号： C07H17/02 , A61K31/675 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , C07F9/65586 , C07F9/65616 , C07H19/00
摘要： Provided herein are compounds, compositions and methods for the treatment of liver disorders, including liver cancer and metabolic diseases, such as diabetes, hyperlipidemia, atherosclerosis, and obesity. Specifically, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-cancer agents.
摘要翻译： 本文提供了用于治疗肝脏疾病的化合物，组合物和方法，包括肝癌和代谢疾病，例如糖尿病，高脂血症，动脉粥样硬化和肥胖症。 具体地，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗癌剂组合施用。
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8.发明授权Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections 有权取代的羰氧基甲基磷酰胺化合物和用于治疗病毒感染的药物组合物公开(公告)号：US09403863B2
公开(公告)日：2016-08-02
申请号：US13610722
申请日：2012-09-11
申请人： Dominique Surleraux , Cyril B. Dousson , Gilles Gosselin , David Dukhan , Claire Pierra , Jerome Peyronnet
发明人： Dominique Surleraux , Cyril B. Dousson , Gilles Gosselin , David Dukhan , Claire Pierra , Jerome Peyronnet
IPC分类号： A01N43/04 , A61K31/70 , C07H19/04 , C07H19/10 , C07H19/048 , C07H19/20 , C07H19/16 , C07H19/207
CPC分类号： C07H19/10 , C07H19/16 , C07H19/207
摘要： Provided herein are compounds, compositions and methods for the treatment of liver disorders, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, provided herein are compounds according to Formula I: or a pharmaceutically acceptable salt, solvate, tautomeric or polymorphic form thereof.
摘要翻译： 本文提供了用于治疗肝脏疾病（包括HCV感染）的化合物，组合物和方法。 在某些实施方案中，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。 在某些实施方案中，本文提供了根据式I的化合物或其药学上可接受的盐，溶剂化物，互变异构体或多晶型物。
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9.发明申请Substituted Carbonyloxymethylphosphoramidate Compounds and Pharmaceutical Compositions for the Treatment of Viral Infections 有权取代的羰氧基甲基磷酰胺化合物和用于治疗病毒感染的药物组合物公开(公告)号：US20130064794A1
公开(公告)日：2013-03-14
申请号：US13610722
申请日：2012-09-11
申请人： Dominique Surleraux , Cyril B. Dousson , Gilles Gosselin , David Dukhan , Claire Pierra , Jerome Peyronnet
发明人： Dominique Surleraux , Cyril B. Dousson , Gilles Gosselin , David Dukhan , Claire Pierra , Jerome Peyronnet
IPC分类号： A61K31/7076 , A61P31/12 , A61P31/14 , A61K38/21 , C07H19/20 , A61K31/708
CPC分类号： C07H19/10 , C07H19/16 , C07H19/207
摘要： Provided herein are compounds, compositions and methods for the treatment of liver disorders, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
摘要翻译： 本文提供了用于治疗肝脏疾病（包括HCV感染）的化合物，组合物和方法。 在某些实施方案中，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。
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公开(公告)号：US20100279974A1
公开(公告)日：2010-11-04
申请号：US11885898
申请日：2006-03-09
IPC分类号： A61K31/70 , C07H19/23 , C07H19/048 , C07H19/12 , A61P31/12
CPC分类号： A61K31/706 , C07H19/04
摘要： A method and composition for treating a host infected with flavivirus, pestivirus or hepacivirus comprising administering an effective flavivirus, pestivirus or hepacivirus treatment amount of a described base-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.
摘要翻译： 提供用于治疗感染黄病毒，瘟病毒或肝炎病毒的宿主的方法和组合物，其包括施用有效的黄病毒，瘟病毒或肝炎病毒处理量的所述碱基修饰的核苷或其药学上可接受的盐或前药。
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