公开(公告)号：US20170057917A1

公开(公告)日：2017-03-02

申请号：US15119294

申请日：2015-02-13

Applicant: Hetero Research Foundation

Inventor： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Jambula Mukunda Reddy ,  Bandi Vamsi Krishna

IPC: C07D211/58

CPC classification number: C07D211/58

Abstract: The present invention provides novel polymorphs of Lomitapide, process for their preparation and pharmaceutical compositions comprising them. The present invention also provides a novel polymorph of Lomitapide mesylate, process for its preparation and pharmaceutical compositions comprising it.

Abstract translation: 本发明提供了洛米他滨的新型多晶型物，其制备方法和包含它们的药物组合物。 本发明还提供了甲磺酸洛美哌啶的新型多晶型物，其制备方法和包含它的药物组合物。

公开(公告)号：US20170029392A1

公开(公告)日：2017-02-02

申请号：US14968034

申请日：2015-12-14

Applicant: HETERO RESEARCH FOUNDATION

Inventor： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Adulla Venkat Narsimha Reddy ,  Bandi Vamsi Krishna

IPC: C07D305/14

CPC classification number: C07D305/14

Abstract: The present invention provides an improved process for the preparation of 4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene (7β,10β-dimethoxy-10-deacetoxybaccatin III). The present invention also provides a novel process for the preparation of cabazitaxel.

Abstract translation: 本发明提供了制备4α-乙酰氧基-2α-苯甲酰氧基-5β，20-环氧-1β，13α-二羟基-7β，10β-二甲氧基-9-氧代-11-紫杉醇（7β，10β-二甲氧基 -10-脱乙酰氧基浆果赤霉素III）。 本发明还提供了一种制备卡巴他赛的新方法。

公开(公告)号：US09175005B2

公开(公告)日：2015-11-03

申请号：US14325869

申请日：2014-07-08

Applicant: HETERO RESEARCH FOUNDATION

Inventor： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Rapolu Raji Reddy ,  Bandi Vamsi Krishna ,  Kesireddy Subash Chander Reddy

IPC: C07D493/04 ,  C07D307/93

CPC classification number: C07D493/04 ,  C07D307/93

Abstract: The present invention provides novel crystalline hydrochloride salt of darunavir, process for its preparation and to pharmaceutical composition comprising it. The present invention also provides novel process for preparation of darunavir amorphous form and pharmaceutical composition comprising it.

Abstract translation: 本发明提供了地瑞那韦的新型结晶盐酸盐，其制备方法和包含其的药物组合物。 本发明还提供了地瑞那韦无定形形式的新方法和包含它的药物组合物。

公开(公告)号：US20150252045A1

公开(公告)日：2015-09-10

申请号：US14436962

申请日：2013-11-01

Applicant: Bandi PARTHASARADHI REDDY ,  Kura RATHNAKAR REDDY ,  Dasari MURALIDHARA REDDY ,  Katham SRINIVASA REDDY ,  Bandi VAMSI KRISHNA ,  HETERO RESEARCH FOUNDATION

Inventor： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Katham Srinivasa Reddy ,  Bandi Vamsi Krishna

IPC: C07D475/08 ,  C07C67/52

CPC classification number: C07D475/08 ,  C07C67/343 ,  C07C67/52 ,  C07C69/76

Abstract: The present invention provides a novel process for the purification of alpha-propargylhomoterephthalic acid dimethyl ester substantially free of homoterephthalic acid dimethyl ester. The present invention also provides a novel process for the purification of pralatrexate.

Abstract translation: 本发明提供了用于纯化基本上不含对苯二甲酸二甲酯的α-炔丙基对苯二甲酸二甲酯的新方法。 本发明还提供了一种纯化普拉钠精油的新方法。

公开(公告)号：US20150141457A1

公开(公告)日：2015-05-21

申请号：US14402234

申请日：2013-05-21

Applicant: HETERO RESEARCH FOUNDATION

Inventor： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Kesireddy Subash Chander Reddy ,  Bandi Vamsi Krishna

IPC: A61K31/47 ,  A61K9/14

CPC classification number: A61K31/47 ,  A61K9/146

Abstract: The present invention provides a novel amorphous solid dispersion of elvitegravir in combination with a pharmaceutically acceptable carrier, process for its preparation and pharmaceutical compositions comprising it. In a preferred embodiment the process for the preparation of amorphous solid dispersion of elvitegravir in combination with a pharmaceutically acceptable carrier comprises: preparing a solution comprising a mixture of elvitegravir and one or more pharmaceutically acceptable carriers selected from copovidone, ethyl cellulose, hydroxypropyl methylcellulose, polyethylene glycol, span 20 or soluplus in a solvent; and removing the solvent from the solution obtained; adding hydrocarbon solvent to the residual solid; and isolating amorphous solid dispersion of elvitegravir in combination with a pharmaceutically acceptable carrier.

Abstract translation: 本发明提供了一种新颖的Elvitegravir的无定形固体分散体与药学上可接受的载体，其制备方法和包含它的药物组合物。 在优选的实施方案中，将Elvitegravir的无定形固体分散体与药学上可接受的载体组合的方法包括：制备包含选自共聚维酮，乙基纤维素，羟丙基甲基纤维素，聚乙烯的一种或多种药学上可接受的载体的混合物的溶液 乙二醇，20或溶剂中的溶剂; 并从所得溶液中除去溶剂; 向残余固体中加入烃溶剂; 并将Elvitegravir的无定形固体分散体与药学上可接受的载体组合。

公开(公告)号：US20140228385A1

公开(公告)日：2014-08-14

申请号：US14113630

申请日：2012-02-16

Applicant: HETERO RESEARCH FOUNDATION

Inventor： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Adulla Venkat Narsimha Reddy ,  Bandi Vamsi Krishna

IPC: C07D239/48 ,  C07C209/74 ,  A61K31/505 ,  C07D239/42

CPC classification number: C07D239/48 ,  A61K31/505 ,  C07C209/74 ,  C07D239/42

Abstract: The present invention provides a novel process for the preparation of 4-(4-hydroxypyrimidin-2-ylamino)benzonitrile. The present invention also provides a novel process for the preparation of 4-iodo-2,6-dimethyl benzenamine. The present invention further provides an improved process for the preparation of rilpivirine. The present invention further provides a tosylate salt of rilpivirine, process for its preparation and pharmaceutical compositions comprising it.

Abstract translation: 本发明提供了制备4-（4-羟基嘧啶-2-基氨基）苄腈的新方法。 本发明还提供了一种制备4-碘-2,6-二甲基苯胺的新方法。 本发明进一步提供了用于制备利比利林的改进方法。 本发明还提供了利妥昔林的甲苯磺酸盐，其制备方法和包含它的药物组合物。