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42 条记录 (耗时 0.025 秒)

    Apparatus for measuring parameters of light spots with a moving knife-edge mask
    31.
    发明授权
    Apparatus for measuring parameters of light spots with a moving knife-edge mask 失效
    用移动的刀刃掩模测量光斑参数的装置

    公开(公告)号：US4663524A

    公开(公告)日：1987-05-05

    申请号：US823017

    申请日：1986-01-27

    申请人： Michael T. Gale ,  Heinrich Meier

    发明人： Michael T. Gale ,  Heinrich Meier

    IPC分类号： G01J1/42 ,  H01J3/14

    CPC分类号： G01J1/4257

    摘要： A two-dimensional knife edge mask comprised of an array of spaced periodic rectangular opaque regions (e.g., a chrome grating pattern layer deposited on one surface of a slide) separated by transparent different given spacing stripes between adjacent rectangular regions in each of the two orthogonal dimensions thereof, is linearly moved at a fixed velocity across an incident light spot, the direction of movement being oblique to the orthogonal dimensions of the rectangular regions and the distance of movement being sufficient to traverse at least one entire spacing strips in each of the two orthogonal dimensions. A photocell (which may be secured to the other side of the slide) senses the occulted light.

    摘要翻译： 二维刀刃掩模由两个间隔的周期性矩形不透明区域（例如，沉积在载玻片的一个表面上的镀铬光栅图案层）阵列组成，在两个正交的每一个中的相邻矩形区域之间分开的透明不同的给定间隔条纹 其尺寸以穿过入射光点的固定速度线性移动，移动方向与矩形区域的正交尺寸倾斜，并且移动距离足以穿过两者中的每一个中的至少一个整个间隔条 正交尺寸。 光电管（其可以固定到幻灯片的另一侧）感测到隐蔽的光。

    Tetrahydro-quinolinylurea derivatives
    36.
    发明授权
    Tetrahydro-quinolinylurea derivatives 失效
    四氢 - 喹啉基脲衍生物

    公开(公告)号：US07683076B2

    公开(公告)日：2010-03-23

    申请号：US10578413

    申请日：2004-10-26

    申请人： Axel Bouchon ,  Nicole Diedrichs ,  Achim Hermann ,  Klemens Lustig ,  Heinrich Meier ,  Josef Pernerstorfer ,  Elke Reiβmüller ,  Muneto Mogi ,  Hiroshi Fujishima ,  Masaomi Tajimi ,  Noriyuki Yamamoto

    发明人： Axel Bouchon ,  Nicole Diedrichs ,  Achim Hermann ,  Klemens Lustig ,  Heinrich Meier ,  Josef Pernerstorfer ,  Elke Reiβmüller ,  Muneto Mogi ,  Hiroshi Fujishima ,  Masaomi Tajimi ,  Noriyuki Yamamoto

    IPC分类号： C07D215/38 ,  A61K31/47

    CPC分类号： C07D215/38

    摘要： This invention relates to tetrahydro-quinolinylurea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The tetrahydro-quinolinylurea derivative of the present invention has vanilloid receptor (VR1) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urological diseases or disorders, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor overactivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pulmonary (or airways) disease (COPD).

    摘要翻译： 本发明涉及可用作药物制剂活性成分的四氢 - 喹啉基脲衍生物及其盐。 本发明的四氢 - 喹啉基脲衍生物具有香草素受体（VR1）拮抗活性，可用于预防和治疗与VR1活性有关的疾病，特别是用于治疗泌尿系统疾病或障碍，例如逼尿肌过度活动 膀胱过度活动），尿失禁，神经源性逼尿肌过度活动（逼尿肌hyperflexia），特发性逼尿肌过度活动（逼尿肌不稳定），良性前列腺增生和下尿路症状; 慢性疼痛，神经性疼痛，术后疼痛，类风湿性关节炎疼痛，神经痛，神经病，痛觉，神经损伤，局部缺血，神经变性，中风和炎性疾病如哮喘和慢性阻塞性肺（或气道）疾病（COPD）。