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    METHOD AND DEVICE FOR PROVIDING AUTOMATIC LOAD ALLEVIATION TO A HIGH LIFT SURFACE SYSTEM, IN PARTICULAR TO A LANDING FLAP SYSTEM, OF AN AIRCRAFT
    1.
    发明申请
    METHOD AND DEVICE FOR PROVIDING AUTOMATIC LOAD ALLEVIATION TO A HIGH LIFT SURFACE SYSTEM, IN PARTICULAR TO A LANDING FLAP SYSTEM, OF AN AIRCRAFT 有权
    用于向自动负载表示系统提供自动负载校正的方法和装置，特别是对于飞机的飞行板系统

    公开(公告)号：US20100044518A1

    公开(公告)日：2010-02-25

    申请号：US12086467

    申请日：2006-12-08

    申请人： Andreas Fleddermann ,  Wolfgang Hartwig ,  Alexandre Darbois ,  Martin Richter

    发明人： Andreas Fleddermann ,  Wolfgang Hartwig ,  Alexandre Darbois ,  Martin Richter

    IPC分类号： B64C13/16

    CPC分类号： B64C13/16

    摘要： A method and a device for providing automatic load alleviation to a high lift surface system, in particular to a landing flap system, of an aircraft when a blockage occurs, wherein in response to a control signal emitted by a control device at least one high lift surface, which is actuated by means of a local mechanical final control element, is brought to a predetermined position by a central drive unit that is connected by way of a rotary shaft arrangement to the local final control element by generating a torque transmitted by the central drive unit to the rotary shaft arrangement. If a signal is registered that indicates that there is a blockage within the high lift surface system, the torque transmitted by the central drive unit to the rotary shaft arrangement is automatically reduced to a predetermined low torque value, and the position of the high lift surface system is fixed.

    摘要翻译： 一种方法和装置，用于在发生堵塞时向飞行器的高升力表面系统（特别是着陆挡板系统）提供自动负载减轻，其中响应于由控制装置发射的控制信号，至少一个高升程 通过局部机械终控制元件致动的表面通过中心驱动单元被带到预定位置，该中心驱动单元通过旋转轴装置连接到局部最终控制元件，通过产生由中心传递的扭矩 驱动单元到旋转轴装置。 如果登记指示高升力面系统内存在阻塞的信号，则由中央驱动单元传递给旋转轴装置的扭矩自动降低到预定的低扭矩值，并且高升程面的位置 系统固定。

    Process for the preparation of clausenamide
    4.
    发明授权
    Process for the preparation of clausenamide 失效
    制备克劳森酰胺的方法

    公开(公告)号：US4731456A

    公开(公告)日：1988-03-15

    申请号：US915309

    申请日：1986-10-03

    申请人： Wolfgang Hartwig

    发明人： Wolfgang Hartwig

    IPC分类号： C07D207/26 ,  C07D207/267 ,  C07D207/273 ,  C07D207/28 ,  C07D207/12

    CPC分类号： C07D207/26 ,  C07D207/273 ,  C07D207/28

    摘要： A new synthetic route to clausenamide having the formula ##STR1## has been found. It has been found that a compound of the formula ##STR2## can be oxidized to provide the stereochemically correctly configured product, clasuenamide. A number of new compounds useful in the total synthesis of clausenamide have also been found. These compounds have the general formula ##STR3## wherein R is ##STR4## and CH.sub.2 OH.

    摘要翻译： 已经找到了具有式“IMAGE”的新的克劳森酰胺的合成路线。 已经发现，式“化合物”的化合物可以被氧化以提供立体化学正确构型的产物巴拉那胺。 还发现了许多用于全合成克劳森酰胺的新化合物。 这些化合物具有通式“IMAGE”，其中R是＆lt; IMAGE＆gt;和CH2OH。

    Process for the preparation of 7-acylamino-3-hydroxy-cephem-4-carboxylic acids and 7-acylamino-3-hydroxy-1-dethia-1-oxacephem-4-carboxylic acids
    5.
    发明授权
    Process for the preparation of 7-acylamino-3-hydroxy-cephem-4-carboxylic acids and 7-acylamino-3-hydroxy-1-dethia-1-oxacephem-4-carboxylic acids 失效
    制备7-酰基氨基-3-羟基 - 头孢烯-4-羧酸和7-酰基氨基-3-羟基-1-脱硫-1-氧代四氢-4-羧酸的方法

    公开(公告)号：US4616084A

    公开(公告)日：1986-10-07

    申请号：US636470

    申请日：1984-07-31

    申请人： Dieter Habich ,  Wolfgang Hartwig

    发明人： Dieter Habich ,  Wolfgang Hartwig

    IPC分类号： C07C205/42 ,  C07D205/085 ,  C07D501/02 ,  C07D501/59 ,  C07D503/00 ,  C07D505/00 ,  A61K31/545

    CPC分类号： C07D505/00 ,  C07C201/12 ,  C07D205/085 ,  C07D503/00 ,  Y02P20/55

    摘要： A process for the preparation of a 7-acylamino-3-hydroxy-2-cephem-4-carboxylic acid, 7-acylamino-3-hydroxy-1-dethia-1-oxa-3-cephem-4-carboxylic acid or derivative thereof of the general formula ##STR1## in which R.sup.1 is hydrogen or optionally substituted alkyl, alkenyl, alkinyl, aralkyl, aryl, heteroaryl, heteroaralkyl, aryloxyalkyl, heteroaryloxyalkyl, alkoxyalkyl, arylthioalkyl, heteroarylthioalkyl, alkylthioalkyl, alkoxy, aryloxy, alkylthio or arylthio,R.sup.2 is hydrogen, a carboxy-protective group or a pharmaceutically useful ester radical, andX is sulphur or oxygen,which comprises:(a) reacting a compound of the formula ##STR2## with (i) a compound of the formula ##STR3## in which R.sup.2 and X have the abovementioned meaning and Y represents diazo (N.sub.2) or hydrogen (H.sub.2) in an inert solvent in the presence of a Lewis acid or proton acid catalyst, or(ii) a compound of the formulaHX--CH.sub.2 --C.tbd.C--COOR.sup.2 to form an intemediate compound having a triple bond, and hydrating the triple bond, the compounds thus obtained, for Y being hydrogen (H.sub.2)--(in case of Y=diazo (N.sub.2) directly the compounds of general formula (2) are obtained) thereby to produce a compound of the formula ##STR4## (b) reacting such compound with an azide in a solvent in the presence of a base to give a compound of the formula ##STR5## (c) converting said compound to the desired product by (i) irradiation in an inert solvent, or(ii) warming in the presence of a catalyst.The end products are, or can be converted to, known .beta.-lactam antibiotics.

    摘要翻译： 制备7-酰基氨基-3-羟基-2-头孢烯-4-羧酸，7-酰基氨基-3-羟基-1-脱硫-1-氧杂-3-头孢烯-4-羧酸或其衍生物的方法 烯基，炔基，芳烷基，芳基，杂芳基，杂芳烷基，芳氧基烷基，杂芳基氧基烷基，烷氧基烷基，芳硫基烷基，杂芳硫基烷基，烷硫基烷基，烷氧基，芳氧基，烷硫基或芳硫基，其中R 1为氢或任选取代的烷基， R2是氢，羧基保护基或药学上有用的酯基，X是硫或氧，其包括：（a）使式（IMAGE）的化合物与（i）下式化合物 其中R2和X具有上述含义，Y代表重氮（N 2）或氢（H 2）在惰性溶剂中，在路易斯酸或质子酸催化剂存在下，或（ii）式HX-CH2- C 3 C COR CO 2，以形成具有三键的中间体化合物，并且使三键水合，该共聚物 （H）在（Y =重氮（N 2）的情况下直接得到通式（2）的化合物），得到下式的化合物：（b）使此 在碱的存在下在溶剂中与叠氮化合物反应，得到下式的化合物：（c）通过（i）在惰性溶剂中照射将所述化合物转化为所需产物，或（ii）在 存在催化剂。 最终产品是或可以转化为已知的β-内酰胺抗生素。

    Peptides and peptidomimetics with structural similarity to human p53 that activate p53 function
    6.
    发明授权
    Peptides and peptidomimetics with structural similarity to human p53 that activate p53 function 失效
    肽和肽模拟物与人p53的结构相似性激活p53功能

    公开(公告)号：US07666983B2

    公开(公告)日：2010-02-23

    申请号：US11684285

    申请日：2007-03-09

    申请人： Thanos Halazonetis ,  Wolfgang Hartwig

    发明人： Thanos Halazonetis ,  Wolfgang Hartwig

    IPC分类号： C07K5/00

    CPC分类号： A61K38/1709 ,  C07K14/4746 ,  C07K14/82

    摘要： The present invention provides peptides and peptidomimetics corresponding to part or to the entirety of the region encompassed by residues 360-386 of human p53, said peptides and peptidomimetics characterized by the ability to activate DNA binding of wild-type p53 and of select tumor-derived p53 mutants. Pharmaceutical compositions of the compounds of the invention and methods of using these compositions therapeutically are also provided.

    摘要翻译： 本发明提供了对应于人p53的残基360-386所包含的部分或整个区域的肽和肽模拟物，所述肽和肽模拟物的特征在于活化野生型p53和选择性肿瘤衍生物的DNA结合的能力 p53突变体。 还提供本发明化合物的药物组合物和治疗性使用这些组合物的方法。

    Peptides and peptidomimetics with structural similarity to human p53 that activate p53 function
    7.
    发明授权
    Peptides and peptidomimetics with structural similarity to human p53 that activate p53 function 有权
    肽和肽模拟物与人p53的结构相似性激活p53功能

    公开(公告)号：US06784157B2

    公开(公告)日：2004-08-31

    申请号：US09829922

    申请日：2001-04-11

    申请人： Thanos Halazonetis ,  Wolfgang Hartwig

    发明人： Thanos Halazonetis ,  Wolfgang Hartwig

    IPC分类号： A61K3800

    CPC分类号： A61K38/1709 ,  C07K14/4746 ,  C07K14/82

    摘要： The present invention provides peptides and peptidomimetics corresponding to part or to the entirety of the region encompassed by residues 360-386 of human p53, said peptides and peptidomimetics characterized by the ability to activate DNA binding of wild-type p53 and to select tumor-derived p53 mutants. Pharmaceutical compositions of the compounds of the invention and methods of using these compositions therapeutically are also provided.

    摘要翻译： 本发明提供了对应于人p53的残基360-386所包含的部分或全部区域的肽和肽模拟物，所述肽和肽模拟物的特征在于活化野生型p53的DNA结合的能力，并选择肿瘤衍生的 p53突变体。 还提供本发明化合物的药物组合物和治疗性使用这些组合物的方法。

    Packing system for unit loads
    8.
    发明授权
    Packing system for unit loads 失效
    单位负荷包装系统

    公开(公告)号：US06269951B1

    公开(公告)日：2001-08-07

    申请号：US09463342

    申请日：2000-03-14

    申请人： Wolfgang Hartwig

    发明人： Wolfgang Hartwig

    IPC分类号： B65D1900

    CPC分类号： B65D19/0012 ,  B65D71/0092 ,  B65D85/46 ,  B65D2519/00019 ,  B65D2519/00054 ,  B65D2519/00104 ,  B65D2519/00278 ,  B65D2519/00288 ,  B65D2519/00318 ,  B65D2519/00343 ,  B65D2519/00373 ,  B65D2519/00557 ,  B65D2571/00117

    摘要： The invention relates to a packing system for unit loads which can be stacked in a plurality of adjacent piles or piles stacked on top of each other to form a substantially stable pile consisting of at least two stacked layers of unit loads. The invention is characterized in that spacers are provided between at least two successive stacked layers so that both stacked layers are vertically interspaced; at least one device is provided on top of and below the stack to protect at least partially the external contour of the unit loads located in the top and lower stack position; at least one fixing device encompassing the other periphery of the stack is included so that it encompasses the stack in such a way that the unit loads in a stack position are pressed against the unit loads in a directly and vertically adjacent stack position; and the fixing device extends over the protection device.

    摘要翻译： 本发明涉及一种用于单元负载的包装系统，其可以堆叠在彼此堆叠的多个相邻的堆叠或堆叠中，以形成由至少两个堆叠的单元负载层组成的基本稳定的桩。 本发明的特征在于，在至少两个连续堆叠的层之间设置间隔物，使得两个堆叠层是垂直间隔的; 在堆叠的顶部和底部设置至少一个装置，以至少部分地保护位于顶部和下部堆叠位置的单元负载的外部轮廓; 包括围绕堆叠的另一个周边的至少一个固定装置被包括，使得它以这样的方式包围堆叠，使得单元在堆叠位置的载荷被压靠在直接和垂直相邻堆叠位置的单元负载上; 并且固定装置延伸越过保护装置。