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公开(公告)号：US20100022579A1
公开(公告)日：2010-01-28
申请号：US12532002
申请日：2008-02-21
申请人： Kai Schiemann , Dirk Finsinger , Christiane Amendt , Frank Zenke
发明人： Kai Schiemann , Dirk Finsinger , Christiane Amendt , Frank Zenke
IPC分类号： A61K31/436 , C07D491/052 , A61P35/00
CPC分类号： C07D491/04
摘要： Compounds of the formula (I), in which R1, R2, R3, R4, R5, X, Y, W, Q1, Q2, Z, s and m have the meanings indicated in claim 1, can be employed, inter alia, for the treatment of tumours.
摘要翻译： 式（I）的化合物，其中R 1，R 2，R 3，R 4，R 5，X，Y，W，Q 1，Q 2，Z，s和m具有权利要求1所示的含义， 用于治疗肿瘤。
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公开(公告)号：US07893082B2
公开(公告)日：2011-02-22
申请号：US11916952
申请日：2006-05-17
申请人： Kai Schiemann , Ulrich Emde , Dirk Finsinger , Christiane Amendt , Nina Heiss , Frank Zenke
发明人： Kai Schiemann , Ulrich Emde , Dirk Finsinger , Christiane Amendt , Nina Heiss , Frank Zenke
IPC分类号： A61K31/4375 , A61K31/436 , C07D491/052 , C07D471/04
CPC分类号： C07D215/42 , C07D401/04 , C07D471/04 , C07D491/04 , C07D491/048 , C07D491/052
摘要： Disclosed are compounds of formula (I), wherein W, R, R1, R2, R3, R4, R5, R6, and R7 have the meanings indicated in claim 1. Said compounds can be used for the treatment of tumors, among other things.
摘要翻译： 公开了式（I）的化合物，其中W，R，R 1，R 2，R 3，R 4，R 5，R 6和R 7具有权利要求1中所示的含义。所述化合物可用于治疗肿瘤， 。
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33.发明申请TETRAHYDROQUINOLINE DERIVATIVES AND THE USE THEREOF FOR THE TREATMENT OF CANCER 审中-公开四氢喹啉衍生物及其用于治疗癌症的用途公开(公告)号：US20100076012A1
公开(公告)日：2010-03-25
申请号：US12531602
申请日：2008-02-22
申请人： Kai Schiemann , Dirk Finsinger , Christiane Amendt , Frank Zenke
发明人： Kai Schiemann , Dirk Finsinger , Christiane Amendt , Frank Zenke
IPC分类号： A61K31/436 , C07D491/147 , C07D507/00 , C07D491/153 , A61K31/4375 , A61K31/437 , A61P35/00
CPC分类号： C07D491/147 , C07D495/14
摘要： Compounds of the formula (I), in which E, R3, R4, R5, X, Y, W, Q1, Q2, Z, s and m have the meanings indicated in claim 1, can be employed, inter alia, for the treatment of tumours.
摘要翻译： 其中E，R3，R4，R5，X，Y，W，Q1，Q2，Z，s和m具有权利要求1所述的含义的式（I）化合物，除其他外，可用于 治疗肿瘤。
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34.发明申请公开(公告)号：US20050014769A1
公开(公告)日：2005-01-20
申请号：US10495108
申请日：2002-10-10
IPC分类号： C07D239/36 , A61K31/36 , A61K31/4035 , A61K31/404 , A61K31/407 , A61K31/415 , A61K31/4184 , A61K31/4245 , A61K31/433 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/443 , A61K31/4436 , A61K31/4709 , A61K31/4725 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/553 , A61P35/00 , A61P35/04 , A61P43/00 , C07D271/12 , C07D285/14 , C07D317/60 , C07D405/04 , C07D405/12 , C07D405/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D487/04 , C07D491/048 , C07D495/04 , C07D498/04 , A61K31/519 , A61K31/4745
CPC分类号： A61K31/4725 , A61K31/4035 , A61K31/415 , A61K31/433 , A61K31/443 , A61K31/4436 , A61K31/4709 , A61K31/501 , A61K31/505
摘要： Use of endothelin receptor antagonists for the preparation of a medicament for the treatment of tumour diseases.
摘要翻译： 内皮素受体拮抗剂用于制备治疗肿瘤疾病的药物的用途。
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![Pyrido [2, 3-B] pyrazine compounds and their therapeutical uses such as for inhibiting ATP consuming proteins and treating diseases associated therewith](/abs-image/US/2015/06/09/US09051318B2/abs.jpg.150x150.jpg)
35.发明授权Pyrido [2, 3-B] pyrazine compounds and their therapeutical uses such as for inhibiting ATP consuming proteins and treating diseases associated therewith 有权吡啶并[2,3-B]吡嗪化合物及其治疗用途，例如用于抑制ATP消耗蛋白质并治疗与之相关的疾病公开(公告)号：US09051318B2
公开(公告)日：2015-06-09
申请号：US14002991
申请日：2012-02-13
IPC分类号： A61K31/4985 , C07D471/04 , A61K45/06 , C07D491/048
CPC分类号： C07D471/04 , A61K31/4985 , A61K45/06 , C07D491/048
摘要： The present invention relates to novel pyrido[2,3-b]pyrazine compounds of formula (I): and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors.
摘要翻译： 本发明涉及式（I）的新型吡啶并[2,3-b]吡嗪化合物：以及使用这样的化合物，其中抑制，调节和/或调节ATP消耗蛋白质如激酶的信号转导 特别是TGF-β受体激酶抑制剂的作用，以及这些化合物用于治疗激酶诱导的疾病，特别是用于治疗肿瘤的用途。
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公开(公告)号：US08987301B2
公开(公告)日：2015-03-24
申请号：US13508090
申请日：2010-10-12
申请人： Alfred Jonczyk , Christiane Amendt , Frank Zenke
发明人： Alfred Jonczyk , Christiane Amendt , Frank Zenke
IPC分类号： A01N43/42 , A61K31/47 , C07D401/12 , C07D401/14 , C07D471/04
CPC分类号： C07D401/12 , C07D401/14 , C07D471/04
摘要： Novel hetarylaminoquinoline derivatives of formula (I) wherein X, Z, Het, R1, R2, R3 and R4 have the meaning according to claim 1, are inhibitors of ATP consuming proteins, and can be employed, inter alia, for the treatment of tumors.
摘要翻译： 其中X，Z，Het，R 1，R 2，R 3和R 4具有权利要求1的含义的式（I）的新颖的杂芳基氨基喹啉衍生物是ATP消耗蛋白质的抑制剂，并且可以用于治疗肿瘤 。
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![2,4-diaryl-substituted [1,8] naphthyridines as kinase inhibitors for use against cancer](/abs-image/US/2014/07/29/US08791113B2/abs.jpg.150x150.jpg)
37.发明授权2,4-diaryl-substituted [1,8] naphthyridines as kinase inhibitors for use against cancer 有权2,4-二芳基取代的[1,8]萘啶作为抗癌剂的激酶抑制剂公开(公告)号：US08791113B2
公开(公告)日：2014-07-29
申请号：US13807119
申请日：2011-05-31
IPC分类号： A61K31/535 , C07D413/00
CPC分类号： C07D491/048 , A61K31/4375 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D471/04 , C07D519/00
摘要： The present invention relates to novel [1,8]naphthyridine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors.
摘要翻译： 本发明涉及式（I）的新颖的[1,8]萘啶衍生物，以及这样的化合物的用途，其中ATP消耗蛋白质如激酶的信号转导的抑制，调节和/或调节起着重要的作用，特别是 TGF-β受体激酶的抑制剂，以及这些化合物用于治疗激酶诱导的疾病，特别是用于治疗肿瘤的用途。
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![PYRIDO [2, 3 - B] PYRAZINE DERIVATIVES AND THEIR THERAPEUTICAL USES](/abs-image/US/2013/12/26/US20130345227A1/abs.jpg.150x150.jpg)
38.发明申请公开(公告)号：US20130345227A1
公开(公告)日：2013-12-26
申请号：US14002991
申请日：2012-02-13
IPC分类号： C07D471/04 , A61K31/4985 , C07D491/048 , A61K45/06
CPC分类号： C07D471/04 , A61K31/4985 , A61K45/06 , C07D491/048
摘要： The present invention relates to novel pyrido[2,3-b]pyrazine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors.
摘要翻译： 本发明涉及式（I）的新颖的吡啶并[2,3-b]吡嗪衍生物，以及其中抑制，调节和/或调节ATP消耗蛋白质如激酶的信号转导的化合物的用途 ，特别是TGF-β受体激酶的抑制剂，以及这些化合物用于治疗激酶诱导的疾病，特别是用于治疗肿瘤的用途。
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![Hetaryl-[1,8]naphthyridine derivatives](/abs-image/US/2013/12/24/US08614226B2/abs.jpg.150x150.jpg)
公开(公告)号：US08614226B2
公开(公告)日：2013-12-24
申请号：US13574282
申请日：2010-12-17
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02
CPC分类号： C07D471/04 , A61K31/4375 , C07D401/14 , C07D413/14 , C07D519/00
摘要： Novel hetaryl-[1,8]naphthyridine derivatives of formula (I) wherein R1, R2, W1, W3, W5 and W6 have the meaning according to claim 1, are inhibitors of ATP consuming proteins, and can be employed, inter alia, for the treatment of tumors.
摘要翻译： 其中R 1，R 2，W 1，W 3，W 5和W 6具有权利要求1的含义的式（I）的新型杂芳基 - [1,8]二氮杂萘衍生物是ATP消耗蛋白质的抑制剂， 用于治疗肿瘤。
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公开(公告)号：US20130102608A1
公开(公告)日：2013-04-25
申请号：US13808369
申请日：2011-06-07
IPC分类号： C07D401/14 , A61K45/06 , A61K31/496 , A61K31/4545 , A61K31/5377 , A61K31/444
CPC分类号： C07D401/14 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D471/04
摘要： The present invention relates to novel bipyridyl derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors.
摘要翻译： 本发明涉及式（I）的新型联吡啶衍生物和其中ATP消耗蛋白质如激酶的信号转导的抑制，调节和/或调节起到特别是TGF-β抑制剂的作用的用途 受体激酶，以及这些化合物用于治疗激酶诱导的疾病，特别是用于治疗肿瘤的用途。
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