Aminodiol derivatives
    36.
    发明授权
    Aminodiol derivatives 失效
    氨基酸衍生物

    公开(公告)号:US5235057A

    公开(公告)日:1993-08-10

    申请号:US723223

    申请日:1991-06-28

    IPC分类号: C07D317/28 C07D405/06

    CPC分类号: C07D405/06 C07D317/28

    摘要: The invention relates to compounds of the formula ##STR1## in which R.sup.1 and R.sup.2 are identical or different and are hydrogen or aralkyl, R.sup.3 is alkyl, cycloalkyl or cycloalkylalkyl, R.sup.4 and R.sup.5 are identical or different and are hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl or a heterocyclic radical and R.sup.6 and R.sup.7 are identical or different and are hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl or arlkyl or R.sup.6 and R.sup.7, together with the carbon atom carrying them, are cycloalkyl. The novel compounds are prepared by a carbonyl olefination according to Wittig. They are intermediates for the preparation of pharmaceuticals, in particular of inhibitors of renin and HIV protease.

    摘要翻译: 本发明涉及下式化合物:其中R 1和R 2相同或不同并且是氢或芳烷基,R 3是烷基,环烷基或环烷基烷基,R 4和R 5是相同或不同的,是氢,烷基,环烷基,环烷基烷基 芳基,芳烷基或杂环基,R 6和R 7相同或不同,为氢,烷基,环烷基,环烷基烷基,芳基或芳烷基或R6和R7与携带它们的碳原子一起为环烷基。 根据Wittig,通过羰基烯化制备新化合物。 它们是用于制备药物的中间体,特别是肾素和HIV蛋白酶的抑制剂。

    Textured polyurethane molded articles having multiple sheet layers
    38.
    发明授权
    Textured polyurethane molded articles having multiple sheet layers 失效
    具有多个片层的纹理聚氨酯模塑制品

    公开(公告)号:US5051310A

    公开(公告)日:1991-09-24

    申请号:US365972

    申请日:1989-06-14

    摘要: The present invention deals with textured, molded articles having multiple sheet layers, comprising:a) an outer coating layer;b) a middle layer of a urethane and/or urea group containing film prepared from a heat curable composition storage stable at room temperature; andc) a backing layer of non-cellular or cellular polyurethane which optionally can contain an insert and/or reinforcing material.Moreover, the invention deals with a process for the preparation of said polyurethane molded articles and their use.

    摘要翻译: 本发明涉及具有多个片层的纹理化模塑制品,其包括:a)外涂层; b)由室温下稳定的热固性组合物制备的含氨基甲酸酯和/或脲基的膜的中间层; 和c)任选地可以包含插入物和/或增强材料的非细胞或细胞聚氨酯的背衬层。 此外,本发明涉及制备所述聚氨酯模塑制品的方法及其用途。

    Intermediates for preparing mono-, bi- and tricyclic amino acids
    40.
    发明授权
    Intermediates for preparing mono-, bi- and tricyclic amino acids 失效
    用于制备单,双和三环氨基酸的中间体

    公开(公告)号:US4977260A

    公开(公告)日:1990-12-11

    申请号:US335443

    申请日:1989-04-10

    摘要: Process for preparing mono-, bi- and tricyclic amino acids, intermediates of this process, and a process for preparing same.The invention relates to a process for preparing compounds of the formula I ##STR1## in which R stands for hydrogen, alkyl or aralkyl and R.sup.1 to R.sup.5 are identical or different radicals, (substituted) alkyl, cycloalkyl or (substituted) aryl or in which the pairs of radicals R.sup.1 and R.sup.2, R.sup.2 and R.sup.3, and R.sup.4 and R.sup.5 together with the carbon atom(s) supporting them form a mono- or bicyclic ring system and the other radicals are hydrogen, by treating a compound of the formula II ##STR2## in which R and R.sup.1 to R.sup.5 have the abovoementioned meaning and R.sup.6 and R.sup.7 denote alkyl or aralkyl or together with the nitrogen atom supporting them form a heterocycle which can additionally contain an oxygen atom, with a reducing agent.

    摘要翻译: 本发明涉及一种制备式I的化合物的方法,其中R代表氢,烷基或芳烷基,R 1至R 5是相同或不同的基团,(取代的)烷基,环烷基或(取代的)芳基或在 其中基团R 1和R 2,R 2和R 3以及R 4和R 5与支持它们的碳原子一起形成单环或双环环系,而其它基团是氢,通过将式II化合物 其中R和R 1和R 5具有上述含义,并且R 6和R 7表示烷基或芳烷基,或与支持它们的氮原子一起形成可另外含有氧原子的杂环与还原剂反应。