公开(公告)号：US08534147B2

公开(公告)日：2013-09-17

申请号：US12517725

申请日：2007-11-21

申请人： Andreas Roither ,  Christian Müller

发明人： Andreas Roither ,  Christian Müller

IPC分类号： F16H25/20

CPC分类号： F16H25/20 ,  A47C20/041 ,  A47C20/042 ,  F16H2025/2031 ,  F16H2025/204 ,  H02K7/06

摘要： An electromotive linear drive, in particular for adjusting parts of an item of furniture, having a multi-part housing which is produced from plastic in an injection-molding process and in which are mounted at least one drive train and a block-shaped spindle nut which engages at least partially around the housing and/or at least partially into the housing. The housing is formed from at least two housing parts and has sliding tracks for the spindle nut, wherein at least the thread flights of the spindle are arranged outside the housing. In one preferred embodiment, the housing is arranged below the region of the spindle in relation to the assembled position of the electromotive linear drive. The housing parts forming the housing are of identical or similar, preferably shell-shaped, design in cross section.

摘要翻译： 一种电动线性驱动器，特别是用于调节一件家具的部件，其具有多个部件壳体，该多部件壳体在注射成型工艺中由塑料制成，并且其中安装有至少一个传动系和块状主轴螺母 其至少部分地围绕壳体和/或至少部分地接合到壳体中。 壳体由至少两个壳体部分形成，并且具有用于主轴螺母的滑动轨道，其中至少主轴的螺纹布置在壳体的外部。 在一个优选实施例中，壳体相对于电动线性驱动器的组装位置布置在心轴的区域的下方。 形成壳体的壳体部分的横截面为相同或相似的，优选为壳形的设计。

公开(公告)号：US08385930B2

公开(公告)日：2013-02-26

申请号：US13002921

申请日：2009-07-09

申请人： Anja Klein ,  Christian Müller ,  Bernhard Raaf

发明人： Anja Klein ,  Christian Müller ,  Bernhard Raaf

IPC分类号： H04Q7/20

CPC分类号： H04W28/06 ,  H04W72/042

摘要： It is described a method for distributing radio resources between a first radio link between a primary network element being assigned to a first hierarchic level of a network and a first secondary network element being assigned to a second hierarchic level and a second radio link between the primary network element and a second secondary network element being assigned to the second hierarchic level. The method includes (a) transmitting respectively a first resource allocation parameter from the first and the second secondary network element to a decision unit, the first resource allocation parameter being indicative for a minimum performance requirement, (b) transmitting respectively a second resource allocation parameter from the first and the second secondary network element to the decision unit, the second resource allocation parameter being indicative for a performance increase for the respective radio link following an allocation of additional radio resources, and (c) distributing the radio resources between the first and the second radio link based on the first and the second resource allocation parameter.

摘要翻译： 描述了一种用于在被分配给网络的第一分级级别的主网络元件和被分配给第二分级级别的第一辅助网络元件之间的第一无线电链路和第一无线链路之间分配无线电资源的方法，以及主网络 网络元件和被分配给第二层级的第二辅助网络元件。 该方法包括：（a）分别从第一和第二辅助网络单元发送第一资源分配参数到决策单元，第一资源分配参数指示最低性能要求，（b）分别发送第二资源分配参数 从所述第一和第二辅助网络单元到所述决策单元，所述第二资源分配参数指示在分配附加无线电资源之后各个无线电链路的性能增加，以及（c）在所述第一和第二辅助网络分配所述第一和第二辅助网络 所述第二无线电链路基于所述第一和第二资源分配参数。

公开(公告)号：US08212082B2

公开(公告)日：2012-07-03

申请号：US12694851

申请日：2010-01-27

申请人： Joaquim Henrique Teles ,  Beatrice Röβler-Feigel ,  Alexander Hauk ,  Christian Müller ,  Michael Schelper ,  Tanja Kirchner ,  Susanne Szeschkus

发明人： Joaquim Henrique Teles ,  Beatrice Röβler-Feigel ,  Alexander Hauk ,  Christian Müller ,  Michael Schelper ,  Tanja Kirchner ,  Susanne Szeschkus

IPC分类号： C07C45/28 ,  A61K8/35 ,  A61K47/08 ,  C11D3/50

CPC分类号： C11B9/0015 ,  C07C45/28 ,  C07C45/62 ,  C07C45/82 ,  Y02P20/582 ,  C07C47/21 ,  C07C47/02

摘要： The present invention relates to a process for preparing at least one compound with Z−1 cycles and 7 to 16 carbon atoms with at least one aldehyde group, at least comprising the stages: (a1) oxidation of a composition (A), at least comprising a cyclic olefin with Z cycles and 7 to 16 carbon atoms and at least two C—C double bonds, by means of dinitrogen monoxide to give a composition (A1), (a2) separating off the at least one cyclic olefin with Z cycles and 7 to 16 carbon atoms with at least two C—C double bonds from the composition (A1) from stage (a1) in order to obtain a composition (A2), (b1) separating off the at least one cyclic compound with Z cycles and 7 to 16 carbon atoms with a keto group from the composition (A2) from step (a2), in order to obtain a composition (B1), comprising at least 50% by weight of the at least one compound with Z−1 cycles and 7 to 16 carbon atoms with at least one aldehyde group and at least two C—C double bonds, where Z may be 1, 2, 3 or 4.

摘要翻译： 本发明涉及至少一种具有Z-1个循环和7-16个碳原子的化合物与至少一个醛基的制备方法，至少包括以下步骤：（a1）组合物（A）的氧化，至少 包含具有Z循环和7至16个碳原子的环烯烃以及至少两个C-C双键的方法，借助于一氧化二氮，得到组合物（A1），（a2）以Z循环分离出至少一种环状烯烃 和从碳（a1）组合物（A1）至少具有两个C-C双键的碳原子数为7〜16的碳原子，以获得组合物（A2），（b1）以Z循环分离出至少一种环状化合物 和具有来自步骤（a2）的组合物（A2）的酮基的7至16个碳原子，以获得组合物（B1），其包含至少50重量％的至少一种Z-1循环的化合物 和具有至少一个醛基和至少两个C-C双键的7至16个碳原子，其中Z可以是1,2,3或4。

公开(公告)号：US08178670B2

公开(公告)日：2012-05-15

申请号：US12349479

申请日：2009-01-06

申请人： Mark Henderson ,  Steven Jungles ,  Gabriele Roidl ,  Robert Baffi ,  Adriano Indolese ,  Christian Müller ,  Philipp Schmidt ,  Stefan Kaiser

发明人： Mark Henderson ,  Steven Jungles ,  Gabriele Roidl ,  Robert Baffi ,  Adriano Indolese ,  Christian Müller ,  Philipp Schmidt ,  Stefan Kaiser

IPC分类号： C07D475/00

CPC分类号： C07D487/04

摘要： The present disclosure provides a method that efficiently produces (6R)-tetrahydrobiopterin of Formula I in high yield and purity. The method includes the step of hydrolyzing diacetylbiopterin to biopterin under basic conditions in a biphasic mixture comprising an organic phase and an aqueous phase. After substantially complete hydrolysis of diacetylbiopterin, the aqueous phase containing biopterin can be separated from the organic phase containing most of the organic impurities, which avoids the time-consuming step of isolating biopterin as a solid. The aqueous solution containing biopterin is stereoselectively hydrogenated to (6R)-tetrahydrobiopterin under basic conditions and high hydrogen pressure in the presence of a metal catalyst (e.g., a platinum catalyst). To improve the purification of an acid addition salt of (6R)-tetrahydrobiopterin (e.g., (6R)-tetrahydrobiopterin dihydrochloride), any residual salts (e.g., sodium salts) in the aqueous solution after the hydrogenation reaction can be removed by contacting the aqueous solution with an ion (e.g., cation) exchange resin or column. Alternatively, removal of residual salts from the aqueous solution can be omitted if an organic amine (e.g., diethylamine or triethylamine) rather than an inorganic base is used in the hydrolysis and/or hydrogenation reactions.

摘要翻译： 本公开提供了以高产率和纯度有效生产式I的（6R） - 四氢生物喋呤的方法。 该方法包括在碱性条件下在包含有机相和水相的两相混合物中将二乙酰生物蝶呤水解成生物蝶呤的步骤。 在二乙酰生物蝶呤基本上完全水解后，含有生物蝶呤的水相可以从含有大部分有机杂质的有机相中分离出来，这避免了将生物蝶呤分离成固体的耗时的步骤。 含有生物蝶呤的水溶液在碱性条件下，在金属催化剂（如铂催化剂）存在下，氢压高，立体选择氢化为（6R） - 四氢生物喋呤。 为了改善（6R） - 四氢生物蝶呤（例如（6R） - 四氢生物喋呤二盐酸盐）的酸加成盐的纯化，氢化反应后的水溶液中的任何残留盐（例如钠盐）可以通过使水溶液 溶液与离子（如阳离子）交换树脂或色谱柱。 或者，如果在水解和/或氢化反应中使用有机胺（例如二乙胺或三乙胺）而不是无机碱，则可以从水溶液中除去残留的盐。

公开(公告)号：US20110117605A1

公开(公告)日：2011-05-19

申请号：US12989340

申请日：2009-04-23

申请人： Anne Bondgaard Tolstrup ,  Lars Soegaard Nielsen ,  Dietmar Weilguny ,  Christian Müller ,  Finn C. Wiberg ,  Jonas Heilskov Graversen

发明人： Anne Bondgaard Tolstrup ,  Lars Soegaard Nielsen ,  Dietmar Weilguny ,  Christian Müller ,  Finn C. Wiberg ,  Jonas Heilskov Graversen

IPC分类号： C12P21/00

CPC分类号： C07K16/00 ,  A61K2039/507

摘要： The invention relates to methods for manufacturing drug products comprising at least two distinct members of a polyclonal protein, for example a polyclonal antibody, where each distinct member is expressed by a separate population of cells. The methods involve at least an initial step in which the cell populations expressing the distinct members of the polyclonal protein are cultured separately. The individual cell populations, or proteins expressed by the individual cell populations, are combined at a later point of the upstream or downstream processing to result in a single drug product comprising the distinct members of the polyclonal protein.

摘要翻译： 本发明涉及用于制备药物制品的方法，其包含多克隆蛋白质，例如多克隆抗体的至少两个不同成员，其中每个不同的成员由单独的细胞群体表达。 该方法涉及至少一个初始步骤，其中分别表达多克隆蛋白质的不同成员的细胞群体。 单个细胞群体或由各个细胞群体表达的蛋白质在上游或下游处理的稍后点组合以产生包含多克隆蛋白质的不同成员的单一药物产品。

公开(公告)号：US20110046413A1

公开(公告)日：2011-02-24

申请号：US12859622

申请日：2010-08-19

申请人： Joaquim Henrique Teles ,  Michael Schelper ,  Kai Gumlich ,  Mathieu Chabanas ,  Christian Müller ,  Anton Meier

发明人： Joaquim Henrique Teles ,  Michael Schelper ,  Kai Gumlich ,  Mathieu Chabanas ,  Christian Müller ,  Anton Meier

IPC分类号： C07C51/16

CPC分类号： C07C51/235 ,  C07C57/03

摘要： The present invention relates to a process for preparing 4-pentenoic acid, at least comprising the oxidation of a mixture (G) comprising 4-pentenal, 3-methyl-2-butanone and cyclopentene oxide, and to the use of a mixture (G) comprising 4-pentenal, 3-methyl-2-butanone and cyclopentene oxide for preparing 4-pentenoic acid. In the context of the present invention, the mixture (G) is preferably obtained as a by-product of the oxidation of cyclopentene to cyclopentanone by means of dinitrogen monoxide.

摘要翻译： 本发明涉及一种制备4-戊烯酸的方法，至少包括包含4-戊烯醛，3-甲基-2-丁酮和环戊烯氧化物的混合物（G）的氧化和使用混合物（G ），其包含4-戊烯醛，3-甲基-2-丁酮和环戊烯氧化物，用于制备4-戊烯酸。 在本发明的上下文中，优选通过一氧化二氮作为环戊烯氧化成环戊酮的副产物获得混合物（G）。

公开(公告)号：US07819036B2

公开(公告)日：2010-10-26

申请号：US10544893

申请日：2004-02-12

申请人： Frank Haneball ,  Christian Müller

发明人： Frank Haneball ,  Christian Müller

IPC分类号： F16H27/02

CPC分类号： H02K7/06 ,  F16H25/20 ,  F16H25/2015 ,  F16H2025/2084 ,  F16H2025/209 ,  H02K5/15 ,  H02K5/225 ,  Y10T74/18656

摘要： An electromotive linear drive unit comprising a housing, a motor pot, a connection piece, a power supply cable, a deployable lifting tube, and a fixed flanged tube is designed in such a way that it can be made at a low cost while being easier to assemble than previously known embodiments thereof. In accordance with the invention, at least the connection zones of the housing (11) to the motor pot (12) and the attachment part (13) are configured in a cylindrical manner while the connection zone are formed by means of a rotary motion of the housing (11) and/or the motor pot (12) and/or the attachment part (13) in a radial direction. The connection zones are configured form-fittingly in an axial direction. This type of connection is realized by means of meshing threads. The linear drive according to the invention is particularly suitable for driving the adjustable components of a slatted frame or armchair.

摘要翻译： 电动线性驱动单元包括壳体，电动机罐，连接件，电源电缆，可展开的提升管和固定的法兰管，以便可以以较低的成本制造，同时更容易 组装比其先前已知的实施例。 根据本发明，壳体（11）至马达罐（12）和安装部分（13）的至少连接区域被构造成圆柱形，而连接区域通过旋转运动形成 壳体（11）和/或电动机罐（12）和/或附接部件（13）。 连接区域沿轴向配置成形。 这种类型的连接是通过啮合线程实现的。 根据本发明的线性驱动器特别适合于驱动板条框架或扶手椅的可调部件。

公开(公告)号：US07714172B2

公开(公告)日：2010-05-11

申请号：US12306827

申请日：2007-06-27

申请人： Joaquim Henrique Teles ,  Beatrice Röβler ,  Rolf Pinkos ,  Gerd Tebben ,  Christian Müller ,  Harald Rust

发明人： Joaquim Henrique Teles ,  Beatrice Röβler ,  Rolf Pinkos ,  Gerd Tebben ,  Christian Müller ,  Harald Rust

IPC分类号： C07C45/27

CPC分类号： C07C45/28 ,  C07C45/62 ,  C07C45/80 ,  C07C45/81 ,  C07C45/82 ,  C07C45/85 ,  C07C2601/18 ,  C07C2601/20 ,  C07C49/607 ,  C07C49/413

摘要： The present invention relates to a process for preparing a cyclic ketone having from 7 to 16 carbon atoms, which comprises at least the steps (a) oxidation of a composition (I) comprising at least one cyclic alkene which has from 7 to 16 carbon atoms and at least one C—C double bond by means of dinitrogen monoxide to give a composition (A), (b) treatment of the composition (A) with at least one base to give a composition (B), (c) hydrogenation of the composition (B) in the presence of at least one catalyst to give a composition (C), (d) purification of the composition (C), comprising at least the steps (di) thermal treatment of the composition (C) with at least one acid or at least one catalyst comprising at least one transition metal, (dii) further purification by a method selected from the group consisting of distillation, extraction and crystallization.

摘要翻译： 本发明涉及一种制备具有7至16个碳原子的环酮的方法，其至少包括步骤（a）氧化包含至少一个具有7至16个碳原子的环烯烃的组合物（I） 和至少一个C-C双键，得到组合物（A），（b）用至少一种碱处理组合物（A），得到组合物（B），（c）氢化 所述组合物（B）在至少一种催化剂的存在下反应以得到组合物（C），（d）组合物（C）的纯化，所述组合物（C）至少包含步骤（ii）组合物（C） 至少一种酸或至少一种包含至少一种过渡金属的催化剂，（dii）通过选自蒸馏，萃取和结晶的方法进一步纯化。

公开(公告)号：US07714171B2

公开(公告)日：2010-05-11

申请号：US12306807

申请日：2007-06-27

申请人： Rolf Pinkos ,  Gerd Tebben ,  Alexander Hauk ,  Christian Müller ,  Harald Rust

发明人： Rolf Pinkos ,  Gerd Tebben ,  Alexander Hauk ,  Christian Müller ,  Harald Rust

IPC分类号： C07C45/27

CPC分类号： C07C45/85 ,  C07C45/33 ,  C07C45/34 ,  C07C45/58 ,  C07C45/62 ,  C07C45/80 ,  C07C45/81 ,  C07C45/82 ,  C07C49/413 ,  C07C49/607

摘要： The present invention relates to a process for purifying a composition (I) comprising at least one cyclic ketone having from 7 to 16 carbon atoms, which comprises thermal treatment of the composition (I) with at least one acid and further purification by means of a process selected from the group consisting of distillation, extraction and crystallization, Furthermore, the present invention relates to a process for preparing cyclododecanone, which comprises such a purification, and the use of at least one acid for purifying a composition (I) comprising at least one cyclic ketone having from 7 to 16 carbon atoms by thermal treatment of the composition (I) with the acid.

摘要翻译： 本发明涉及一种纯化包含至少一种具有7至16个碳原子的环酮的组合物（I）的方法，其包括用至少一种酸对组合物（I）进行热处理，并进一步通过 选自蒸馏，萃取和结晶的方法。此外，本发明涉及一种制备环十二烷酮的方法，其包括这种纯化，以及使用至少一种酸来纯化至少包含（I）的组合物 一种具有7-16个碳原子的环酮，通过组合物（I）与酸的热处理。

公开(公告)号：US20090281357A1

公开(公告)日：2009-11-12

申请号：US12306841

申请日：2007-06-27

申请人： Joaquim Henrique Teles ,  Beatrice Rössler ,  Rolf Pinkos ,  Gerd Tebben ,  Christian Müller

发明人： Joaquim Henrique Teles ,  Beatrice Rössler ,  Rolf Pinkos ,  Gerd Tebben ,  Christian Müller

IPC分类号： C07C45/27

CPC分类号： C07C45/28 ,  C07C45/62 ,  C07C45/85 ,  C07C2601/20 ,  C07C49/607 ,  C07C49/413

摘要： The present invention relates to a process for preparing a cyclic ketone having from 7 to 16 carbon atoms, which comprises at least the steps (a) oxidation of a composition (I) comprising at least one cyclic olefin which has from 7 to 16 carbon atoms and at least one C—C double bond by means of dinitrogen monoxide to give a composition (A), (b) treatment of the composition (A) with at least one base to give a composition (B).

摘要翻译： 本发明涉及一种制备具有7至16个碳原子的环酮的方法，其至少包括步骤（a）包含至少一种具有7至16个碳原子的环烯烃的组合物（I）的氧化 和至少一个CC双键，得到组合物（A），（b）用至少一个碱处理组合物（A）以得到组合物（B）。