公开(公告)号：US08178670B2

公开(公告)日：2012-05-15

申请号：US12349479

申请日：2009-01-06

申请人： Mark Henderson ,  Steven Jungles ,  Gabriele Roidl ,  Robert Baffi ,  Adriano Indolese ,  Christian Müller ,  Philipp Schmidt ,  Stefan Kaiser

发明人： Mark Henderson ,  Steven Jungles ,  Gabriele Roidl ,  Robert Baffi ,  Adriano Indolese ,  Christian Müller ,  Philipp Schmidt ,  Stefan Kaiser

IPC分类号： C07D475/00

CPC分类号： C07D487/04

摘要： The present disclosure provides a method that efficiently produces (6R)-tetrahydrobiopterin of Formula I in high yield and purity. The method includes the step of hydrolyzing diacetylbiopterin to biopterin under basic conditions in a biphasic mixture comprising an organic phase and an aqueous phase. After substantially complete hydrolysis of diacetylbiopterin, the aqueous phase containing biopterin can be separated from the organic phase containing most of the organic impurities, which avoids the time-consuming step of isolating biopterin as a solid. The aqueous solution containing biopterin is stereoselectively hydrogenated to (6R)-tetrahydrobiopterin under basic conditions and high hydrogen pressure in the presence of a metal catalyst (e.g., a platinum catalyst). To improve the purification of an acid addition salt of (6R)-tetrahydrobiopterin (e.g., (6R)-tetrahydrobiopterin dihydrochloride), any residual salts (e.g., sodium salts) in the aqueous solution after the hydrogenation reaction can be removed by contacting the aqueous solution with an ion (e.g., cation) exchange resin or column. Alternatively, removal of residual salts from the aqueous solution can be omitted if an organic amine (e.g., diethylamine or triethylamine) rather than an inorganic base is used in the hydrolysis and/or hydrogenation reactions.

摘要翻译： 本公开提供了以高产率和纯度有效生产式I的（6R） - 四氢生物喋呤的方法。 该方法包括在碱性条件下在包含有机相和水相的两相混合物中将二乙酰生物蝶呤水解成生物蝶呤的步骤。 在二乙酰生物蝶呤基本上完全水解后，含有生物蝶呤的水相可以从含有大部分有机杂质的有机相中分离出来，这避免了将生物蝶呤分离成固体的耗时的步骤。 含有生物蝶呤的水溶液在碱性条件下，在金属催化剂（如铂催化剂）存在下，氢压高，立体选择氢化为（6R） - 四氢生物喋呤。 为了改善（6R） - 四氢生物蝶呤（例如（6R） - 四氢生物喋呤二盐酸盐）的酸加成盐的纯化，氢化反应后的水溶液中的任何残留盐（例如钠盐）可以通过使水溶液 溶液与离子（如阳离子）交换树脂或色谱柱。 或者，如果在水解和/或氢化反应中使用有机胺（例如二乙胺或三乙胺）而不是无机碱，则可以从水溶液中除去残留的盐。

公开(公告)号：US08281677B2

公开(公告)日：2012-10-09

申请号：US11816202

申请日：2006-02-16

申请人： Heinrich Dück ,  Christian Müller

发明人： Heinrich Dück ,  Christian Müller

IPC分类号： F16H29/20

CPC分类号： H02K7/102 ,  B65D73/0085 ,  F16H25/2454 ,  F16H2025/2463 ,  H02K7/06 ,  Y10T74/18576 ,  Y10T74/18704

摘要： An electromotive linear drive with a drive unit having a drive motor and a spindle driven by the drive unit. The drive includes a spindle nut disposed on the spindle. The spindle nut is movable longitudinally on the spindle. A lifting tube is operatively connected to the spindle nut so that the spindle nut moves together with the lifting tube. A connecting part is disposed on a free end of the lifting tube. A braking assembly is disposed in the lifting tube and is operatively connected to the spindle nut via an adjustable, frictional connection. The braking assembly is manipulable. During operation of the drive motor, the spindle nut frictionally engages the braking assembly, preventing rotation of the spindle nut. The frictional connection may be adjusted to permit the spindle nut to rotate with respect to the spindle, thereby manipulating a linear speed component of the lifting tube.

摘要翻译： 具有驱动单元的电动线性驱动器，其具有驱动电动机和由驱动单元驱动的主轴。 驱动器包括设置在主轴上的主轴螺母。 主轴螺母可在主轴上纵向移动。 提升管可操作地连接到主轴螺母，使得主轴螺母与提升管一起移动。 连接部件设置在提升管的自由端上。 制动组件设置在提升管中，并通过可调节的摩擦连接与主轴螺母可操作地连接。 制动组件是可操作的。 在驱动电机运行期间，主轴螺母与制动组件摩擦接合，防止主轴螺母旋转。 可以调节摩擦连接以允许主轴螺母相对于主轴旋转，从而操纵提升管的线速度部件。

公开(公告)号：US20120157719A1

公开(公告)日：2012-06-21

申请号：US13380207

申请日：2010-01-19

申请人： Joaquim Henrique Teles ,  Peter Resch ,  Wilhelm Ruppel ,  Ulrike Wegerle ,  Wolfgang Gerliing ,  Beatrice Rössler-Feigel ,  Anton Meier ,  Christian Müller

发明人： Joaquim Henrique Teles ,  Peter Resch ,  Wilhelm Ruppel ,  Ulrike Wegerle ,  Wolfgang Gerliing ,  Beatrice Rössler-Feigel ,  Anton Meier ,  Christian Müller

IPC分类号： C07C45/00 ,  B01J19/00

CPC分类号： B01J19/2425 ,  B01J4/001 ,  B01J19/006 ,  B01J2219/00085 ,  B01J2219/00166 ,  F28D7/16 ,  F28F9/0265 ,  F28F9/0275 ,  F28F9/0278 ,  Y02P20/582

摘要： The invention relates to a tube bundle reactor with a flat feed hood. Alternatively, the release hood may also have a flat design. The flat design reduces the heat of reaction which arises in the hood in the case of reaction types which take place not only in the tube bundle (uncatalyzed reactions and reactions with homogeneously distributed catalyst). This greatly suppresses undesired reactions which already take place in the hood owing to accumulated heat, which achieves a higher selectivity in the case of thermally sensitive reactions. In addition, the thermal distribution within the hoods can be controlled precisely.The tube bundle reactor comprises a tube bundle which has a feed end which is connected to a feed hood of the tube bundle reactor, wherein the feed hood is configured in a flat design with a cross-sectional area at the feed end and an internal volume, and the ratio of internal volume to cross-sectional area is less than 0.35 m. The invention is further implemented by means of a process for operating a tube bundle reactor, comprising: introducing a reactant mixture into a tube bundle and converting at least a proportion of the reactant mixture within the tube bundle to a product. The introducing comprises: feeding the reactant mixture into an interior of a feed hood of the tube bundle reactor and passing the reactant mixture on into a feed end of the tube bundle in the form of a fluid stream. The fluid stream has a cross-sectional area on entry into the feed end, and the interior of the feed hood through which the fluid stream flows has an internal volume; where the ratio of internal volume to cross-sectional area is less than 0.35 m.

摘要翻译： 本发明涉及具有扁平进料罩的管束反应器。 或者，释放罩也可以具有平坦的设计。 在反应类型不仅在管束（未催化的反应和具有均匀分布的催化剂的反应）的情况下，扁平设计减少了发动机罩中产生的反应热。 这大大地抑制了由于积热而在罩中发生的不期望的反应，这在热敏反应的情况下实现了更高的选择性。 此外，可以精确地控制罩内的热分布。 管束反应器包括管束，其具有连接到管束反应器的进料罩的进料端，其中进料罩构造成平坦设计，在进料端具有横截面积，内部体积 ，内部体积与横截面积的比值小于0.35μm。 通过用于操作管束反应器的方法进一步实现本发明，其包括：将反应物混合物引入管束并将至少一部分管束内的反应物混合物转化成产物。 引入包括：将反应物混合物进料到管束反应器的进料罩的内部，并将反应物混合物以流体流的形式送入管束的进料端。 流体流在进入进料端时具有横截面面积，流体流流过的进料罩的内部具有内部容积; 其中内部体积与横截面积的比值小于0.35μm。

公开(公告)号：US20110171965A1

公开(公告)日：2011-07-14

申请号：US13002921

申请日：2009-07-09

申请人： Anja Klein ,  Christian Müller ,  Bernhard Raaf

发明人： Anja Klein ,  Christian Müller ,  Bernhard Raaf

IPC分类号： H04W72/04 ,  H04B7/14

CPC分类号： H04W28/06 ,  H04W72/042

摘要： It is described a method for distributing radio resources between a first radio link between a primary network element being assigned to a first hierarchic level of a network and a first secondary network element being assigned to a second hierarchic level and a second radio link between the primary network element and a second secondary network element being assigned to the second hierarchic level. The method includes (a) transmitting respectively a first resource allocation parameter from the first and the second secondary network element to a decision unit, the first resource allocation parameter being indicative for a minimum performance requirement, (b) transmitting respectively a second resource allocation parameter from the first and the second secondary network element to the decision unit, the second resource allocation parameter being indicative for a performance increase for the respective radio link following an allocation of additional radio resources, and (c) distributing the radio resources between the first and the second radio link based on the first and the second resource allocation parameter.

摘要翻译： 描述了一种用于在被分配给网络的第一分级级别的主网络元件和被分配给第二分级级别的第一辅助网络元件之间的第一无线电链路和第一无线链路之间分配无线电资源的方法，以及主网络 网络元件和被分配给第二层级的第二辅助网络元件。 该方法包括：（a）分别从第一和第二辅助网络单元发送第一资源分配参数到决策单元，第一资源分配参数指示最低性能要求，（b）分别发送第二资源分配参数 从所述第一和第二辅助网络单元到所述决策单元，所述第二资源分配参数指示在分配附加无线电资源之后各个无线电链路的性能增加，以及（c）在所述第一和第二辅助网络分配所述第一和第二辅助网络 所述第二无线电链路基于所述第一和第二资源分配参数。

公开(公告)号：US07865719B2

公开(公告)日：2011-01-04

申请号：US10204473

申请日：2001-02-10

申请人： Christian Müller ,  Alexis Trolin ,  Siegfried Ergezinger ,  Anita Döhler

发明人： Christian Müller ,  Alexis Trolin ,  Siegfried Ergezinger ,  Anita Döhler

IPC分类号： H04L9/00

CPC分类号： H04L63/083 ,  G06F21/00 ,  G06F21/33 ,  G06F21/42 ,  H04L63/0846 ,  H04L63/18 ,  H04W12/06

摘要： The invention relates to a process and a device for establishing the authenticity of the identity of a service user relative to a service provider for release of an access authorization (password) for a service using two different data input terminals, a registration server and a message converter.

摘要翻译： 本发明涉及一种用于建立服务用户相对于服务提供商的身份的真实性的过程和设备，用于释放使用两个不同的数据输入终端，注册服务器和消息的服务的访问授权（密码） 转换器。

公开(公告)号：US20100272272A1

公开(公告)日：2010-10-28

申请号：US12743211

申请日：2008-11-07

申请人： Christian Müller ,  Ivan Jørgensen ,  Franz Treue ,  Christian C. Bürger

发明人： Christian Müller ,  Ivan Jørgensen ,  Franz Treue ,  Christian C. Bürger

IPC分类号： H04R29/00

CPC分类号： H04R25/658 ,  H04R25/305 ,  H04R25/604 ,  H04R25/70 ,  H04R2420/05

摘要： The invention regards a hearing aid comprising a receiver and a signal processing device, wherein the signal processing device is electrically coupled to a connection socket operable to detachably connect the receiver to the socket and whereby the signal processing device further comprise a detector operable to detect a characteristics of the receiver which is connected to the signal processing device through the connection socket. The present invention addresses the problem of identification of individual receiver properties as well as of identifying different types of receivers.

摘要翻译： 本发明涉及一种包括接收器和信号处理装置的助听器，其中信号处理装置电耦合到可操作以将接收器可拆卸地连接到插座的连接插座，由此信号处理装置还包括可操作以检测 通过连接插座连接到信号处理装置的接收器的特性。 本发明解决了识别各个接收机属性以及识别不同类型的接收机的问题。

公开(公告)号：US07790930B2

公开(公告)日：2010-09-07

申请号：US12306815

申请日：2007-06-27

申请人： Rolf Pinkos ,  Gerd Tebben ,  Christian Müller ,  Harald Rust

发明人： Rolf Pinkos ,  Gerd Tebben ,  Christian Müller ,  Harald Rust

IPC分类号： C07C45/27

CPC分类号： C07C45/85 ,  C07C45/34 ,  C07C45/62 ,  C07C2601/20 ,  C07C49/607 ,  C07C49/413

摘要： The present invention relates to a process for purifying a composition (I) comprising at least one cyclic ketone having from 7 to 16 carbon atoms, which comprises thermal treatment of the composition (I) with a catalyst comprising at least one transition metal and further purification by means of a process selected from the group consisting of distillation, extraction and crystallization. Furthermore, the present invention relates to a process for preparing cyclododecanone, which comprises such a purification, and the use of at least one catalyst comprising at least one transition metal for purifying a composition (I) comprising at least one cyclic ketone having from 7 to 16 carbon atoms by thermal treatment of the composition (I) with a catalyst comprising at least one transition metal.

摘要翻译： 本发明涉及一种纯化包含至少一种具有7至16个碳原子的环酮的组合物（I）的方法，其包括用包含至少一种过渡金属的催化剂热处理组合物（I）并进一步纯化 通过选自蒸馏，萃取和结晶的方法。 此外，本发明涉及一种制备环十二烷酮的方法，其包括这种纯化，以及至少一种包含至少一种过渡金属的催化剂用于纯化组合物（I）的用途，所述组合物（I）包含至少一种具有7〜 16个碳原子通过用包含至少一种过渡金属的催化剂热处理组合物（I）。

公开(公告)号：US20090169537A1

公开(公告)日：2009-07-02

申请号：US12300209

申请日：2007-05-10

申请人： Michael Bausch ,  Rainer Wetzler ,  Christian Müller

发明人： Michael Bausch ,  Rainer Wetzler ,  Christian Müller

IPC分类号： A61K38/50 ,  A61P35/00

CPC分类号： A61K38/50 ,  A61K31/198 ,  A61K2300/00

摘要： The present invention relates to a pharmaceutical combination product for cancer therapy. The combination product comprises the two active ingredients glutaminase and 6-diazo-5-oxo-L-norleucine (DON). The invention further relates to the use of such a combination product for the treatment of cancers.

摘要翻译： 本发明涉及用于癌症治疗的药物组合产品。 组合产品包含两种活性成分谷氨酰胺酶和6-重氮-5-氧代-L-正亮氨酸（DON）。 本发明还涉及这种组合产品用于治疗癌症的用途。

公开(公告)号：US07037181B1

公开(公告)日：2006-05-02

申请号：US09786731

申请日：1999-09-08

申请人： Jürg Faas ,  Beat Näf ,  Christian Sauter ,  Yücel Yildirim ,  Roland Styner ,  Roland Bischof ,  Christian Müller

发明人： Jürg Faas ,  Beat Näf ,  Christian Sauter ,  Yücel Yildirim ,  Roland Styner ,  Roland Bischof ,  Christian Müller

IPC分类号： B24B29/08

CPC分类号： B24B29/005 ,  B24B3/60 ,  B24B19/18 ,  B24B47/22 ,  B24B55/06 ,  B24D13/10 ,  D01G15/38

摘要： A grinding device for the flats of a card comprises elastically bendable elements which enter between the clothing points, brush over the side flanks of the points and thereby grind the points. Additional grinding elements are provided in order to treat the front sides of the clothing points. The ground-off material may be removed by a suction device.

公开(公告)号：US06998880B2

公开(公告)日：2006-02-14

申请号：US10675244

申请日：2003-09-29

申请人： Christian Müller ,  Henrik Icking ,  Martin Glas

发明人： Christian Müller ,  Henrik Icking ,  Martin Glas

IPC分类号： H03B1/00

CPC分类号： H03K17/165 ,  H03K17/0822 ,  H03K17/102 ,  H03K19/00315 ,  H03K2217/0018

摘要： The invention relates to a driver circuit with a circuit node (10), at least two first transistors (P1, P2), the load sections of which are switched in series and connect the circuit node (10) with a first voltage (U10), at least two second transistors (N1, N2), the load sections of which are switched in series and connect the circuit node (10) with a reference potential, and a control circuit (P3–P6, N3, D1–D4, R1, 16), which is formed in order to regulate at least a first control voltage (Up2) on at least one transistor (P2) of the at least two first transistors (P1, P2) and at least a second control voltage (UN2) on at least one transistor (N2) of the at least two second transistors (N1, N2) dependent on a voltage at the circuit node (10).

摘要翻译： 本发明涉及一种驱动电路