公开(公告)号：US20080221430A1

公开(公告)日：2008-09-11

申请号：US12030893

申请日：2008-02-14

申请人： Hisaaki OCHI ,  Yo Taniguchi ,  Yoshihisa Soutome ,  Yoshitaka Bito

发明人： Hisaaki OCHI ,  Yo Taniguchi ,  Yoshihisa Soutome ,  Yoshitaka Bito

IPC分类号： A61B5/055

CPC分类号： G01R33/5601 ,  G01R33/54 ,  G01R33/5616 ,  G01R33/5617

摘要： A magnetic resonance imaging (MRI) apparatus for high-speed and high-accuracy detection of cell positions labeled with magnetic nanoparticles. A transmitter coil is controlled to generate amplitude-modulated burst RF pulses as excitation RF pulses whose amplitude is modulated by a function that repeatedly inverts the polarity of multiple high-frequency magnetic field sub-pulses separated time-wise and changes the amplitude at each polarity inversion, moreover the time interval of the amplitude-modulated burst RF pulse is set to effectively 1/(2×a first frequency), and the transmitter coil controlled so the carrier frequency of the amplitude-modulated burst RF pulse is set to a second frequency shifted substantially from the first frequency of the magnetic resonance frequency of the proton at the magnetic field strength in the MRI apparatus. The first frequency is here determined based on magnetic nanoparticle information loaded from the magnetic nanoparticle information storage unit and the magnetic resonance frequency of the proton in the static magnetic field. The MRI apparatus can in this way detect the position of cells labeled with magnetic nanoparticles, with high-speed and high accuracy.

摘要翻译： 一种磁共振成像（MRI）装置，用于高速和高精度检测用磁性纳米颗粒标记的细胞位置。 发射器线圈被控制以产生幅度调制的突发RF脉冲作为激励RF脉冲，其幅度通过重复地反转时间间隔分离的多个高频磁场子脉冲的极性并改变每个极性的振幅的函数来调制 此外，调幅脉冲串RF脉冲的时间间隔被有效地设置为1 /（2×a第一频率），并且被控制的发射机线圈被调制的调幅脉冲串RF脉冲的载波频率设置为第二频移 基本上从MRI装置中的磁场强度的质子的磁共振频率的第一频率开始。 这里基于从磁性纳米颗粒信息存储单元加载的磁性纳米颗粒信息和静态磁场中质子的磁共振频率来确定第一频率。 MRI装置可以以这种方式以高速和高精度检测用磁性纳米颗粒标记的细胞的位置。

公开(公告)号：US20110175616A1

公开(公告)日：2011-07-21

申请号：US12519832

申请日：2007-12-13

申请人： Hisaaki Ochi ,  Yoshihisa Soutome ,  Yoshitaka Bito ,  Takeshi Yatsuo ,  Hiroyuki Takeuchi

发明人： Hisaaki Ochi ,  Yoshihisa Soutome ,  Yoshitaka Bito ,  Takeshi Yatsuo ,  Hiroyuki Takeuchi

IPC分类号： G01R33/44

CPC分类号： G01R33/385 ,  G01R33/34076 ,  G01R33/4215 ,  G01R33/422 ,  G01R33/5659

摘要： There is provided a coil unit having a large region of homogeneous sensitivity for the axial direction even with a shortened rung length of birdcage type RF coil.The coil unit comprises a gradient coil which is disposed along a static magnetic field generating source, and a radio frequency coil which is disposed along the gradient coil in a test region at a position closer to the center of the test region compared with the gradient coil, and a conductor part which is disposed between the gradient coil and the radio frequency coil, and covers periphery of the radio frequency coil. The radio frequency coil comprises a first loop coil and a second loop coil locating in planes substantially perpendicular to direction of the static magnetic field, a plurality of linear conductors connecting the first loop coil and the second loop coil and substantially parallel to the direction of the static magnetic field, and a plurality of first capacitors disposed in the first loop coil and the second loop coil. The coil unit further comprises a first connecting part, which electrically connects the radio frequency coil and the conductor part via a second capacitor and comprises an electric power supply circuit disposed in parallel to the second capacitor, and a second connecting part which connects the radio frequency coil and the conductor part via a third capacitor.

摘要翻译： 提供了一种线圈单元，即使在鸟笼型RF线圈的长度较短的情况下也具有轴向均匀的灵敏度大的区域。 线圈单元包括沿着静磁场发生源设置的梯度线圈，以及与梯度线圈相比更靠近测试区域的中心的位置处的测试区域中的沿梯度线圈布置的射频线圈 以及布置在所述倾斜线圈和所述射频线圈之间并且覆盖所述射频线圈的周围的导体部。 射频线圈包括位于基本上垂直于静磁场方向的平面中的第一环形线圈和第二环形线圈，连接第一环形线圈和第二环形线圈并且基本上平行于静态磁场方向的多个线性导体 静磁场和设置在第一环形线圈和第二环形线圈中的多个第一电容器。 线圈单元还包括第一连接部分，其经由第二电容器电连接射频线圈和导体部分，并且包括与第二电容器并联设置的电源电路，以及连接射频 线圈和导体部分经由第三电容器。

公开(公告)号：US20090108842A1

公开(公告)日：2009-04-30

申请号：US12260612

申请日：2008-10-29

申请人： Hideta HABARA ,  Yoshitaka Bito

发明人： Hideta HABARA ,  Yoshitaka Bito

IPC分类号： G01R33/48

CPC分类号： G01R33/3607 ,  G01R33/288 ,  G01R33/4833 ,  G01R33/4836

摘要： An MRI apparatus comprises a waveform controlling means for calculating a radio frequency pulse and applying the pulse to an irradiating means, and the waveform controlling means reads out a radio frequency pulse waveform vector from a first memory means which memorizes multiple radio frequency pulse waveform vectors, calculates a simulated irradiation pattern, and calculates a radio frequency pulse waveform which gives the minimum value of weighted sum of squares of differences of absolute values and squares of differences of phases for an ideal irradiation pattern and the simulated irradiation pattern. An RF pulse waveform showing superior ideal irradiation pattern reproducibility and providing reduced power of the RF waveform is formed, and safety of MRI subject is improved by performing imaging using such an RF pulse.

摘要翻译： MRI装置包括波形控制装置，用于计算射频脉冲并将脉冲施加到照射装置，波形控制装置从存储多个射频脉冲波形向量的第一存储装置读出射频脉冲波形向量， 计算模拟照射图案，并计算给出理想照射图案和模拟照射图案的相位差绝对值和平方差的加权平方和的最小值的射频脉搏波形。 形成显示优异的理想照射图案再现性并且提供RF波形的功率降低的RF脉冲波形，并且通过使用这样的RF脉冲进行成像来提高MRI对象的安全性。

公开(公告)号：US08115486B2

公开(公告)日：2012-02-14

申请号：US12260612

申请日：2008-10-29

申请人： Hideta Habara ,  Yoshitaka Bito

发明人： Hideta Habara ,  Yoshitaka Bito

IPC分类号： G01V3/00 ,  A61B5/055 ,  G06K9/00

CPC分类号： G01R33/3607 ,  G01R33/288 ,  G01R33/4833 ,  G01R33/4836

摘要： An MRI apparatus comprises a waveform controlling means for calculating a radio frequency pulse and applying the pulse to an irradiating means, and the waveform controlling means reads out a radio frequency pulse waveform vector from a first memory means which memorizes multiple radio frequency pulse waveform vectors, calculates a simulated irradiation pattern, and calculates a radio frequency pulse waveform which gives the minimum value of weighted sum of squares of differences of absolute values and squares of differences of phases for an ideal irradiation pattern and the simulated irradiation pattern. An RF pulse waveform showing superior ideal irradiation pattern reproducibility and providing reduced power of the RF waveform is formed, and safety of MRI subject is improved by performing imaging using such an RF pulse.

摘要翻译： MRI装置包括波形控制装置，用于计算射频脉冲并将脉冲施加到照射装置，波形控制装置从存储多个射频脉冲波形向量的第一存储装置读出射频脉冲波形向量， 计算模拟照射图案，并计算给出理想照射图案和模拟照射图案的相位差绝对值和平方差的加权平方和的最小值的射频脉搏波形。 形成显示优异的理想照射图案再现性并且提供RF波形的功率降低的RF脉冲波形，并且通过使用这样的RF脉冲进行成像来提高MRI对象的安全性。

公开(公告)号：US09678187B2

公开(公告)日：2017-06-13

申请号：US14240171

申请日：2012-07-27

申请人： Toru Shirai ,  Yoshitaka Bito ,  Satoshi Hirata ,  Yoshihisa Soutome

发明人： Toru Shirai ,  Yoshitaka Bito ,  Satoshi Hirata ,  Yoshihisa Soutome

IPC分类号： G01R33/46 ,  G01R33/485 ,  G01R33/565 ,  A61B5/055

CPC分类号： G01R33/4625 ,  A61B5/055 ,  G01R33/485 ,  G01R33/56518

摘要： An object of the present invention is to suppress artifacts generated by correction of spectral distortion induced by eddy currents in MRI devices with a simple method, and thereby improve accuracy of the correction.

公开(公告)号：US09459331B2

公开(公告)日：2016-10-04

申请号：US13984855

申请日：2012-02-01

申请人： Yosuke Otake ,  Yoshihisa Soutome ,  Ryota Sato ,  Yoshitaka Bito ,  Koji Hirata

发明人： Yosuke Otake ,  Yoshihisa Soutome ,  Ryota Sato ,  Yoshitaka Bito ,  Koji Hirata

IPC分类号： G01R33/3415 ,  G01R33/36 ,  G01R33/422 ,  G01R33/34

CPC分类号： G01R33/365 ,  G01R33/34053 ,  G01R33/34069 ,  G01R33/34076 ,  G01R33/3415 ,  G01R33/3635 ,  G01R33/3657 ,  G01R33/3678 ,  G01R33/422

摘要： To provide a technique for sufficiently eliminating magnetic coupling between RF coils and improving image quality when a multi-element multi-tuned RF coil is used as a receive RF coil for an MRI device. In the invention, each of RF coils which constitute a multi-element multi-tuned RF coil which is used as a receive RF coil for an MRI device is provided with an inter-coil magnetic coupling prevention circuit which resonates at each frequency to which each RF coil is tuned and provides a high impedance. The inter-coil magnetic coupling prevention circuit adjusts an inductor and a capacitor so that both of a circuit on the side of a pre-amplifier viewed from both ends of a signal reception circuit and a circuit on the side of the signal reception circuit viewed from both ends of a serial resonance circuit connected to the pre-amplifier resonate at a plurality of frequencies to which the respective RF coils are tuned.

摘要翻译： 提供一种用于充分消除RF线圈之间的磁耦合并且当多元素多调谐RF线圈用作MRI装置的接收RF线圈时提高图像质量的技术。 在本发明中，构成用作MRI装置的接收RF线圈的多元素多调谐RF线圈的每个RF线圈都设置有线圈间磁耦合防止电路，该电路在每个频率下共振， RF线圈被调谐并提供高阻抗。 线圈间磁耦合防止电路调整电感器和电容器，使得从信号接收电路的两端观看的前置放大器侧的电路和从信号接收电路侧观察的电路 连接到前置放大器的串联谐振电路的两端以相应的RF线圈调谐到的多个频率谐振。

公开(公告)号：US08193810B2

公开(公告)日：2012-06-05

申请号：US12292449

申请日：2008-11-19

申请人： Yosuke Otake ,  Yoshihisa Soutome ,  Koji Hirata ,  Yoshitaka Bito

发明人： Yosuke Otake ,  Yoshihisa Soutome ,  Koji Hirata ,  Yoshitaka Bito

IPC分类号： G01V3/00

CPC分类号： G01R33/34046 ,  G01R33/34053 ,  G01R33/34069 ,  G01R33/341 ,  G01R33/3415 ,  G01R33/3635

摘要： An RF coil having at least three different resonance frequencies, wherein one of the resonance frequencies is adjusted to be a frequency fA of a magnetic resonance signal generated by a test subject, and the coil is adjusted so that ratio of difference between the frequency fA and a first frequency fB lower than fA and nearest to fA among the resonance frequencies (fA−fB), and difference between the frequency fA and a second resonance frequency fC higher than fA and nearest to the frequency fA among the resonance frequencies (fC−fA), should be from 0.5 to 2.0. There is provided a technique for receiving magnetic resonance signals always with high detection efficiency by an RF coil of an MRI apparatus even if significant loss is caused in the RF coil, or test subject is changed.

摘要翻译： 具有至少三个不同谐振频率的RF线圈，其中谐振频率之一被调整为由测试对象产生的磁共振信号的频率fA，并且调节线圈，使得频率fA与 在谐振频率（fA-fB）中比fA低且最接近fA的第一频率fB，以及频率fA与谐振频率（fC-fA）之间的最接近频率fA的fA的第二谐振频率fC之间的差 ），应为0.5〜2.0。 提供了一种用于通过MRI装置的RF线圈始终具有高检测效率的磁共振信号的技术，即使在RF线圈中引起显着的损失，或者测试对象发生变化。

公开(公告)号：US10267879B2

公开(公告)日：2019-04-23

申请号：US14240441

申请日：2012-07-27

申请人： Suguru Yokosawa ,  Yo Taniguchi ,  Yoshitaka Bito ,  Yoshihisa Soutome

发明人： Suguru Yokosawa ,  Yo Taniguchi ,  Yoshitaka Bito ,  Yoshihisa Soutome

IPC分类号： G01R33/54 ,  G01R33/483 ,  A61B5/055 ,  A61B5/00

摘要： A technique in a medical imaging apparatus being capable of setting any plane in three-dimensional space as an imaging slice is provided, allowing an automatically-set imaging slice to be configured to suit user's preferences, and determine a position of the imaging slice being configured, with respect to an imaging target subject automatically with a high degree of accuracy. Reference information for specifying the imaging slice, set by the user for each imaging site, is associated with the anatomical feature of the imaging site, so as to generate an imaging slice parameter. Upon actual imaging, the imaging slice parameter and the anatomical feature of the imaging target subject obtained by scout imaging are used to determine the imaging slice position of the imaging target subject.

公开(公告)号：US20130214785A1

公开(公告)日：2013-08-22

申请号：US13881739

申请日：2011-10-26

申请人： Toru Shirai ,  Yoshitaka Bito ,  Satoshi Hirata ,  Yoshihisa Soutome ,  Yo Taniguchi

发明人： Toru Shirai ,  Yoshitaka Bito ,  Satoshi Hirata ,  Yoshihisa Soutome ,  Yo Taniguchi

IPC分类号： G01R33/36

CPC分类号： G01R33/3621 ,  A61B5/055 ,  G01R33/465 ,  G01R33/4828 ,  G01R33/485 ,  G01R33/5611

摘要： Images of two or more kinds of substances showing different chemical shifts, such as water image and metabolite image, are obtained without extending measurement time. For example, images of two or more kinds of desired substances showing different chemical shifts, such as water image and metabolite image, are obtained by one time of execution of an imaging sequence. In this execution, a pre-pulse is applied so that signals of the substances to be separated shift on the image, and magnetic resonance signals are received with receiver RF coils in a number not smaller than the number of types of the substances to be separated. An image reconstructed from the magnetic resonance signals is separated into images of the individual substances using sensitivity maps of the receiver RF coils. Then, correction is performed for returning the shifted image to the original position. Further, residual signals induced by errors generated in the measurement and the separation processing are eliminated by using spectroscopic images obtained after the separation.

摘要翻译： 在不延长测量时间的情况下，获得显示不同化学位移的两种或更多种物质的图像，例如水图像和代谢物图像。 例如，通过一次执行成像序列，可以获得显示不同化学位移的两种或更多种所需物质的图像，例如水图像和代谢物图像。 在该执行中，施加预脉冲，使得要分离的物质的信号在图像上移动，并且用接收器RF线圈​​接收不少于待分离物质的数量的数量的磁共振信号 。 使用接收机RF线圈的灵敏度图将从磁共振信号重构的图像分离成各个物质的图像。 然后，执行用于将移动的图像返回到原始位置的校正。 此外，通过使用分离后获得的分光图像来消除由测量和分离处理中产生的误差引起的残留信号。

公开(公告)号：US07733092B2

公开(公告)日：2010-06-08

申请号：US12018287

申请日：2008-01-23

申请人： Yosuke Otake ,  Yoshihisa Soutome ,  Koji Hirata ,  Yoshitaka Bito

发明人： Yosuke Otake ,  Yoshihisa Soutome ,  Koji Hirata ,  Yoshitaka Bito

IPC分类号： G01V3/00

CPC分类号： G01R33/341 ,  G01R33/34046 ,  G01R33/34053 ,  G01R33/34069 ,  G01R33/34076 ,  G01R33/3635

摘要： Provided is an RF coil which can highly efficiently and uniformly irradiate a RF magnetic field having two or more magnetic resonance frequencies close to each other, and receive magnetic resonance signals of two or more magnetic resonance frequencies close to each other with high sensitivity and uniform sensitivity profile in an MRI apparatus. Two or more frequencies to which the coil is tuned are adjusted so as to be between resonance frequencies of series resonant circuits constituting the RF coil.

摘要翻译： 提供一种可以高效地均匀地照射具有两个或更多个磁共振频率彼此接近的RF磁场的RF线圈，并以高灵敏度和均匀的灵敏度接收彼此接近的两个或更多个磁共振频率的磁共振信号 在MRI设备中。 线圈调谐到的两个或更多个频率被调整为在构成RF线圈的串联谐振电路的谐振频率之间。