公开(公告)号：US20180188156A1

公开(公告)日：2018-07-05

申请号：US15736399

申请日：2016-06-30

Applicant: IMEC VZW

Inventor： Peter Peumans ,  Liesbet Lagae ,  Willem Van Roy ,  Tim Stakenborg ,  Pol Van Dorpe

IPC: G01N21/17 ,  G01N21/64

CPC classification number: G01N21/1717 ,  G01N21/645 ,  G01N21/648 ,  G01N2021/1731

Abstract: A sensor device for quantifying luminescent targets comprises a light source, a detector, a modulator, and a processor. The light source is adapted for exciting the luminescent target. The detector is adapted for detecting the luminescence of the luminescent target resulting in a measured signal which comprises a desired signal originating from the luminescent target and a background signal. The modulator is adapted for modulating a physical parameter resulting in a modulation of the desired signal which is different from the modulation of the background signal. The processor is configured to correlate the modulation of the physical parameter with the modulation of the desired signal and/or the modulation of the background signal.

公开(公告)号：US20180156788A1

公开(公告)日：2018-06-07

申请号：US15577076

申请日：2016-06-30

Applicant: IMEC VZW

Inventor： Willem Van Roy ,  Tim Stakenborg ,  Kris Covens

IPC: G01N33/543 ,  C12Q1/00 ,  C12Q1/6825 ,  G01N33/52

Abstract: A device (1) for sensing an analyte, the device (1) comprises at least a sample inlet (10) for receiving a sample, affinity probes (111) selected to have a preferential binding to the analyte, a transducer (11) sensitive to a characteristic of the analyte and/or a label attached to the analyte, the transducer not being a FET transducer, and a desalting unit (13) for desalting the received sample.

公开(公告)号：US20180149643A1

公开(公告)日：2018-05-31

申请号：US15577311

申请日：2016-06-28

Applicant: IMEC VZW

Inventor： Rita Vos ,  Karolien Jans ,  Tim Stakenborg

IPC: G01N33/543 ,  G01N33/531

CPC classification number: G01N33/54353 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00677 ,  B01J2219/00725 ,  B01J2219/0074 ,  G01N33/531 ,  G01N33/54386

Abstract: A method for immobilizing an analyte-recognizing molecule (1) on a surface (2′) functionalized with chemical groups Y1 suitable for reacting with a chemical group X2 of a coupling molecule (7) to form a reaction product comprising a chemical group Y2 suitable for reacting with the analyte-recognizing molecule (1), the method comprising the steps of: a) Providing the functionalized surface (2′), b) Contacting the functionalized surface (2′) with a solution (6) comprising simultaneously: i) The coupling molecule (7), and ii) The analyte-recognizing molecule (1).