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    Electrotransport system having flexible connector means
    33.
    发明授权
    Electrotransport system having flexible connector means 失效
    具有柔性连接器装置的电子运输系统

    公开(公告)号：US5919155A

    公开(公告)日：1999-07-06

    申请号：US374006

    申请日：1995-01-18

    申请人： Gary A. Lattin ,  J. Richard Gyory ,  Charles Albert ,  Scott Jay Gilbert

    发明人： Gary A. Lattin ,  J. Richard Gyory ,  Charles Albert ,  Scott Jay Gilbert

    IPC分类号： A61N1/30 ,  A61N1/32

    CPC分类号： A61N1/044 ,  A61N1/30 ,  A61N1/303 ,  A61N1/325 ,  A61N1/0448 ,  Y10S439/909

    摘要： A device (10) for the electrically assisted delivery of a therapeutic agent is described. The device (10) has rigid zones or regions (12, 14) which are physically connected by a flexible means (16) such as a web. The flexible means (16) permits the rigid zones (12, 14) to move independently with respect to each other while remaining physically connected or coupled. In a preferred embodiment, the rigid zones are physically and electronically coupled by the flexible means. In another embodiment, the device (500) comprises one or more rigid zones, the skin side of the rigid zone having a radius of curvature (520) which approximates that of the body site to which the device (500) is to be attached. A method of increasing the body surface conformability of an electrotransport device (50, 150, 170) is described. The method involves the step of intentionally placing rigid subcomponents (58, 36, 37) of the device in physically separate zones (52, 54; 152, 154, 156, 158; 172, 174, 176, 178) within the device. The rigid zones (52, 54; 152, 154, 156, 158; 172, 174, 176, 178) are separate and are coupled by flexible connector means (56, 62; 160, 162). In this manner, a conformable mosaic of rigid zones which comprises the device is created.

    摘要翻译： 描述了用于电辅助递送治疗剂的装置（10）。 装置（10）具有刚性区域或区域（12,14），其通过诸如腹板的柔性装置（16）物理连接。 柔性装置（16）允许刚性区域（12,14）相对于彼此独立地移动，同时保持物理连接或联接。 在优选实施例中，刚性区域通过柔性装置物理地和电子地联接。 在另一个实施例中，装置（500）包括一个或多个刚性区域，刚性区域的皮肤侧具有近似于装置（500）所附着的身体部位的曲率半径（520）。 描述了增加电输送装置（50,150,170）的体表顺应性的方法。 该方法包括将装置的刚性子部件（58,36,37）有意地放置在装置内的物理上分离的区域（52,54; 152,154,156,158,172,174,176,178）中的步骤。 刚性区域（52,54; 152,154,156,158,172,174,176,178）是分开的并且通过柔性连接器装置（56,​​62; 160,162）联接。 以这种方式，创建包括该装置的刚性区域的一致的马赛克。

    Electrotransport system with ion exchange material providing enhanced drug delivery
    34.
    发明授权
    Electrotransport system with ion exchange material providing enhanced drug delivery 失效
    具有离子交换材料的电子运输系统，提供增强的药物递送

    公开(公告)号：US5871460A

    公开(公告)日：1999-02-16

    申请号：US418967

    申请日：1995-04-06

    申请人： J. Bradley Phipps ,  Lyn C. Moodie ,  J. Richard Gyory ,  Felix Theeuwes

    发明人： J. Bradley Phipps ,  Lyn C. Moodie ,  J. Richard Gyory ,  Felix Theeuwes

    IPC分类号： A61N1/30

    CPC分类号： A61N1/0448 ,  A61N1/0444

    摘要： An electrotransport apparatus using dispersed ion exchange material (19,93) is disclosed. The ion exchange material (19,93) may be dispersed in either the donor electrode assembly (10), the counter electrode assembly (10) or both electrode assemblies. The dispersed ion exchange material (93) comprises mobile ionic species (C2) and substantially immobile ionic species (P). The dispersed ion exchange material (93) is consumed during electrotransport of drug or agent (A) in an electrotransport process in which substantially no species which compete with the drug or agent for electrotransport are generated. Electrotransport devices exhibiting reduced polarization are also disclosed.

    摘要翻译： 公开了一种使用分散离子交换材料的电输送装置（19,93）。 离子交换材料（19,93）可以分散在施主电极组件（10），对电极组件（10）或两个电极组件中。 分散的离子交换材料（93）包括可移动离子物质（C2）和基本上不可移动的离子物质（P）。 分散的离子交换材料（93）在药物或药剂（A）的电转运期间在电转运过程中消耗，其中基本上不产生与用于电转运的药物或药剂竞争的物质。 还公开了表现出减小的极化的电子传输器件。

    Device and method of iontophoretic drug delivery
    35.
    发明授权
    Device and method of iontophoretic drug delivery 失效

    公开(公告)号：US5857992A

    公开(公告)日：1999-01-12

    申请号：US607534

    申请日：1996-02-27

    申请人： Ronald P. Haak ,  J. Richard Gyory ,  Felix Theeuwes

    发明人： Ronald P. Haak ,  J. Richard Gyory ,  Felix Theeuwes

    IPC分类号： A61N1/30

    CPC分类号： A61N1/0444 ,  A61N1/0448 ,  A61N1/0436

    摘要： A selectively permeable membrane (14) is positioned between the agent reservoir (15) and the electrode (11) of a donor electrode assembly (8) in an iontophoretic delivery device (10). Optionally, an electrolyte reservoir (13) is positioned intermediate the electrode (11) and the agent reservoir (15). In certain embodiments, the membrane (14) is permeable to species of less than a predetermined molecular weight and substantially less permeable to species of greater than the predetermined molecular weight. The agent is capable of dissociating into agent ions and counter ions. The size selectivity of the membrane (14), the molecular weight of the agent ions, the molecular weight of the counter ions, and optionally the molecular weight of the electrolyte ions are selected to (A) inhibit agent ions from interacting with the electrode (11), and from permeating into the electrolyte reservoir (13), where they might otherwise be degraded and (B) inhibit electrolyte ions, having a charge similar to that of the agent ions, from permeating into the agent reservoir (15) and competing with the agent ions for iontophoretic delivery into the patient.

    Composition and method enhancing transdermal electrotransport agent delivery
    36.
    发明授权
    Composition and method enhancing transdermal electrotransport agent delivery 失效
    组合物和方法增强透皮电转运剂递送

    公开(公告)号：US5668170A

    公开(公告)日：1997-09-16

    申请号：US612378

    申请日：1996-03-07

    申请人： J. Richard Gyory

    发明人： J. Richard Gyory

    IPC分类号： A61N1/30 ,  A61K9/00 ,  A61K47/16 ,  A01N43/02

    CPC分类号： A61K9/0009

    摘要： A composition comprises an agent to be delivered through a body surface and an electrotransport enhancer having a hydrophobic tail and a polar head of specific characteristics. An electrotransport delivery device is also provided having a reservoir comprising the agent to be delivered and the electrotransport enhancer of the invention. The electrotransport enhancers increase the electrotransport delivery rate of the agent through the surface while reducing the electrical resistance of the surface during electrotransport of the agent.

    摘要翻译： 组合物包含通过身体表面递送的药剂和具有疏水性尾巴和具有特定特征的极性头的电转运增强剂。 还提供了一种电输送输送装置，其具有包含本发明的待递送剂和电运输增强剂的储存器。 电传递增强剂增加了药剂通过表面的电传送速率，同时在试剂的电传输期间降低了表面的电阻。

    Transdermal delivery device
    37.
    发明授权
    Transdermal delivery device 失效
    透皮递送装置

    公开(公告)号：US5464387A

    公开(公告)日：1995-11-07

    申请号：US330031

    申请日：1994-10-27

    申请人： Ronald P. Haak ,  Felix Theeuwes ,  J. Richard Gyory ,  Gary A. Lattin

    发明人： Ronald P. Haak ,  Felix Theeuwes ,  J. Richard Gyory ,  Gary A. Lattin

    IPC分类号： A61K9/00 ,  A61K9/70 ,  A61N1/30

    CPC分类号： A61K9/7084 ,  A61K9/0009 ,  A61K9/7092 ,  A61N1/0448 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/0444

    摘要： A transdermal drug delivery device (20) is provided having both an active drug reservoir (24) and a passive drug reservoir (26). Drug is actively delivered by iontophoresis from the active drug reservoir (24) by an electric field generated by a power source (21). Simultaneously, drug is delivered from passive reservoir (26) by passive (i.e., non-electrically assisted) diffusion. In one embodiment, the passive drug reservoir (26) is electrically insulated from the active drug reservoir (24). In a second embodiment, both the active and the passive drug are contained in the same reservoir (34). In the second embodiment, the active drug is ionizable while the passive drug is non-ionizable. Most preferably, the active drug is an ionizable form (i.e., a salt form) of the passive drug.

    摘要翻译： 提供具有活性药物储存器（24）和被动药物储存器（26）的透皮药物递送装置（20）。 药物通过离子电渗从活性药物储存器（24）通过由电源（21）产生的电场积极递送。 同时，药物通过被动（即非电辅助）扩散从被动储存器（26）输送。 在一个实施例中，被动药物储存器（26）与活性药物贮存器（24）电绝缘。 在第二实施方案中，活性和被动药物都包含在相同的储存器（34）中。 在第二实施方案中，活性药物是可离子化的，而被动药物是不可离子化的。 最优选地，活性药物是被动药物的可离子化形式（即盐形式）。

    Iontophoretic delivery device and method of hydrating same
    38.
    发明授权
    Iontophoretic delivery device and method of hydrating same 失效
    离子渗透输送装置及其水合方法

    公开(公告)号：US5385543A

    公开(公告)日：1995-01-31

    申请号：US85466

    申请日：1993-06-30

    申请人： Ronald P. Haak ,  J. Richard Gyory ,  Felix Theeuwes ,  Robert M. Myers

    发明人： Ronald P. Haak ,  J. Richard Gyory ,  Felix Theeuwes ,  Robert M. Myers

    IPC分类号： A61N20060101 ,  A61N1/30

    CPC分类号： A61N1/0436 ,  A61N1/0448 ,  A61N1/044

    摘要： A dry-state iontophoretic drug delivery device (10, 20) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. In one embodiment of the invention, a passageway (21, 22) is provided through the backing layer (13) and the electrode layer (11, 12) of both the donor electrode assembly (8) and the counter electrode assembly (9). Water or other liquid can be introduced through these passageways (21, 22) in order to hydrate the drug and electrolyte reservoirs (15, 16) and activate the device (10). In another embodiment of the device (20), the drug and electrolyte reservoirs (15, 16) are initially separated from their respective electrodes (11, 12). After the reservoirs (15, 16) are hydrated, they are placed in electrical contact with their respective electrodes (11, 12). By joining the reservoir (15, 16) to the electrode (11, 12) after hydration occurs, delamination problems are reduced.

    摘要翻译： 提供了干态离子电渗药物输送装置（10,20）。 该装置具有最初处于非水合状态的药物和电解质储存器（15,16）。 在本发明的一个实施例中，通过支撑层（13）和施主电极组件（8）和对电极组件（9）的电极层（11,12）提供通道（21,22）。 水或其它液体可以通过这些通道（21,22）引入，以便水合药物和电解质储存器（15,16）并激活装置（10）。 在装置（20）的另一个实施例中，药物和电解质储存器（15,16）最初与它们各自的电极（11,12）分离。 在储存器（15,16）水合之后，它们与它们各自的电极（11,12）电接触。 通过在水合发生之后将储存器（15,16）连接到电极（11,12），降低了层叠问题。