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74 条记录 (耗时 0.046 秒)

    Blind rivet method
    31.
    发明授权
    Blind rivet method 有权
    盲铆法

    公开(公告)号：US07650681B2

    公开(公告)日：2010-01-26

    申请号：US11652962

    申请日：2007-01-12

    申请人： Steven V. Jones ,  Stephen Morris ,  James Hughes

    发明人： Steven V. Jones ,  Stephen Morris ,  James Hughes

    IPC分类号： B21D39/00 ,  F16B13/04

    CPC分类号： F16B19/1054 ,  Y10T29/4992 ,  Y10T29/49943 ,  Y10T29/49956

    摘要： There is provided a blind rivet including an axially extending hollow tubular body having a tail end face at one end and a pre-formed radially enlarged flange at the other end, together with a mandrel having a stem which extends co-axially though the body and having enlarged head adjacent the tail end of the body, the stem having a weakened region immediately adjacent the head. There is also provided a method of fastening at least two workpieces using such a blind rivet, including providing the blind side of the workpieces with a countersunk region to accommodate the conically deformed tail end of the body after setting, substantially flush therewith.

    摘要翻译： 提供了一种盲铆钉，其包括轴向延伸的中空管状体，其在一端具有尾端面，在另一端具有预成形的径向扩大的凸缘，以及具有杆的心轴，所述心轴具有贯穿本体的同轴延伸， 具有邻近身体的尾端的扩大的头部，杆具有紧邻头部的弱化区域。 还提供了一种使用这种盲铆钉紧固至少两个工件的方法，包括提供工件的盲侧，其具有埋头区域，以在安装之后基本上与其平齐地适应身体的锥形变形的尾端。

    Tissue positioning device
    32.
    发明申请
    Tissue positioning device 审中-公开
    组织定位装置

    公开(公告)号：US20090048683A1

    公开(公告)日：2009-02-19

    申请号：US12228560

    申请日：2008-08-13

    申请人： Stephen Morris ,  Thomas Weisel ,  Roger Pisarnwongs

    发明人： Stephen Morris ,  Thomas Weisel ,  Roger Pisarnwongs

    IPC分类号： A61F2/28

    CPC分类号： A61F2/40 ,  A61B17/56 ,  A61F2/30749 ,  A61F2/4657 ,  A61F2002/30583 ,  A61F2002/4088 ,  A61F2210/0085 ,  A61M29/02

    摘要： A tissue positioning device comprising a biocompatible member having a size and shape suitable for placement within a space adjacent to a tissue to be positioned and which acts to maintain the tissue in a desired position. The member may be a rigid or flexible spacer having a defined shape, or a bladder capable of receiving and being at least partially expanded by a filler material. The device can made from a variety of materials or a composite of materials as needed, and may include one or more attachment means by which it can be secured to nearby tissues such that it is maintained in a desired spatial location. The filler material can be any of a number of substances, including liquids, gases, a curable liquid such as bone cement or urethane foam, or a spring.

    摘要翻译： 一种组织定位装置，其包括生物相容性构件，其具有适于放置在与要定位的组织相邻的空间内的尺寸和形状，并且用于将组织保持在期望位置。 该构件可以是具有限定形状的刚性或柔性间隔件，或者能够接收并且至少部分地被填充材料膨胀的囊。 该装置可以根据需要由各种材料或材料的复合材料制成，并且可以包括一个或多个附接装置，通过该装置可将其固定到附近的组织，使得其保持在期望的空间位置。 填充材料可以是许多物质中的任何一种，包括液体，气体，诸如骨水泥或聚氨酯泡沫的可固化液体或弹簧。

    Self-piercing blind rivet
    33.
    发明申请
    Self-piercing blind rivet 有权
    自穿盲铆钉

    公开(公告)号：US20080178454A1

    公开(公告)日：2008-07-31

    申请号：US12075138

    申请日：2008-03-07

    申请人： Stephen Morris ,  Dan Smith

    发明人： Stephen Morris ,  Dan Smith

    IPC分类号： B21J15/10 ,  F16B13/04 ,  B23P11/00 ,  B21J15/02 ,  F16B19/08 ,  B23P19/00

    CPC分类号： F16B19/1054 ,  B21J15/025 ,  B21J15/043 ,  B21J15/14 ,  B21J15/32 ,  B21J15/36 ,  F16B19/086 ,  Y10T29/49837 ,  Y10T29/4994 ,  Y10T29/49943 ,  Y10T29/5343 ,  Y10T29/5373 ,  Y10T29/5377

    摘要： A self-piercing blind fastener comprising a mandrel having an elongate cylindrical shell mounted on a stem of such mandrel and which extends co-axially about a central elongate axis of the blind fastener, the shell having a radially extending flange at one end and a tail-end portion at the opposite end for insertion through a workpiece, the mandrel further having a mandrel head in operative engagement with the tail-end of the fastener for transmitting a setting force thereto during setting of such fastener, the blind fastener further comprising a longitudinally extending indenting member extending co-axial with and away from the tail-end of the blind fastener, which indenting member having a cross sectional area less than the cross sectional area of the shell.

    摘要翻译： 一种自穿孔盲链扣件，其包括具有安装在这种心轴的杆上的细长圆柱形壳体的心轴，并且围绕盲紧固件的中心细长轴线同轴地延伸，壳体在一端具有径向延伸的凸缘和尾部 在所述相对端的用于插入穿过工件的端部，所述心轴还具有心轴头部，所述心轴头部与所述紧固件的尾端有效接合，用于在所述紧固件的设置期间传递固定力，所述盲紧固件还包括纵向 延伸的缩进构件与盲链紧固件的尾端同轴并与其远离，该缩进构件的横截面积小于壳的横截面面积。

    Blind rivet method
    35.
    发明申请
    Blind rivet method 有权
    盲铆法

    公开(公告)号：US20070110540A1

    公开(公告)日：2007-05-17

    申请号：US11652962

    申请日：2007-01-12

    申请人： Steven Jones ,  Stephen Morris ,  James Hughes

    发明人： Steven Jones ,  Stephen Morris ,  James Hughes

    IPC分类号： F16B13/04

    CPC分类号： F16B19/1054 ,  Y10T29/4992 ,  Y10T29/49943 ,  Y10T29/49956

    摘要： There is provided a blind rivet comprising an axially extending hollow tubular body having a tail end face at one end and a pre-formed radially enlarged flange at the other end, together with a mandrel having a stem which extends co-axially though the body and having enlarged head adjacent the tail end of the body, the stem having a weakened region immediately adjacent the head, whereby the mandrel head having an outer diameter greater than an outer diameter of said body, usually by between 4% and 9%, and which has a uniform conical shoulder extending between said outer diameter of the head and the stem, so as to exert a setting force having an axial component for compressing the rivet body axially and an angular component effecting conical deformation of the tail end radially. There is also provided a method of fastening at least two workpieces using such a blind rivet, including providing the blind side of the workpieces with a countersunk region to accommodate the conically deformed tail end of the body after setting, substantially flush therewith.

    摘要翻译： 提供了一种盲铆钉，其包括轴向延伸的中空管状体，其在一端具有尾端面，在另一端具有预成型的径向扩大的凸缘，以及具有杆的心轴，所述心轴具有贯穿本体并且同轴延伸的杆， 具有与主体的尾端相邻的头部扩大的头部，杆具有紧邻头部的弱化区域，由此心轴头部的外径大于所述主体的外径，通常在4％和9％之间，并且其中 具有在所述头部和所述杆的所述外径之间延伸的均匀锥形肩部，以便施加具有轴向部件的固定力，以轴向压缩所述铆钉体，并且所述角部件径向地影响所述尾端的锥形变形。 还提供了一种使用这种盲铆钉紧固至少两个工件的方法，包括提供工件的盲侧，其具有埋头区域，以在安装之后基本上与其平齐地适应身体的锥形变形的尾端。

    Methods for killing PSMA-expressing, taxane-resistant cancer cells
    40.
    发明授权
    Methods for killing PSMA-expressing, taxane-resistant cancer cells 有权
    杀死PSMA表达，紫杉烷耐药性癌细胞的方法

    公开(公告)号：US09242012B2

    公开(公告)日：2016-01-26

    申请号：US13030105

    申请日：2011-02-17

    申请人： Dangshe Ma ,  William C. Olson ,  Stephen Morris ,  Robert J. Israel

    发明人： Dangshe Ma ,  William C. Olson ,  Stephen Morris ,  Robert J. Israel

    IPC分类号： A61K47/48 ,  A61K39/395

    CPC分类号： A61K47/48415 ,  A61K47/48638 ,  A61K47/6811 ,  A61K47/6869

    摘要： Methods of killing prostate-specific membrane antigen (PSMA)-expressing, taxane-resistant cancer cells are provided. In particular, PSMA-expressing, taxane-resistant cancer cells are contacted with an antibody-drug conjugate (ADC) that comprises an antibody or antigen-binding fragment thereof that specifically binds to PSMA conjugated to monomethylauristatin norephedrine or monomethylauristatin phenylalanine.

    摘要翻译： 提供了杀伤前列腺特异性膜抗原（PSMA）表达抗紫杉烷抗癌细胞的方法。 特别地，表达PSMA的抗紫杉类抗癌癌细胞与抗体 - 药物偶联物（ADC）接触，抗体 - 药物偶联物（ADC）包含特异性结合至与单甲基三磷酸脑奈他丹麻黄碱或单甲基海因素苯丙氨酸结合的PSMA的抗体或其抗原结合片段。