公开(公告)号：US06210408B1

公开(公告)日：2001-04-03

申请号：US09256977

申请日：1999-02-24

申请人： Verivada Chandrasekaran ,  Zihong Guo ,  Brooke Qin Ren ,  Byron Fedie

发明人： Verivada Chandrasekaran ,  Zihong Guo ,  Brooke Qin Ren ,  Byron Fedie

IPC分类号： A61B1818

CPC分类号： A61B18/1492 ,  A61B2017/22038 ,  A61B2017/22094 ,  A61B2018/00214 ,  A61B2018/00261 ,  A61B2018/00279 ,  A61B2018/00285 ,  A61B2018/0041 ,  A61B2018/00422 ,  A61B2018/00625 ,  A61B2018/1213 ,  A61B2018/1253 ,  A61B2018/1435 ,  A61B2018/144 ,  A61M25/09 ,  A61M25/10 ,  A61M2025/1047

摘要： A system for recanalizing an occluded blood vessel including a centering catheter employed to center an ablative guide wire within the blood vessel as the guide wire traverses the occlusion. The centering catheter includes a catheter body with an operative lumen through which the ablative guide wire is slidingly disposed. The centering catheter further includes a distally disposed centering mechanism that, when activated, centers the ablative guide wire within the blood vessel as it traverses the occlusion. The centering mechanism can comprise various embodiments including a single inflatable balloon or segmented inflatable balloon, which is in fluid communication with an inflation lumen. An airless preparation lumen may be disposed within the inflation lumen for ease of centering catheter preparation. The ablative guide wire includes insulation that is preferably formed of heat shrink tubing, which is stretched prior or concurrently with the heating process. The ablative guide wire includes a distal ablation tip having a non-traumatic structure and at least one discontinuous feature for creating high current densities for more efficient tissue ablation.

公开(公告)号：USD983896S1

公开(公告)日：2023-04-18

申请号：US29841112

申请日：2022-06-02

申请人： Zihong Guo

设计人： Zihong Guo

公开(公告)号：US09139351B2

公开(公告)日：2015-09-22

申请号：US12927981

申请日：2010-11-29

申请人： Fong-Li Chou ,  Geoffrey F. Deane ,  William Gates ,  Zihong Guo ,  Roderick A. Hyde ,  Edward K. Y. Jung ,  Nathan P. Myhrvold ,  Nels R. Peterson ,  Clarence T. Tegreene ,  Charles Whitmer ,  Lowell L. Wood, Jr.

发明人： Fong-Li Chou ,  Geoffrey F. Deane ,  William Gates ,  Zihong Guo ,  Roderick A. Hyde ,  Edward K. Y. Jung ,  Nathan P. Myhrvold ,  Nels R. Peterson ,  Clarence T. Tegreene ,  Charles Whitmer ,  Lowell L. Wood, Jr.

IPC分类号： B65D1/24 ,  B65D1/36 ,  B65D25/04 ,  B65D57/00 ,  B65D85/00 ,  F17C1/00 ,  F17C3/00 ,  F17C13/00 ,  F25D23/00 ,  A47J39/00 ,  A47J41/00 ,  B65D81/38 ,  A61J1/00 ,  F28D20/02

CPC分类号： B65D81/3806 ,  A61J1/00 ,  A61J2200/40 ,  F28D20/02

摘要： Substantially thermally sealed containers including flexible connectors joining an aperture in the exterior of the container to an aperture in a substantially thermally sealed storage region within the container are described. The flexible connectors include a duct forming an elongated thermal pathway between the exterior of the container and the substantially thermally sealed storage region within the container. The flexible connectors include compression units mated to each end of the duct and a plurality of compression strands connected between the compression units.

摘要翻译： 描述了基本上热密封的容器，其包括将容器的外部中的孔与容器内基本上热密封的存储区中的孔接合的柔性连接器。 柔性连接器包括在容器的外部和容器内基本上热密封的存储区域之间形成细长的热路径的管道。 柔性连接器包括与管道的每个端部配合的压缩单元和连接在压缩单元之间的多个压缩股。

公开(公告)号：US20130319900A1

公开(公告)日：2013-12-05

申请号：US13485027

申请日：2012-05-31

申请人： Lawrence Morgan Fowler ,  Zihong Guo ,  Jenny Hu ,  John Arthur Ohrt

发明人： Lawrence Morgan Fowler ,  Zihong Guo ,  Jenny Hu ,  John Arthur Ohrt

IPC分类号： B65D21/032 ,  B29C49/04

CPC分类号： B65D23/102 ,  B65D1/04 ,  B65D1/18 ,  B65D21/0231

摘要： The present disclosure relates to vessels and processes that may be used to fabricate vessels.

摘要翻译： 本公开涉及可用于制造血管的血管和过程。

公开(公告)号：US20120315364A1

公开(公告)日：2012-12-13

申请号：US13492664

申请日：2012-06-08

申请人： Cary Richard Champlin ,  Lawrence Morgan Fowler ,  Zihong Guo ,  Jenny E. Hu ,  Ian Fletcher Kent ,  Ian Murray ,  Nathan John Pegram ,  Shannon Weise Stone ,  Sarah Patricia Walters ,  Lowell L. Wood, JR. ,  Ozgur Emek Yildirim ,  Christopher C. Young

发明人： Cary Richard Champlin ,  Lawrence Morgan Fowler ,  Zihong Guo ,  Jenny E. Hu ,  Ian Fletcher Kent ,  Ian Murray ,  Nathan John Pegram ,  Shannon Weise Stone ,  Sarah Patricia Walters ,  Lowell L. Wood, JR. ,  Ozgur Emek Yildirim ,  Christopher C. Young

IPC分类号： A23C3/02

CPC分类号： A23L3/003 ,  A23C3/023 ,  A23L3/16

摘要： The present disclosure relates to methods, systems, and devices that may be used to heat treat and store one or more fluids.

摘要翻译： 本公开涉及可用于热处理和储存一种或多种流体的方法，系统和装置。

公开(公告)号：US08052604B2

公开(公告)日：2011-11-08

申请号：US11831048

申请日：2007-07-31

申请人： Michael P. H. Lau ,  Gregory Paul Darlington ,  Michael J. Connolly ,  Zihong Guo

发明人： Michael P. H. Lau ,  Gregory Paul Darlington ,  Michael J. Connolly ,  Zihong Guo

IPC分类号： A61B8/00 ,  A61B8/14

CPC分类号： A61B8/12 ,  A61B8/4209 ,  A61B8/4272 ,  A61B8/4281 ,  A61B8/445 ,  A61B17/2202 ,  A61B17/2256 ,  A61B17/4241 ,  A61B2017/2253 ,  A61B2017/4216 ,  A61B2018/00029 ,  A61B2090/3782 ,  A61B2090/3784 ,  A61N7/022

摘要： A combined imaging/HIFU probe includes an imaging scan head, a HIFU transducer, and an outlet port that delivers a flow of fluid across the HIFU transducer. At least a portion of the body cavity is filled with fluid in which the probe is immersed. The fluid provides a coupling for transmission of ultrasound energy between the probe and the patient. A flow of fluid may also be used to flush obstructions from an area of tissue near the HIFU transducer. Further described herein is a cuff to help retain fluid in the body cavity, a regulator to regulate fluid flow with respect to the body cavity according to a desired fluid pressure, and a cover for the HIFU transducer that has at least one perforation defined therethrough to allow fluid to flow through the cover. Further disclosed herein are methods of deploying a combined imaging/HIFU probe in a body cavity.

摘要翻译： 组合的成像/ HIFU探头包括成像扫描头，HIFU换能器和输出流体穿过HIFU换能器的出口。 体腔的至少一部分填充有探针浸入其中的流体。 流体提供用于在探针和患者之间传输超声能量的耦合。 流体流也可用于冲洗HIFU换能器附近的组织区域的障碍物。 本文进一步描述的是用于帮助保持体腔中的流体的袖带，根据期望的流体压力调节流体相对于体腔的流体的调节器，以及用于HIFU换能器的覆盖物，其具有至少一个穿过其定义的穿孔 允许流体流过盖子。 本文进一步公开的是将组合成像/ HIFU探针部署在体腔中的方法。

公开(公告)号：US20100213200A1

公开(公告)日：2010-08-26

申请号：US12658579

申请日：2010-02-08

申请人： Geoffrey F. Deane ,  Lawrence Morgan Fowler ,  William Gates ,  Zihong Guo ,  Roderick A. Hyde ,  Edward K.Y. Jung ,  Jordin T. Kare ,  Nathan P. Myhrvold ,  Nathan Pegram ,  Nels R. Peterson ,  Clarence T. Tegreene ,  Charles Whitmer ,  Lowell L. Wood, JR.

发明人： Geoffrey F. Deane ,  Lawrence Morgan Fowler ,  William Gates ,  Zihong Guo ,  Roderick A. Hyde ,  Edward K.Y. Jung ,  Jordin T. Kare ,  Nathan P. Myhrvold ,  Nathan Pegram ,  Nels R. Peterson ,  Clarence T. Tegreene ,  Charles Whitmer ,  Lowell L. Wood, JR.

IPC分类号： B65D81/38 ,  B23P11/00 ,  B65D79/00

CPC分类号： B65D81/3802 ,  B65D81/3811 ,  B65D81/3813 ,  B65D81/3823 ,  B65D81/3825 ,  B65D81/3834 ,  B65D81/3888 ,  B65D81/3897 ,  B65D2203/10 ,  Y10T29/49826

摘要： A substantially thermally sealed storage container includes an outer assembly, including one or more sections of ultra efficient insulation material substantially defining at least one thermally sealed storage region, and an inner assembly, including at least one heat sink unit within the at least one thermally sealed storage region, and at least one stored material dispenser unit, wherein the at least one stored material dispenser unit includes one or more interlocks.

摘要翻译： 基本上热密封的存储容器包括外部组件，其包括基本上限定至少一个热密封存储区域的一个或多个超高效绝缘材料部分和内部组件，所述内部组件包括至少一个热密封的至少一个散热器单元 存储区域和至少一个储存材料分配器单元，其中所述至少一个储存的材料分配器单元包括一个或多个互锁。

公开(公告)号：US20100144698A1

公开(公告)日：2010-06-10

申请号：US12703610

申请日：2010-02-10

申请人： Thomas Bannister ,  Cassandra Celatka ,  Nizal S. Chandrakumar ,  Hongfeng Deng ,  Zihong Guo ,  Lei Jin ,  Tsveltelina Lazarova ,  Jian Lin ,  Scott T. Moe ,  Pamela Nagafuji ,  Manuel Navia ,  Amy Ripka ,  Michael J. Rynkiewicz ,  Kerry L. Spear ,  James E. Stickler ,  Roger Xie

发明人： Thomas Bannister ,  Cassandra Celatka ,  Nizal S. Chandrakumar ,  Hongfeng Deng ,  Zihong Guo ,  Lei Jin ,  Tsveltelina Lazarova ,  Jian Lin ,  Scott T. Moe ,  Pamela Nagafuji ,  Manuel Navia ,  Amy Ripka ,  Michael J. Rynkiewicz ,  Kerry L. Spear ,  James E. Stickler ,  Roger Xie

IPC分类号： A61K31/397 ,  C07D205/04 ,  A61P9/00 ,  A61P7/00

CPC分类号： C07D405/06 ,  C07D205/08 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/14

摘要： Compounds are provided which have the structure Wherein A, B, C, D, m, Y, Ra, Rc, Rd, and Rd′ are as described herein, and which are useful as inhibitors of tryptase, thrombin, trypsin, Factor Xa, Factor VIIa, Factor XIa, and urokinase-type plasminogen activator and may be employed in preventing and/or treating asthma, chronic asthma, allergic rhinitis, and thrombotic disorders.

摘要翻译： 提供具有其中A，B，C，D，m，Y，Ra，Rc，Rd和Rd'如本文所述的结构的化合物，其可用作类胰蛋白酶，凝血酶，胰蛋白酶，因子Xa， 因子VIIa，因子XIa和尿激酶型纤溶酶原激活剂，可用于预防和/或治疗哮喘，慢性哮喘，过敏性鼻炎和血栓形成障碍。

公开(公告)号：US07501404B2

公开(公告)日：2009-03-10

申请号：US11398438

申请日：2006-04-04

申请人： Thomas Bannister ,  Cassandra Celatka ,  Nizal S. Chandrakumar ,  Hongfeng Deng ,  Zihong Guo ,  Lei Jin ,  Tsvetelina Lazarova ,  Jian Lin ,  Scott T. Moe ,  Pamela Nagafuji ,  Manuel Navia ,  Amy Ripka ,  Michael J. Rynkiewicz ,  Kerry L. Spear ,  James E. Stickler ,  Roger Xie

发明人： Thomas Bannister ,  Cassandra Celatka ,  Nizal S. Chandrakumar ,  Hongfeng Deng ,  Zihong Guo ,  Lei Jin ,  Tsvetelina Lazarova ,  Jian Lin ,  Scott T. Moe ,  Pamela Nagafuji ,  Manuel Navia ,  Amy Ripka ,  Michael J. Rynkiewicz ,  Kerry L. Spear ,  James E. Stickler ,  Roger Xie

IPC分类号： C07D205/08 ,  C07D205/085 ,  C07D401/14 ,  C07D401/12 ,  C07D401/06 ,  C07D403/12 ,  C07D403/14 ,  C07D403/04 ,  A61K31/397 ,  A61K31/506 ,  A61K31/4427 ,  A61K31/41

CPC分类号： C07D405/06 ,  C07D205/08 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/14

摘要： Compounds are provided which have the structure Wherein A, B, C, D, m, Y, Ra, Rc, Rd, and Rd′ are as described herein, and which are useful as inhibitors of tryptase, thrombin, trypsin, Factor Xa, Factor VIIa, Factor XIa, and urokinase-type plasminogen activator and may be employed in preventing and/or treating asthma, chronic asthma, allergic rhinitis, and thrombotic disorders.

摘要翻译： 提供具有其中A，B，C，D，m，Y，Ra，Rc，Rd和Rd'如本文所述的结构的化合物，其可用作类胰蛋白酶，凝血酶，胰蛋白酶，因子Xa， 因子VIIa，因子XIa和尿激酶型纤溶酶原激活剂，可用于预防和/或治疗哮喘，慢性哮喘，过敏性鼻炎和血栓形成障碍。

公开(公告)号：US06855722B2

公开(公告)日：2005-02-15

申请号：US10058215

申请日：2002-01-29

申请人： Tianbo Lu ,  Louis V. LaFrance ,  Thomas P. Markotan ,  Juan J. Marugan Sanchez ,  Victor J. Marder ,  David C. U'Prichard ,  Beth M. Anaclerio ,  Zihong Guo ,  Wenzi Pan ,  Kristi A. Leonard ,  Bruce E. Tomczuk

发明人： Tianbo Lu ,  Louis V. LaFrance ,  Thomas P. Markotan ,  Juan J. Marugan Sanchez ,  Victor J. Marder ,  David C. U'Prichard ,  Beth M. Anaclerio ,  Zihong Guo ,  Wenzi Pan ,  Kristi A. Leonard ,  Bruce E. Tomczuk

IPC分类号： A61K31/404 ,  A61K31/4375 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/5383 ,  A61P3/06 ,  A61P3/10 ,  A61P7/06 ,  A61P9/00 ,  A61P9/10 ,  A61P19/10 ,  A61P25/00 ,  A61P25/04 ,  A61P25/08 ,  A61P25/18 ,  A61P25/22 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D209/08 ,  C07D213/74 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D471/04 ,  C07D498/04

CPC分类号： C07D213/74 ,  C07D209/08 ,  C07D401/12 ,  C07D401/14 ,  C07D471/02 ,  C07D471/04 ,  C07D471/14

摘要： The present invention relates to novel substituted indole compounds that are antagonists of alpha V (αv) integrins, for example αvβ3 and αvβ5 integrins, their pharmaceutically acceptable salts, and pharmaceutical compositions thereof. The compounds may be used in the treatment of pathological conditions mediated by αvβ3 and αvβ5 integrins, including such conditions as tumor growth, metastasis, restenosis, osteoporosis, inflammation, macular degeneration, diabetic retinopathy, and rheumatoid arthritis. The compounds have the general formula: where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, D, X, W, a, m, n, i, j, k and v are defined herein.

摘要翻译： 本发明涉及作为αV（alphav）整联蛋白的拮抗剂的新型取代的吲哚化合物，例如阿尔法博3和阿尔法肽5整联蛋白，其药学上可接受的盐及其药物组合物。 这些化合物可以用于治疗由α1和α2融合蛋白介导的病理状态，包括肿瘤生长，转移，再狭窄，骨质疏松症，炎症，黄斑变性，糖尿病性视网膜病变和类风湿性关节炎等病症。 化合物具有以下通式：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8， R 9，R 10，R 11，R 12，R 13，R 14，D，X，W，a，m，n，i，j，k和v 。